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Volumn 27, Issue 4, 1997, Pages 213-224

Hepatitis viruses: Genetic variants and clinical significance

Author keywords

Genotypes; Hepatitis viruses; Mutants; Quasi species; Variants

Indexed keywords

ANTIVIRUS AGENT; HEPATITIS VACCINE;

EID: 0031408138     PISSN: 09405437     EISSN: None     Source Type: Journal    
DOI: 10.1007/s005990050001     Document Type: Review
Times cited : (6)

References (182)
  • 11
    • 0025895537 scopus 로고
    • Inapparent transmission of hepatitis C: Footprints in the sand
    • Alter MJ. Inapparent transmission of hepatitis C: footprints in the sand (editorial). Hepatology 1991; 14: 389.
    • (1991) Hepatology , vol.14 , pp. 389
    • Alter, M.J.1
  • 13
    • 0027367336 scopus 로고
    • Molecular virology and pathogenesis of hepatitis B
    • Lau JYN, Wright TL. Molecular virology and pathogenesis of hepatitis B. Lancet 1993; 342: 1335.
    • (1993) Lancet , vol.342 , pp. 1335
    • Lau, J.Y.N.1    Wright, T.L.2
  • 14
    • 0018084546 scopus 로고
    • A virus similar to human hepatitis B virus associated with hepatitis and hepatoma in woodchucks
    • Summers J, Smolec JM, Snyder R. A virus similar to human hepatitis B virus associated with hepatitis and hepatoma in woodchucks. Proc Natl Acad Sci USA 1978; 75: 4533.
    • (1978) Proc Natl Acad Sci USA , vol.75 , pp. 4533
    • Summers, J.1    Smolec, J.M.2    Snyder, R.3
  • 16
    • 0019133611 scopus 로고
    • Virus of Pekin ducks with structural and biological relatedness to human hepatitis B virus
    • Mason WS, Seal G, Summers J. Virus of Pekin ducks with structural and biological relatedness to human hepatitis B virus. J Virol 1980; 36: 829.
    • (1980) J Virol , vol.36 , pp. 829
    • Mason, W.S.1    Seal, G.2    Summers, J.3
  • 17
    • 0023803399 scopus 로고
    • Isolation and characterization of a hepatitis B virus endemic in herons
    • Sprengel R, Kaleta EF, Will H. Isolation and characterization of a hepatitis B virus endemic in herons. J Virol 1988; 62: 3832.
    • (1988) J Virol , vol.62 , pp. 3832
    • Sprengel, R.1    Kaleta, E.F.2    Will, H.3
  • 18
    • 0027409855 scopus 로고
    • Hepatitis B virus transactivator HBx uses a tumour promoter signalling pathway
    • Kekule AS, Lauer U, Weiss L, Luber B, Hofschneider PH. Hepatitis B virus transactivator HBx uses a tumour promoter signalling pathway. Nature 1993; 361: 742.
    • (1993) Nature , vol.361 , pp. 742
    • Kekule, A.S.1    Lauer, U.2    Weiss, L.3    Luber, B.4    Hofschneider, P.H.5
  • 19
    • 0028064554 scopus 로고
    • The X protein of hepatitis B virus has a ribo/deoxy ATPase activity
    • Medina T de, Haviv I, Noiman S, Shaul Y. The X protein of hepatitis B virus has a ribo/deoxy ATPase activity. Virology 1994; 202: 401.
    • (1994) Virology , vol.202 , pp. 401
    • De Medina, T.1    Haviv, I.2    Noiman, S.3    Shaul, Y.4
  • 20
    • 0029986179 scopus 로고    scopus 로고
    • Proteasome complex as a potential cellular target of hepatitis B virus X protein
    • Huang J, Kwong J, Sun EC-Y, Liang TJ. Proteasome complex as a potential cellular target of hepatitis B virus X protein. J Virol 1996; 70: 5582.
    • (1996) J Virol , vol.70 , pp. 5582
    • Huang, J.1    Kwong, J.2    Sun, E.C.-Y.3    Liang, T.J.4
  • 21
    • 0027524806 scopus 로고
    • Clinical aspects of hepatitis B virus infection
    • Wright TL, Lau JYN. Clinical aspects of hepatitis B virus infection. Lancet 1993; 342: 1340.
    • (1993) Lancet , vol.342 , pp. 1340
    • Wright, T.L.1    Lau, J.Y.N.2
  • 22
    • 0026569260 scopus 로고
    • Characterization of a cis element required for packaging and replication of the human hepatitis B virus
    • Chiagn PW, Jeng KS, Hu CP, Chang CM. Characterization of a cis element required for packaging and replication of the human hepatitis B virus. Virology 1992; 186: 701.
    • (1992) Virology , vol.186 , pp. 701
    • Chiagn, P.W.1    Jeng, K.S.2    Hu, C.P.3    Chang, C.M.4
  • 23
    • 0027424119 scopus 로고
    • A novel hepatitis B virus (HBV) genetic element with Rev response element-like properties that is essential for expression of HBV gene products
    • Huang J, Liang T. A novel hepatitis B virus (HBV) genetic element with Rev response element-like properties that is essential for expression of HBV gene products. Mol Cell Biol 1993; 13: 7476.
    • (1993) Mol Cell Biol , vol.13 , pp. 7476
    • Huang, J.1    Liang, T.2
  • 24
    • 0028308495 scopus 로고
    • Hepadnavirus reverse transcription initiates within the stem-loop of the RNA packaging signal and employs a novel strand transfer
    • Tavis JE, Perri S, Ganem D. Hepadnavirus reverse transcription initiates within the stem-loop of the RNA packaging signal and employs a novel strand transfer. J Virol 1994; 68: 3536.
    • (1994) J Virol , vol.68 , pp. 3536
    • Tavis, J.E.1    Perri, S.2    Ganem, D.3
  • 25
    • 0019949367 scopus 로고
    • Replication of the genome of a hepatitis B-like virus by reverse transcription of an RNA intermediate
    • Summers J, Mason WS. Replication of the genome of a hepatitis B-like virus by reverse transcription of an RNA intermediate. Cell 1982; 29: 403.
    • (1982) Cell , vol.29 , pp. 403
    • Summers, J.1    Mason, W.S.2
  • 26
    • 0027494086 scopus 로고
    • Novel mechanism for reverse transcription in hepatitis B viruses
    • Wang GH, Seeger C. Novel mechanism for reverse transcription in hepatitis B viruses. J Virol 1993; 67: 6507.
    • (1993) J Virol , vol.67 , pp. 6507
    • Wang, G.H.1    Seeger, C.2
  • 27
    • 0028091053 scopus 로고
    • Reverse transcription in hepatitis B viruses is primed by a tyrosine residue of the polymerase
    • Zoulim F, Seeger C. Reverse transcription in hepatitis B viruses is primed by a tyrosine residue of the polymerase. J Virol 1994; 68: 6.
    • (1994) J Virol , vol.68 , pp. 6
    • Zoulim, F.1    Seeger, C.2
  • 28
    • 0024509701 scopus 로고
    • Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome
    • Choo QL, Kuo G, Weiner AJ, Overby LR, Bradley DW, Houghton M. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science 1989; 244: 359.
    • (1989) Science , vol.244 , pp. 359
    • Choo, Q.L.1    Kuo, G.2    Weiner, A.J.3    Overby, L.R.4    Bradley, D.W.5    Houghton, M.6
  • 29
    • 0030912338 scopus 로고    scopus 로고
    • The molecular virology of hepatitis C
    • Major ME, Feinstone SM. The molecular virology of hepatitis C. Hepatology 1997; 25: 1527.
    • (1997) Hepatology , vol.25 , pp. 1527
    • Major, M.E.1    Feinstone, S.M.2
  • 30
    • 0025862146 scopus 로고
    • Molecular biology of the hepatitis C viruses: Implications for diagnosis, development and control of viral disease
    • Houghton M, Weiner A, Han J, Kuo G, Choo QL. Molecular biology of the hepatitis C viruses: implications for diagnosis, development and control of viral disease. Hepatology 1991; 14: 381.
    • (1991) Hepatology , vol.14 , pp. 381
    • Houghton, M.1    Weiner, A.2    Han, J.3    Kuo, G.4    Choo, Q.L.5
  • 32
    • 0030740520 scopus 로고    scopus 로고
    • Transcripts from a single full-length cDNA clone of hepatitis C virus are infectious when directly transfected into the liver of a chimpanzee
    • Yanagi M, Purcell RH, Emerson SU, Bukh J. Transcripts from a single full-length cDNA clone of hepatitis C virus are infectious when directly transfected into the liver of a chimpanzee. Proc Natl Acad Sci USA 1997; 94: 8738.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 8738
    • Yanagi, M.1    Purcell, R.H.2    Emerson, S.U.3    Bukh, J.4
  • 37
    • 0030976826 scopus 로고    scopus 로고
    • Measuring hepatitis C viremia in clinical samples: Can we trust the assays?
    • Pawlotsky J-M. Measuring hepatitis C viremia in clinical samples: can we trust the assays? Hepatology 1997; 26: 1.
    • (1997) Hepatology , vol.26 , pp. 1
    • Pawlotsky, J.-M.1
  • 39
    • 0020959879 scopus 로고
    • The delta agent
    • Rizzetto M. The delta agent. Hepatology 1983; 3: 729.
    • (1983) Hepatology , vol.3 , pp. 729
    • Rizzetto, M.1
  • 40
    • 0026349347 scopus 로고
    • Hepatitis delta virus
    • Taylor J. Hepatitis delta virus. J Hepatol 1991; 13 [Suppl 4]: S114
    • (1991) J Hepatol , vol.13 , Issue.4 SUPPL.
    • Taylor, J.1
  • 41
    • 0027268535 scopus 로고
    • Delta hepatitis: Molecular biology and clinical and epidemiological features
    • Polish LB, Gallagher M, Fields HA, Hadler SC. Delta hepatitis: molecular biology and clinical and epidemiological features. Clin Microbiol Rev 1993; 6: 211.
    • (1993) Clin Microbiol Rev , vol.6 , pp. 211
    • Polish, L.B.1    Gallagher, M.2    Fields, H.A.3    Hadler, S.C.4
  • 42
    • 0017806301 scopus 로고
    • Nucleotide sequence heterogeneity of a RNA phage population
    • Domingo E, Sabo D, Taniguchi T, Weissmann C. Nucleotide sequence heterogeneity of a RNA phage population. Cell 1978; 13: 735.
    • (1978) Cell , vol.13 , pp. 735
    • Domingo, E.1    Sabo, D.2    Taniguchi, T.3    Weissmann, C.4
  • 43
    • 0027402533 scopus 로고
    • Viral genetic variation: Hepatitis B virus as a clinical example
    • Carman W, Thomas H, Domingo E. Viral genetic variation: hepatitis B virus as a clinical example. Lancet 1993; 341: 349.
    • (1993) Lancet , vol.341 , pp. 349
    • Carman, W.1    Thomas, H.2    Domingo, E.3
  • 44
    • 0025779319 scopus 로고
    • Persistence of hepatitis B viral DNA after serological recovery from hepatitis B virus infection
    • Blum HE, Liang TJ, Galun E, Wands JR. Persistence of hepatitis B viral DNA after serological recovery from hepatitis B virus infection. Hepatology 1991; 14: 56.
    • (1991) Hepatology , vol.14 , pp. 56
    • Blum, H.E.1    Liang, T.J.2    Galun, E.3    Wands, J.R.4
  • 45
    • 0027979134 scopus 로고
    • Enhanced replication of a hepatitis B virus mutant associated with an epidemic of fulminant hepatitis
    • Hasegawa K, Huang J, Rogers SA, Blum HE, Liang TJ. Enhanced replication of a hepatitis B virus mutant associated with an epidemic of fulminant hepatitis. J Virol 1994; 68: 1651.
    • (1994) J Virol , vol.68 , pp. 1651
    • Hasegawa, K.1    Huang, J.2    Rogers, S.A.3    Blum, H.E.4    Liang, T.J.5
  • 46
    • 0024316283 scopus 로고
    • Mutation rate of the hepadnavirus genome
    • Girones R, Miller RH. Mutation rate of the hepadnavirus genome. Virology 1989; 170: 595.
    • (1989) Virology , vol.170 , pp. 595
    • Girones, R.1    Miller, R.H.2
  • 48
    • 0026327252 scopus 로고
    • Independent emergence of a vaccine-induced escape mutant of hepatitis B virus
    • Harrison TJ, Hopes EA, Oon CJ, Zanetti AR, Zuckermann AJ. Independent emergence of a vaccine-induced escape mutant of hepatitis B virus. J Hepatol 1991; 13 [Suppl 4]: S105.
    • (1991) J Hepatol , vol.13 , Issue.4 SUPPL.
    • Harrison, T.J.1    Hopes, E.A.2    Oon, C.J.3    Zanetti, A.R.4    Zuckermann, A.J.5
  • 49
    • 0027054058 scopus 로고
    • Loss of the common "a" determinant of hepatitis B surface antigen by a vaccine-induced escape mutant
    • Waters JA, Kennedy M, Voet P, Hauser P, Petre J, Carman W, Thomas HC. Loss of the common "a" determinant of hepatitis B surface antigen by a vaccine-induced escape mutant. J Clin Invest 1992; 90: 2543.
    • (1992) J Clin Invest , vol.90 , pp. 2543
    • Waters, J.A.1    Kennedy, M.2    Voet, P.3    Hauser, P.4    Petre, J.5    Carman, W.6    Thomas, H.C.7
  • 51
    • 0026640961 scopus 로고
    • Mutations within the S gene of hepatitis B virus transmitted from mothers to babies immunized with hepatitis B immune globulin and vaccine
    • Okamoto H, Yano K, Nozaki Y, Matsui A, Miyazaki H, Yamamoto K, Tsuda F, Machida A, Mishiro S. Mutations within the S gene of hepatitis B virus transmitted from mothers to babies immunized with hepatitis B immune globulin and vaccine. Pediatr Res 1992; 32: 264.
    • (1992) Pediatr Res , vol.32 , pp. 264
    • Okamoto, H.1    Yano, K.2    Nozaki, Y.3    Matsui, A.4    Miyazaki, H.5    Yamamoto, K.6    Tsuda, F.7    Machida, A.8    Mishiro, S.9
  • 52
    • 0028265185 scopus 로고
    • Naturally occurring escape mutants of hepatitis B virus with various mutations in the S gene in carriers seropositive for antibody to hepatitis B surface antigen
    • Yamamoto K, Horikita M, Tsuda F, Itoh K, Akahane Y, Yotsumoto S, Okamoto H, Miyakawa Y, Mayumi M. Naturally occurring escape mutants of hepatitis B virus with various mutations in the S gene in carriers seropositive for antibody to hepatitis B surface antigen. J Virol 1994; 68: 2671.
    • (1994) J Virol , vol.68 , pp. 2671
    • Yamamoto, K.1    Horikita, M.2    Tsuda, F.3    Itoh, K.4    Akahane, Y.5    Yotsumoto, S.6    Okamoto, H.7    Miyakawa, Y.8    Mayumi, M.9
  • 53
    • 0028352854 scopus 로고
    • Breakthrough infections and identification of a viral variant in Gambian children immunized with hepatitis B vaccine
    • Fortuin M, Karthigesu V, Allison L, Howard C, Hoare S, Mendy M, Whittle HC. Breakthrough infections and identification of a viral variant in Gambian children immunized with hepatitis B vaccine. J Infect Dis 1994; 169: 1374.
    • (1994) J Infect Dis , vol.169 , pp. 1374
    • Fortuin, M.1    Karthigesu, V.2    Allison, L.3    Howard, C.4    Hoare, S.5    Mendy, M.6    Whittle, H.C.7
  • 54
    • 0026598059 scopus 로고
    • Genetic alterations in the gene encoding the major HBsAg: DNA and immunological analysis of recurrent HBsAg derived from monoclonal antibody-treated liver transplant patients
    • McMahon G, Ehrlich PH, Moustafa ZA, McCarthy LA, Dottavio D, Tolpin MD, Nadler PI, Ostberg L. Genetic alterations in the gene encoding the major HBsAg: DNA and immunological analysis of recurrent HBsAg derived from monoclonal antibody-treated liver transplant patients. Hepatology 1992; 15: 757.
    • (1992) Hepatology , vol.15 , pp. 757
    • McMahon, G.1    Ehrlich, P.H.2    Moustafa, Z.A.3    McCarthy, L.A.4    Dottavio, D.5    Tolpin, M.D.6    Nadler, P.I.7    Ostberg, L.8
  • 57
    • 0027295660 scopus 로고
    • Infectious hepatitis B virus variant defective in preS2 protein expression in a chronic carrier
    • Fernholz D, Galle PR, Stemler M, Brunetto M, Bonino F, Will H. Infectious hepatitis B virus variant defective in preS2 protein expression in a chronic carrier. Virology 1993; 194: 137.
    • (1993) Virology , vol.194 , pp. 137
    • Fernholz, D.1    Galle, P.R.2    Stemler, M.3    Brunetto, M.4    Bonino, F.5    Will, H.6
  • 58
    • 0027474474 scopus 로고
    • Significance of pre-S region-defective hepatitis B virus that emerged during exacerbation of chronic type B hepatitis
    • Minami M, Okanoue T, Nakajima E, Yasui K, Kagawa K, Kashima K. Significance of pre-S region-defective hepatitis B virus that emerged during exacerbation of chronic type B hepatitis. Hepatology 1993; 17: 558.
    • (1993) Hepatology , vol.17 , pp. 558
    • Minami, M.1    Okanoue, T.2    Nakajima, E.3    Yasui, K.4    Kagawa, K.5    Kashima, K.6
  • 59
    • 0028244888 scopus 로고
    • Properties of hepatitis B virus pre-S1 deletion mutants
    • Melegari M, Bruno S, Wands JR. Properties of hepatitis B virus pre-S1 deletion mutants. Virology 1994; 199: 292.
    • (1994) Virology , vol.199 , pp. 292
    • Melegari, M.1    Bruno, S.2    Wands, J.R.3
  • 60
    • 0028267823 scopus 로고
    • PreS1 deleted variants of hepatitis B virus in patients with chronic hepatitis
    • Nakajima E, Minami M, Ochiya T, Kagawa K, Okanoue T. PreS1 deleted variants of hepatitis B virus in patients with chronic hepatitis. J Hepatol 1994; 20: 329.
    • (1994) J Hepatol , vol.20 , pp. 329
    • Nakajima, E.1    Minami, M.2    Ochiya, T.3    Kagawa, K.4    Okanoue, T.5
  • 61
    • 0029655254 scopus 로고    scopus 로고
    • Intracellular retention of surface protein by a hepatitis B virus mutant that releases virion particles
    • Xu Z, Yen TSB. Intracellular retention of surface protein by a hepatitis B virus mutant that releases virion particles. J Virol 1996; 70: 133.
    • (1996) J Virol , vol.70 , pp. 133
    • Xu, Z.1    Yen, T.S.B.2
  • 63
  • 65
    • 0029838758 scopus 로고    scopus 로고
    • The hepatitis B virus persists for decades after patients' recovery from acute viral hepatitis despite active maintenance of a cytotoxic T-lymphocyte response
    • Rehermann B, Ferrari C, Pasquinelli C, Chisari FV. The hepatitis B virus persists for decades after patients' recovery from acute viral hepatitis despite active maintenance of a cytotoxic T-lymphocyte response. Nat Med 1996; 2: 1104.
    • (1996) Nat Med , vol.2 , pp. 1104
    • Rehermann, B.1    Ferrari, C.2    Pasquinelli, C.3    Chisari, F.V.4
  • 66
    • 0029968180 scopus 로고    scopus 로고
    • A molecular analysis of viral persistence in surface antigen-negative chronic hepatitis B
    • Kato J, Hasegawa K, Torii N, Yamauchi K, Hayashi N. A molecular analysis of viral persistence in surface antigen-negative chronic hepatitis B. Hepatology 1996; 23: 389.
    • (1996) Hepatology , vol.23 , pp. 389
    • Kato, J.1    Hasegawa, K.2    Torii, N.3    Yamauchi, K.4    Hayashi, N.5
  • 67
    • 0025231364 scopus 로고
    • A trans-activator function is generated by integration of hepatitis B virus preS/S sequences in human hepatocellular carcinoma DNA
    • Caselmann WH, Meyer M, Kekule AS, Lauer U, Hofschneider PH, Koshy R. A trans-activator function is generated by integration of hepatitis B virus preS/S sequences in human hepatocellular carcinoma DNA. Proc Natl Acad Sci USA 1990; 87: 2970.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 2970
    • Caselmann, W.H.1    Meyer, M.2    Kekule, A.S.3    Lauer, U.4    Hofschneider, P.H.5    Koshy, R.6
  • 68
    • 0027952647 scopus 로고
    • The hepatitis B virus preS2/St transactivator utilizes AP-1 and other transcription factors for transactivation
    • Lauer U, Weiss L, Lipp M, Hofschneider PH, Kekule AS. The hepatitis B virus preS2/St transactivator utilizes AP-1 and other transcription factors for transactivation. Hepatology 1994; 19: 23.
    • (1994) Hepatology , vol.19 , pp. 23
    • Lauer, U.1    Weiss, L.2    Lipp, M.3    Hofschneider, P.H.4    Kekule, A.S.5
  • 71
    • 0025012035 scopus 로고
    • Chronic active hepatitis with hepatitis B virus DNA and antibody against e antigen in the serum. Disturbed synthesis and secretion of e antigen from hepatocytes due to a point mutation in the precore region
    • Akahane Y, Yamanaka T, Suzuki H, Sugai Y, Tsuda F, Yotsumoto S, Omi S, Okamoto H, Miyakawa Y, Mayumi M. Chronic active hepatitis with hepatitis B virus DNA and antibody against e antigen in the serum. Disturbed synthesis and secretion of e antigen from hepatocytes due to a point mutation in the precore region. Gastroenterology 1990; 99: 1113.
    • (1990) Gastroenterology , vol.99 , pp. 1113
    • Akahane, Y.1    Yamanaka, T.2    Suzuki, H.3    Sugai, Y.4    Tsuda, F.5    Yotsumoto, S.6    Omi, S.7    Okamoto, H.8    Miyakawa, Y.9    Mayumi, M.10
  • 73
    • 0025739721 scopus 로고
    • Mutations in the precore region of hepatitis B virus DNA in patients with fulminant and severe hepatitis
    • Omata M, Ehata T, Yokosuka O, Hosoda K, Ohio M. Mutations in the precore region of hepatitis B virus DNA in patients with fulminant and severe hepatitis. N Engl J Med 1991; 324: 1699.
    • (1991) N Engl J Med , vol.324 , pp. 1699
    • Omata, M.1    Ehata, T.2    Yokosuka, O.3    Hosoda, K.4    Ohio, M.5
  • 74
    • 0025738478 scopus 로고
    • A hepatitis B virus mutant associated with an epidemic of fulminant hepatitis
    • Liang TJ, Hasegawa K, Rimon N, Wands JR, Ben Porath E. A hepatitis B virus mutant associated with an epidemic of fulminant hepatitis. N Engl J Med 1991; 324: 1705.
    • (1991) N Engl J Med , vol.324 , pp. 1705
    • Liang, T.J.1    Hasegawa, K.2    Rimon, N.3    Wands, J.R.4    Ben Porath, E.5
  • 76
    • 0025236260 scopus 로고
    • Hepatitis B viruses with precore region defects prevail in persistently infected hosts along with seroconversion to the antibody against e antigen
    • Okamoto Y, Yotsumoto S, Akahane Y, Yamanaka T, Miyazaki Y, Sugai Y, Tsuda F, Tanaka T, Miyakawa Y, Mayumi M. Hepatitis B viruses with precore region defects prevail in persistently infected hosts along with seroconversion to the antibody against e antigen. J Virol 1990; 64: 1298.
    • (1990) J Virol , vol.64 , pp. 1298
    • Okamoto, Y.1    Yotsumoto, S.2    Akahane, Y.3    Yamanaka, T.4    Miyazaki, Y.5    Sugai, Y.6    Tsuda, F.7    Tanaka, T.8    Miyakawa, Y.9    Mayumi, M.10
  • 77
    • 0025647137 scopus 로고
    • Defects in the precore region of hepatitis B virus DNA in a plasma pool from carriers seropositive for antibody against e antigen and with infectivity in chmpanzees
    • Omi S, Okamoto H, Tsuda F, Mayumi M. Defects in the precore region of hepatitis B virus DNA in a plasma pool from carriers seropositive for antibody against e antigen and with infectivity in chmpanzees. J Gastroenterol Hepatol 1990; 5: 646.
    • (1990) J Gastroenterol Hepatol , vol.5 , pp. 646
    • Omi, S.1    Okamoto, H.2    Tsuda, F.3    Mayumi, M.4
  • 78
    • 0026452893 scopus 로고
    • Hepatitis B virus precore mutants are identical in carriers from various ethnic origins and are associated with a range of liver disease severity
    • Tur Kaspa R, Klein A, Aharonson S. Hepatitis B virus precore mutants are identical in carriers from various ethnic origins and are associated with a range of liver disease severity. Hepatology 1992; 16: 1338.
    • (1992) Hepatology , vol.16 , pp. 1338
    • Tur Kaspa, R.1    Klein, A.2    Aharonson, S.3
  • 79
    • 0027275693 scopus 로고
    • Nucleotide sequence analysis of the precore region in patients with fulminant hepatitis B in the United States
    • Laskus T, Persing DH, Nowicki MJ, Mosley JW, Rakela J. Nucleotide sequence analysis of the precore region in patients with fulminant hepatitis B in the United States. Gastroenterology 1993; 105: 1173.
    • (1993) Gastroenterology , vol.105 , pp. 1173
    • Laskus, T.1    Persing, D.H.2    Nowicki, M.J.3    Mosley, J.W.4    Rakela, J.5
  • 81
    • 0026527598 scopus 로고
    • Variations in codons 84-101 in the core nucleotide sequence correlate with hepatocellular injury in chronic hepatitis B virus infection
    • Ehata J, Omata M, Yokosuka O, Hosoda K, Ohto M. Variations in codons 84-101 in the core nucleotide sequence correlate with hepatocellular injury in chronic hepatitis B virus infection. J Clin Invest 1992; 89: 332.
    • (1992) J Clin Invest , vol.89 , pp. 332
    • Ehata, J.1    Omata, M.2    Yokosuka, O.3    Hosoda, K.4    Ohto, M.5
  • 82
    • 0027394588 scopus 로고
    • Mutations in core nucleotide sequence of hepatitis B virus correlate with fulminant and severe hepatitis
    • Ehata T, Omata M, Chuang WL, Yokosuka O, Ito Y, Hosoda K, Ohto M. Mutations in core nucleotide sequence of hepatitis B virus correlate with fulminant and severe hepatitis. J Clin Invest 1993; 91: 1206.
    • (1993) J Clin Invest , vol.91 , pp. 1206
    • Ehata, T.1    Omata, M.2    Chuang, W.L.3    Yokosuka, O.4    Ito, Y.5    Hosoda, K.6    Ohto, M.7
  • 84
    • 0030892283 scopus 로고    scopus 로고
    • Cytotoxic T cells and viral hepatitis
    • Chisari FV. Cytotoxic T cells and viral hepatitis. J Clin Invest 1997; 99: 1472.
    • (1997) J Clin Invest , vol.99 , pp. 1472
    • Chisari, F.V.1
  • 85
    • 0028916425 scopus 로고
    • Hepatitis B virus immunopathogenesis
    • Chisari FV, Ferrari C. Hepatitis B virus immunopathogenesis. Annu Rev Immunol 1995; 13: 29.
    • (1995) Annu Rev Immunol , vol.13 , pp. 29
    • Chisari, F.V.1    Ferrari, C.2
  • 86
  • 87
  • 88
    • 0029860096 scopus 로고    scopus 로고
    • Mutations in the hepatitis B virus precore/core gene and core promoter in patients with severe recurrent disease following liver transplantation
    • McMillan JS, Bowden DS, Angus PW, McCaughan GW, Locarnini SA. Mutations in the hepatitis B virus precore/core gene and core promoter in patients with severe recurrent disease following liver transplantation. Hepatology 1996; 24: 1371.
    • (1996) Hepatology , vol.24 , pp. 1371
    • McMillan, J.S.1    Bowden, D.S.2    Angus, P.W.3    McCaughan, G.W.4    Locarnini, S.A.5
  • 89
    • 0030842372 scopus 로고    scopus 로고
    • A pretransplant infection with precore mutants of hepatitis B virus does not influence the outcome of orthotopic liver transplantation in patients on high dose anti-hepatitis B virus surface antigen immunoprophylaxis
    • Naumann U, Protzer-Knolle U, Berg T, Leder K, Lobeck H, Bechstein W-O, Gerken G, Hopf U, Neuhaus P A pretransplant infection with precore mutants of hepatitis B virus does not influence the outcome of orthotopic liver transplantation in patients on high dose anti-hepatitis B virus surface antigen immunoprophylaxis. Hepatology 1997; 26: 478.
    • (1997) Hepatology , vol.26 , pp. 478
    • Naumann, U.1    Protzer-Knolle, U.2    Berg, T.3    Leder, K.4    Lobeck, H.5    Bechstein, W.-O.6    Gerken, G.7    Hopf, U.8    Neuhaus, P.9
  • 92
    • 0026525117 scopus 로고
    • Anti-HBe-positive chronic hepatitis B with HBV-DNA in the serum: Response to a 6-month course of lymphoblastoid interferon
    • Pastore G, Santantonio T, Milella M, Monno L, Mariano N, Moschetta R, Pollice L. Anti-HBe-positive chronic hepatitis B with HBV-DNA in the serum: response to a 6-month course of lymphoblastoid interferon. J Hepatol 1992; 14: 221.
    • (1992) J Hepatol , vol.14 , pp. 221
    • Pastore, G.1    Santantonio, T.2    Milella, M.3    Monno, L.4    Mariano, N.5    Moschetta, R.6    Pollice, L.7
  • 96
    • 0001655748 scopus 로고
    • Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3
    • Wang XW, Forrester K, Yeh H, Feitelson MA, Gu JR, Harris CC. Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3. Proc Natl Acad Sci USA 1994; 91: 2230.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 2230
    • Wang, X.W.1    Forrester, K.2    Yeh, H.3    Feitelson, M.A.4    Gu, J.R.5    Harris, C.C.6
  • 98
    • 0029586977 scopus 로고
    • X-gene product antagonizes the p53-mediated inhibition of hepatitis B virus replication through regulation of the pregenomic/core promoter
    • Lee H, Lee Y-H, Huh Y-S, Moon H, Yun Y. X-gene product antagonizes the p53-mediated inhibition of hepatitis B virus replication through regulation of the pregenomic/core promoter. J Biol Chem 1995; 270: 1405.
    • (1995) J Biol Chem , vol.270 , pp. 1405
    • Lee, H.1    Lee, Y.-H.2    Huh, Y.-S.3    Moon, H.4    Yun, Y.5
  • 99
    • 0028853994 scopus 로고
    • Hepatitis B virus x protein interacts with a probable cellular DNA repair protein
    • Lee T-H, Elledge SJ, Butel JS. Hepatitis B virus x protein interacts with a probable cellular DNA repair protein. J Virol 1995; 69: 1107.
    • (1995) J Virol , vol.69 , pp. 1107
    • Lee, T.-H.1    Elledge, S.J.2    Butel, J.S.3
  • 100
    • 0028858588 scopus 로고
    • Hepatitis B virus HBx protein deregulates cell cycle checkpoint controls
    • Benn J, Schneider RJ. Hepatitis B virus HBx protein deregulates cell cycle checkpoint controls. Proc Natl Acad Sci USA 1995; 92: 11 215.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 11215
    • Benn, J.1    Schneider, R.J.2
  • 102
    • 0027326201 scopus 로고
    • Effect of X protein on transactivation of hepatitis B virus promoters and on viral replication
    • Nakatake H, Chisaka O, Yamamoto S, Matsubara K, Koshy R. Effect of X protein on transactivation of hepatitis B virus promoters and on viral replication. Virology 1993; 195: 305.
    • (1993) Virology , vol.195 , pp. 305
    • Nakatake, H.1    Chisaka, O.2    Yamamoto, S.3    Matsubara, K.4    Koshy, R.5
  • 103
    • 0028342986 scopus 로고
    • Human hepatitis virus X gene encodes a regulatory domain that represses transactivation of X protein
    • Murakami S, Cheong JH, Kaneko S. Human hepatitis virus X gene encodes a regulatory domain that represses transactivation of X protein. J Biol Chem 1994; 269: 15 118.
    • (1994) J Biol Chem , vol.269 , pp. 15118
    • Murakami, S.1    Cheong, J.H.2    Kaneko, S.3
  • 105
    • 0028013064 scopus 로고
    • Woodchuck hepatitis virus X protein is required for viral infection in vivo
    • Zoulim F, Saputelli J, Seeger C. Woodchuck hepatitis virus X protein is required for viral infection in vivo. J Virol 1994; 68: 2026.
    • (1994) J Virol , vol.68 , pp. 2026
    • Zoulim, F.1    Saputelli, J.2    Seeger, C.3
  • 106
    • 0025311110 scopus 로고
    • Trans-activation function of a 3′ truncated X gene-cell fusion product from integrated hepatitis B virus DNA in chronic hepatitis tissues
    • Takada S, Koike K. Trans-activation function of a 3′ truncated X gene-cell fusion product from integrated hepatitis B virus DNA in chronic hepatitis tissues. Proc Natl Acad Sci USA 1990; 87: 5628.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 5628
    • Takada, S.1    Koike, K.2
  • 107
    • 0024240296 scopus 로고
    • A trans-activating function encoded in the hepatitis B virus X gene is conserved in the integrated state
    • Wollersheim M, Debelka U, Hofschneider PH. A trans-activating function encoded in the hepatitis B virus X gene is conserved in the integrated state. Oncogene 1988; 3: 545.
    • (1988) Oncogene , vol.3 , pp. 545
    • Wollersheim, M.1    Debelka, U.2    Hofschneider, P.H.3
  • 108
    • 0025120706 scopus 로고
    • Sequence of a replication competent hepatitis B virus genome with a preX open reading frame
    • Loncarevic IF, Zentgraf H, Schröder CH. Sequence of a replication competent hepatitis B virus genome with a preX open reading frame. Nucleic Acids Res 1990; 18: 4940.
    • (1990) Nucleic Acids Res , vol.18 , pp. 4940
    • Loncarevic, I.F.1    Zentgraf, H.2    Schröder, C.H.3
  • 110
    • 0026713023 scopus 로고
    • Replication of a mutant hepatitis B virus with a fused X-C reading frame in hepatoma cells
    • Kim SH, Hong SP, Kim SK, Lee WS, Rho HM. Replication of a mutant hepatitis B virus with a fused X-C reading frame in hepatoma cells. J Gen Virol 1992; 73: 2421
    • (1992) J Gen Virol , vol.73 , pp. 2421
    • Kim, S.H.1    Hong, S.P.2    Kim, S.K.3    Lee, W.S.4    Rho, H.M.5
  • 111
    • 0027938519 scopus 로고
    • Biology of hepatitis B virus variants
    • Feitelson MA. Biology of hepatitis B virus variants. Lab Invest 1994; 71: 324.
    • (1994) Lab Invest , vol.71 , pp. 324
    • Feitelson, M.A.1
  • 112
    • 0026078074 scopus 로고
    • Naturally occurring missense mutation in the polymerase gene terminating hepatitis B virus replication
    • Blum HE, Galun E, Liang TJ, Weizsäcker F von, Wands JR. Naturally occurring missense mutation in the polymerase gene terminating hepatitis B virus replication. J Virol 1991; 65: 1836.
    • (1991) J Virol , vol.65 , pp. 1836
    • Blum, H.E.1    Galun, E.2    Liang, T.J.3    Von Weizsäcker, F.4    Wands, J.R.5
  • 114
    • 0029815110 scopus 로고    scopus 로고
    • Selection of mutations in the hepatitis B virus polymerase during therapy of transplant recipients with lamivudine
    • Ling R, Mutimer D, Ahmed M, Boxall EH, Elias E, Dusheiko GM, Harrison TJ. Selection of mutations in the hepatitis B virus polymerase during therapy of transplant recipients with lamivudine. Hepatology 1996; 24: 711.
    • (1996) Hepatology , vol.24 , pp. 711
    • Ling, R.1    Mutimer, D.2    Ahmed, M.3    Boxall, E.H.4    Elias, E.5    Dusheiko, G.M.6    Harrison, T.J.7
  • 118
    • 0029786768 scopus 로고    scopus 로고
    • Accumulation and persistence of hepatitis B virus core gene deletion mutants in renal transplant patients are associated with end-stage liver disease
    • Günther S, Baginski S, Kissel H, Reinke P, Kruher DH, Will H, Meisel H. Accumulation and persistence of hepatitis B virus core gene deletion mutants in renal transplant patients are associated with end-stage liver disease. Hepatology 1996; 24: 751.
    • (1996) Hepatology , vol.24 , pp. 751
    • Günther, S.1    Baginski, S.2    Kissel, H.3    Reinke, P.4    Kruher, D.H.5    Will, H.6    Meisel, H.7
  • 119
    • 0027992963 scopus 로고
    • Hepatitis B virus with mutations in the core promoter for an e antigen-negative phenotype in carriers with antibody to e antigen
    • Okamoto H, Tsuda F, Akahane Y, Sugai Y, Yoshiba M, Moriyama K, Tanaka K, Miyakawa Y, Mayumi M. Hepatitis B virus with mutations in the core promoter for an e antigen-negative phenotype in carriers with antibody to e antigen. J Virol 1994; 68: 8102.
    • (1994) J Virol , vol.68 , pp. 8102
    • Okamoto, H.1    Tsuda, F.2    Akahane, Y.3    Sugai, Y.4    Yoshiba, M.5    Moriyama, K.6    Tanaka, K.7    Miyakawa, Y.8    Mayumi, M.9
  • 120
    • 0029829534 scopus 로고    scopus 로고
    • Two core promoter mutations identified in a hepatitis B virus strain associated with fulminant hepatitis result in enhanced viral replication
    • Baumert TF, Rogers SA, Hasegawa K, Liang TJ. Two core promoter mutations identified in a hepatitis B virus strain associated with fulminant hepatitis result in enhanced viral replication. J Clin Invest 1996; 98: 2268
    • (1996) J Clin Invest , vol.98 , pp. 2268
    • Baumert, T.F.1    Rogers, S.A.2    Hasegawa, K.3    Liang, T.J.4
  • 121
    • 0027946212 scopus 로고
    • Precore and contiguous regions of hepatitis B virus in liver transplantation for end-stage hepatitis B
    • Laskus T, Rakela J, Steers JL, Wiesner RH, Persing DH. Precore and contiguous regions of hepatitis B virus in liver transplantation for end-stage hepatitis B. Gastroenterology 1994; 107: 1774.
    • (1994) Gastroenterology , vol.107 , pp. 1774
    • Laskus, T.1    Rakela, J.2    Steers, J.L.3    Wiesner, R.H.4    Persing, D.H.5
  • 122
    • 0030979383 scopus 로고    scopus 로고
    • A hepatitis B virus mutant with a new hepatocyte nuclear factor binding site emerging in transplant transmitted fulminant hepatitis B
    • Pult I, Chouard T, Wieland S, Klemenz R, Yaniv M, Blum HE. A hepatitis B virus mutant with a new hepatocyte nuclear factor binding site emerging in transplant transmitted fulminant hepatitis B. Hepatology 1997; 25: 1507.
    • (1997) Hepatology , vol.25 , pp. 1507
    • Pult, I.1    Chouard, T.2    Wieland, S.3    Klemenz, R.4    Yaniv, M.5    Blum, H.E.6
  • 123
    • 0027214322 scopus 로고
    • At least 12 genotypes of hepatitis C virus predicted by sequence analysis of the putative E1 gene of isolates collected worldwide
    • Bukh J, Purcell RH, Miller RH. At least 12 genotypes of hepatitis C virus predicted by sequence analysis of the putative E1 gene of isolates collected worldwide. Proc Natl Acad Sci USA 1993; 90: 8234.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 8234
    • Bukh, J.1    Purcell, R.H.2    Miller, R.H.3
  • 124
    • 0027055062 scopus 로고
    • Fuli-length nucleotide sequence of a Japanese hepatitis C virus isolate (HC-J1) with high homology to USA isolates
    • Okamoto H, Kanai N, Mishiro S. Fuli-length nucleotide sequence of a Japanese hepatitis C virus isolate (HC-J1) with high homology to USA isolates. Nucleic Acids Res 1992; 20: 6410.
    • (1992) Nucleic Acids Res , vol.20 , pp. 6410
    • Okamoto, H.1    Kanai, N.2    Mishiro, S.3
  • 125
    • 0026563204 scopus 로고
    • Typing hepatitis C virus by polymerase chain reaction with type-specific primers: Application to clinical surveys and tracing infectious sources
    • Okamoto H, Sugiyama Y, Okada S, Kurai K, Akahane Y, Sugai Y, Tanaka T, Sato K, Tsuda F, Mtyakawa Y, et al. Typing hepatitis C virus by polymerase chain reaction with type-specific primers: application to clinical surveys and tracing infectious sources. J Gen Virol 1992; 73: 673.
    • (1992) J Gen Virol , vol.73 , pp. 673
    • Okamoto, H.1    Sugiyama, Y.2    Okada, S.3    Kurai, K.4    Akahane, Y.5    Sugai, Y.6    Tanaka, T.7    Sato, K.8    Tsuda, F.9    Mtyakawa, Y.10
  • 126
    • 0026748387 scopus 로고
    • Long-term follow-up of hepatitis B vaccination in susceptible hospital personnel
    • Chan CY, Lee SD, Tsai YT, Lo KJ. Long-term follow-up of hepatitis B vaccination in susceptible hospital personnel. J Gastroenterol Hepatol 1992; 7: 266.
    • (1992) J Gastroenterol Hepatol , vol.7 , pp. 266
    • Chan, C.Y.1    Lee, S.D.2    Tsai, Y.T.3    Lo, K.J.4
  • 128
    • 0026637302 scopus 로고
    • Genomic typing of hepatitis C viruses present in China
    • Liu K, Hu Z, Li H, Prince AM, Inchauspe G. Genomic typing of hepatitis C viruses present in China. Gene 1992; 114: 245.
    • (1992) Gene , vol.114 , pp. 245
    • Liu, K.1    Hu, Z.2    Li, H.3    Prince, A.M.4    Inchauspe, G.5
  • 130
    • 0027152163 scopus 로고
    • Genetic variation of the hepatitis C virus (HCV) genome: Random events or a clinically relevant issue?
    • Brechot C, Kremsdorf D. Genetic variation of the hepatitis C virus (HCV) genome: random events or a clinically relevant issue? J Hepatol 1993; 17: 265.
    • (1993) J Hepatol , vol.17 , pp. 265
    • Brechot, C.1    Kremsdorf, D.2
  • 132
    • 0028007736 scopus 로고
    • Sequence variability of hepatitis C virus and its clinical relevance
    • Dusheiko G, Simmonds P. Sequence variability of hepatitis C virus and its clinical relevance. J Viral Hepatitis 1994; 1: 3.
    • (1994) J Viral Hepatitis , vol.1 , pp. 3
    • Dusheiko, G.1    Simmonds, P.2
  • 133
    • 0026728652 scopus 로고
    • Sequence analysis of the 5′ noncoding region of hepatitis C virus
    • Bukh J, Purcell RH, Miller RH. Sequence analysis of the 5′ noncoding region of hepatitis C virus. Proc Natl Acad Sci USA 1992; 89: 4942.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 4942
    • Bukh, J.1    Purcell, R.H.2    Miller, R.H.3
  • 134
    • 0026742307 scopus 로고
    • Identification of hepatitis C viruses with a nonconserved sequence of the 5′ untranslated region
    • Lee CH, Cheng C, Wang J, Lumeng L. Identification of hepatitis C viruses with a nonconserved sequence of the 5′ untranslated region. J Clin Microbiol 1992; 30: 1602.
    • (1992) J Clin Microbiol , vol.30 , pp. 1602
    • Lee, C.H.1    Cheng, C.2    Wang, J.3    Lumeng, L.4
  • 135
    • 0026334457 scopus 로고
    • Nucleotide sequence and mutation rate of the H strain of hepatitis C virus
    • Ogata N, Alter HJ, Miller RH, Purcell RH. Nucleotide sequence and mutation rate of the H strain of hepatitis C virus. Proc Natl Acad Sci USA 1991; 88: 3392.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 3392
    • Ogata, N.1    Alter, H.J.2    Miller, R.H.3    Purcell, R.H.4
  • 137
    • 0026565572 scopus 로고
    • Clinical backgrounds of the patients having different types of hepatitis C virus genomes
    • published erratum appears in J Hepatol 1992; 14: 435
    • Takada N, Takase S, Enomoto N, Takada A, Date T. Clinical backgrounds of the patients having different types of hepatitis C virus genomes (published erratum appears in J Hepatol 1992; 14: 435). J Hepatol 1992; 14: 35.
    • (1992) J Hepatol , vol.14 , pp. 35
    • Takada, N.1    Takase, S.2    Enomoto, N.3    Takada, A.4    Date, T.5
  • 140
    • 0026663653 scopus 로고
    • Heterogeneity within the nonstructural protein 5′-encoding region of hepatitis C viruses from a single patient
    • Murakawa K, Esumi M, Kato T, Kambara H, Shikata T. Heterogeneity within the nonstructural protein 5′-encoding region of hepatitis C viruses from a single patient. Gene 1992; 117: 229.
    • (1992) Gene , vol.117 , pp. 229
    • Murakawa, K.1    Esumi, M.2    Kato, T.3    Kambara, H.4    Shikata, T.5
  • 141
    • 0026550241 scopus 로고
    • Molecular cloning of hepatitis C virus genome from a single Japanese carrier: Sequence variation within the same individual and among infected individuals
    • Tanaka T, Kato N, Nakagawa M, Ootsuyama Y, Cho MJ, Nakazawa T, Hijikata M, Ishimura Y, Shimotohno K. Molecular cloning of hepatitis C virus genome from a single Japanese carrier: sequence variation within the same individual and among infected individuals. Virus Res 1992; 23: 39.
    • (1992) Virus Res , vol.23 , pp. 39
    • Tanaka, T.1    Kato, N.2    Nakagawa, M.3    Ootsuyama, Y.4    Cho, M.J.5    Nakazawa, T.6    Hijikata, M.7    Ishimura, Y.8    Shimotohno, K.9
  • 143
    • 0031055840 scopus 로고    scopus 로고
    • Analysis of histopathological manifestations of chronic hepatitis C virus infection with respect to virus genotype
    • Mihm S, Fayyazi A, Hartmann H, Ramadori G. Analysis of histopathological manifestations of chronic hepatitis C virus infection with respect to virus genotype. Hepatology 1997; 25: 735.
    • (1997) Hepatology , vol.25 , pp. 735
    • Mihm, S.1    Fayyazi, A.2    Hartmann, H.3    Ramadori, G.4
  • 144
    • 0027522571 scopus 로고
    • Correlation of plasma hepatitis C virus RNA levels with serum alanine aminotransferase in non-A, non-B chronic liver disease
    • Kurosaki M, Enomoto N, Sato C, Sakamoto N, Hoshino Y, Haritani H, Marumo F. Correlation of plasma hepatitis C virus RNA levels with serum alanine aminotransferase in non-A, non-B chronic liver disease. J Med Virol 1993; 39: 246.
    • (1993) J Med Virol , vol.39 , pp. 246
    • Kurosaki, M.1    Enomoto, N.2    Sato, C.3    Sakamoto, N.4    Hoshino, Y.5    Haritani, H.6    Marumo, F.7
  • 146
    • 0029878608 scopus 로고    scopus 로고
    • Intrahepatic hepatitis C RNA levels do not correlate with degree of liver injury in patients with chronic hepatitis C
    • McGuinness PH, Bishop GA, Painter DM, Chan R, McCaughan GW. Intrahepatic hepatitis C RNA levels do not correlate with degree of liver injury in patients with chronic hepatitis C. Hepatology 1996; 23: 676.
    • (1996) Hepatology , vol.23 , pp. 676
    • McGuinness, P.H.1    Bishop, G.A.2    Painter, D.M.3    Chan, R.4    McCaughan, G.W.5
  • 147
    • 0029908438 scopus 로고    scopus 로고
    • Phylogenetic analysis of hepatitis C virus isolates and their correlation to viremia, liver function tests, and histology
    • Zeuzem S, Franke A, Lee J-H, Herrman G, Rüster B, Roth WK. Phylogenetic analysis of hepatitis C virus isolates and their correlation to viremia, liver function tests, and histology. Hepatology 1996; 24: 1003.
    • (1996) Hepatology , vol.24 , pp. 1003
    • Zeuzem, S.1    Franke, A.2    Lee, J.-H.3    Herrman, G.4    Rüster, B.5    Roth, W.K.6
  • 148
    • 0031012253 scopus 로고    scopus 로고
    • Lack of correlation between hepatitis C virus genotypes and clinical course of hepatitis C virus-related cirrhosis
    • Benvegnu L, Pontisso P, Cavalletto D, Noventa F, Ghemello L, Alberti A. Lack of correlation between hepatitis C virus genotypes and clinical course of hepatitis C virus-related cirrhosis. Hepatology 1997; 25: 211.
    • (1997) Hepatology , vol.25 , pp. 211
    • Benvegnu, L.1    Pontisso, P.2    Cavalletto, D.3    Noventa, F.4    Ghemello, L.5    Alberti, A.6
  • 152
    • 0028140138 scopus 로고
    • Neutralizing antibodies against hepatitis C virus and the emergence of neutralization escape mutant viruses
    • Shimizu YK, Hijikata M, Twamoto A, Alter HJ, Purcell RH, Yoshikura H. Neutralizing antibodies against hepatitis C virus and the emergence of neutralization escape mutant viruses. J Virol 1994; 68: 1494.
    • (1994) J Virol , vol.68 , pp. 1494
    • Shimizu, Y.K.1    Hijikata, M.2    Twamoto, A.3    Alter, H.J.4    Purcell, R.H.5    Yoshikura, H.6
  • 157
    • 0028215071 scopus 로고
    • Prediction of interferon effect in chronic hepatitis C by both quantification and genotyping of HCV-RNA
    • Yamada G, Takahashi M, Miyamoto R, Tsuji T, Yoshizawa H, Okamoto H. Prediction of interferon effect in chronic hepatitis C by both quantification and genotyping of HCV-RNA (letter). Dig Dis Sci 1994; 39: 441.
    • (1994) Dig Dis Sci , vol.39 , pp. 441
    • Yamada, G.1    Takahashi, M.2    Miyamoto, R.3    Tsuji, T.4    Yoshizawa, H.5    Okamoto, H.6
  • 158
    • 0026777128 scopus 로고
    • HCV genotypes in chronic hepatitis C and response to interferon
    • Kanai K, Kako M, Okamoto H. HCV genotypes in chronic hepatitis C and response to interferon (letter). Lancet 1992; 339: 1543.
    • (1992) Lancet , vol.339 , pp. 1543
    • Kanai, K.1    Kako, M.2    Okamoto, H.3
  • 159
    • 0026703267 scopus 로고
    • The degree of variability in the amino terminal region of the E2/NS1 protein of hepatitis C virus correlates with responsiveness to interferon therapy in viremic patients
    • Okada S, Akahane Y, Suzuki H, Okamoto H, Mishiro S. The degree of variability in the amino terminal region of the E2/NS1 protein of hepatitis C virus correlates with responsiveness to interferon therapy in viremic patients. Hepatology 1992; 16: 619.
    • (1992) Hepatology , vol.16 , pp. 619
    • Okada, S.1    Akahane, Y.2    Suzuki, H.3    Okamoto, H.4    Mishiro, S.5
  • 160
    • 0026734297 scopus 로고
    • Detection of hepatitis C virus by polymerase chain reaction and response to interferon-alpha therapy: Relationship to genotypes of hepatitis C virus
    • Yoshioka K, Kakumu S, Wakita T, Ishikawa T, Itoh Y, Takayanagi M, Higashi Y, Shibata M, Morishima T. Detection of hepatitis C virus by polymerase chain reaction and response to interferon-alpha therapy: relationship to genotypes of hepatitis C virus. Hepatology 1992; 16: 293.
    • (1992) Hepatology , vol.16 , pp. 293
    • Yoshioka, K.1    Kakumu, S.2    Wakita, T.3    Ishikawa, T.4    Itoh, Y.5    Takayanagi, M.6    Higashi, Y.7    Shibata, M.8    Morishima, T.9
  • 161
    • 0030911115 scopus 로고    scopus 로고
    • Hepatitis C virus genome complexity correlates with response to interferon therapy: A study in French patients with chronic hepatitis C
    • Le Guen B, Squadrito G, Nalpas B, Berthelot P, Pol S, Brechot C. Hepatitis C virus genome complexity correlates with response to interferon therapy: a study in French patients with chronic hepatitis C. Hepatology 1997; 25: 1250.
    • (1997) Hepatology , vol.25 , pp. 1250
    • Le Guen, B.1    Squadrito, G.2    Nalpas, B.3    Berthelot, P.4    Pol, S.5    Brechot, C.6
  • 162
    • 0029908439 scopus 로고    scopus 로고
    • The clinical significance of changes in genetic heterogeneity of the hypervariable region 1 in chronic hepatitis C with interferon therapy
    • Shindo M, Hamada K, Koya S, Arai K, Sokawa Y, Okundo T. The clinical significance of changes in genetic heterogeneity of the hypervariable region 1 in chronic hepatitis C with interferon therapy. Hepatology 1996; 24: 3018.
    • (1996) Hepatology , vol.24 , pp. 3018
    • Shindo, M.1    Hamada, K.2    Koya, S.3    Arai, K.4    Sokawa, Y.5    Okundo, T.6
  • 163
    • 0029161576 scopus 로고
    • Comparison of full-length sequences of interferon-sensitive and resistant hepatitis C virus 1b. Sensitivity to interferon is conferred by amino acid substitutions in the NS5A region
    • Enomoto N, Sakuma I, Asahina Y, Kurosaki M, Murakami T, Yamamoto C, Izumi N, Marumo F, Sato C. Comparison of full-length sequences of interferon-sensitive and resistant hepatitis C virus 1b. Sensitivity to interferon is conferred by amino acid substitutions in the NS5A region. J Clin Invest 1995; 96: 224.
    • (1995) J Clin Invest , vol.96 , pp. 224
    • Enomoto, N.1    Sakuma, I.2    Asahina, Y.3    Kurosaki, M.4    Murakami, T.5    Yamamoto, C.6    Izumi, N.7    Marumo, F.8    Sato, C.9
  • 164
    • 9144257569 scopus 로고    scopus 로고
    • Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infection
    • Enomoto N, Sakuma I, Asahina Y, Kurosaki M, Murakami T, Yamamoto C, Ogura Y, et al. Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infection. N Engl J Med 1996; 334: 77.
    • (1996) N Engl J Med , vol.334 , pp. 77
    • Enomoto, N.1    Sakuma, I.2    Asahina, Y.3    Kurosaki, M.4    Murakami, T.5    Yamamoto, C.6    Ogura, Y.7
  • 165
  • 167
    • 0031056446 scopus 로고    scopus 로고
    • Mutations in the nonstructural 5A gene of European hepatitis C virus isolates and response to interferon alfa
    • Zeuzem S, Lee JH, Roth WK. Mutations in the nonstructural 5A gene of European hepatitis C virus isolates and response to interferon alfa. Hepatology 1997; 25: 740.
    • (1997) Hepatology , vol.25 , pp. 740
    • Zeuzem, S.1    Lee, J.H.2    Roth, W.K.3
  • 169
    • 0029860025 scopus 로고    scopus 로고
    • Evidence that the HLA DQA1*03 allele confers protection from chronic HCV-infection in northern European Caucasoids
    • Tibbs C, Donaldson P, Underhill J, Thomson L, Manabe K, Williams R. Evidence that the HLA DQA1*03 allele confers protection from chronic HCV-infection in northern European Caucasoids. Hepatology 1996; 24: 1342.
    • (1996) Hepatology , vol.24 , pp. 1342
    • Tibbs, C.1    Donaldson, P.2    Underhill, J.3    Thomson, L.4    Manabe, K.5    Williams, R.6
  • 170
    • 0030933395 scopus 로고    scopus 로고
    • Natural history of liver fibrosis progression in patients with chronic hepatitis C
    • Poynard T, Bedossa P, Opolon P. Natural history of liver fibrosis progression in patients with chronic hepatitis C. Lancet 1997; 349: 825.
    • (1997) Lancet , vol.349 , pp. 825
    • Poynard, T.1    Bedossa, P.2    Opolon, P.3
  • 171
    • 0030800166 scopus 로고    scopus 로고
    • Epidemiological factors affecting the severity of hepatitis C virus-related liver disease: A French survey of 6,664 patients
    • Roudot-Thoraval F, Bastie A, Pawlotsky J-M, Dhumeaux D. Epidemiological factors affecting the severity of hepatitis C virus-related liver disease: a French survey of 6,664 patients. Hepatology 1997; 26: 485.
    • (1997) Hepatology , vol.26 , pp. 485
    • Roudot-Thoraval, F.1    Bastie, A.2    Pawlotsky, J.-M.3    Dhumeaux, D.4
  • 172
    • 0029858721 scopus 로고    scopus 로고
    • The "gold-standard", accuracy, and the current concepts: Hepatitis C virus genotype and viremia
    • Ohno T, Lau JYN. The "gold-standard", accuracy, and the current concepts: hepatitis C virus genotype and viremia. Hepatology 1996, 24: 1312.
    • (1996) Hepatology , vol.24 , pp. 1312
    • Ohno, T.1    Lau, J.Y.N.2
  • 173
    • 0031047358 scopus 로고    scopus 로고
    • The natural history of chronic hepatitis C and what we should do about it
    • Dienstag JL. The natural history of chronic hepatitis C and what we should do about it. Gastroenterology 1997; 112: 651.
    • (1997) Gastroenterology , vol.112 , pp. 651
    • Dienstag, J.L.1
  • 174
    • 0026351238 scopus 로고
    • The molecular basis of heterogeneity of hepatitis delta virus
    • Lai MM, Lee CM, Bih FY, Govindarajan S. The molecular basis of heterogeneity of hepatitis delta virus. J Hepatol 1991; 13 [Suppl 4]: S121.
    • (1991) J Hepatol , vol.13 , Issue.4 SUPPL.
    • Lai, M.M.1    Lee, C.M.2    Bih, F.Y.3    Govindarajan, S.4
  • 177
    • 0025362010 scopus 로고
    • Cloning and sequencing of RNA of hepatitis delta virus isolated from human serum
    • Saldanha JA, Thomas HC, Monjardino JP. Cloning and sequencing of RNA of hepatitis delta virus isolated from human serum. J Gen Virol 1990; 71: 1603.
    • (1990) J Gen Virol , vol.71 , pp. 1603
    • Saldanha, J.A.1    Thomas, H.C.2    Monjardino, J.P.3
  • 178
    • 0025514049 scopus 로고
    • Heterogeneity and evolution rates of delta virus RNA sequences
    • Imazeki F, Omata M, Ohto M. Heterogeneity and evolution rates of delta virus RNA sequences. J Virol 1990; 64: 5594.
    • (1990) J Virol , vol.64 , pp. 5594
    • Imazeki, F.1    Omata, M.2    Ohto, M.3
  • 180
  • 181
    • 0029089248 scopus 로고
    • Genotyping of hepatitis D virus by restriction-fragment length polymorphism and relation to outcome of hepatitis D
    • Wu JC, Choo KB, Chen CM Chen TZ, Huo TL Lee SD. Genotyping of hepatitis D virus by restriction-fragment length polymorphism and relation to outcome of hepatitis D. Lancet 1995; 346: 939.
    • (1995) Lancet , vol.346 , pp. 939
    • Wu, J.C.1    Choo, K.B.2    Chen, C.M.3    Chen, T.Z.4    Huo, T.L.5    Lee, S.D.6
  • 182
    • 0031043256 scopus 로고    scopus 로고
    • The predominance of hepatitis delta virus genotype I among chronically infected Italian patients
    • Niro GA, Smedile A, Andriulli A, Rizzetto M, Gerin JL, Casey JL. The predominance of hepatitis delta virus genotype I among chronically infected Italian patients. Hepatology 1997; 25: 728.
    • (1997) Hepatology , vol.25 , pp. 728
    • Niro, G.A.1    Smedile, A.2    Andriulli, A.3    Rizzetto, M.4    Gerin, J.L.5    Casey, J.L.6


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