-
1
-
-
0027404779
-
Pathogenesis of cystic fibrosis
-
Koch C, Hoiby N. 1993. Pathogenesis of cystic fibrosis. Lancet 341:1065-69
-
(1993)
Lancet
, vol.341
, pp. 1065-1069
-
-
Koch, C.1
Hoiby, N.2
-
2
-
-
0028433414
-
The changing epidemiology of cystic fibrosis
-
FitzSimmons SC. 1994. The changing epidemiology of cystic fibrosis. Curr. Probl. Pediatr. 24:171-79
-
(1994)
Curr. Probl. Pediatr.
, vol.24
, pp. 171-179
-
-
FitzSimmons, S.C.1
-
3
-
-
0026315322
-
The cystic fibrosis heteozygote - Advantage in surviving cholera?
-
Rodman DM, Zamudio S. 1991. The cystic fibrosis heteozygote - advantage in surviving cholera? Med. Hypotheses 36:253-58
-
(1991)
Med. Hypotheses
, vol.36
, pp. 253-258
-
-
Rodman, D.M.1
Zamudio, S.2
-
4
-
-
8044240993
-
-
Bethesda, MD: Cystic Fibrosis Found
-
Patient Registry. 1994. Annual Data Report, August 1995. Bethesda, MD: Cystic Fibrosis Found.
-
(1994)
Annual Data Report, August 1995
-
-
-
6
-
-
0024411916
-
Progress toward human gene therapy
-
Friedmann T. 1989. Progress toward human gene therapy. Science 244:1275-81
-
(1989)
Science
, vol.244
, pp. 1275-1281
-
-
Friedmann, T.1
-
7
-
-
0029053687
-
Gene therapy for respiratory diseases: Potential applications and difficulties
-
Alton EW, Geddes DM. 1995. Gene therapy for respiratory diseases: potential applications and difficulties. Thorax 50:484-86
-
(1995)
Thorax
, vol.50
, pp. 484-486
-
-
Alton, E.W.1
Geddes, D.M.2
-
8
-
-
0029257496
-
The cryptic life style of adeno-associated virus
-
Berns KI, Linden RM. 1995. The cryptic life style of adeno-associated virus. Bioessays 17:237-45
-
(1995)
Bioessays
, vol.17
, pp. 237-245
-
-
Berns, K.I.1
Linden, R.M.2
-
9
-
-
0026941523
-
Adeno-associated virus vectors
-
Carter BJ. 1992. Adeno-associated virus vectors. Curr. Opin. Biotechnol. 3:533-39
-
(1992)
Curr. Opin. Biotechnol.
, vol.3
, pp. 533-539
-
-
Carter, B.J.1
-
10
-
-
0028965269
-
Gene therapy approaches for cystic fibrosis
-
Coutelle C. 1995. Gene therapy approaches for cystic fibrosis. Biologicals 23:21-25
-
(1995)
Biologicals
, vol.23
, pp. 21-25
-
-
Coutelle, C.1
-
12
-
-
0029151404
-
Adeno-associated virus vectors for gene therapy
-
Flotte TR, Carter BJ. 1995. Adeno-associated virus vectors for gene therapy. Gene Ther. 2:357-62
-
(1995)
Gene Ther.
, vol.2
, pp. 357-362
-
-
Flotte, T.R.1
Carter, B.J.2
-
13
-
-
0028870361
-
Gene therapy for cystic fibrosis
-
Johnson LG. 1995. Gene therapy for cystic fibrosis. Chest 107:77-83S
-
(1995)
Chest
, vol.107
-
-
Johnson, L.G.1
-
14
-
-
0028948924
-
Adenovirus and adeno-associated virus mediated gene transfer
-
Kremer EJ, Perricaudet M. 1995. Adenovirus and adeno-associated virus mediated gene transfer. Br. Med. Bull. 51:31-44
-
(1995)
Br. Med. Bull.
, vol.51
, pp. 31-44
-
-
Kremer, E.J.1
Perricaudet, M.2
-
15
-
-
0028074301
-
Somatic gene therapy for cystic fibrosis
-
O'Neal WK, Beaudet AL. 1994. Somatic gene therapy for cystic fibrosis. Hum. Mol. Genet. 3(Spec. No.):1497-502
-
(1994)
Hum. Mol. Genet.
, vol.3
, Issue.SPEC. NO.
, pp. 1497-1502
-
-
O'Neal, W.K.1
Beaudet, A.L.2
-
16
-
-
0030026531
-
Gene therapy for cystic fibrosis
-
Rosenfeld MA, Collins FS. 1996. Gene therapy for cystic fibrosis. Chest 109:241-52
-
(1996)
Chest
, vol.109
, pp. 241-252
-
-
Rosenfeld, M.A.1
Collins, F.S.2
-
17
-
-
0343930665
-
Liposomal DNA vectors for cystic fibrosis gene therapy. Current applications, limitations, and future directions
-
In press
-
Schreier H, Sawyer SM. 1996. Liposomal DNA vectors for cystic fibrosis gene therapy. Current applications, limitations, and future directions. Adv. Drug Deliv. Rev. In press
-
(1996)
Adv. Drug Deliv. Rev.
-
-
Schreier, H.1
Sawyer, S.M.2
-
18
-
-
0029182966
-
The development of gene transfer for cystic fibrosis
-
Welsh MJ. 1995. The development of gene transfer for cystic fibrosis. Adv. Intern. Med. 40:429-44
-
(1995)
Adv. Intern. Med.
, vol.40
, pp. 429-444
-
-
Welsh, M.J.1
-
19
-
-
0030563195
-
Adenoviruses as gene-delivery vehicles
-
Wilson JM. 1996. Adenoviruses as gene-delivery vehicles. N. Engl. J. Med. 334: 1185-87
-
(1996)
N. Engl. J. Med.
, vol.334
, pp. 1185-1187
-
-
Wilson, J.M.1
-
20
-
-
0024453308
-
Identification of the cystic fibrosis gene: Chromosome walking and jumping
-
Rommens JM, Inanuzzi MC, Kerem B-S, et al. 1989. Identification of the cystic fibrosis gene: chromosome walking and jumping. Science 245:1059-73
-
(1989)
Science
, vol.245
, pp. 1059-1073
-
-
Rommens, J.M.1
Inanuzzi, M.C.2
Kerem, B.-S.3
-
21
-
-
0024424270
-
Identification of the cystic fibrosis gene: Cloning and characterisation of the complementary DNA
-
Riordan JR, Rommens JM, Kerem B-S, et al. 1989. Identification of the cystic fibrosis gene: cloning and characterisation of the complementary DNA. Science 245:1066-73
-
(1989)
Science
, vol.245
, pp. 1066-1073
-
-
Riordan, J.R.1
Rommens, J.M.2
Kerem, B.-S.3
-
22
-
-
0024423668
-
Identification of the cystic fibrosis gene: Genetic analysis
-
Kerem B-S, Rommens JM, Buchanan JA, et al. 1989. Identification of the cystic fibrosis gene: genetic analysis. Science 245: 1073-80
-
(1989)
Science
, vol.245
, pp. 1073-1080
-
-
Kerem, B.-S.1
Rommens, J.M.2
Buchanan, J.A.3
-
23
-
-
0027162649
-
Molecular mechanisms of CFTR chloride channel dysfunction in cystic fibrosis
-
Welsh MJ, Smith AE. 1993. Molecular mechanisms of CFTR chloride channel dysfunction in cystic fibrosis. Cell 73: 1251-54
-
(1993)
Cell
, vol.73
, pp. 1251-1254
-
-
Welsh, M.J.1
Smith, A.E.2
-
24
-
-
0028982894
-
CFTR as a cAMP-dependent regulator of sodium channels
-
Stutts MJ, Canessa CM, Olsen JC, et al. 1995. CFTR as a cAMP-dependent regulator of sodium channels. Science 269:847-50
-
(1995)
Science
, vol.269
, pp. 847-850
-
-
Stutts, M.J.1
Canessa, C.M.2
Olsen, J.C.3
-
25
-
-
0026949597
-
Chloride channels of intracellular organelles and their potential role in cystic fibrosis
-
al-Awqati Q, Barasch J, Landry D. 1992. Chloride channels of intracellular organelles and their potential role in cystic fibrosis. J. Exp. Biol. 172:245-66
-
(1992)
J. Exp. Biol.
, vol.172
, pp. 245-266
-
-
Al-Awqati, Q.1
Barasch, J.2
Landry, D.3
-
26
-
-
0028920643
-
Cystic fibrosis epithelial cells have a receptor for pathogenic bacteria on their apical surface
-
Imundo L, Barasch J, Prince A, Al-Awgati Q. 1995. Cystic fibrosis epithelial cells have a receptor for pathogenic bacteria on their apical surface. Proc. Natl. Acad. Sci. USA 92:3019-52
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 3019-3052
-
-
Imundo, L.1
Barasch, J.2
Prince, A.3
Al-Awgati, Q.4
-
27
-
-
0024345843
-
Increased sulfation of glycoconjugates by cultured nasal epithelial cells from patients with cystic fibrosis
-
Cheng PW, Boat TF, Cranfill K, et al. 1989. Increased sulfation of glycoconjugates by cultured nasal epithelial cells from patients with cystic fibrosis. J. Clin. Invest. 84:68-72
-
(1989)
J. Clin. Invest.
, vol.84
, pp. 68-72
-
-
Cheng, P.W.1
Boat, T.F.2
Cranfill, K.3
-
28
-
-
0030021470
-
Role of mutant CFTR in hypersusceptibility of cystic fibrosis patients to lung infections
-
Pier GB, Grout M, Zaidi TS, et al. 1996. Role of mutant CFTR in hypersusceptibility of cystic fibrosis patients to lung infections. Science 271:64-67
-
(1996)
Science
, vol.271
, pp. 64-67
-
-
Pier, G.B.1
Grout, M.2
Zaidi, T.S.3
-
29
-
-
0029870085
-
Cystic fibrosis airway epithelia fail to kill bacteria because of abnormal airway surface fluid
-
Smith JJ, Travis SM, Greenberg EP, Welsh MJ. 1996. Cystic fibrosis airway epithelia fail to kill bacteria because of abnormal airway surface fluid. Cell 85:229-36
-
(1996)
Cell
, vol.85
, pp. 229-236
-
-
Smith, J.J.1
Travis, S.M.2
Greenberg, E.P.3
Welsh, M.J.4
-
30
-
-
0025094612
-
Correction of the cystic fibrosis defect in vitro by retrovirus-mediated gene transfer
-
Drumm ML, Pope HA, Cliff WH, et al. 1990. Correction of the cystic fibrosis defect in vitro by retrovirus-mediated gene transfer. Cell 62:1227-33
-
(1990)
Cell
, vol.62
, pp. 1227-1233
-
-
Drumm, M.L.1
Pope, H.A.2
Cliff, W.H.3
-
31
-
-
0025155528
-
Expression of cystic fibrosis transmembrane conductance regulator corrects defective chloride channel regulation in cystic fibrosis airway epithelial cells
-
Rich DP, Anderson MP, Gregory RJ, et al. 1990. Expression of cystic fibrosis transmembrane conductance regulator corrects defective chloride channel regulation in cystic fibrosis airway epithelial cells. Nature 347:358-63
-
(1990)
Nature
, vol.347
, pp. 358-363
-
-
Rich, D.P.1
Anderson, M.P.2
Gregory, R.J.3
-
32
-
-
0027475701
-
Correction of the ion transport defect in cystic fibrosis transgenic mice by gene therapy
-
Hyde SC, Gill DR, Higgins CF, et al. 1993. Correction of the ion transport defect in cystic fibrosis transgenic mice by gene therapy. Nature 362:250-55
-
(1993)
Nature
, vol.362
, pp. 250-255
-
-
Hyde, S.C.1
Gill, D.R.2
Higgins, C.F.3
-
33
-
-
0028557095
-
Correction of lethal intestinal defect in a mouse model of cystic fibrosis by human CFTR
-
Zhou L, Dey CR, Wert SE, et al. 1994. Correction of lethal intestinal defect in a mouse model of cystic fibrosis by human CFTR. Science 266:1705-8
-
(1994)
Science
, vol.266
, pp. 1705-1708
-
-
Zhou, L.1
Dey, C.R.2
Wert, S.E.3
-
34
-
-
0026530097
-
Human gene therapy
-
Anderson WF. 1992. Human gene therapy. Science 256:808-13
-
(1992)
Science
, vol.256
, pp. 808-813
-
-
Anderson, W.F.1
-
35
-
-
0026043883
-
Expression of the cystic fibrosis transmembrane conductance regulator in the respiratory tract of normal individuals and individuals with cystic fibrosis
-
Trapnell BC, Chu CS, Paakko PK, et al. 1991. Expression of the cystic fibrosis transmembrane conductance regulator in the respiratory tract of normal individuals and individuals with cystic fibrosis. Proc. Natl. Acad. Sci. USA 88:6565-69
-
(1991)
Proc. Natl. Acad. Sci. USA
, vol.88
, pp. 6565-6569
-
-
Trapnell, B.C.1
Chu, C.S.2
Paakko, P.K.3
-
36
-
-
0026951303
-
Submucosal glands are the predominant site of CFTR expression in the human bronchus
-
Engelhardt JF, Yankaskas JR, Ernst SA, et al. 1993. Submucosal glands are the predominant site of CFTR expression in the human bronchus. Nat. Genet. 2:240-48
-
(1993)
Nat. Genet.
, vol.2
, pp. 240-248
-
-
Engelhardt, J.F.1
Yankaskas, J.R.2
Ernst, S.A.3
-
37
-
-
0028210022
-
Expression of the cystic fibrosis gene in adult human lung
-
Engelhardt JF, Zepeda M, Cohn JA, et al. 1994. Expression of the cystic fibrosis gene in adult human lung. J. Clin. Invest. 93: 737-49
-
(1994)
J. Clin. Invest.
, vol.93
, pp. 737-749
-
-
Engelhardt, J.F.1
Zepeda, M.2
Cohn, J.A.3
-
38
-
-
0026336412
-
Reconstitution of tracheal grafts with a genetically modified epithelium
-
Engelhardt JF, Allen ED, Wilson JM. 1991. Reconstitution of tracheal grafts with a genetically modified epithelium. Proc. Natl. Acad. Sci. USA 88:11192-96
-
(1991)
Proc. Natl. Acad. Sci. USA
, vol.88
, pp. 11192-11196
-
-
Engelhardt, J.F.1
Allen, E.D.2
Wilson, J.M.3
-
39
-
-
0029058097
-
Progenitor cells of the adult human airway involved in submucosal gland development
-
Engelhardt JF, Schlossberg H, Yankaskas JR, Dudus L. 1995. Progenitor cells of the adult human airway involved in submucosal gland development. Development 121:2031-46
-
(1995)
Development
, vol.121
, pp. 2031-2046
-
-
Engelhardt, J.F.1
Schlossberg, H.2
Yankaskas, J.R.3
Dudus, L.4
-
40
-
-
0026656343
-
Extensive posttranslational deletion of the coding sequences for part of nucleotide-binding fold 1 in respiratory epithelial mRNA transcripts of the cystic fibrosis transmembrane conductance regulator gene is not associated with the clinical manifestation of cystic fibrosis
-
Chu SC-S, Trapnell BC, Curristin SM, et al. 1992. Extensive posttranslational deletion of the coding sequences for part of nucleotide-binding fold 1 in respiratory epithelial mRNA transcripts of the cystic fibrosis transmembrane conductance regulator gene is not associated with the clinical manifestation of cystic fibrosis. J. Clin. Invest. 90:785-90
-
(1992)
J. Clin. Invest.
, vol.90
, pp. 785-790
-
-
Chu, S.C.-S.1
Trapnell, B.C.2
Curristin, S.M.3
-
41
-
-
0027249601
-
Cystic fibrosis transmembrane conductance regulator splice variants are not conserved and fail to produce chloride channels
-
Delaney SJ, Rich DP, Thomson SA, et al. 1993. Cystic fibrosis transmembrane conductance regulator splice variants are not conserved and fail to produce chloride channels. Nat. Genet. 4:426-30
-
(1993)
Nat. Genet.
, vol.4
, pp. 426-430
-
-
Delaney, S.J.1
Rich, D.P.2
Thomson, S.A.3
-
42
-
-
0026918861
-
Efficiency of gene transfer for restoration of normal airway epithelial function in cystic fibrosis
-
Johnson LG, Olsen JC, Sarkadi B, et al. 1992. Efficiency of gene transfer for restoration of normal airway epithelial function in cystic fibrosis. Nat. Genet. 2:21-25
-
(1992)
Nat. Genet.
, vol.2
, pp. 21-25
-
-
Johnson, L.G.1
Olsen, J.C.2
Sarkadi, B.3
-
43
-
-
0028912888
-
Normalization of raised sodium absorption and raised calcium-mediated chloride secretion by adenovirus-mediated expression of cystic fibrosis transmembrane conductance regulator in primary human cystic fibrosis airway epithelial cells
-
Johnson LG, Boyles SE, Wilson J, Boucher RC. 1995. Normalization of raised sodium absorption and raised calcium-mediated chloride secretion by adenovirus-mediated expression of cystic fibrosis transmembrane conductance regulator in primary human cystic fibrosis airway epithelial cells. J. Clin. Invest. 95:1377-82
-
(1995)
J. Clin. Invest.
, vol.95
, pp. 1377-1382
-
-
Johnson, L.G.1
Boyles, S.E.2
Wilson, J.3
Boucher, R.C.4
-
44
-
-
0030039896
-
Biosynthetic and growth abnormalities are associated with high-level expression of CFTR in heterologous cells
-
Schiavi SC, Abdelkader N, Reber S, et al. 1996. Biosynthetic and growth abnormalities are associated with high-level expression of CFTR in heterologous cells. Am. J. Physiol. 270:C341-51
-
(1996)
Am. J. Physiol.
, vol.270
-
-
Schiavi, S.C.1
Abdelkader, N.2
Reber, S.3
-
45
-
-
0026919711
-
Human cystic fibrosis transmembrane conductance regulator directed to respiratory epithelial cells of transgenic mice
-
Whitsett JA, Dey CR, Stripp BR, et al. 1992. Human cystic fibrosis transmembrane conductance regulator directed to respiratory epithelial cells of transgenic mice. Nat. Genet. 2:13-20
-
(1992)
Nat. Genet.
, vol.2
, pp. 13-20
-
-
Whitsett, J.A.1
Dey, C.R.2
Stripp, B.R.3
-
46
-
-
0028913411
-
Liposome mediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis
-
Caplen NJ, Alton EWFW, Middleton PG. 1995. Liposome mediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis. Nat. Med. 1:39-46
-
(1995)
Nat. Med.
, vol.1
, pp. 39-46
-
-
Caplen, N.J.1
Alton, E.W.F.W.2
Middleton, P.G.3
-
47
-
-
0029100239
-
A controlled study of adenoviral-vector-mediated gene transfer in the nasal epithelium of patients with cystic fibrosis
-
Knowles MR, Hohneker KW, Zhou Z, et al. 1995. A controlled study of adenoviral-vector-mediated gene transfer in the nasal epithelium of patients with cystic fibrosis. N. Engl. J. Med. 333:823-31
-
(1995)
N. Engl. J. Med.
, vol.333
, pp. 823-831
-
-
Knowles, M.R.1
Hohneker, K.W.2
Zhou, Z.3
-
48
-
-
0027377523
-
Adenovirus-mediated gene transfer transiently corrects the chloride transport defect in nasal epithelia of patients with cystic fibrosis
-
Zabner J, Couture LA, Gregory RJ, et al. 1993. Adenovirus-mediated gene transfer transiently corrects the chloride transport defect in nasal epithelia of patients with cystic fibrosis. Cell 75:207-16
-
(1993)
Cell
, vol.75
, pp. 207-216
-
-
Zabner, J.1
Couture, L.A.2
Gregory, R.J.3
-
49
-
-
0028168641
-
Administration of an adenovirus containing the human CFTR cDNA to the respiratory tract of individuals with cystic fibrosis
-
Crystal RG, McElvaney NG, Rosenfeld MA, et al. 1994. Administration of an adenovirus containing the human CFTR cDNA to the respiratory tract of individuals with cystic fibrosis. Nat. Genet. 8:42-51
-
(1994)
Nat. Genet.
, vol.8
, pp. 42-51
-
-
Crystal, R.G.1
McElvaney, N.G.2
Rosenfeld, M.A.3
-
50
-
-
0028991826
-
In vivo nasal potential difference: Techniques and protocols for assessing efficacy of gene transfer in cystic fibrosis
-
Knowles MR, Paradiso AM, Boucher RC. 1995. In vivo nasal potential difference: techniques and protocols for assessing efficacy of gene transfer in cystic fibrosis. Hum. Gene Ther. 6:445-55
-
(1995)
Hum. Gene Ther.
, vol.6
, pp. 445-455
-
-
Knowles, M.R.1
Paradiso, A.M.2
Boucher, R.C.3
-
51
-
-
0026076460
-
Method for rapid evaluation of topically applied agents to cystic fibrosis airways
-
Wine JJ, King VV, Lewiston NJ. 1991. Method for rapid evaluation of topically applied agents to cystic fibrosis airways. Am. J. Physiol. 261:L218-21
-
(1991)
Am. J. Physiol.
, vol.261
-
-
Wine, J.J.1
King, V.V.2
Lewiston, N.J.3
-
52
-
-
0027933841
-
Gene therapy of cystic fibrosis lung disease using E1 deleted adenoviruses: A phase I trial
-
Wilson JM, Engelhardt JF, Grossman M, et al. 1994. Gene therapy of cystic fibrosis lung disease using E1 deleted adenoviruses: a phase I trial. Hum. Gene Ther. 5:501-19
-
(1994)
Hum. Gene Ther.
, vol.5
, pp. 501-519
-
-
Wilson, J.M.1
Engelhardt, J.F.2
Grossman, M.3
-
53
-
-
0028059466
-
Gene therapy of cystic fibrosis utilizing a replication deficient recombinant adenovirus vector to deliver the human cystic fibrosis transmembrane conductance regulator cDNA to the airways. A phase I study
-
Wilmott RW, Whitsett JA, Trapnell RC, et al. 1994. Gene therapy of cystic fibrosis utilizing a replication deficient recombinant adenovirus vector to deliver the human cystic fibrosis transmembrane conductance regulator cDNA to the airways. A phase I study. Hum. Gene Ther. 5:1019-57
-
(1994)
Hum. Gene Ther.
, vol.5
, pp. 1019-1057
-
-
Wilmott, R.W.1
Whitsett, J.A.2
Trapnell, R.C.3
-
54
-
-
13344286312
-
Repeat administration of an adenovirus vector encoding cystic fibrosis transmembrane conductance regulator to the nasal epithelium of patients with cystic fibrosis
-
Zabner J, Ramsey BW, Meeker DP, et al. 1996. Repeat administration of an adenovirus vector encoding cystic fibrosis transmembrane conductance regulator to the nasal epithelium of patients with cystic fibrosis. J. Clin. Invest. 97:1504-11
-
(1996)
J. Clin. Invest.
, vol.97
, pp. 1504-1511
-
-
Zabner, J.1
Ramsey, B.W.2
Meeker, D.P.3
-
55
-
-
0029102198
-
A phase 1 study, in cystic fibrosis patients, of the safety, toxicity, and biological efficacy of a single administration of a replication deficient, recombinant adenovirus carrying the cDNA of the normal cystic fibrosis transmembrane conductance regulator gene in the lung
-
Crystal RG, Jaffe A, Brody S, et al. 1995. A phase 1 study, in cystic fibrosis patients, of the safety, toxicity, and biological efficacy of a single administration of a replication deficient, recombinant adenovirus carrying the cDNA of the normal cystic fibrosis transmembrane conductance regulator gene in the lung. Hum. Gene Ther. 6:643-66
-
(1995)
Hum. Gene Ther.
, vol.6
, pp. 643-666
-
-
Crystal, R.G.1
Jaffe, A.2
Brody, S.3
-
56
-
-
0029165356
-
Evaluation of repeat administration of a replication deficient, recombinant adenovirus containing the normal cystic fibrosis transmembrane conductance regulator cDNA to the airways of individuals with cystic fibrosis
-
Crystal RG, Mastrangeli A, Sanders A, et al. 1995. Evaluation of repeat administration of a replication deficient, recombinant adenovirus containing the normal cystic fibrosis transmembrane conductance regulator cDNA to the airways of individuals with cystic fibrosis. Hum. Gene Ther. 6: 667-703
-
(1995)
Hum. Gene Ther.
, vol.6
, pp. 667-703
-
-
Crystal, R.G.1
Mastrangeli, A.2
Sanders, A.3
-
58
-
-
3142639564
-
Aerosol administration to cystic fibrosis patients of a replication defective adenovirus expressing the CFTR gene (AD.CFTR): A phase I clinical trial
-
Bellon G, Calmard L, Thouvenot D, et al. 1995. Aerosol administration to cystic fibrosis patients of a replication defective adenovirus expressing the CFTR gene (AD.CFTR): a phase I clinical trial. Pediatr. Pulm. 12(Suppl.):228
-
(1995)
Pediatr. Pulm.
, vol.12
, Issue.SUPPL.
, pp. 228
-
-
Bellon, G.1
Calmard, L.2
Thouvenot, D.3
-
59
-
-
0029898764
-
Clinical protocol: A phase I study of adeno-associated virus-CFTR gene vector in adult CF patients with mild lung disease
-
Flotte TR, Carter B, Conrad CK, et al. 1996. Clinical protocol: a phase I study of adeno-associated virus-CFTR gene vector in adult CF patients with mild lung disease. Hum. Gene Ther. 7:1145-59
-
(1996)
Hum. Gene Ther.
, vol.7
, pp. 1145-1159
-
-
Flotte, T.R.1
Carter, B.2
Conrad, C.K.3
-
60
-
-
8044254718
-
Clinical protocol: Evaluation of adeno-associated virus mediated gene transfer of CFTR in the maxillary sinuses of CF patients with antrostomies
-
Wagner JA, Daifuku R, Moran ML, et al. 1995. Clinical protocol: evaluation of adeno-associated virus mediated gene transfer of CFTR in the maxillary sinuses of CF patients with antrostomies. Pediatr. Pulm. 12(Suppl.):227
-
(1995)
Pediatr. Pulm.
, vol.12
, Issue.SUPPL.
, pp. 227
-
-
Wagner, J.A.1
Daifuku, R.2
Moran, M.L.3
-
61
-
-
0028670906
-
Gene therapy for cystic fibrosis using cationic liposome mediated gene transfer: A phase I trial of safety and efficacy in the nasal airway
-
Sorscher EJ, Logan JJ, Frizzell RA, et al. 1994. Gene therapy for cystic fibrosis using cationic liposome mediated gene transfer: a phase I trial of safety and efficacy in the nasal airway. Hum. Gene Ther. 5:1259-77
-
(1994)
Hum. Gene Ther.
, vol.5
, pp. 1259-1277
-
-
Sorscher, E.J.1
Logan, J.J.2
Frizzell, R.A.3
-
62
-
-
13744264519
-
Gene therapy strategies for pulmonary disease
-
Crystal RG. 1992. Gene therapy strategies for pulmonary disease. Am. J. Med. 92:44-52S
-
(1992)
Am. J. Med.
, vol.92
-
-
Crystal, R.G.1
-
63
-
-
0027737463
-
Development and analysis of recombinant adenoviruses for gene therapy of cystic fibrosis
-
Rich DP, Couture LA, Cardoza LM, et al. 1993. Development and analysis of recombinant adenoviruses for gene therapy of cystic fibrosis. Hum. Gene Ther. 4:461-76
-
(1993)
Hum. Gene Ther.
, vol.4
, pp. 461-476
-
-
Rich, D.P.1
Couture, L.A.2
Cardoza, L.M.3
-
64
-
-
0027507752
-
Cystic fibrosis. Vehicles for gene therapy
-
Wilson JM. 1993. Cystic fibrosis. Vehicles for gene therapy. Nature 365:691-92
-
(1993)
Nature
, vol.365
, pp. 691-692
-
-
Wilson, J.M.1
-
65
-
-
0027755939
-
Adenovirus-mediated transfer of the CFTR gene to lung of nonhuman primates: Biological efficacy study
-
Engelhardt JF, Simon RH, Yang Y, et al. 1993. Adenovirus-mediated transfer of the CFTR gene to lung of nonhuman primates: biological efficacy study. Hum. Gene Ther. 4:759-69
-
(1993)
Hum. Gene Ther.
, vol.4
, pp. 759-769
-
-
Engelhardt, J.F.1
Simon, R.H.2
Yang, Y.3
-
66
-
-
0027984919
-
In vivo evaluation of the safety of adenovirus-mediated transfer of the human cystic fibrosis transmembrane conductance regulator cDNA to the lung
-
Yei S, Mittereder N, Wert S, et al. 1994. In vivo evaluation of the safety of adenovirus-mediated transfer of the human cystic fibrosis transmembrane conductance regulator cDNA to the lung. Hum. Gene Ther. 5:731-44
-
(1994)
Hum. Gene Ther.
, vol.5
, pp. 731-744
-
-
Yei, S.1
Mittereder, N.2
Wert, S.3
-
67
-
-
0028429545
-
Adenovirus-mediated gene transfer for cystic fibrosis: Quantitative evaluation of repeated in vivo vector administration to the lung
-
Yei S, Mittereder N, Tang K, et al. 1994. Adenovirus-mediated gene transfer for cystic fibrosis: quantitative evaluation of repeated in vivo vector administration to the lung. Gene Ther. 1:192-200
-
(1994)
Gene Ther.
, vol.1
, pp. 192-200
-
-
Yei, S.1
Mittereder, N.2
Tang, K.3
-
68
-
-
0028318416
-
Safety and efficacy of repetitive adenovirus-mediated transfer of CFTR cDNA to airway epithelia of primates and cotton rats
-
Zabner J, Petersen DM, Puga AP, et al. 1994. Safety and efficacy of repetitive adenovirus-mediated transfer of CFTR cDNA to airway epithelia of primates and cotton rats. Nat. Genet. 6:75-83
-
(1994)
Nat. Genet.
, vol.6
, pp. 75-83
-
-
Zabner, J.1
Petersen, D.M.2
Puga, A.P.3
-
69
-
-
0027735897
-
Adenovirus-mediated transfer of the CFTR gene to lung of nonhuman primates: Toxicity study
-
Simon RH, Engelhardt JF, Yang Y, et al. 1993. Adenovirus-mediated transfer of the CFTR gene to lung of nonhuman primates: toxicity study. Hum. Gene Ther. 4:771-80
-
(1993)
Hum. Gene Ther.
, vol.4
, pp. 771-780
-
-
Simon, R.H.1
Engelhardt, J.F.2
Yang, Y.3
-
70
-
-
0028802876
-
Modification of nasal epithelial potential differences of individuals with cystic fibrosis consequent to local administration of a normal CFTR cDNA adenovirus gene transfer vector
-
Hay JG, McElvaney NG, Herena J, Crystal RG. 1995. Modification of nasal epithelial potential differences of individuals with cystic fibrosis consequent to local administration of a normal CFTR cDNA adenovirus gene transfer vector. Hum. Gene Ther. 6:1487-96
-
(1995)
Hum. Gene Ther.
, vol.6
, pp. 1487-1496
-
-
Hay, J.G.1
McElvaney, N.G.2
Herena, J.3
Crystal, R.G.4
-
71
-
-
0028618419
-
Prolonged transgene expression in cotton rat lung with recombinant adenoviruses defective in E2a
-
Engelhardt JF, Litzky L, Wilson JM. 1994. Prolonged transgene expression in cotton rat lung with recombinant adenoviruses defective in E2a. Hum. Gene Ther. 5:1217-29
-
(1994)
Hum. Gene Ther.
, vol.5
, pp. 1217-1229
-
-
Engelhardt, J.F.1
Litzky, L.2
Wilson, J.M.3
-
72
-
-
0029966514
-
Recombinant adenovirus deleted of all viral genes for gene therapy of cystic fibrosis
-
Fisher KJ, Choi H, Burda J, et al. 1996. Recombinant adenovirus deleted of all viral genes for gene therapy of cystic fibrosis. Virology 217:11-22
-
(1996)
Virology
, vol.217
, pp. 11-22
-
-
Fisher, K.J.1
Choi, H.2
Burda, J.3
-
73
-
-
0029664338
-
Elimination of both E1 and E2a from adenovirus vectors further improves prospects for in vivo human gene therapy
-
Gorziglia MI, Kadan MJ, Yei S, et al. 1996. Elimination of both E1 and E2a from adenovirus vectors further improves prospects for in vivo human gene therapy. J. Virol. 70:4173-78
-
(1996)
J. Virol.
, vol.70
, pp. 4173-4178
-
-
Gorziglia, M.I.1
Kadan, M.J.2
Yei, S.3
-
74
-
-
0029582770
-
A packaging cell line for propagation of recombinant adenovirus vectors containing two lethal gene-region deletions
-
Wang Q, Jia X-C, Finer MH. 1995. A packaging cell line for propagation of recombinant adenovirus vectors containing two lethal gene-region deletions. Gene Ther. 2: 775-83
-
(1995)
Gene Ther.
, vol.2
, pp. 775-783
-
-
Wang, Q.1
Jia, X.-C.2
Finer, M.H.3
-
75
-
-
0029934048
-
Transient immunosuppression permits successful repetitive intravenous administration of an adenovirus vector
-
In press
-
Smith TAG, White BD, Gardner JM, et al. 1996. Transient immunosuppression permits successful repetitive intravenous administration of an adenovirus vector. Gene Ther. In press
-
(1996)
Gene Ther.
-
-
Smith, T.A.G.1
White, B.D.2
Gardner, J.M.3
-
76
-
-
0029944988
-
Transient immune blockade prevents formation of neutralizing antibody to recombinant adenovirus and allows repeated gene transfer to mouse liver
-
In press
-
Yang Y, Greenough K, Wilson JM. 1996. Transient immune blockade prevents formation of neutralizing antibody to recombinant adenovirus and allows repeated gene transfer to mouse liver. Gene Ther. In press
-
(1996)
Gene Ther.
-
-
Yang, Y.1
Greenough, K.2
Wilson, J.M.3
-
77
-
-
0028991829
-
Persistence of replication-deficient adenovirus-mediated gene transfer lungs of immune-deficient (nu/nu) nice
-
Zsengeller ZK, Wert SE, Hull WM, et al. 1995. Persistence of replication-deficient adenovirus-mediated gene transfer lungs of immune-deficient (nu/nu) nice. Hum. Gene Ther. 6:457-67
-
(1995)
Hum. Gene Ther.
, vol.6
, pp. 457-467
-
-
Zsengeller, Z.K.1
Wert, S.E.2
Hull, W.M.3
-
78
-
-
0027484584
-
Stable in vivo expression of the cystic fibrosis transmembrane conductance regulator with an adeno-associated virus vector
-
Flotte TR, Afione SA, Conrad C, et al. 1993. Stable in vivo expression of the cystic fibrosis transmembrane conductance regulator with an adeno-associated virus vector. Proc. Natl. Acad. Sci. USA 90: 10613-17
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 10613-10617
-
-
Flotte, T.R.1
Afione, S.A.2
Conrad, C.3
-
80
-
-
0026917078
-
Gene expression from adeno-associated virus vectors in airway epithelial cells
-
Flotte TR, Solow R, Owens RA, et al. 1992. Gene expression from adeno-associated virus vectors in airway epithelial cells. Am. J. Respir. Cell. Mol. Biol. 7:349-56
-
(1992)
Am. J. Respir. Cell. Mol. Biol.
, vol.7
, pp. 349-356
-
-
Flotte, T.R.1
Solow, R.2
Owens, R.A.3
-
81
-
-
0029923638
-
Second-strand synthesis is a rate limiting step for efficient transduction by recombinant adeno-associated virus vectors
-
Ferrari FK, Samulski T, Shenk T, Samulski RJ. 1996. Second-strand synthesis is a rate limiting step for efficient transduction by recombinant adeno-associated virus vectors. J. Virol. 70:3227-34
-
(1996)
J. Virol.
, vol.70
, pp. 3227-3234
-
-
Ferrari, F.K.1
Samulski, T.2
Shenk, T.3
Samulski, R.J.4
-
82
-
-
0029655894
-
Transduction with recombinant adeno-associated virus for gene therapy is limited by leading-strand synthesis
-
Fisher KJ, Gao G-P, Weitzman MD, et al. 1996. Transduction with recombinant adeno-associated virus for gene therapy is limited by leading-strand synthesis. J. Virol. 70:520-32
-
(1996)
J. Virol.
, vol.70
, pp. 520-532
-
-
Fisher, K.J.1
Gao, G.-P.2
Weitzman, M.D.3
-
83
-
-
0028534879
-
Adeno-associated virus vector gene expression occurs in nondividing cells in the absence of vector DNA integration
-
Flotte TR, Afione SA, Zeitlin PL. 1994. Adeno-associated virus vector gene expression occurs in nondividing cells in the absence of vector DNA integration. Am. J. Respir. Cell. Mol. Biol. 11:517-21
-
(1994)
Am. J. Respir. Cell. Mol. Biol.
, vol.11
, pp. 517-521
-
-
Flotte, T.R.1
Afione, S.A.2
Zeitlin, P.L.3
-
84
-
-
9244234931
-
An in vivo of adeno-associated virus vector persistence and rescue
-
Afione SA, Conrad CK, Kearns WG, et al. 1996. An in vivo of adeno-associated virus vector persistence and rescue. J. Virol. 70: 3235-41
-
(1996)
J. Virol.
, vol.70
, pp. 3235-3241
-
-
Afione, S.A.1
Conrad, C.K.2
Kearns, W.G.3
-
85
-
-
0028024919
-
Enhanced gene delivery and mechanism studies with a novel series of cationic lipid formulations
-
Felgner JH, Kumar R, Sridhar CN, et al. 1994. Enhanced gene delivery and mechanism studies with a novel series of cationic lipid formulations. J. Biol. Chem. 269: 2550-61
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 2550-2561
-
-
Felgner, J.H.1
Kumar, R.2
Sridhar, C.N.3
-
86
-
-
0027361622
-
Non-invasive liposome-mediated gene delivery can correct the ion transport defect in cystic fibrosis mutant mice
-
Alton EW, Middleton PG, Caplen NJ, et al. 1993. Non-invasive liposome-mediated gene delivery can correct the ion transport defect in cystic fibrosis mutant mice. Nat. Genet. 5:135-42
-
(1993)
Nat. Genet.
, vol.5
, pp. 135-142
-
-
Alton, E.W.1
Middleton, P.G.2
Caplen, N.J.3
-
87
-
-
0028230613
-
Nasal application of the cationic liposome DC-Chol:DOPE does not alter ion transport, lung function or bacterial growth
-
Middleton PG, Caplen NJ, Gao X, et al. 1994. Nasal application of the cationic liposome DC-Chol:DOPE does not alter ion transport, lung function or bacterial growth. Eur. Respir. J. 7:442-45
-
(1994)
Eur. Respir. J.
, vol.7
, pp. 442-445
-
-
Middleton, P.G.1
Caplen, N.J.2
Gao, X.3
-
88
-
-
0026829648
-
Gene transfer to respiratory epithelial cells via the receptor-mediated endocytosis pathway
-
Curiel DT, Agarwal S, Romer MU, et al. 1992. Gene transfer to respiratory epithelial cells via the receptor-mediated endocytosis pathway. Am. J. Respir. Cell. Mol. Biol. 6:247-52
-
(1992)
Am. J. Respir. Cell. Mol. Biol.
, vol.6
, pp. 247-252
-
-
Curiel, D.T.1
Agarwal, S.2
Romer, M.U.3
-
89
-
-
0028117742
-
Psoralen treatment of adenovirus particles eliminates virus replication and transcription while maintaining the endosomolytic activity of the virus capsid
-
Cotten M, Saltik M, Kursa M, et al. 1994. Psoralen treatment of adenovirus particles eliminates virus replication and transcription while maintaining the endosomolytic activity of the virus capsid. Virology 205: 254-61
-
(1994)
Virology
, vol.205
, pp. 254-261
-
-
Cotten, M.1
Saltik, M.2
Kursa, M.3
-
90
-
-
0027269967
-
Direct in vivo gene transfer to airway employing adenovirus-polylysine-DNA complexes
-
Gao L, Wagner E, Cotten M, et al. 1994. Direct in vivo gene transfer to airway employing adenovirus-polylysine-DNA complexes. Hum. Gene Ther. 4:17-24
-
(1994)
Hum. Gene Ther.
, vol.4
, pp. 17-24
-
-
Gao, L.1
Wagner, E.2
Cotten, M.3
-
91
-
-
0029941321
-
A novel DNA/peptide complex for efficient gene transfer and expression in mammalian cells
-
In press
-
Gottschalk S, Sparrow JT, Hauer J, et al. 1996. A novel DNA/peptide complex for efficient gene transfer and expression in mammalian cells. Gene Ther. In press
-
(1996)
Gene Ther.
-
-
Gottschalk, S.1
Sparrow, J.T.2
Hauer, J.3
-
92
-
-
0028799484
-
Gene transfer into airway epithelium of animals by targeting the polymeric immunoglobulin receptor
-
Ferkol T, Perales JC, Eckman E, et al. 1995. Gene transfer into airway epithelium of animals by targeting the polymeric immunoglobulin receptor. J. Clin. Invest. 95: 493-502
-
(1995)
J. Clin. Invest.
, vol.95
, pp. 493-502
-
-
Ferkol, T.1
Perales, J.C.2
Eckman, E.3
|