Detection of DNA double-Strand breaks through the cell cycle after exposure to x-rays, bleomycin, etoposide and 125idurd

International Journal of Radiation Biology

Volumn 64, Issue 4, 1993, Pages 349-358

  Olive, P L ^a   Banath J P ^a  

^a BRITISH COLUMBIA CANCER RESEARCH CENTRE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BLEOMYCIN; ETOPOSIDE; IDOXURIDINE I 125; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CYCLE; CELL STRAIN V 79; CONTROLLED STUDY; DNA STRAND BREAKAGE; PRIORITY JOURNAL; X IRRADIATION;

ANIMAL; BLEOMYCIN; CELL CYCLE; CELL LINE; CRICETULUS; DNA; DNA DAMAGE; ETOPOSIDE; HAMSTERS; IDOXURIDINE; SUPPORT, NON-U.S. GOV'T;

EID: 0027429286     PISSN: 09553002     EISSN: None     Source Type: Journal    
DOI: 10.1080/09553009314551531     Document Type: Article

References (40)

1. Preferential cooperative binding of DNA topoisomerase II to scaffold-associated regions
2. Application of 2-D gel electrophoresis in the study of cytoskeletal protein regulation during growth activation and differentiation
3. The nuclear protein matrix: isolation, structure and functions
4. Proteins tightly bound to DNA at nuclear matrix attachment sites
5. The localization of replication origins on ARS plasmids in S. cerevisiae
6. Activated bleomycin: a transient complex of drug, iron and oxygen that degraded DNA
7. 125I decays
8. Topoisomerase-targeting antitumor drugs
9. Matrix attachment regions are positioned near replication initiation sites, genes and an interamplicon junctions in the amplified dihydrofolate reductase domain of Chinese hamster ovary cells
10. Localization of topoisomerase II in mitotic chromosomes
11. Nuclear matrix targets for anticancer agents
12. Spatial and temporal distribution of DNA replication sites localized by immunofluorescence and confocal microscopy in mouse fibroblasts
13. The mode of action of 1 α-d-arabinofuranosylcytosine in inhibiting DNA repair; new evidence using a sensitive assay for repair DNA synthesis and ligation in permeable cells
14. Induction and repair of DNA strand breaks in CHO cells irradiated in various phases of the cycle
15. Topoisomerase II: a specific marker for cell proliferation
16. 125I decay
17. Type II DNA topoisomerases: enzymes that can unknot a topologically knotted DNA molecule via a reversible double-strand break
18. Range of radiochemical damage to DNA with decay of iodine-125
19. The sequence specificity of bleomycin-induced DNA damage in intact cells
20. Mapping replicational sites in the eucaryotic cell nucleus
21. Structural organizations of replicon domains during DNA synthetic phase in the mammalian nucleus
22. Variation through the cell cycle in the dose-response of DNA neutral filter elution in X-irradiated synchronous CHO cells
23. Induction and rejoining of radiation-induced DNA single-strand breaks: tail moment as a function of position in the cell cycle
24. Factors influencing DNA migration from individual cells subjected to gel electrophoresis
25. DNA double-strand breaks measured in individual cells subjected to gel electrophoresis
26. Biochemical basis for the interactions of type I and type II topoisomerases with DNA
27. Bleomycin, in contrast to ionizing radiation, induces extreme variation of DNA strand breakage from cell to cell
28. Very high cytotoxicity of bleomycin introduced into the cytosol of cells in culture
29. Topoisomerase inhibitors: why do they work? Why do they fail?
30. Aphidicolin synchronization of mouse L cells perturbs the relationship between the cell killing and DNA double-strand breakage after X-irradiation
31. 125I-induced DNA double-strand breaks: use in calibration of the neutral filter elution technique and comparison with X-ray induced breaks
32. Detection of induced DNA strand breaks with improved sensitivity in human cells
33. Bleomycin-induced DNA damage and repair in human cells permeabilized with lysophosphatidylcholine
34. Asymmetric field inversion gel electrophoresis: a new method for detecting DNA double-strand breaks in mammalian cells
35. Cell cycle effect on the induction of DNA double-strand breaks by X-rays
36. Flow microfluorometric analysis of nuclear DNA in cells from solid tumors and cell suspensions. A new method for rapid isolation and staining of nuclei
37. Neutral filter elution detects differences in chromatin organization which can influence cellular radiosensitivity
38. 125I decay produced lesions in chromatin
39. Eukaryotic topoisomerases recognize nucleoid acid topology by preferentially interacting with DNA crossovers