Oligonephronia, not exuberant apoptosis, accounts for the development of glomerulosclerosis in the bcl-2 knockout mouse

Nephrology Dialysis Transplantation

Volumn 13, Issue 10, 1998, Pages 2509-2518

  Gassler, N ^a,e   Elger, M ^a   Inoue, D ^b,c   Kriz, W ^a   Amling, M ^b,d  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF TOKUSHIMA   (Japan)

^d UNIVERSITY OF HAMBURG   (Germany)

^e UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

Author keywords

bcl 2; Glomerulosclerosis; Pathology

Indexed keywords

PROTEIN BCL 2; URIDINE TRIPHOSPHATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; B CELL LEUKEMIA; B CELL LYMPHOMA; CONTROLLED STUDY; DNA NICK TRANSLATION; GLOMERULOSCLEROSIS; KIDNEY DEVELOPMENT; KIDNEY FAILURE; KIDNEY HYPERTROPHY; MALE; MORPHOMETRICS; MOUSE; NEPHRON; NONHUMAN; PRIORITY JOURNAL; PROTO ONCOGENE;

ANIMALS; APOPTOSIS; CELL COUNT; FEMALE; FOLLOW-UP STUDIES; GENE DELETION; GENES, BCL-2; GLOMERULOSCLEROSIS, FOCAL SEGMENTAL; HYPERTROPHY; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; KIDNEY GLOMERULUS; MALE; MICE; MICE, KNOCKOUT;

EID: 0031664217     PISSN: 09310509     EISSN: None     Source Type: Journal    
DOI: 10.1093/ndt/13.10.2509     Document Type: Article

References (39)

1. Hockenbery DM, Nunez G, Milliman C, Schreiber RD, Korsmeyer SJ. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 1990; 348: 334-336
2. Korsmeyer SJ. Bcl-2 initiates a new category of oncogenes: regulators of cell death. Blood 1992; 80: 879-886
3. Reed JC. Bcl-2 and the regulation of programmed cell death J Cell Biol 1993; 124: 1-6
4. Kane DJ, Sarafian TA, Anton R et al. Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species Science 1993; 262: 1274-1277
5. Rudin CM, Thompson CB. Apoptosis and disease Annu Rev Med 1997; 48: 267-281
6. Amling M, Neff L, Tanaka S et al. Bcl-2 lies downstream of PTHrP in a signaling pathway that regulates chondrocyte maturation during skeletal development. J Cell Biol 1997; 136: 205-213
7. Zhang KZ, Westberg JA, Hölttä E, Andersson L. Bcl2 regulates neural differentiation. Proc Natl Acad Sci USA 1996; 93: 4504-4508
8. Lu QL, Poulsom R, Wong L, Hanby AM. Bcl-2 expression in adult and embryonic non-hematopoietic tissues. J Pathol 1993; 169: 431-437
9. Koseki C, Herzlinger D, Al Awquati Q. Apoptosis in metanephric development. J Cell Biol 1992; 119: 1327-1333
10. Chandler D, El-Naggar AK, Brisbay S, Redline R, McDonnell T. Apoptosis and expression of the bcl-2 protooncogene in the fetal and adult human kidney: evidence for the contribution of bcl-2 expression to renal carcinogenesis. Hum Pathol 1994; 25: 789-796
11. Nakopoulou L, Stefanaki K, Papadakis J et al. Expression of bcl-2 oncoprotein in various types of glomerulonephritis and renal allografts. Nephrol Dial Transplant 1996; 11: 997-1002
12. Veis DJ, Sorenson CM, Shutter JR, Korsmeyer SJ. Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair. Cell 1993; 75: 229-240
13. Nakayama K, Nakayama KI, Negishi I, Kuida K, Sawa H, Loh DY. Targeted disruption of Bcl-2ab in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopenia. Proc Natl Acad Sci USA 1994; 91: 3700-3704
14. Nagata M, Nakauchi H, Nakayama K-I, Nakayma K, Loh D, Watanabe T. Apoptosis during an early stage of nephrogenesis induces renal hypoplasia in bcl-2 deficient mice. Am J Pathol 1996; 148: 1601-1611
15. Sorenson CM, Padanilam BJ, Hammerman MR. Abnormal postpartum renal development and cystogenesis in the bcl-2 (-/-) mouse. Am J Physiol 1996; 271: F184-F193
16. Sorenson CM, Rogers SA, Korsmeyer SJ, Hammerman MR. Fulminant metanephric apoptosis and abnormal kidney development in bcl-2-deficient mice. Am J Physiol 1995; 268: F73-F81
17. Savill J, Mooney A, Hughes J. What role does apoptosis play in progression of renal diseases? Curr Opin Nephrol Hypertens 1996; 5: 369-374
18. Baker AJ, Mooney A, Hughes J, Lombardi D, Johnson RJ, Savill J. Mesangial cell apoptosis: the major mechanism for resolution of glomerular hypercellularity in experimental mesangial proliferative nephritis. J Clin Invest 1994; 94: 2105-2116
19. Savill J. Apoptosis in resolution of inflammation. J Leukoc Biol 1997; 61: 375-380
20. Sugiyama H, Kashihara N, Makino H, Yamasaki Y, Ota Z. Apoptosis in glomerular sclerosis. Kidney Int 1996; 49: 103-111
21. Gunderson HJ. Estimators of the number of objects per area unbiased by edge effects. Microsc Acta 1978; 81: 107-117
22. Weibel ER. Stereological methods: Practical methods for biological morphometry, Academic Press, Inc., London, 1979; 35-51
23. G) from single sections using the Weibel-Gomez (WG) method. (abstract) JASN 1997; 8: 621A
24. Majno G, Joris I. Apoptosis, oncosis, and necrosis. Am J Pathol 1995; 146: 3-15
25. Kerr JFR, Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 1972; 26: 239-257
26. Gavrieli Y, Sherman Y, Ben-Sasson SH. Identification of programmed cell death in situ via specific labelling of nuclear DNA fragmentation. J Cell Biol 1992; 119: 493-501
27. Arends MJ, Morris KG, Wyllie AH, Apoptosis. The role of the endonuclease. Am J Pathol 1990; 136: 593-608
28. Hostetter TH. Progression of renal disease and renal hypertrophy. Annu Rev Physiol 1995; 57: 263-278
29. Anderson S, Brenner BM. The role of nephron mass and of intraglomerular pressure in initiation and progresson of experimental hypertensive-renal disorders. ln: Laragh JH, Brenner BM, ed. Hypertension, Pathophysiology, Diagnosis and Management. Raven Press, New York., 1989; 1553-1568
30. Kriz W, Kretzler M, Nagata M et al. A frequent pathway to glomerulosclerosis: Deterioration of tuft arehitecture-podocyte damage-segmental sclerosis. Kidney Blood Press Res 1996; 19: 245-253
31. Kriz W. Progressive renal failure-inabilily of podocytes to replicate and the consequences for development of glomerulosclerosis. Nephrol Dial Transplant 1996; 11: 1738-1742
32. Floege J, Hackmann B, Kliem V et al. Age-related glomerulosclerosis and interstitial fibrosis in Milan normotensive rats: A podocyte disease. Kidney Int 1997; 51: 230-243
33. Shirato I, Hosser H, Kimura K, Sakai T, Tomino Y, Kriz W. The development of focal segmental glomerulosclerosis in Masugi nephritis is based on progressive podocyte damage. Virchows Arch 1996; 429: 255-273
34. Kriz W. Evolving role of the podocyte in chronic renal failure. Kidney Blood Press Res 1997; 20: 180-183
35. Foster SV, Hawkins EP. Deficient metanephric blastema - a cause of oligomeganphronia? Pediatr Pathol 1994; 14: 935-943
36. Nomura S, Osawa G. Focal glomerular sclerotic lesions in a patient with unilateral oligomeganphronia and agenesis of the contralateral kidney: a case report. Clin Nephrol 1990; 33: 7-11
37. Elfenbein IB, Baluarte HJ, Gruskin AB. Renal hypoplasia with oligomeganephronia. Arch Pathol 1974; 97: 143-149
38. Morita T, Wenzl J, McGoy J, Porch J, Kimmelstiel P. Bilateral renal hypoplasia with oligomeganephronia: quantitative and electron microscopic study. Am J Clin Pathol 1973; 59: 104-112
39. Rennke HG, Klein PS. Pathogenesis and significance of nonprimary focal and segmental glomerulosclerosis. Am J Kidney Dis 1989; 13: 443-456