Additional evidence for an association between the dopamine D4 receptor (D4DR) exon III seven-repeat allele and substance abuse in opioid dependent subjects: Relationship of treatment retention to genotype and personality

Addiction Biology

Volumn 3, Issue 4, 1998, Pages 473-481

  Mel, Haim ^a   Horowitz, Ronit ^a   Ohel, Naomi ^a   Kramer, Ilana ^b   Kotler, Moshe ^a   Cohen, Hagit ^a   Gritsenko, Inga ^c   Ebstein, Richard P ^c  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^b HAEMEK MEDICAL CENTER   (Israel)

^c HERZOG HOSPITAL   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

DIAMORPHINE; DOPAMINE 3 RECEPTOR; DOPAMINE 4 RECEPTOR; OPIATE;

ADULT; ALLELE; ARTICLE; ATTENTION DEFICIT DISORDER; AVOIDANCE BEHAVIOR; CONTROLLED STUDY; DRUG DEPENDENCE; EXON; GENETIC POLYMORPHISM; GENOTYPE; HEROIN DEPENDENCE; HIGH RISK POPULATION; HUMAN; IMPULSIVENESS; MAJOR CLINICAL STUDY; MALE; PERSONALITY; PRIORITY JOURNAL; RECEPTOR GENE; SUBSTANCE ABUSE;

EID: 0031659309     PISSN: 13556215     EISSN: None     Source Type: Journal    
DOI: 10.1080/13556219872029     Document Type: Article

References (57)

1. Kotler M, Cohen H, Segman R et al. Excess dopamine D4 receptor (D4DR) exon III seven repeat allele in opioid-dependent subjects. Mol Psychiatry 1997;2:251-4.
2. Ebstein RP, Novick O, Umansky R et al. Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of novelty seeking. Nat Genet 1996;12:78-80.
3. Benjamin J, Li L, Patterson C, Greenberg BD, Murphy DL, Hamer DH. Population and familial association between the D4 dopamine receptor gene and measures of novelty seeking. Nat Genet 1996;12:81-4.
4. Ebstein RP, Belmaker RH. Saga of an adventure gene: novelty seeking, substance abuse and the dopamine D4 receptor (D4DR) exon III repeat polymorphism. Mol Psychiatry 1997;2:381-4.
5. Malhotra AK, Virkkunen M, Rooney W, Eggert M, Linnoila M, Goldman D. The association between the dopamine D4 receptor (D4DR) 16 amino acid repeat polymorphism and novelty seeking. Mol Psychiatry 1996;1:388-91.
6. Vandenbergh DJ, Zonderman AB, Wang J, Uhl GR, Costa Jr PT. No association between novelty seeking and dopamine D4 receptor (D4DR) exon III seven repeat alleles in Baltimore Longitudinal Study of Aging participants. Mol Psychiatry 1997; 2:417-19.
7. Jonsson EG, Nothen MM, Gustavsson JP et al. Lack of evidence for allelic association between personality traits and the dopamine D4 receptor gene polymorphisms. Am J Psychiatry 1997;154: 697-9.
8. Ono Y, Manki H, Yoshimura K et al. Association between dopamine D4 receptor (D4DR) exon III polymorphism and novelty seeking in Japanese subjects [In Process Citation]. Am J Med Genet 1997; 74:501-3.
9. Howard MO, Kivlahan D, Walker RD. Cloninger's tridimensional theory of personality and psychopathology: applications to substance use disorders. J Stud Alcohol 1997;58:48-66.
10. Downey KK, Stelson FW, Pomerleau OF, Giordani B. Adult attention deficit hyperactivity disorder: psychological test profiles in a clinical population. J Nerv Ment Dis 1997;185:32-8.
11. Carroll KM, Rounsaville BJ. History and significance of childhood attention deficit disorder in treatment-seeking cocaine abusers. Compr Psychiatry 1993;34:75-82.
12. LaHoste GJ, Swanson JM, Wigal SB et al. Dopamine D4 receptor gene polymorphism is associated with attention deficit hyperactivity disorder. Mol Psychiatry 1996;1:121-4.
13. Cloninger CR, Sigvardsson S, Przybeck TR, Svrakic DM. Personality antecedents of alcoholism in a national area probability sample. Eur Arch Psychiatry Clin Neurosci 1995;245:239-44.
14. Cloninger CR, Sigvardsson S, Gilligan SB, von Knorring AL, Reicht T, Bohman M. Genetic heterogeneity and the classification of alcoholism. Adv Alcohol Subst Abuse 1988;7:3-16.
15. Nestler EJ, Hope BT, Widnell KL. Drug addiction: a model for the molecular basis of neural plasticity. Neuron 1993;11:995-1006.
16. Koob GF, Nestler EJ. The neurobiology of drug addiction. J Neuropsychiatry Clin Neurosci 1997; 9:482-97.
17. Jaber M, Jones S, Giros B, Caron MG. The dopamine transporter: a crucial component regulating dopamine transmission. Mov Disord 1997;12: 629-33.
18. Volkow ND, Fowler JS, Galley SJ et al. PET evaluation of the dopamine system of the human brain. J Nucl Med 1996;37:1242-56.
19. Tiihonen J, Kuikka J, Bergstrom K, et al. Altered striatal dopamine re-uptake site densities in habitually violent and non-violent alcoholics. Nat Med 1995;1:654-7.
20. Volkow ND, Wang GJ, Fowler JS. Imaging studies of cocaine in the human brain and studies of the cocaine addict. Ann N Y Acad Sci 1997;820:41-54; discussion 54-5.
21. Volkow ND, Wang GJ, Fowler JS et al. Decreased striatal dopaminergic responsiveness in detoxified cocaine-dependent subjects. Nature 1997;386: 830-3.
22. Volkow ND, Wang GJ, Fischman MW, et al. Relationship between subjective effects of cocaine and dopamine transporter occupancy. Nature 1997; 386:827-30.
23. Lichter JB, Barr CL, Kennedy JL, Van Tol HH, Kidd KK, Livak KJ. A hypervariable segment in the human dopamine receptor D4 (DRD4) gene. Hum Mol Genet 1993;2:767-73.
24. Asghari V, Sanyal S, Buchwaldt S, Paterson A, Jovanovic V, Van Tol HH. Modulation of intracellular cyclinc AMP levels by different human dopamine D4 receptor variants. J Ncurochem 1995;65: 1157-65.
25. Van Tol HH, Bunzow JR, Guan HC et al. Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine. Nature 1991;350:610-14.
26. Van Tol HH, Wu CM, Guan HC et al. Multiple dopamine D4 receptor variants in the human population. Nature 1992;358:149-52.
27. Van Tol HH. The dopamine D4 receptor. NIDA Res Monogr 1996;161:20-38.
28. Rubinstein M, Phillips TJ, Bunzow JR et al. Mice lacking dopamine D4 receptors are supersensitive to ethanol, cocaine, and methamphetamine. Cell 1997;90:991-1001.
29. Li T, Xu K, Deng H et al. Association analysis of the dopamine D4 gene exon III VNTR and heroin abuse in Chinese subjects. Mol Psychiatry 1997;2: 413-16.
30. Muramatsu T, Higuchi S, Murayama M, Matsushita S, Hayashida M. Association between alcoholism and the dopamine D4 receptor gene. J Med Genet 1996;33:113-15.
31. Geijer T, Jonsson E, Neiman J et al. Tyrosine hydroxylase and dopamine D4 receptor allelic distribution in Scandinavian chronic alcoholics. Alcohol Clin Exp Res 1997;21:35-9.
32. Goldman D, Knowler WC, Hanson RL et al. Autosome-wide scan for alcohol dependence in southwestern American indians provides suggestive evidence for loci on chromosomes 4 and 11. Am J Med Genet (Neuropsychiatric Genet) 1997;74: 574-5.
33. Crocq MA Mant R, Asherson P et al. Association between schizophrenia and homozygosity at the dopamine D3 receptor gene. J Med Genet 1992; 29:858-60.
34. Chen CH, Liu MY, Wei FC, Koong FJ, Hwu HG, Hsiao KJ. Further evidence of no association between Ser9Gly polymorphism of dopamine D3 receptor gene and schizophrenia. Am J Med Genet 1997;74:40-3.
35. Ebstein RP, Macciardi F, Heresco-Levi U et al. Evidence for an association between the dopamine D3 receptor gene DRD3 and schizophrenia. Hum Hered 1997;47:6-16.
36. Adamson MD, Kennedy J, Petronis A et al. DRD4 dopamine receptor genotype and CSF monoamine metabolites in Finnish alcoholics and controls. Am J Med Genet 1995;60:199-205.
37. Falk CT, Rubenstein P. Haplotype relative risk: an easy reliable way to construct a proper control sample for risk calculations. Ann Hum Genet 1987; 51:227-33.
38. Goldin LR, Martinez MM, Gershon ES. Sampling strategies for linkage studies. Eur Arch Psychiatry Clin Neurosci 1991;240:182-7.
39. Spielman RS, McGinnis RE, Ewans WJ. Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet 1993;52:506-16.
40. Sterling RC, Gottheil E, Glassman SD, Weinstein SP, Scrota RD. Patient treatment choice and compliance. Data from a substance abuse treatment program. Am J Addict 1997;6:168-76.
41. Madden PA, Bucholz KK, Dinwiddie SH et al. Nicotine withdrawal in women. Addiction 1997; 92:889-902.
42. McKay JR, Cacciola JS, McLellan AT, Alterman AI, Wirtz PW. An initial evaluation of the psychosocial dimensions of the American Society of Addiction Medicine criteria for inpatient versus intensive outpatient substance abuse rehabilitation. J Stud Alcohol 1997;58:239-52.
43. Gottheil E, Thornton CC, Weinstein SP. Treatment structure, client coping methods, and response to brief individual counseling: preliminary findings in a substance dependent sample. J Addict Dis 1997; 16:51-65.
44. Hedeker D, Mermelstein RJ. Application of random-effects regression models in relapse research. Addiction 1996;91 Suppl:S211-29.
45. Breteler MH, Van den Hurk AA, Schippers GM, Meerkerk GJ. Enrollment in a drug-free detention program: the prediction of successful behavior change of drug-using inmates, Addict Behav 1996; 21:665-9.
46. Meehan W, Le OC, Berry JW, Weiss J, Morrison A, Acampora A. Guilt, shame, and depression in clients in recovery from addiction. J Psychoact Drugs 1996;28:125-34.
47. Cacciola JS, Alterman AI, Rutherford MJ, Snider EC. Treatment response of antisocial substance abusers. J Nerv Ment Dis 1995;183:166-71.
48. Battaglia M, Przybeck TR, Bellodi L, Cloninger CR. Temperament dimensions explain the comorbidity of psychiatric disorders. Compr Psychiatry 1996;37:292-8.
49. Vukov M, Bab-Milkic N, Lecic D, Mijalkovic S, Marinkovic J. Personality dimensions of opiate addicts. Acta Psychiatr Scand 1995;91:103-7.
50. Bulik CM, Sullivan PF, McKee M, Weltzin TE, Kaye WH. Characteristics of bulimic women with and without alcohol abuse. Am J Drug Alcohol Abuse 1994;20:273-83.
51. Sutherland I. The development and application of a questionnaire to assess the changing personalities of substance addicts during the first year of recovery. J Clin Psychol 1997;53:253-62.
52. Lamon BC, Alonzo A. Stress among males recovering from substance abuse. Addict Behav 1997;22:195-205.
53. Chien AJ, Dunner DL. The Tridimensional Personality Questionnaire in depression: state versus trait issues. J Psychiatr Res 1996;30:21-7.
54. Yoshino A, Kato M, Takeuchi M, Ono Y, Kitamura T. Examination of the tridimensional personality hypothesis of alcoholism using empirically multivariate typology. Alcohol Clin Exp Res 1994;18: 1121-4.
55. Cannon DS, Keefe CK, Clark LA. Persistence predicts latency to relapse following inpatient treatment for alcohol dependence. Addict Behav 1997; 22:535-43.
56. Sellman JD, Mulder RT, Sullivan PF, Joyce PR. Low persistence predicts relapse in alcohol dependence following treatment. J Stud Alcohol 1997;58: 257-63.
57. Tsuang M, Lyons MJ, Eisen SA et al. Genetic influences on DSM-III-R drug abuse and dependence: a study of 3,372 twin pairs. Am J Med Genet (Neuropsychiatr Genet) 1996;67:473-7.