Multiple pathways for the regulation of telomerase activity

European Journal of Cancer Part A

Volumn 33, Issue 5, 1997, Pages 761-766

  Holt, S E ^a   Wright, W E ^a   Shay, J W ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

differentiation; immortalisation; quiescence; senescence; stem cells; telomeres

Indexed keywords

TELOMERASE;

ARTICLE; CANCER RECURRENCE; CELL AGING; CELL DIFFERENTIATION; CELL IMMORTALIZATION; DOWN REGULATION; ENZYME ACTIVITY; ENZYME REGULATION; GROWTH REGULATION; HUMAN; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; TELOMERE;

CELL AGING; CELL DIVISION; HUMANS; LYMPHOCYTES; NEOPLASM PROTEINS; NEOPLASMS; SIGNAL TRANSDUCTION; STEM CELLS; TELOMERASE; TELOMERE;

EID: 0030988271     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-8049(97)00066-X     Document Type: Article

References (52)

1. Allsopp RC, Vaziri H, Patterson C, et al. Telomere length predicts replicative capacity of human fibroblasts. Proc Natl Acad Sci USA 1992, 89, 10114-10118.
2. Levy MZ, Allsopp RC, Futcher AB, Greider CW, Harley CB. Telomere end-replication problem and cell aging. J Mol Biol 1992, 225, 951-960.
3. Olovnikov AM. Principles of marginotomy in template synthesis of polynucleotides. Dokl Akad Nauk SSSR 1971, 201, 1496-1499.
4. Watson JD. Origin of concatameric T4 DNA. Nature New Biol 1972, 239, 197-201.
5. Wright WE, Shay JW. The two-stage mechanism controlling cellular senescence and immortalization. Exp Geron 1992, 27, 383-389.
6. Shay JW, Wright WE. Mechanisms of escaping human cellular senescence. Radiat Oncol Invest 1996, 3, 284-289.
7. Wright WE, Pereira-Smith OM, Shay JW. Reversible cellular senescence: implications for a two-stage model for the immortalization of normal human diploid fibroblasts. Mol Cell Biol 1989, 9, 3088-3092.
8. Shay JW, Pereira-Smith OM, Wright WE. A role for both RB and p53 in the regulation of human cellular senescence. Exp Cell Res 1991, 196, 33-39.
9. Shay JW, Wright WE, Brasiskyte D, Van Der Haegen BA. E6 of human papillomavirus type 16 can overcome the M1 stage of immortalization in human mammary epithelial cells but not in human fibroblasts. Oncogene 1993, 8, 1407-1413.
10. Counter CM, Avilion AA, LeFeuvre CE, et al. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J 1992, 11, 1921-1929.
11. Kim NW, Pitayszek MA, Prowse KR, et al. Specific association of human telomerase activity with immortal cells and cancer. Science 1994, 266, 2011-2015.
12. Piatyszek MA, Kim NW, Weinrich SL, et al. Detection of telomerase activity in human cells and tumors by a telomeric repeat amplification protocol (TRAP). Meth Cell Sci 1995, 17, 1-15.
13. Broccoli D, Young JW, de Lange T. Telomerase activity in normal and malignant hematopoietic cells. Proc Natl Acad Sci USA 1995, 92, 9082-9086.
14. Counter CM, Hirte HW, Bacchetti S, Harley CB. Telomerase activity in human ovarian carcinoma. Proc Natl Acad Sci USA 1994, 91, 2900-2904.
15. Counter CM, Gupta J, Harley CB, Leber B, Bacchetti S. Telomerase activity in normal leukocytes and in hematological malignancies. Blood 1995, 85, 2315-2320.
16. Hiyama E, Hiyama K, Yokoyama T, Matsuura Y, Piatyszek MA, Shay JW. Correlation of telomerase activity level with human neuroblastoma outcomes. Nature Med 1995, 1, 249-257.
17. Hiyama K, Hiyama E, Ishoika S, et al. Telomerase activity in small-cell and non-small-cell lung cancers. J Natl Cancer Inst 1995, 87, 895-902.
18. Hiyama K, Hirai Y, Kyoizumi S, et al. Activation of telomerase in human lymphocytes and hematopoietic progenitor cells. J Immunol 1995, 155, 3711-3715.
19. Hiyama E, Gollahon L, Kataoka T, et al. Telomerase activity in human breast tumors. J Natl Cancer Inst 1996, 88, 116-122.
20. Wright WE, Piatyszek MA, Rainey WE, Byrd W, Shay JW. Telomerase activity in human germline and embryonic tissues and cells. Devel Genet 1996, 18, 173-179.
21. Sommerfeld HJ, Meeker AK, Piatyszek MA, Bova HS, Shay JW, Coffey DS. Telomerase activity: a prevalent marker of malignant human prostate tissue. Cancer Res 1995, 56, 218-222.
22. Langford LA, Piatyszek MA, Xu R, Schold SC, Shay JW. Telomerase activity in human brain tumours. Lancet 1995, 346, 1267-1268.
23. Taylor RS, Ramirez RD, Ogoshi M, Chaffins M, Piatyszek MA, Shay JW. Detection of telomerase activity in malignant and nonmalignant skin conditions. J Invest Dermatol 1996, 106, 759-765.
24. Ramirez RD, Wright WE, Shay JW, Taylor RS. Telomerase activity concentrates in the mitotically active segments of human hair follicles. J Invest Dermatol 1996, 108, 113-117.
25. Bryan TM, Englezou A, Gupta J, Bacchetti S, Reddel RR. Telomere elongation in immortal human cells without detectable telomerase activity. EMBO J 1995, 14, 4240-4248.
26. Murnane JB, Sabatier L, Marder BA, Morgan WF. Telomere dynamics in an immortal human cell line. EMBO J 1994, 13, 4953-4962.
27. Mantell LL, Greider CW. Telomerase activity in germline and embryonic cells of Xenopus. EMBO J 1994, 13, 3211-3217.
28. Holt SE, Wright WE, Shay JW. Regulation of telomerase activity in immortal cell lines. Mol Cell Biol 1996, 16, 2932-2939.
29. Buckovich KJ, Greider CW. Telomerase regulation during entry into the cell cycle in normal human T cells. Mol Cell Biol 1996, 7, 1443-1454.
30. Vaziri H, Dragowska W, Allsopp RC, Thomas TE, Harley CB, Lansdorp PM. Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age. Proc Natl Acad Sci USA 1994, 91, 9857-9860.
31. Vaziri H, Schaechter F, Uchida I, et al. Loss of telomeric DNA during aging in normal and trisomy 21 human lymphocytes. Am J Hum Genet 1993, 52, 662-667.
32. Bodnar AG, Kim NW, Effros RB, Chiu CP. Mechanism of telomerase induction during T cell activation. Exp Cell Res 1997, 228, 58-64.
33. Albanell J, Han W, Mellado B, et al. Telomerase activity is repressed during differentiation of maturation-sensitive but not resistant human tumor cell lines. Cancer Res 1996, 56, 1503-1508.
34. Bestilny LJ, Brown CB, Miura Y, Robertson LD, Riabowol KT. Selective inhibition of telomerase activity during terminal differentiation of immortal cell lines. Cancer Res 1996, 56, 3796-3802.
35. Sharma HW, Sokoloski JA, Perez JR, et al. Differentiation of immortal cells inhibits telomerase activity. Proc Natl Acad Sci USA 1995, 92, 12343-12346.
36. Zhang W, Piatyszek MA, Kobayashi T, et al. Telomerase activity in human acute myelogenous leukemia: inhibition of telomerase activity by differentiation-inducing agents. Clin Cancer Res 1996, 2, 799-803.
37. Scott RE. The differentiation therapy of cancer: past, present, and future. Mol Cell Diff 1995, 3, 157-173.
38. Wright WE, Brasiskyte D, Piatyszek MA, Shay JW. Experimental elongation of telomeres in immortal human cells extends the lifespan of immortal x normal cell hybrids. EMBO J 1996, 15, 1734-1741.
39. Ohmura H, Tahara H, Suzuki M, et al. Restoration of the cellular senescence program and repression of telomerase by human chromosome 3. Jpn J Cancer Res 1995, 86, 899-904.
40. Daly MC, Xiang R-H, Buchlagen D, et al. A homozygous deletion on chromosome 3 in a small cell lung cancer cell line correlates with a region of tumor suppression activity. Oncogene 1993, 8, 1721-1729.
41. Killary AM, Wolf ME, Giambernardi TA, Naylor SL. Definition of a tumor suppressor locus within human chromosome 3p21-p22. Proc Natl Acad Sci USA 1992, 89, 10877-10881.
42. Sekido Y, Bader S, Latif F, et al. Molecular analysis of the von Hippel-Lindau disease tumor suppressor gene in human lung cancer cell lines. Oncogene 1994, 9, 1599-1604.
43. Whang-Peng J, Kao-Shan CS, Lee EC, et al. Specific chromosome defect associated with human small-cell lung cancer: deletion 3p(14-23). Science 1982, 215, 181-182.
44. Chong L, van Steensel B, Broccoli D, et al. A human telomeric protein. Science 1995, 270, 1663-1667.
45. Lundblad V, Wright WE. Telomeres and telomerase: a simple picture becomes complex. Cell 1996, 87, 369-375.
46. Holt SE, Shay JW, Wright WE. Refining the telomere-telomerase hypothesis of aging and cancer. Nature Biotech 1996, 14, 834-837.
47. Norton JC, Piatyszek MA, Wright WE, Shay JW, Corey DR. Inhibition of human telomerase activity by peptide nucleic acids. Nature Biotech 1996, 14, 615-619.
48. Shippen-Lentz D, Blackburn EH. Functional evidence for an RNA template in telomerase. Science 1990, 247, 546-552.
49. Greider CW, Blackburn EH. A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis. Nature 1989, 337, 331-337.
50. Morin GB. The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats. Cell 1989, 59, 521-529.
51. Strahl C, Blackburn EH. Effects of reverse transcriptase inhibitors on telomere length and telomerase activity in two immortalized human cell lines. Mol Cell Biol 1996, 16, 53-65.
52. Melek M, Greene EC, Shippen DE. Processing of nontelomeric 3′ ends by telomerase: default template alignment and endonucleolytic cleavage. Mol Cell Biol 1996, 16, 3437-3445.