A pretransplant infection with precore mutants of hepatitis B virus does not influence the outcome of orthotopic liver transplantation in patients on high dose anti-hepatitis B virus surface antigen immunoprophylaxis

Hepatology

Volumn 26, Issue 2, 1997, Pages 478-484

  Naumann, Uta ^a,c   Protzer Knolle, Ulrike ^b   Berg, Thomas ^a   Leder, Korinna ^a   Lobeck, Hartmut ^a   Bechstein, Wolf Otto ^a   Gerken, Guido ^b   Hopf, Uwe ^a   Neuhaus, Peter ^a  

^a HUMBOLDT UNIVERSITY   (Germany)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

HEPATITIS B ANTIBODY; HEPATITIS B SURFACE ANTIBODY; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B(E) ANTIBODY; HEPATITIS B(E) ANTIGEN; HYPERIMMUNE GLOBULIN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M;

ADULT; ARTICLE; CONTROLLED STUDY; DRUG MEGADOSE; FEMALE; GRAFT INFECTION; GRAFT SURVIVAL; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; HUMAN TISSUE; IMMUNOPROPHYLAXIS; INTRAVENOUS DRUG ADMINISTRATION; LIVER CIRRHOSIS; LIVER TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; TREATMENT OUTCOME; VIRUS CORE; VIRUS MUTANT;

ADULT; DNA, VIRAL; FEMALE; HEPATITIS B; HEPATITIS B SURFACE ANTIGENS; HUMANS; IMMUNOGLOBULINS; LIVER TRANSPLANTATION; MALE; MIDDLE AGED; RECURRENCE;

EID: 0030842372     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.510260232     Document Type: Article

References (26)

1. Blumhardt G, Neuhaus P, Bechstein WO, Steffen R, Hopf U, Möller B, Raakow R, et al. Liver transplantation in HBsAg positive patients. Transplant Proc 1990;22:1517-1518.
2. Todo S, Demetris AJ, Van Thiel D, Teperman L, Fung JJ, Starzl TE. Orthotopic liver transplantation for patients with hepatitis B virus-related liver disease. HEPATOLOGY 1991;13:619-626.
3. O'Grady JG, Smith HM, Davies SE, Daniels HM, Donaldson PT, Tan KC, Portmann B, et al. Hepatitis B reinfection after liver transplantation. Serological and clinical implications. J Hepatol 1992;14:104-111.
4. Samuel D, Müller R, Alexander G, Fassati L, Ducot B, Benhamou JP, Bismuth H. Liver transplantation in European patients with the hepatitis B surface antigen. N Engl J Med 1993;329:1842-1847.
5. König V, Hopf U, Neuhaus P, Bauditz J, Schmidt CA, Blumhardt G, Bechstein WO, et al. Long-term follow-up of hepatitis B virus-infected recipients after orthotopic liver transplantation. Transplantation 1994;58:553-559.
6. Samuel D, Bismuth A, Mathieu D, Arulnaden JL, Reynes M, Benhamou JP, Brechot C, et al. Passive immunoprophylaxis after liver transplantation in HBsAg-positive patients. Lancet 1991;337:813-815.
7. Müller R, Gubernatis G, Parle M, Niehoff G, Klein H, Wittekind C, Tusch G, et al. Liver transplantation in HBs antigen (HBsAg) carriers: prevention of hepatitis B virus (HBV) recurrence by passive immunization. J Hepatol 1991;13:90-96.
8. Devlin J, Smith HM, O'Grady JG, Portmann B, Tan KC, Williams R. Impact of immunoprophylaxis and patient selection on outcome of transplantation for HBsAg positive liver recipients. J Hepatol 1994;21:204-210.
9. Müller R, Samuel D, Fassati LR, Benhamou JP, Bismuth H, Alexander GJM. "EUROHEP" consensus report on the management of liver transplantation for hepatitis B virus infection. J Hepatol 1994;21:1140-1143.
10. Angus PW, Locarnini SA, McCaughan GW, Jones RM, McMillan JS, Bowden DS. Hepatitis B virus mutant infection is associated with severe recurrent disease after liver transplantation. HEPATOLOGY 1995;21:14-18.
11. Davies SE, Portmann B, O'Grady J, Aldis PM, Chaggar K, Alexander GJM, Williams R. Hepatic histology following transplantation for chronic hepatitis B virus infection including a unique pattern of fibrosing cholestatic hepatitis. HEPATOLOGY 1991;13:150-157.
12. Fang JW, Tung FYT, Davis GL, Dolson DJ, Van Thiel DH, Lau JYN. Fibrosing cholestatic hepatitis in a transplant recipient with hepatitis B virus precore mutant. Gastroenterology 1993;105:901-904.
13. Fang JW, Wright TL, Lau JY. Fibrosing cholestatic hepatitis in a patient with HIV and hepatitis B [Letter]. Lancet 1993;342:1175.
14. Booth JCL, Goldin RD, Brown JL, Karayiannis P, Thomas HC. Fibrosing cholestatic hepatitis in a renal transplant recipient associated with the hepatitis B virus precore mutant. J Hepatol 1995;22:500-503.
15. Chen CH, Chen PJ, Chu JS, Yeh KH, Lai MY, Chen DS. Fibrosing cholestatic hepatitis in a hepatitis B surface antigen carrier after renal transplantation. Gastroenterology 1994;107:1514-1518.
16. McIvor C, Morton J, Bryant A, Cooksley WG, Durrant S, Walker N. Fatal reactivation of precore mutant hepatitis B virus associated with fibrosing cholestatic hepatitis after bone marrow transplantation. Ann Intern Med 1994;121:274-275.
17. Carman WF, Jacyna MR, Hadzyanis S, Karayiannis P, McGarvey MJ, Makris A, Thomas HC. Mutation preventing formation of hepatitis B e antigens in patients with chronic hepatitis B infection. Lancet 1989;ii:588-590.
18. Laras A, Aygidis J, Koskinas J, Hadziyannis SJ. High incidence of HBV precore gene translation initiation mutations in e antigen negative patients [Abstract]. HEPATOLOGY 1995;22:269A.
19. Tur Kaspa R, Klein A, Aharonson S. Hepatitis B virus precore mutants are identical in carriers from various ethnic origins and are associated with a range of liver disease severity. HEPATOLOGY 1992;16:1338-1342.
20. Lindh M, Horal P, Dhillon AP, Furuta Y, Norkrans G. Hepatitis B virus carriers without precore mutations in hepatitis B e antigen-negative stage show more severe liver damage. HEPATOLOGY 1996;24:494-501.
21. Hopf U, Neuhaus P, Lobeck H, König V, Küther S, Bauditz J, Bechstein WO, Blumhardt G, Steffen R, Neuhaus R, Huhn D. Follow-up of recurrent hepatitis B and delta infection in liver allograft recipients after treatment with recombinant interferon-alpha. J Hepatol 1991;13:339-346.
22. Haller G, Bechstein WO, Neuhaus R, Raakow R, Berg T, Hopf U, Neuhaus P. Famcyclovir therapy for recurrent HBV infection after liver transplantation. Transpl Int 1996;9:475-477.
23. Neuhaus P, Blumhardt G, Bechstein WO, Platz KP, Jonas S, Mueller AR, Langrehr JM, Lohmann R, Schattenfroh N, Knoop M, et al. Comparison of FK506 and cyclosporine-based immunosuppression in primary orthotopic liver transplantation. A single center experience. Transplantation 1995;59:31-40.
24. Neuhaus P, Bechstein WO, Blumhardt G, Wiens M, Lemmens P, Langrehr JM, Lohmann R, et al. Comparison of quadruple immunosuppression after liver transplantation with ATG or IL-2 receptor antibody. Transplantation 1993;55:1320-1327.
25. Butterworth LA, Prior SL, Buda PJ, Faoagali JL, Cooksley WGE. Comparison of four methods for quantitative measurement of hepatitis B viral DNA. J Hepatol 1996;24:686-691.
26. Protzer U, Goergen B, Hopf U, Neuhaus P, Meyer zum Büschenfelde KH, Gerken G. Pre-core mutants of hepatitis B virus in patients receiving immunosuppressive treatment after orthotopic liver transplantation. J Med Virology 1996;50:135-144.