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Khoury SJ, Akalin E, Chandraker A, Turka LA, Linsley PS, Sayegh MH, Hancock WW: CD28-B7 costimulatory blockade by CTLA4lg prevents actively induced experimental autoimmune encephalomyelitis and inhibits Th1 but spares Th2 cytokines in the central nervous system. J Immunol 1995, 155:4521-4524.
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Onodera K, Hancock WW, Graser E, Lehmann M, Sayegh MH, •• Strom TB, Volk HD, Kupiec-Weglinski JW: Type 2 helper T cell-type cytokines and the development of 'infectious' tolerance in rat cardiac allograft recipients. J Immunol 1997,158:1572-1581. Non-depleting anti-CD4 mAb treatment blocked cardiac allograft rejection in LEW rats. Moreover, T cells isolated from these animals were able to transfer the graft tolerance to recipients. These T cells showed significantly diminished Th1 cytokine production but greatly enhanced Th2 cytokine production. Inhibition of Th2 cytokine production abrogated tolerance transfer capacities of these T cells.
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Onodera K, Lehmann M, Akalin E, Volk HD, Sayegh MH, Kupiec-Weglinski JW: Induction of "infectious" tolerance to MHC-incompatible cardiac allografts in CD4 monoclonal antibody-treated sensitized rat recipients. J Immunol 1996, 157:1944-1950.
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Blockade of CD28/B7-1 interaction prevents epitope spreading and clinical relapses of murine EAE
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Miller SD, Vanderlugt CL, Lenschow DJ, Pope JG, Karandikar NJ, Dal Canto MC, Bluestone JA: Blockade of CD28/B7-1 interaction prevents epitope spreading and clinical relapses of murine EAE Immunity 1995, 3:739-745.
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Effect of CD80 and CD86 blockade and anti-interleukin-12 treatment on mouse acute graft-versus-host disease
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Manipulation of the Th1/Th2 balance in autoimmune disease
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Nicholson LB, Kuchroo VK: Manipulation of the Th1/Th2 balance in autoimmune disease. Curr Opin Immunol 1996, 8:837-842.
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Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse
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Lenschow DJ, Ho SC, Sattar H, Rhee L, Gray G, Nabavi N, Herold KC, Bluestone JA: Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse. J Exp Med 1995, 181:1145-1155.
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B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy
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Larsen, C.P.1
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Prevention and amelioration of collagen-induced arthritis by blockade of the CD28 co-stimulatory pathway: Requirement for both B7-1 and B7-2
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Preferential dependence of autoantibody production in murine lupus on CD86 costimulatory molecule
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Schweitzer AN, Borriello F, Wong RCK, Abbas AK, Sharpe AH: •• Role of costimulators in T cell differentiation. J Immunol 1997, 158:2713-2722. Cytokine profiles of T cells stimulated by splenic APCs from CD80 or CD86 knockout mice were investigated. Both IL-4 and IFN-γ production were significantly reduced in T cells stimulated by CD86-negative APCs.
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