Saga of an adventure gene: Novelty seeking, substance abuse and the dopamine D4 receptor (D4DR) exon III repeat polymorphism

Molecular Psychiatry

Volumn 2, Issue 5, 1997, Pages 381-384

  Ebstein, R P ^a   Belmaker, R H ^b  

^a HERZOG HOSPITAL   (Israel)

^b BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

DOPAMINE 2 RECEPTOR; DOPAMINE 4 RECEPTOR; DRD4 PROTEIN, HUMAN;

ADDICTION; ARTICLE; EXON; EXPLORATORY BEHAVIOR; FEMALE; GENETIC POLYMORPHISM; GENETICS; HUMAN; MALE; PERSONALITY; PHYSIOLOGY;

EXONS; EXPLORATORY BEHAVIOR; FEMALE; HUMANS; MALE; PERSONALITY; POLYMORPHISM, GENETIC; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D4; SUBSTANCE-RELATED DISORDERS;

EID: 0031229919     PISSN: 13594184     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.mp.4000315     Document Type: Article

References (7)

1. Vandenbergh DJ, Zonderman AB, Wang J, Uhl GR, Costa FT Jr. No association between Novelty Seeking and dopamine d4 receptor (D4DR) exon III seven repeat alleles in Baltimore Longitudinal Study of Aging participants. Mol Psychiatry 1997; 2: 417-419.
2. Li T, Xu K, Deng H, Cai G, Liu J, Liu X, Wang R, Xiang X, Zhao J, Murray RM, Sham PC, Collier DA. Association analysis of the dopamine D4 exon III VNTR and heroin abuse in Chinese subjects. Mol Psychiatry 1997; 2: 413-416.
3. Ebstein RP, Novick O, Umansky R, Priel B, Osher Y, Blaine D, Bonnett ER, Nemanov L, Katz M, Belmaker RH. D4DR exon III poly-morphism associated with the personality trait of Novelty Seekino in normal human volunteers. Nature Genet 1996; 12: 78-80.
4. Benjamin J, Greenberg B, Murphy DL, Li L, Patterson C, Hamer D. Mapping personality traits to genes: population and family association between the D4 dopamine receptor and measures of novelty seeking. Nature Genet 1996; 12: 81-84.
5. Malhotra AK, Virkunnen M, Rooney W, Eggert M, Linnoila M, Goldman D. The association between the dopamine D4 receptor (D4DR) 16 amino acid repeat polymorphism and Novelty Seeking. Mol Psychiatry 1996; 1: 388-391.
6. Jonsson EG, Nothen MM, Gustavsson JP, Neidt H, Brene S, Tylec A, Propping P, Sedvall GC. Lack of evidence for allelic association between personality traits and the dopamine D4 receptor gene polymorphisms. Am J Psychiatry 1997; 154: 697-699.
7. Ono Y, Manki H, Yoshimura K, Muramatsu T, Higuchi S, Yagi G, Kanba S, Asai M. Association between dopamine D4 receptor (D4DR) exon III polymorphism and Novelty Seeking in Japanese subjects. Am J Med Genetics (Neuropsychiatric Gen) 1997; (in press).