α2-Adrenergic receptor blockade markedly potentiates duloxetine- and fluexetine-induced increases in noradrenaline, dopamine, and serotonin levels in the frontal cortex of freely moving rats

Journal of Neurochemistry

Volumn 69, Issue 6, 1997, Pages 2616-2619

  Gobert, A ^a   Rivet, J M ^a   Cistarelli, L ^a   Melon, C ^a   Millan, M J ^a  

^a INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

Author keywords

Adrenergic receptors; Cortex; Microdialysis; Monoamines; Uptake inhibitors

Indexed keywords

1 (2 PYRIMIDINYL)PIPERAZINE; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; ANTIDEPRESSANT AGENT; ATIPAMEZOLE; DOPAMINE; DULOXETINE; FLUOXETINE; NORADRENALIN; SEROTONIN; ADRENERGIC RECEPTOR AFFECTING AGENT; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; BIOGENIC AMINE; SEROTONIN UPTAKE INHIBITOR; THIOPHENE DERIVATIVE;

ALPHA ADRENERGIC RECEPTOR BLOCKING; ARTICLE; CONTROLLED STUDY; DOPAMINE RELEASE; DRUG EFFICACY; DRUG POTENTIATION; FRONTAL CORTEX; MALE; NONHUMAN; NORADRENALIN RELEASE; PRIORITY JOURNAL; RAT; SEROTONIN RELEASE; SUBCUTANEOUS DRUG ADMINISTRATION; ANIMAL; FRONTAL LOBE; METABOLISM; WISTAR RAT;

ADRENERGIC ALPHA-ANTAGONISTS; ADRENERGIC UPTAKE INHIBITORS; ANIMALS; BIOGENIC MONOAMINES; DOPAMINE; FLUOXETINE; FRONTAL LOBE; MALE; NOREPINEPHRINE; RATS; RATS, WISTAR; SEROTONIN; SEROTONIN UPTAKE INHIBITORS; THIOPHENES;

EID: 0030613812     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1997.69062616.x     Document Type: Article

References (20)

1. 1A antagonists. Trends Neurosci. 19, 378-383.
2. Broekkamp C. L. E., Leysen D., Peeters B. W. M. M., and Pinder R. M. (1995) Prospects for improved antidepressants. J. Med. Chem. 38, 4615-4633.
3. De Boer T., Nefkens F., Van Helvoirt A., and Van Delft A. M. L. (1996) Differences in modulation of noradrenergic and serotonergic transmission by the alpha-2 adrenoceptor antagonists, mirtazapine, mianserin and idazoxan. J. Pharmacol. Exp. Ther. 277, 852-860.
4. Galzin A. M., Moret C., and Langer S. Z. (1984) Evidence that the exogenous but not endogenous norepinephrine activates the presynaptic alpha-2 adrenoceptors on serotonergic nerve endings in the rat hypothalamus. J. Pharmacol. Exp. Ther. 228, 725-732.
5. 1A receptor antagonist and an SSRI in vivo: effects on 5-HT cell firing and extracellular 5-HT. Br. J. Pharmacol. 115, 1064-1070.
6. 1A receptor agonists and antagonists: a comparison to adrenergic and dopaminergic neurons in rats. J. Pharmacol. Exp. Ther. 273, 1032-1046.
7. 1B receptors with WAY 100,635 and GR 127,935. J. Neurochem. 68, 1159-1163.
8. Gresch P. J., Sved A. F., Zigmond M. J., and Finlay J. M. (1995) Local influence of endogenous norepinephrine on extracellular dopamine in rat medial prefrontal cortex. J. Neurochem. 65, 111-116.
9. Haddjeri N., Blier P., and De Montigny C. (1996) Effect of the alpha-2 adrenoceptor antagonist mirtazapine on the 5-hydroxytryptamine system in the rat brain. J. Pharmacol. Exp. Ther. 277, 861-871.
10. 1-adrenoceptors in the inhibition of 5-HT release. I. BMY7378 and prazosin. Neuropharmacology 34, 615-620.
11. Kotrla K. J. and Weinberger D. R. (1995) Brain imaging in schizophrenia. Annu. Rev. Med. 46, 113-122.
12. Lauritzen L., Clemmesen L., Klysner R., Loldrup D., Lunde M., Schaumburg E., Waarst S., and Bech P. (1992) Combined treatment with imipramine and mianserin. A controlled pilot study. Pharmacopsychiatry 25, 182-186.
13. 1A receptors. Eur. J. Pharmacol. 260, 79-83.
14. 2-adrenoceptor subtypes. Naunyn Schmiedebergs Arch. Pharmacol. 345, 410-416.
15. 2-adrenergic receptors (ARs). Soc. Neurosci. Abstr. 21, 1416.
16. Pollack M. H. and Hammerness P. (1993) Adjunctive yohimbine for treatment in refractory depression. Biol. Psychiatry 33, 220-221.
17. Tanda G., Carboni E., Frau R., and Di Chiara G. (1994) Increase of extracellular dopamine in the prefrontal cortex: a trait of drugs with antidepressant potential? Psychopharmacology (Berlin) 115, 285-288.
18. 2-autoreceptors. Naunyn Schmiedebergs Arch. Pharmacol. 349, 25-33.
19. Wiech N. L. and Ursillo R. C. (1980) Acceleration of desipramine-induced decrease of rat corticocerebral β-adrenergic receptors by yohimbine. Commun. Psychopharmacol. 4, 95-100.
20. Zacharko R. M. and Anisman H. (1991) Stressor-induced anhedonia in the mesocorticolimbic system. Neurosci. Biobehav. Rev. 15, 391-405.