Characterization of YM90K, a selective and potent antagonist of AMPA receptors, in rat cortical mRNA-injected Xenopus oocytes

European Journal of Pharmacology

Volumn 309, Issue 3, 1996, Pages 299-306

  Okada, Masamichi ^a   Kohara, Atsuyuki ^a   Yamaguchi, Tokio ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

Allosteric regulation; Cyclothiazide; GYKI 52466; NBQX (2,3 dihydroxy 6 nitro 7 sulfamoyl benzo(F)quinoxaline)

Indexed keywords

1 (4 AMINOPHENYL) 4 METHYL 7,8 METHYLENEDIOXY 5H 2,3 BENZODIAZEPINE; 6 (1 IMIDAZOLYL) 7 NITRO 2,3 QUINOXALINEDIONE; 6 NITRO 7 SULFAMOYLBENZO[F]QUINOXALINE 2,3 DIONE; AMPA RECEPTOR; CYCLOTHIAZIDE; KAINIC ACID; MESSENGER RNA; QUINOXALINE DERIVATIVE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING SITE; BRAIN CORTEX; CONTROLLED STUDY; DOSE RESPONSE; IN VITRO STUDY; MALE; NONHUMAN; OOCYTE; PRIORITY JOURNAL; RAT; RNA TRANSPORT; VOLTAGE CLAMP; XENOPUS;

EID: 0030586774     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(96)00321-4     Document Type: Article

References (41)

1. Blake, J.F., R.G. Yates, M.W. Brown and G.L. Collingridge, 1989, 6-Cyano-7-nitroquinoxaline-2,3-dione as an excitatory amino acid antagonist in area CA1 of rat hippocampus, Br. J. Pharmacol. 97, 71.
2. Brorson, J.R., P.A. Manzolillo, S.J. Gibbons and R.J. Miller, 1995, AMPA receptor desensitization predicts the selective vulnerability of cerebellar Purkinje cells to excitotoxicity, J. Neurosci. 15, 4515.
3. Bullock, R., D.I. Graham, S. Swanson and J. McCulloch, 1994, Neuroprotective effect of the AMPA receptor antagonist LY-293558 in focal cerebral ischemia in the cat, J. Cereb. Blood Flow Metab. 14, 466.
4. Choi, D.W. 1988, Glutamate neurotoxicity and diseases of the nervous system, Neuron 1, 623.
5. Collingridge, G.L. and W. Singer, 1990, Excitatory amino acid receptors and synaptic plasticity. Trends Pharmacol. Sci. 11, 290.
6. Desai, M.A., J.P. Burnett, P.L. Ornstein and D.D. Schoepp, 1995, Cyclothiazide acts at a site on the α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor complex that does not recognize competitive or noncompetitive AMPA receptor antagonists, J. Pharmacol. Exp. Ther. 272, 38.
7. Fadda, E., W. Danysz, J.T. Wroblewski and E. Costa, 1988, Glycine and D-serine increase the affinity of N-methyl-D-aspartate sensitive glutamate binding sites in rat brain synaptic membranes, Neuropharmacology 27, 1183.
8. Fletcher, E.J., D. Martin, J.A. Aram, D. Lodge and T. Honoré 1988, Quinoxalinediones selectively block quisqualate and kainate receptors and synaptic events in rat neocortex and hippocampus and frog spinal cord in vitro, Br. J. Pharmacol. 95, 585.
9. Gill, R., L. Nordholm and D. Lodge, 1992, The neuroprotective actions of 2.3-dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline (NBQX) in a rat focal ischemia model. Brain Res. 580, 35.
10. Kaplita, R.V. and J.W. Ferkany, 1990, Evidence for direct interactions between the NMDA and glycine recognition sites in brain, Eur. J. Phramacol. 188, 175.
11. Keinänen, K., W. Wisden, B. Sommer, P. Werner, A. Herb, T.A. Verdoorn, B. Sakmann and P.H. Seerburg, 1990, A family of AMPA-selective glutamate receptors, Science 249, 556.
12. Koh, J.-Y., M.P. Goldberg, D.M. Hartley and D.W. Choi, 1990. Non-NMDA receptor mediated neurotoxicity in cortical culture, J. Neurosci. 10, 693.
13. Le Peillet, E., B. Arvin, C. Moncada and B.S. Meldrum, 1992, The non-NMDA antagonists, NBQX and GYKI 52466, protect against cortical and striatal cell loss following transient global ischaemia in the rat, Brain Res. 571, 115.
14. May, P.C. and P.M. Robison, 1993, Cyclothiazide treatment unmasks AMPA excitotoxicity in rat primary hippocampal cultures, J. Neurochem. 60, 1171.
15. McDonald, J.W. and M.V. Johnston, 1990, Physiological and pathophysiological roles of excitatory amino acids during central nervous system development, Brain Res. Rev. 15, 41.
16. Meldrum, B. and J. Garthwaite, 1990, Excitatory amino acid neurotoxicity and neurodegenerative disease, Trends Pharmacol. Sci. 11, 379.
17. Monaghan, D.T., H.J. Olverman, L. Nguyen, J.C. Watkins and C.W. Cotman, 1988, Two classes of N-methyl-D-aspartate recognition sites: differential distribution and differential regulation by glycine, Proc. Natl. Acad. Sci. 85, 9836.
18. Ohmori, J, S. Sakamoto, H. Kubota, M. Shimizu-Sasamata, M. Okada, S. Kawasaki, K. Hidaka, J. Togami, T. Furuya and K. Murase, 1994, 6-{1 H-imidazol-1-yl)-7-nitro-2.3(1 H,4 H)-quinoxalinedione hydrochloride (YM90K) and related compounds: structure-activity relationships for the AMPA-type non-NMDA receptor, J. Med. Chem. 37, 467.
19. Palmer, A.J. and D. Lodge, 1993, Cyclothiazide reverses AMPA receptor antagonism of the 2,3-benzodiazepine, GYKI 53655, Eur. J. Pharmacol. Mol. Pharmacol. 244, 193.
20. Parker, I., C.B. Gundersen and R. Miledi, 1986, Actions of pentobarbital on rat brain receptors expressed in Xenopus oocytes, J. Neurosci. 6. 2290.
21. Parsons, C.G., R. Gruner and J. Rozental, 1994, Comparative patch clamp studies on the kinetics and selectivity of glutamate receptor antagonism by 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline (NBQX) and 1-(4-amino-phenyl)-4-methyl-7,8-methyl-endioxyl-5 H-2,3-benzodiazepine (GYKI 52466), Neuropharmacology 33, 589.
22. Partin, K.M., D.K. Patneau, C.A. Winters, M.L.Mayer and A. Buonanno, 1993, Selective modulation of desensitization at AMPA versus kainate receptors by cyclothiazide and concanavalin A, Neuron 11, 1069.
23. Partin, K.M., D.K. Patneau and M.L. Mayer, 1994, Cyclothiazide differentially modulates desensitization of α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor splice variants, Mol. Pharmacol. 46, 129.
24. Patneau, D.K. and M.L. Mayer, 1991, Kinetic analysis of interactions between kainate and AMPA: evidence for activation of a single receptor in mouse hippocampal neurons, Neuron 6, 785.
25. Patneau, D.K., L. Jr. Vyklicky and M.L. Mayer, 1993, Hippocampal neurons exhibit cyclothiazide-sensitive rapidly desensitizing responses to kainate, J. Neurosci. 13, 3496.
26. Rammes, G., C. Parsons, W. Müller and D. Swandulla, 1994, Modulation of fast excitatory synaptic transmission by cyclothiazide and GYKI 52466 in the rat hippocampus, Neurosci. Lett. 175, 21.
27. Rammes, G., C.G. Parsons, D. Swandulla and G.L. Collingridge, 1995, Modulation of fast glutamatergic excitatory synaptic transmission by NBQX and cyclothiazide in the CA1 region of hippocampal slices, Soc. Neurosci. Abstr. 21, 841.
28. Rammes, G., D. Swandulla, G.L. Collingridge, S. Hartmann and C.G. Parsons, 1996, Interactions of 2,3-benzodiazepines and cyclothiazide at AMPA receptors: patch clamp recordings in cultured neurones and area CA1 in hippocampal slices, Br. J. Pharmacol. 117, 1209.
29. Rock, D.M. and G.W. Campbell, 1993, Cyclothiazide and GYKI-52466 affect AMPA-induced neuronal damage of cultured cortical neurons by actions at distinct sites, Soc. Neurosci. Abstr. 19, 294.
30. Rothman, S.M., J.H. Thurston and R.E. Hauhart, 1987, Delayed neurotoxicity of excitatory amino acids in vitro, Neuroscience 22, 471.
31. Sheardown, M.J., E.O. Nielsen, A.J. Hansen, P. Jacobsen and T. Honore, 1990, 2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: a neuroprotectant for cerebral ischemia, Science 247, 571.
32. Shimizu-Sasamata, M., S. Kawasaki-Yatsugi, M. Okada, S. Sakamoto, S. Yatsugi, J. Togami, K. Hatanaka, J. Ohmori, K. Koshiya, S. Usuda and K. Murase, 1996, YM90K: pharmacological characterization as a selective and potent α-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA)/kainate receptor antagonist, J. Pharmacol. Exp. Ther. 276, 84.
33. Smith, S.E. and B.S. Meldrum, 1992, Cerebroprotective effect of a non-N-methyl-D-aspartale antagonist, GYKI 52466, after focal ischemia in the rat, Stroke 23, 861.
34. Tang, C.-M., M. Dichter and M. Morad, 1989, Quisqualate activates a rapidly inactivating high conductance ionic channel in hippocampal neurons, Science 243, 1474.
35. Trussel, L.O., L.L. Thio, C.F. Zorumski and G.D. Fishbach, 1988, Rapid desensitization of glutamate receptors in vertebrate central neurons, Proc. Natl. Acad. Sci. USA 85, 4562.
36. Verdoorn, T.A. and R. Dingledine, 1988, Excitatory amino acid expressed in Xenopus oocytes: agonist pharmacology, Mol. Pharmacol. 34, 298.
37. Verdoorn, T.A., N.W. Kleckner and R. Dingledine, 1989, N-Methyl-D-aspartate/glucine and quisqualate/kainate receptors expressed in Xenopus oocytes: antagonist pharmacology, Mol. Pharmacol. 35, 360.
38. Yamada, K.A. and C.-M. Tang, 1993, Benzothiadiazides inhibit rapid glutamate receptor desensitization and enhance glutamatergic synaptic currents, J. Neurosci. 13, 3904.
39. Yatsugi, S., S. Takahashi, S. Kawasaki-Yatsugi, K. Koshiya, S. Sakamoto, D. Uematsu and M. Shimizu-Sasamata, 1996, Neuroptotective effect of YM90K, AMPA/kainate receptor antagonist, in focal cerebral ischemia in cats, J. Cereb. Blood Flow Metab. (in press).
40. Zorumski, C.F., L.L. Thio, G.D. Clark and D.E. Clifford, 1990, Blockade of desensitization augments quisqualate excitotoxicity in hippocampal neurons, Neuron 5, 61.
41. Zorumski, C.F., K.A. Yamada, M.T. Price and J.W. Olney, 1993, A benzodiazepine recognition site associated with the non-NMDA glutamate receptor, Neuron 10, 61.