MK-801 induces apoptotic neuronal death in the rat retrosplenial cortex: Prevention by cycloheximide and R(-)-2-hexyl-N-methylpropargylamine

Journal of Neuroscience Research

Volumn 46, Issue 1, 1996, Pages 82-89

  Zhang, Xia ^a   Boulton, Alan A ^a   Zuo, Dong Mei ^a   Yu, Peter H ^a  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

Author keywords

aliphatic N methylpropargylamines; apoptosis; cycloheximide; MK 801; psychosis

Indexed keywords

CYCLOHEXIMIDE; DIZOCILPINE; MONOAMINE OXIDASE B INHIBITOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; N METHYLPROPARGYLAMINE; PROTEIN SYNTHESIS INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN CORTEX; BRAIN ISCHEMIA; BRAIN PROTECTION; CONTROLLED STUDY; DEMENTIA; DOSE RESPONSE; LIMBIC SYSTEM; MALE; NERVE CELL NECROSIS; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PSYCHOSIS; RAT; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0029740221     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4547(19961001)46:1<82::AID-JNR10>3.0.CO;2-E     Document Type: Article

References (50)

1. Allen HL, Iversen LL (1990): Phencyclidine, dizocilpine, and cerebrocortical neurons. Science 247:221.
2. Aniline O, Pitts F (1982): Phencyclidine (PCP): A review and perspectives. CRC Crit Rev Toxicol 10:145-177.
3. Ansari KS, Zhang F, Holland DP, Yu PH, Tatton WG (1993): R(-)-deprenyl, not its major metabolites, rescues axotomized immature rat facial motoneurons. Proceedings of the 23rd Neuroscience Meeting, Washington, DC, p 441.
4. Clifford DB, Olney JW, Benz AM, Fuller TA, Zorumski CF (1990): Ketamine, phencyclidine, and MK-801 protect against kainic acid-induced seizure-related brain damage. Epilepsia 31:382-390.
5. Clow DW, Lee SJ, Hammer RP (1991): Competitive (AP7) and non-competitive (MK-801) NMDA receptor antagonists differentially alter glucose utilization in rat cortex. Synapse 7:260-268.
6. Cohen JJ (1994): Apoptosis: Physiological cell death. J Lab Clin Med 124:761-765.
7. Corso TD, Neafsey EJ, Collins MA (1992): Ethanol-induced degeneration of dentate gyms, entorhinal cortex and other olfactory related areas in rats: Effects of coadministration of MK-801, DNQX, or nimodipine. Soc Neurosci Abstr 18:227.7.
8. Davis BA, Yu PH, Paterson IA, Li XM, Durden DA, Tatton WG, Boulton AA (1995): Neurorescue by the optically active enantiomers of some aliphatic N-propargylamines. 26th American Neurochemistry Society Meeting, Santa Monica, CA, p S67.
9. Ellison G (1994): Neuronal degeneration following both competitive and non-competitive NMDA antagonists. NeuroReport 5:2688-2692.
10. Ellison G (1995): The N-methyl-D-aspartate antagonists phencyclidine, ketamine and dizocilpine as both behavioral and anatomical models of the dementias. Brain Res Rev 20:250-267.
11. Farber NB, Olney JW (1995): Alpha-2 adrenergic agonists prevent NMDA antagonist neurotoxicity. Soc Neurosci Abstr 21:694.12.
12. Fix AS, Horn JW, Johnson CA, Truex LL, Smith R, Gomez E (1993a): Onset of neuronal vacuolization induced by the NMDA antagonist MK(+)801 in the rat retrosplenial cortex. Vet Pathol 30(Abstr):464.
13. Fix AS, Horn JW, Wightman KA, Johnson CA, Long GG, Storts RW, Farber N, Wozniak DF, Olney JW (1993b): Neuronal vacuolization and necrosis induced by the noncompetitive N-methyl-D-asparate (NMDA) antagonist MK(+)801 (dizocilpine maleate): A light and electron microscopic evaluation of the rat retrosplenial cortex. Exp Neurol 123:204-215.
14. Fix AS, Horn JW, Truex LL, Smith RA, Gomez E (1994a): Neuronal vacuole formation in the rat posterior cingulate/retrosplenial cortex after treatment with the N-methyl-D-aspartate (NMDA) antagonist MK-801 (dizocilpine maleate). Acta Neuropathol 88:511-519.
15. Fix AS, Long GG, Wozniak DF, Olney JW (1994b): Pathomorphologic effects of N-methyl-D-aspartate antagonists in the rat posterior cingulate/retrosplenial cerebral cortex: A review. Drug Dev Res 32:147-152.
16. Fritschy J-M, Grzanna R (1992): Degeneration of rat locus coeruleus neurons is not accompanied by an irreversible loss of ascending projections. Evidence for reestablishment of forebrain innervation by surviving neurons. Ann NY Acad Sci 648:275-278.
17. Fritschy J-M, Geffard M, Grzanna R (1990): The response of noradrenergic axons to systematically administered DSP-4 in the rat: An immunohistochemical study using antibodies to noradrenaline and dopamine-β-hydroxylase. J Chem Neuroanat 3:309-321.
18. Gill R, Foster AC, Woodruff GN (1987): Systemic administration of MK-801 protects against ischemia-induced hippocampal neurodegeneration in the gerbil. J Neurosci 7:3343-3349.
19. Gill R, Foster AC, Woodruff GN (1988): MK-801 is neuroprotective in gerbils when administered during the post-ischemic period. Neuroscience 25:847-855.
20. Hargreaves RJ, Rigby M, Smith D, Hill RG, Iversen LL (1993): Competitive as well as non-competitive N-methyl-D-aspartate receptor antagonists affect cortical neuronal morphology and glucose metabolism. Neurochem Res 18:1263-1269.
21. Hockenbery D (1995): Defining apoptosis. Am J Pathol 146:16-20.
22. Horvath Z, Buzsaki G (1993): MK-801-induced neuronal damage in normal rats. Soc Neurosci Abstr 19:148.1.
23. Jevtovic-Todirivic V, Ishimaru M, Price MT, Olney JW (1995): Isoflurane, halothane and propofol protect against MK-801 neurotoxicity in rat brain. Soc Neurosci Abstr 21:37.7.
24. Kemp JA, Foster AC, Wong EHF (1987): Non-competitive antagonists of excitatory amino acid receptors. Trends Neurosci 10: 294-298.
25. Kerr JFR, Wyllie AH, Currie AR (1972): Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 26:239-257.
26. Koek W, Woods J, Winger G (1988): MK-801, a proposed non-competitive antagonist of excitatory amino acid neurotransmission, produced phencyclidine-like behavioral effects in pigeons, rats and rhesus monkeys. J Pharmacol Exp Ther 245: 969-974.
27. Kurumaji A, McCulloch J (1990): Effects of MK-801 upon local cerebral glucose utilization in conscious rats following unilateral lesion of caudal entorhinal cortex. Brain Res 531:72-82.
28. Kurumaji A, Nehls DG, Park CK, McCulloch J (1989): Effects of NMDA antagonists, MK-801 and CPP, upon local cerebral glucose use. Brain Res 496:268-284.
29. Nehls DG, Kurumaji A, Park CK, McCulloch J (1988): Differential effects of competitive and non-competitive N-methyl-D-aspartate antagonists on glucose use in the limbic system. Neurosci Lett 91:204-210.
30. Nehls DG, Park CK, MacCormack AG, McCulloch J (1990): The effects of N-methyl-D-aspartate receptor blockade with MK-801 upon the relationship between cerebral blood flow and glucose utilisation. Brain Res 511:271-279.
31. Olney JW, Labruyere J, Price MT (1989): Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs. Science 244:1360-1362.
32. Olney JW, Labruyere J, Wang G, Wozniak DF, Price MT, Sesma MA (1991): NMDA antagonist neurotoxicity: Mechanism and prevention. Science 254:1515-1518.
33. Paxinos G, Watson C (eds) (1982): "The Rat Brain in Stereotaxic Coordinates." Sydney: Academic Press.
34. Paxinos G, Watson C (eds) (1986): "The Rat Brain in Stereotaxic Coordinates." Sydney: Academic Press.
35. Pollard H, Charraiut-Marlangue C, Cantagrel S, Represa A, Robain O, Moreau J, Ben-Ari Y (1994): Kainate-induced apoptotic cell death in hippocampal neurons. Neuroscience 63:7-18.
36. Rubin LL, Philpott KL, Brooks SF (1993): The cell cycle and cell death. Curr Biol 3:391-394.
37. Schreiber SS, Tocco G, Najm I, Thompson RF, Baudry M (1993): Cycloheximide prevents kainate-induced neuronal death and c-fos expression in adult rat brain. J Mol Neurosci 4:149-159.
38. Simon RP, Swan JH, Griffiths T, Meldrum BS (1984): Blockade of N-methyl-D-aspartate receptors may protect against ischemic damage in the brain. Science 226:850-853.
39. Thompson HJ, Strange R, Schedin PJ (1992): Apoptosis in the genesis and prevention of cancer. Cancer Epidemiol Biomarkers Prev 1:597-602.
40. Wozniak DF, McEwen M, Sesma MA, Olney JW, Fix AS (1993): MK-801 induces extensive necrosis in posterior cingulate/retrosplenial cortices. Soc Neurosci Abstr 19:727.3.
41. Wozniak DF, Nardi A, Corso TD, Olney JW (1995): Scopolamine and pentobarbital attenuate MK-801-induced neuronal necrosis. Soc Neurosci Abstr 21:37.8.
42. Yu PH, Davis BA, Boulton AA (1992): Aliphatic propargylamines: Potent selective irreversible monoamine oxidase-B inhibitors. J Med Chem 35:3705-3713.
43. Yu PH, Davis BA, Durden DA, Barber A, Terleckyj I, Nicklas WG, Boulton AA (1994a): Neurochemical and neuroprotective effects of some aliphatic propargylamine MAO-B inhibitors. J Neurochem 62:697-704.
44. Yu PH, Davis BA, Fang J, Boulton AA (1994b): Neuroprotective effects of different monoamine oxidase-B inhibitors against DSP-4 induced noradrenaline depletion in mouse hippocampus. J Neurochem 63:1820-1828.
45. Yu PH, Davis BA, Zhang X, Zuo DM, Fang J, Lai CT, Li XM, Paterson IA, Boulton AA (1995): Neurochemical, neuroprotective and neurorescue effects of aliphatic N-methylpropargylamines; new MAO-B inhibitors without amphetamine-like properties. Prog Brain Res 106:113-121.
46. Zhang X, Yu PH (1995): Depletion of NOS activity in the rat dentate gyrus neurons by DSP-4 and protection by deprenyl. Brain Res Bull 38:307-311.
47. Zhang X, Yu PH, Davis BA, Boulton AA (1995a): Stereospecific neurorescue effect of deprenyl and aliphatic N-methylpropargylamines in kainic acid induced epileptic rats; HSP70 expression as a marker of neuronal damage. Soc Neurosci Abstr 21: 230.1.
48. Zhang X, Zuo DM, Davis BA, Boulton AA, Yu PH (1996): Immunohistochemical evidence of neuroprotection by R(-)-deprenyl and N-(2-hexyl)-N-methylpropargylamine on DSP-4 induced degeneration of rat brain noradrenergic axons and terminals. J Neurosci Res 43:482-489.
49. Zhang X, Zuo DM, Yu PH (1995c): Neuroprotection by R(-)-deprenyl and N-2-hexyl-N-methylpropargylamine on DSP-4, a neurotoxin, induced degeneration of noradrenergic neurons in the rat locus coeruleus. Neurosci Lett 186:45-48.
50. Zuo DM, Yu PH (1995): Increase of survival of dopamine neuroblastoma in cocultures with C-6 glioma by 1-deprenyl. Prog Brain Res 106:199-206.