Therapeutic Actions of L-Deprenyl in Dogs: A Model of Human Brain Aging

Advances in Pharmacology

Volumn 42, Issue C, 1997, Pages 316-319

  Ruehl, W W ^a   Neilson, J ^b   Hart, B ^b   Head, E ^c   Bruyette, D S ^d   Cummings, B J ^e  

^a Deprenyl Animal Health Inc   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d Veterinary Centers of America   (United States)

^e HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 77956779134     PISSN: 10543589     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S1054-3589(08)60753-X     Document Type: Article

References (7)

1. Ruehl W.W., Bruyette D.S., DePaoli A., Cotman C.W., Head E., Milgram N.W., and arid Cummings B.J. Canine cognitive dysfunction as a model for human age-related cognitive decline, dementia and Alzheimer's disease: Clinical presentation, cognitive testing, pathology and response to I-deprenyl therapy. Prog. Brain Res. 106 (1995) 217-225
2. Cummings B.J., Head E., Ruehl W., Milgram N.W., and Cotman C.W. The canine as an animal model of human aging and dementia. Neurobiol. Aging 17 (1996) 259-268
3. Tariot P.N., Schneider L.S., Patel S.V., and Goldstein B. Alzheimer's disease and I-deprenyl: Rationales and findings. In: Szelenyi I. (Ed). Inhibitors of Monoamine Oxidase B (1993), Birkhauser Verlag, Basel 301-317
4. Bruyette D.S., Ruehl W.W., and Smidberg T.L. Canine pituitary-dependent hyperadrenocorticism: A spontaneous animal model for neurodegenerative disorders and their treatment with 1-deprenyl. Prog. Brain Res. 106 (1995) 207-215
5. Tatton W.G., and Greenwood C.E. Rescue of dying neurons: A new action for deprenyl in MPTP Parkinsonism. J. Neurosci. Res. 30 (1991) 666-672
6. Sano M., Ernesto C., Thomas R.G., Klauber M.R., Schafer K., Grundman M., Woodbury P., Growdon J., Cotman C.W., Pfeiffer E., Schneider L.S., and Thal L.J. A controlled trial of selegiline, alphatocopherol, or both as treatment for Alzheimer's disease. N. Engl. J. Med. 336 (1997) 1216-1222
7. Head E., Hartley J., Kameka A.M., Mehta R., Ivy G.O., Ruehl W.W., and Milgram N.W. The effects of I-deprenyl on spatial short term memory in young and aged dogs. Prog. Neuropsychophurmacol. Biol. Psychiatr. 20 (1996) 515-530