A frequent pathway to glomerulosclerosis: Deterioration of tuft architecture - podocyte damage - segmental sclerosis

Kidney and Blood Pressure Research

Volumn 19, Issue 5, 1996, Pages 245-253

  Kriz, Wilhelm ^a   Kretzler, Matthias ^b   Nagata, Michio ^c   Provoost, Abraham P ^d   Shirato, Isvao ^e   Uiker, Sören ^f   Sakai, Tatsuo ^e   Lemley, Kevin V ^g  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^c UNIVERSITY OF TSUKUBA   (Japan)

^d ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

^e JUNTENDO UNIVERSITY   (Japan)

^f Heinrich Lanz Krankenhaus   (Germany)

^g STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Focal segmental glomerulosclerosis; Glomerular architecture; Podocyte damage

Indexed keywords

ARCHITECTURE; ARTICLE; CAPILLARY; CELL ADHESION; CELL DAMAGE; FOCAL GLOMERULOSCLEROSIS; GLOMERULOSCLEROSIS; MECHANICAL STRESS; MESANGIUM; MICROANEURYSM; PODOCYTE; PRIORITY JOURNAL;

ANIMALS; GLOMERULOSCLEROSIS, FOCAL SEGMENTAL; HUMANS; KIDNEY GLOMERULUS; RATS;

EID: 0029946426     PISSN: 14204096     EISSN: 14230143     Source Type: Journal    
DOI: 10.1159/000174083     Document Type: Article

References (33)

1. Krctzler M, Koeppen-Hagemann I, Kriz W: Po-docytc damage is a critical step in the development of glomerulosclerosis in the uninephrec-tomised-dcsoxycortieosterone rat, Virchows Arch [A] 1994:452:181-193.
2. Nagala M, Scharecr K, Kriz W: Glomerular damage after uninephrectomy in young rats, I, Hypertrophy and distortion of capillary architecture, Kidney Int 1992:42:136-147.
3. Nagata M, Kriz W: Glomerular damage after uninephrectomy in young rats, II, Mechanical stress on podocyles as a pathway to sclerosis, Kidney Int 1992:42:148-160.
4. Kriz W: Progressive renal failure inability of podocytcs to replicate and resulting consequences for development of glomerulosclerosis, Nephrol Dial Transplant 1996:11:1738-1742.
5. Kriz VV, I lahnet B, Rdsencr S, Eiger M: Longterm treatment of rats with FGF-2 results in focal segmental glomerulosclerosis, Kidney Int 1995:48:1435-1450.
6. Shirato I, Sakai T, Kimura K, Tomino Y, Kriz W: Cytoskeletal changes in podocytes associated with foot process effaccmcnt in Masugi nephritis, Am .1 Pathol 1996:148:1283-1296.
7. Shirato J, Hosser H, Kimura K, Sakai T, Tomino Y, Kriz VV: The development of focal segmental glomerulosclerosis in Masugi nephritis is based on progressing podocyte damage, Virchows Arch 1996: in press.
8. Kriz VV, Hosser H, Provoost AP: Podocyte damage is a major step in the development of glomerulosclerosis in the Fawn-hooded rat (abstract), Kidney Int 1995:47:986.
9. Sakai T, Kriz VV: The structural relationship between mesangial cells and basement membrane of the renal glomerulus, Anal Embryol 1987; 176:373-386.
10. Lemley KV, Eiger M, Koeppen-Hagemann I, Krctzler M, Nagata M, Sakai T, Uiker S, Kriz VV: The glomerular mesangium: Capillary support function and its failure under experimental conditions, Clin Invest 1992:70:843-856.
11. Kriz VV, Hackcnthal E, Nobiling R, Sakai T, Eiger M: A role for podocytes to counteract capillary wall distension, Kidney Int 1994:45:369-376.
12. Kriz VV, Mündel P, Elger M: The contractile apparatus of podocytes is arranged to counteract GBM expansion, ContrNephrol, Basel, Karger. 1994, vol 107, pp 1-9.
13. Kriz VV, Elger M, Mündel P, Lemley KV: Structure-stabilizing forces in the glomerular tuft, .J Am Soc Nephrol 1995:5:1731-1739.
14. Mündel P, Kriz VV: Structure and function of podocytes: An update, Anat Embryol 1995:192: 385-397.
15. Sakai T, Lemley KV, Hackenthal E, Nagata M, Nobiling R, Kriz W; Changes in glomerular structure following acute mesangial failure in the isolated perfused kidney, Kidney Int 1992: 41:533-541.
16. Miller PL, Meyer TW: Methods in laboratory investigation: Effects of tissue preparation on glomerular volume and capillary structure in the rat, Lab Invest 1990:63:862-866.
17. Riser BL, Cortes P, Zhao X, Bernstein J, Dum-ler F, Narins RG: Intraglomcrular pressure and mesangial stretching stimulate extracellular matrix formation in the rat, J Clin Invest 1992: 90:1932-1943.
18. Cortes P, Zhao X, Riser BL, Narins RG: Regulation of glomerular volume in normal and partially nephrectomizcd rats, Am .1 Physiol 1996: 270:F356-F370.
19. Welling LW, Zupka MT, Welling DJ: Mechanical properties of basement membrane, News Physiol Sei 1995:10:30-35.
20. Andrews PM: Morphological alterations of the glomerular (visceral) epithelium in response to pathological and experimental situations, J Elcctr Microsc Tech 1988:9:115-144.
21. Vasmant D, Maurice M, Feldmann G: Cytoske-leton ultrastructure of podocytes and glomerular endothelial cells in man and in the rat, Anat Rcc 1984;210:17-24.
22. Drcnckhahn D, Franke RP: Ultrastructural organization of contractile and cytoskeletal proteins in glomerular podocytes of chicken, rat, and man, Lab Invest 1988:59:673-682.
23. Cybulsky AV, Carbonetto S, Huang Q, McTav-ish AJ, Cyr M-D: Adhesion of rat glomerular epithelial cells to extracellular matrices: Roleof hintegrins, Kidney Int 1992:42:1099-1106.
24. Kcrjaschki D, Ojha PP, Susani M, Horvat R, Binder S, Hovorka A, Hillemanns P, Pytela R: A 31 -integrin receptor for fibronectin in human kidney glomeruli, Am J Pathol 1989:134:481-489.
25. Kriz W, Eiger M, Nagata M, Krctzler M, Uiker S, Koeppen-Hagemann I, Tenschcrt S, Lemley KV: The role of podocytes in the development of glomerular sclerosis, Kidney Int 1994: 45(suppl 45):S64-S72.
26. Uiker S, Kriz VV: Structural analysis of the formation of glomerular microaneurysms in the I tabu venom model, Virchows Arch 1995:426: 281-293.
27. Fries JW, Sandstrom DJ, Meyer TW, Rennke HG: Glomerular hypertrophy and epithelial cell injury modulate progressive glomerulosclerosis in the rat, Lab Invest 1989:60:205-218.
28. Nagata M, Yamaguchi Y, Komatsu Y, Ito K: Mi-tosisand the presence of binueleate cells among glomerular podocytes in diseased human kidneys, Nephron 1995:70:68-71.
29. O’Meara YM, Natori Y, Minto AW, Goldstein DJ, Manning F.C, Salant DJ: Ncphritogenic antiserum identifies a b I-integrin on rat glomerular epithelial cells, Am J Physiol 1992; 262: F1083-F1091.
30. Cho CR, Lumsden CJ, Whiteside Cl: Epithelial cell detachment in the nephrotic glomerulus: A receptor co-operativity model, J Theoret Biol 1993:160:407-426.
31. Rennke HG: How does glomerular epithelial cell injury contribute to progressive glomerular damage? Kidney Int 1994:45(suppl 45):S58-S63.
32. Howie AJ, Kizaki T, Beaman M, Morland CM, Birtwistle RJ, Adu D, Michael J, Williams AJ, Walls J, Matsuyama M, Shimizu F: Different types of segmental sclerosing glomerular lesions in six experimental models of proteinuria, J Pathol 1989:157:141-151.
33. Daniels BS, Hostettcr TH: Adverse effects of growth in the glomerular microcirculation, Am J Physiol 1990:258: F1409-F1416.