The α-adrenoceptor antagonist idazoxan is an agonist at 5-HT(1A) autoreceptors modulating serotonin synthesis in the rat brain in vivo

Neuroscience Letters

Volumn 218, Issue 2, 1996, Pages 111-114

  Lladó, Jerònia ^a   Esteban, Susana ^a   García Sevilla, Jesús A ^a  

^a UNIVERSITAT DE LES ILLES BALEARS   (Spain)

Author keywords

2 Autoreceptors; 2 Heteroreceptors; 5 HT(1A) autoreceptors; Dopa 5 HTP synthesis; Idazoxan; Phentolamine; Rat brain; Rauwolscine

Indexed keywords

5 HYDROXYTRYPTOPHAN; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; AUTORECEPTOR; DOPA; IDAZOXAN; N TERT BUTYL 3 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL] 2 PHENYLPROPIONAMIDE; PHENTOLAMINE; RAUWOLSCINE; SEROTONIN 1A RECEPTOR; SEROTONIN ANTAGONIST; SEROTONIN; SEROTONIN AGONIST; YOHIMBINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; ANIMAL; BRAIN CORTEX; DOSE RESPONSE; DRUG EFFECT; HIPPOCAMPUS; METABOLISM; SPRAGUE DAWLEY RAT;

ANIMALS; CEREBRAL CORTEX; DIHYDROXYPHENYLALANINE; DOSE-RESPONSE RELATIONSHIP, DRUG; HIPPOCAMPUS; IDAZOXAN; MALE; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN; SEROTONIN AGONISTS; YOHIMBINE;

EID: 0030273912     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(96)13132-3     Document Type: Article

References (17)

1. [1] Carlsson, A., Davis, J.N., Kehr, W., Lindqvist, M. and Atack, C.V., Simultaneous measurement of tyrosine and tryptophan hydroxylase activities in brain in vivo using an inhibitor of the aromatic amino acid decarboxylase, Naunyn-Schmiedeberg's Arch. Pharmacol, 275 (1972) 153-168.
2. 2-adrenoceptor antagonists and potential antidepressants, J. Med. Chem, 26 (1983) 823-831.
3. 1A receptors in human frontal cortex membranes, Eur. J. Pharmacol. (Mol. Pharmacol. Section), 207 (1991) 1-8.
4. [4] Dennis, T., Heureux, R.L., Carter, C. and Scatton, B., Presynaptic alpha-2 adrenoceptors play a major role in the effects of idazoxan on cortical noradrenaline release (as measured by in vivo dialysis), J. Pharmacol. Exp. Ther., 241 (1987) 642-649.
5. 2-adrenoceptors, Br. J. Pharmacol., 78 (1983) 489-505.
6. 2-adrenoceptor subtypes, Naunyn-Schmiedeberg's Arch. Pharmacol., 353 (1996) 391-399.
7. [7] Fernstrom, M.H., Massoudi, M.S. and Fernstrom, J.D., Effect of 8-hydroxy-2(di-N-propylamino)-tetralin on the tryptophan-induced increase in 5-hydroxytryptophan accumulation in rat brain, Life Sci., 47 (1990) 283-289.
8. 1A receptors, Eur. J. Pharmacol., 237 (1993) 283-291.
9. [9] Haddjeri, N., Blier, P. and De Montigny, C, Effect of the alpha-2 adrenoceptor antagonist mirtazapine on the 5-hydroxytryptamine system in the rat brain, J. Pharmacol. Exp. Ther., 277 (1996) 861-871.
10. 1 recognition sites, J. Recept. Res., 8 (1988) 59-81.
11. 1A receptors, Arzneim. Forsch. (Drug Res.), 44 (1994) 1-3.
12. 1A receptors, Eur. J. Pharmacol., 199 (1991) 263-265.
13. 1A receptors in the rat brain, Eur. J. Pharmacol., (1996) in press.
14. [14] Michel, M.C. and Ernsberger, P., Keeping an eye on the I site: imidazoline-preferring receptors, Trends Pharmacol. Sci., 13 (1992) 369-370.
15. 3H]RX821002 (2-methoxy idazoxan) in the human and rat brains, J. Pharmacol. Exp. Ther., 264 (1993) 1187-1197.
16. [16] Pazos, A. and Palacios, J.M., Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptors, Brain Res., 346 (1985) 205-230.
17. 2-Autoreceptor-mediated modulation of tyrosine hydroxylase activity in noradrenergic regions of the rat brain in vivo, Naunyn-Schmiedeberg's Arch. Pharmacol., 345 (1992) 653-660.