Synthesis and interactions with thymidylate synthase of 2,4-dithio analogues of dUMP and 5-fluoro-dUMP

Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology

Volumn 1293, Issue 1, 1996, Pages 1-8

  Dzik, Jolanta M ^a   Bretner, Maria ^b   Kulikowski, Tadeusz ^b   Gołos, Barbara ^a   Jarmuła, Adam ^a   Poznański, Jarosław ^b   Rode, Wojciech ^a   Shugar, David ^b  

^a NENCKI INSTITUTE OF EXPERIMENTAL BIOLOGY   (Poland)

^b INSTITUTE OF BIOCHEMISTRY AND BIOPHYSICS   (Poland)

Author keywords

2,4 dithio 5 fluoro dUMP; 2,4 dithio dUMP; Aromaticity; Inhibition; Thymidylate synthase

Indexed keywords

2' DEOXY 2,4 DITHIOURIDINE 5' PHOSPHATE; 2' DEOXY 5 FLUORO 2,4 DITHIOURIDINE 5' PHOSPHATE; ANTINEOPLASTIC AGENT; DEOXYURIDINE PHOSPHATE; FLOXURIDINE; FLUOROURACIL DERIVATIVE; THIOURACIL DERIVATIVE; THYMIDYLATE SYNTHASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG RESISTANCE; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME BINDING; ENZYME KINETICS; ENZYME PURIFICATION; LEUKEMIA L 1210; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; REACTION ANALYSIS; SPECTROPHOTOMETRY; THEORY;

EID: 0029873740     PISSN: 01674838     EISSN: None     Source Type: Journal    
DOI: 10.1016/0167-4838(95)00219-7     Document Type: Article

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