Nuclear translocation of the catalytic component of DNA-dependent protein kinase upon growth stimulation in normal human T lymphocytes

Cell Structure and Function

Volumn 22, Issue 6, 1997, Pages 585-594

  Nagasawa, Masayuki ^a   Watanabe, Fumiaki ^b   Suwa, Akira ^c   Yamamoto, Kohtaro ^b   Tsukada, Kinji ^b   Teraoka, Hirobumi ^b  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^c Tokyo Metropolitan Ohtsuka Hospital   (Japan)

Author keywords

Cell cycle; DNA dependent protein kinase; Ku protein; Nuclear localization; T lymphocptes

Indexed keywords

PROTEIN KINASE;

ARTICLE; CELL NUCLEUS; ENZYME ACTIVITY; GROWTH STIMULATION; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; LYMPHOCYTE PROLIFERATION; MONONUCLEAR CELL; NORMAL HUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 0031406636     PISSN: 03867196     EISSN: None     Source Type: Journal    
DOI: 10.1247/csf.22.585     Document Type: Article

References (38)

1. CARTER, T., VANCUROVA, I., SUN, I., LOU, W., and DELEON, S. 1990. A DNA-activated protein kinase from HeLa cell nuclei. Mol. Cell Biol., 10: 6460-6471.
2. LEES-MILLER, S.P., CHEN, Y.-R., and ANDEERSON, C.W. 1990. Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40 T antigen, mouse p53, and the human Ku autoantigen. Mol. Cell Biol., 10: 6472-6481.
3. IIJIMA, S., TERAOKA, H., DATE, T., and TSUKADA, K. 1992. DNA-activated protein kinase in Raji Burkitt's lymphoma cells: Phosphorylation of c-Myc oncoprotein. Eur. J. Biochem., 206: 595-603.
4. LEES-MILLER, S.P., SAKAGUCHI, K., ULLRICH, S.J., APPELLA, E., and ANDERSON, C.W. 1992. Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53. Mol. Cell Biol., 12: 5041-5049.
5. DVIR, A., STEIN, L.Y., CALORE, B.L., and DYNAN, W.S. 1993. Purification and characterization of a template-associated protein kinase that phosphorylates RNA polymerase II. J. Biol. Chem., 268: 10440-10447.
6. ANDERSON, C.W. 1993. DNA damage and the DNA-activated protein kinase. Trends Biochem. Soc., 18: 433-437.
7. WATANABE, F., TERAOKA, H., IIJIMA, S., MIMORI, T., and TSUKADA, K. 1994. Molecular properties, substrate specificity and regulation of DNA-dependent protein kinase from Raji Burkitt's lymphoma cells. Biochim. Biophys. Acta, 1223: 255-260.
8. PAN, Z.-Q., AMIN, A.A., GIBBS, E., NIU, H., and HURWITZ, J. 1994. Phosphorylation of the p34 subunit of human single-stranded-DNA binding protein in cyclin A-activated G1 extracts is catalyzed by cdk-cyclin A complex and DNA-dependent protein kinase. Proc. Natl. Acad. Sci. USA, 91: 8343-8347.
9. CHIBAZAKURA, T., WATANABE, F., KITAJIMA, S., TSUKADA, K., YASUKOCHI, Y., and TERAOKA, H. 1997. Phosphorylation of human general transcription factors TBP and TFIIB by DNA-dependent protein kinase: Synergistic stimulation of RNA polymerase II basal transcription in vitro. Eur. J. Biochem., 247: 1166-1173.
10. DVIR, A., PETERSON, S.R., KNUTH, M.W., LU, H., and DYNAN, W.S. 1992. Ku autoantigen is the regulatory component of a template-associated protein kinase that phosphorylates RNA polymerase II. Proc. Natl. Acad. Sci. USA, 89: 11920-11924.
11. GOTTLIEB, T.M. and JACKSON, S.P. 1993. The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen. Cell, 72: 131-142.
12. MIMORI, T. and HARDIN, J.A. 1986. Mechanism of interaction between Ku protein and DNA. J. Biol. Chem., 261: 10375-10379.
13. MOROZOV, V.E., FALZON, M., ANDERSON, C.W., and KUFF, E.L. 1994. DNA-dependent protein kinase is activated by nicks and larger single-stranded gaps. J. Biol. Chem., 269: 16684-16688.
14. MIMORI, T., AKIZUKI, M., YAMAGATA, H., INADA, S., YOSHIDA, S., and HOMMA, M. 1981. Characterization of a high molecular weight acidic nuclear protein recognized by antibodies in sera from patients with polymyositis-scleroderma overlap syndrome. J. Clin. Invest., 68: 611-620.
15. SUWA, A., HIRAKATA, M., TAKEDA, Y., JESCH, S.A., MIMORI, T., and HARDIN, J.A. 1994. DNA-dependent protein kinase (Ku protein-p350 complex) assembles on double-stranded DNA. Proc. Natl. Acad. Sci. USA, 91: 6904-6908.
16. SMIDER, V., RATHMELL, W.K., LIEBER, M.R., and CHU, G. 1994. Restoration of X-ray resistance and V(D)J recombination in mutant cells by Ku cDNA. Science, 266: 288-291.
17. TACCIOLI, G.E., GOTTLIEB, T.M., BLUNT, T., PRIESTLEY, A., DEMENGEOT, J., MIZUTA, R., LEHMANN, A.R., ALT, F.W., JACKSON, S.P., and JEGGO, P.A. 1994. Ku80: Product of the XRCC5 gene and its role in DNA repair and V(D)J recombination. Science, 265: 1442-1445.
18. FINNIE, N.J., GOTTLIEB, T.M., BLUNT, T., JEGGO, P.A., and JACKSON, S.P. 1995. DNA-dependent protein kinase is absent in xrs-6 cells: Implication for site-specific recombination and DNA double-stranded break repair. Proc. Natl. Acad. Sci. USA, 92: 320-324.
19. BLUNT, T., FINNIE, N.J., TACCIOLI, G.E., SMITH, G.C.M., DEMENGEOT, J., GOTTLIEB, T.M., MIZUTA, R., VARGHESE, A.J., ALT, F.W., JEGGO, P.A., and JACKSON, S.P. 1995. Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation. Cell, 80: 813-823.
20. KIRCHGESSNER, C.U., PATIL, C.K., EVANS, J.W., CUOMO, C.A., FRIED, L.M., CARTER, T., OETTINGER, M.A., and BROWN, J.M. 1995. DNA-dependent protein kinase (p350) as a candidate gene for the murine SCID defect. Science, 267: 1178-1183.
21. PETERSON, S.R., KURIMASA, A., OSHIMURA, M., DYNAN, W.S., BRADBURY, E.M., and CHEN, D.J. 1995. Loss of the catalytic subunit of the DNA-dependent protein kinase in DNA double-strand-break-repair mutant mammalian cells. Proc. Natl. Acad. Sci. USA, 92: 3171-3174.
22. CHAN, D.W. and LEES-MILLER, S.P. 1996. The DNA-dependent protein kinase is inactivated by autophosphorylation of the catalytic subunit. J. Biol. Chem., 271: 8936-8941.
23. WATANABE, F., SHIRAKAWA, H., YOSHIDA, M., TSUKADA, K., and TERAOKA, H. 1994. Stimulation of DNA-dependent protein kinase by high mobility group proteins 1 and 2. Biochem. Biophys. Res. Comm., 202: 736-742.
24. PIL, P.M., CHOW, C.S., and RIPPARD, S.J. 1993. High-mobility-group 1 protein mediates DNA bending as determined by ring closures. Proc. Natl. Acad. Sci. USA, 90: 9465-9469.
25. CHAN, D.W., MODY, C.H., TING, N.S., and LEES-MILLER, S.P. 1996. Purification and characterization of the double-stranded DNA-activated protein kinase, DNA-PK, from human placenta. Biochem. Cell Biol., 74: 67-73.
26. Rb phosphorylation during cell cycle progression of normal human T cells. J. Immunol., 148: 1804-1811.
27. SUWA, A., HIRAKATA, M., TAKEDA, Y., OKANO, Y., MIMORI, T., INADA, S., WATANABE, F., TERAOKA, H., DYNAN, W.S., and HARDIN, J.A. 1996. Autoantibodies to DNA-dependent protein kinase. Probes for the catalytic subunit. J. Clin. Invest., 97: 1417-1421.
28. SAWAI, M., TAKASE, K., TERAOKA, H., and TSUKADA, K. 1990. Reversible G1 arrest in the cell cycle of human lymphoid cell lines by dimethyl sulfoxide. Exp. Cell Res., 187: 4-10.
29. cdc2 kinases. Cell Growth Differ., 5: 1051-1059.
30. YAMAMOTO, K. and OSATO, T. 1977. Differential induction of Epstein-Barr virus-related antigens in heterokaryon cultures. Int. J. Cancer, 19: 767-774.
31. YANEVA, M. and JHIANG, S. 1991. Expression of the Ku protein during cell proliferation. Biochim. Biophys. Acta, 1090: 181-187.
32. ANDERSON, C.W. and LEES-MILLER, S.P. 1992. The nuclear serine/threonine protein kinase DNA-PK. Crt. Rev. Eukaryot. Gene Exp., 2: 283-314.
33. BLUNT, T., GELI, D., FOX, M., TACCIOLI, G.E., LEHMANN, A.R., JACKSON, S.P., and JEGGO, P.A. 1996. Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse. Proc. Natl. Acad. Sci. USA, 93: 10285-10290.
34. CONNELLY, M.A., ZHANG, H., KIELECZAWA, J., and ANDERSON, C.W. 1996. Alternate splice-site utilization in the gene for the catalytic subunit of the DNA-activated protein kinase, DNA-PKcs. Gene, 175: 271-273.
35. CASCIOLA-ROSEN, L.A., NICHOLSON, D.W., CHONG, T., ROWAN, K.R., THORNBERRY, N.A., MILLER, D.K., and ROSEN, A. 1996. Apopain/CPP32 cleaves proteins that are essential for cellular repair: a fundamental principle of apoptotic death. J. Exp. Med., 183: 1957-1964.
36. SONG, Q., LEES-MILLER, S.P., KUMAR, S., ZHANG, N., CHAN, D.W., SMITH, G.C.M., JACKSON, S.P., ALNEMRI, E.S., LITWACK, G., KHANNA, K.K., and LAVIN, M.F. 1996. DNA-dependent protein kinase catalytic subunit: a target for an ICE-like protease in apoptosis. EMBO J., 15: 3238-3246.
37. TERAOKA, H., YUMOTO, Y., WATANABE, F., TSUKADA, K., SUWA, A., ENARI, M., and NAGATA, S. 1996. CPP32/Yama/apopain cleaves the catalytic component of DNA-dependent protein kinase in the holoenzyme. FEBS Lett., 393: 1-6.
38. HAN, Z., MALIK, N., CARTER, T., REEVES, W.H., WYCHE, J.H., and HENDRICKSON, E.A. 1996. DNA-dependent protein kinase is a target for a CPP32-like apoptotic protease. J. Biol. Chem., 271: 25035-25040.