DNA damage from oxidants: Influence of lesion complexity and chromatin organization

Oncology Research

Volumn 9, Issue 6-7, 1997, Pages 287-294

  Olive, Peggy L ^a   Johnston, Peter J ^a  

^a BRITISH COLUMBIA CANCER RESEARCH CENTRE   (Canada)

Author keywords

Dna damage; Double strand breaks; Multiply damaged sites; Single strand breaks

Indexed keywords

ANTINEOPLASTIC AGENT; DNA; DOXORUBICIN; ETOPOSIDE; OXIDIZING AGENT; SINGLE STRANDED DNA; TIRAPAZAMINE; TRIAZINE DERIVATIVE;

ANIMAL; ARTICLE; CELL DEATH; CHROMATIN; CRICETULUS; DNA DAMAGE; DRUG EFFECT; FIBROBLAST; HAMSTER; METABOLISM; MOUSE; PHYSIOLOGY; ULTRASTRUCTURE;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL DEATH; CHROMATIN; CRICETINAE; CRICETULUS; DNA; DNA DAMAGE; DNA, SINGLE-STRANDED; DOXORUBICIN; ETOPOSIDE; FIBROBLASTS; MICE; OXIDANTS; TRIAZINES;

EID: 0031306970     PISSN: 09650407     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Ward, J. F. Some biochemical consequences of the spatial distribution of ionizing radiation-produced free radicals. Radiât. Res. 86:185-195; 1981.
2. Rydberg, B. Clusters of DNA damage induced by ionizing radiation: Formation of short DNA fragments. II. Experimental detection. Radiât. Res. 145:200-209; 1996.
3. Holley, W. R.; Chatterjee, A. Clusters of DNA damage induced by ionizing radiation: Formation of short DNA fragments. I. Theoretical modeling. Radiât. Res. 145:188-199; 1996.
4. Elia, M. C.; Bradley, M. O. Influence of chromatin structure on the induction of DNA double-strand breaks by ionizing radiation. Cancer Res. 52:1580-1586; 1992.
5. Olive, P. L.; Banath, J. P. Radiation-induced DNA doublestrand breaks produced in histone-depleted nuclei measured using the neutral comet assay. Radial. Res. 142:144-152; 1995.
6. Chiu, S. M.; Xue, L. Y.; Friedman, L. R.; Oleinick, N. L. Differential dependence on chromatin structure for copper and iron ion induction of DNA double-strand breaks. Biochemistry 34:2653-2661; 1995.
7. Chiu, S. M.; Xue, L. Y.; Friedman, L. R.; Oleinick, N. L. Copper ion-mediated sensitization of nuclear matrix attachment sites to ionizing radiation. Biochemistry 32:6214-6219; 1993.
8. Ward, J. F. The complexity of DNA damage: Relevance to biological consequences. Int. J. Radiât. Biol. 66:427-432; 1994.
9. Ward, J. F.; Evans, J. W.; Limoli, C. L.; Calabro-Jones, P. M. Radiation and hydrogen peroxide induced free radical damage to DNA. Br. J. Cancer 55(Suppl. V1I1):105-112; 1987.
10. Brown, J. M. SR 4233 (Tirapazamine): A new anticancer drug exploiting hypoxia in solid tumours. Br. J. Cancer 67:1163-1170;1993.
11. Caspary, W. J.; Lanzo, D. A.; Niziak, C. Effect of deoxyribonucleic acid on the production of reduced oxygen by bleomycinand iron. Biochemistry 21:334-338; 1982.
12. Roy, S. N.; Horwitz, S. B. Characterisation of the association of radiolabelled bleomycin A2 with HeLa cells. Cancer Res. 44:1541-1546; 1984.
13. Razin, S. V.; Vassetzky, Y. S.; Hancock, R. Nuclear matrix attachment regions and topoisomerase II binding and reaction sites in the vicinity of a chicken DNA replication origin. Biochem. Biophys. Res. Commun. 177:265-270; 1991.
14. Gasser, S. M.; Laemmli, U. K. The organisation of chromatin loops: Characterisation of a scaffold attachment site. EMBO J. 5:511-518 1986.
15. Johnston, P. J.; Bryant, P. E. A component of DNA double strand break repair is dependent on the spatial orientation of
16. the lesions with the higher order structures of chromatin. Int. J. Radial. Biol. 66:531-536; 1994.
17. Johnston, P. J.; Olive, P. L.; Bryant, P. E. Higher order chromatin structure dependent repair of DNA double strand breaks: Modeling the elution of DNA from nucleoids. Radial. Res. (in press).
18. Olive, P. L.; Wlodek, D.; Banath, J. P. DNA double-strand breaks measured in individual cells subjected to gel electrophoresis. Cancer Res. 51:4671-4676; 1991.
19. Bradley M. O.; Kohn K. W. X-ray induced DNA doublestrand break production and repair in mammalian cells as measured by neutral filter elution. Nucleic Acids Res. 7:793-804; 1979.
20. Chen, G. L.; Yang, L.; Rowe, T. C.; Halligan, B. D.; Tewey, K. M.; Liu, L. F. Nonintercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II. J. Biol. Chem. 259:13560-13566; 1984.
21. Olive, P. L. Detection of hypoxia by measurement of DNA damage in individual cells from spheroids and murine tumors exposed to bioreductive drugs. I. Tirapazamine. Br. J. Cancer 71:529-536; 1995.
22. Cantoni, O.; Cattabeni, F.; Stocchi, V.; Meyn, R. E.; Cerutti, P.; Murray, D. Hydrogen peroxide insult in cultured mammalian cells: Relationships between DNA single-strand breakage, poly(ADP-ribose) metabolism and cell killing. Biochem. Bio. phys. Acta 1014:1-7; 1989.
23. D'Arpa, P.; Beardmore, C.; Liu, L. F. Involvement of nucleic acid synthesis in cell killing mechanisms of topoisomerase poisons. Cancer Res. 50:6919-6924; 1990.
24. Chow, K. C.; King, C. K.; Ross, W. E. Abrogation of etoposide-mediated cytotoxicity by cycloheximide. Biochem. Pharmacol. 37:1117-1122; 1988.
25. Bonner, J. A.; Lawrence, T. S. Protection of doxorubicin cytotoxicity by cycloheximide. Int. J. Radiât. Oncol. Biol. Phys. 16:1209-1212; 1989.
26. Preston, R. J.; Gooch, P. C. The induction of chromosometype aberrations in Gl by methyl methanesulfonate and 4nitroquinoline-N,-oxide, and the non-requirement of an Sphase for their production. Mutât. Res. 83:395-402; 1981.
27. Wang, J.; Biedermann, K. A.; Brown, J. M. Repair of DNA and chromosome breaks in cells exposed to SR 4233 under hypoxia or to ionizing radiation. Cancer Res. 52:4473-4477; 1992.
28. Oya, Y.; Yamamoto, K.; Tonomura, A. The biological activity of hydrogen peroxide. 1. Induction of chromosome-type aberrations susceptible to inhibition by scavengers of hydroxyl radicals in human embryonic fibroblasts. Mutât. Res. 172: 245-253;1986.
29. Palitti, F. Mechanism of induction of chromosomal aberrations by inhibitors of DNA topoisomerases. Environ. Mol. Mutagen. 22:275-277; 1993
30. Ikeda, S. H.; Yamagishi, T.; Nakaike, S.; Nakane, S.; phsawa, M. Efficient induction of chromosome-type aberrations by topoisomerase II inhibitors closely associated with stabilization of the cleavable complex in cultured fibroblastic cells. Mutât. Res. 328:151-161; 1995.
31. Tewey, K. M.; Rowe, T. C.; Yang, L.; Halligan, B. D.; Liu, L. F. Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase II. Science 226:466-468; 1984.
32. Lown, J. W. Anthracycline and anthraquinone anticancer agents: Current status and recent developments. Pharmacol. Ther. 60:185-214; 1994.
33. Dordal, M. S.; Jackson-Stone, M.; Ho, A. C.; Winter, J. N.; Atkinson, A. J. Decreased intracellularcompartmentalization of doxorubicin in cell lines expressing P-glycoprotein. J. Pharmacol. Exp. Ther. 271:1286-1290; 1994.
34. Sum, B. G.; van Zijl, P. L.; Brown, J. M. Tirapazamineinduced DNA damage measured using the comet assay correlates with cytotoxicity towards hypoxic tumour cells in vitro. Br. J. Cancer 73:952-960; 1996.
35. Suva, J. M.; O'Brien, P. J. Molecular mechanisms of SR 4233-induced hepatocyte toxicity under aerobic versus hypoxic conditions. Br. J. Cancer 68:484-491; 1993.
36. Elwell, J. H.; Sum, B. G.; Evans, J. W.; Brown, J. M. Adaptation of human cells to tirapazamine under aerobic conditions: Implications of increased antioxidant enzyme activity to mechanism of aerobic cytotoxicity. Biochem. Pharmacol. (in press).
37. Olive, P. L.; Banath, J. P. Detection of DNA double-strand breaks through the cell cycle after exposure to X-rays, bleomycin, etoposide and '"'idllrd. Int. J. Radiât. Biol. 64:349-358; 1993.