Down-Regulation of IL-12, Not a Shift from a T Helper-1 to a T Helper-2 Phenotype, Is Responsible for Impaired IFN-γ Production in Mammary Tumor-Bearing Mice

Journal of Immunology

Volumn 158, Issue 1, 1997, Pages 280-286

  Handel Fernandez, Mary Ellen ^a   Cheng, Xiaofang ^a   Herbert, Lynn M ^a   Lopez, Diana M ^a,b  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MIAMI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 12; RECOMBINANT PROTEIN;

ANIMAL; ARTICLE; BAGG ALBINO MOUSE; BIOSYNTHESIS; CELL CULTURE; CELL DIFFERENTIATION; DOWN REGULATION; DRUG EFFECT; EXPERIMENTAL NEOPLASM; FEMALE; GENETICS; IMMUNOLOGY; MACROPHAGE; MALE; METABOLISM; MOUSE; NUCLEOTIDE SEQUENCE; T LYMPHOCYTE; TH1 CELL; TH2 CELL;

ANIMALS; BASE SEQUENCE; CELL DIFFERENTIATION; DOWN-REGULATION; FEMALE; INTERFERON TYPE II; INTERLEUKIN-12; MACROPHAGES; MALE; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MICE, INBRED BALB C; RECOMBINANT PROTEINS; T-LYMPHOCYTES; TH1 CELLS; TH2 CELLS; TUMOR CELLS, CULTURED;

EID: 0030641489     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Zhou, P., M. C. Sieve, J. Bennett, K. J. Kwon-Chung, R. P. Tewari, R. T. Gazzinelli, A. Sher, and R. A. Seder. 1995. II-12 prevents mortality in mice infected with Histoplasma cupsulatum through induction of IFN-γ. J. Immunol. 155:785.
2. Stevenson, M. M., M. F. Tam, S. F. Wolf, and A. Sher. 1995. IL-12-induced protection against blood-stage plasmodium chabaudi AS requires IFN-γ and TNF-α and occurs via a nitric oxide-dependent mechanism. J. Immunol. 155: 2545.
3. Manetti, R., F. Gerosa, M. G. Giudizi, R. Biagiotti, P. Parronchi, M.-P. Piccinni, S. Sampognaro, E. Maggi, S. Romagnani, and G. Trinchieri. 1994. Interleukin 12 induces stable priming for interferon γ (IFN-γ) production during differentiation of human T helper (Th) cells and transient IFN-γ production in established Th2 cell clones. J. Exp. Med. 179:1273.
4. Brunda, M. J., L. Luistro, R. R. Warrier, R. B. Wright, B. R. Hubbard, M. Murphy, S. F. Wolf, and M. K. Gately. 1993. Antitumor and antimetastatic activity of interleukin 12 against murine tumors. J. Exp. Med. 178:1223.
5. Coughlin, C. M., M. Wysocka, H. L. Kurzawa, W. M. F. Lee, G. Trinchieri, and S. L. Eck. 1995. B7-1 and interleukin 12 synergistically induce effective antitumor immunity. Cancer Res. 55:4980.
6. Tahara, H., L. Zitvogel, W. J. Storkus, H. J. Zeh, T. G. McKinney, R. D. Schreiber, U. Gubler, P. D. Robbins, and M. T. Lotze. 1995. Effective eradication of established murine tumors with IL-12 gene therapy using a polycistronic retroviral vector. J. Immunol. 154:6466.
7. Wiggington, J. M., D. B. Kuhns, T. C. Back, M. J. Brunda, R. H. Wiltrout, and G. W. Cox. 1996. Interleukin 12 primes macrophages for nitric oxide production in vivo and restores depressed nitric oxide production by macrophages from tumor-bearing mice: implications for anti-tumor activity of IL-12 and/or interleukin 2. Cancer Res. 56:1131.
8. Sotomayor, E. M., X-F. Cheng, Y.-X. Fu, A. Hawkins, C. Calderon-Higginson, and D. M. Lopez. 1993. Impaired activation of tumoricidal function in macrophages from mammary tumor bearers: the role of IFN-γ. Int. J. Oncol. 3:719.
9. Ghosh, P., K. L. Komschlies, M. Cippitelli, D. L. Longo, J. Subleski, J. Ye, A. Sica, H. A. Young, R. H. Wiltrout, and A. C. Ochoa. 1995. Gradual loss of T-helper 1 populations in spleens of mice with progressive tumor growth. J. Natl. Cancer Inst. 87:1478.
10. Medina, D., and K. B. DeOme. 1969. Response of hyperplastic alveolar nodule outgrowth line D1 to mammary tumor virus, nodule-inducing virus, and prolonged hormonal stimulation acting singly and in combination. J. Natl. Cancer Inst. 42:303.
11. Pennline, K. J. 1981. Adherence to plastic or glass surfaces. In Manual of Macrophage Methodology: Collection, Characterization, and Function. J. A. Bellanti and A. Ghaffar, eds. Marcel Dekker, New York, p. 63.
12. Coutelier, J-P., J. Van Broeck, and S. F. Wolf. 1995. Interleukin-12 gene expression after viral infections in the mouse. J. Virol. 69:1955.
13. Heinzel, F. P., M. D. Sadick, B. J. Holaday, R. L. Coffman, and R. M. Locksley. 1989. Reciprocal expression of interferon γ or interleukin 4 during the resolution or progression of murine leishmaniasis: evidence for expansion of distinct helper T subsets. J. Exp. Med. 169:59.
14. Paul, W. E., and R. A. Seder. 1994. Lymphocyte responses and cytokines. Cell 76:241.
15. Chen, Y., V. K. Kuchroo, J. Inobe, D. A. Hafler, and H. L. Weiner. 1994. Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science 265:1237.
16. Gazzinelli, R. T., S. Heiny, T. A. Wynn, S. Wolf, and A. Sher. 1993. Interleukin 12 is required for the T-lymphocyte-independent induction of Interferon γ by an intracellular parasite and induces resistance in T-cell-deficient hosts. Proc. Natl. Acad. Sci. USA 90:6115.
17. Heinzel, F. P., R. M. Rerko, F. Ahmed, and E. Pearlman. 1995. Endogenous IL-12 is required for control of the Th2 cytokine responses capable of exacerbating Leishmaniasis in normally resistant mice. J. Immunol. 155:730.
18. Fallarino, F., C. Uyttenhove, T. Boon, and T. F. Gajewski. 1996. Endogenous IL-12 is necessary for rejection of P815 tumor variants in vivo. J. Immunol. 156:1095.
19. Trinchieri, G. 1995. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol. 13:251.
20. D'Andrea, A., M. Aste-Amezaga, N. M. Valiante, X. Ma, M. Kubin, and G. Trinchieri. 1993. Interleukin 10 (IL-10) inhibits human lymphocyte interferon γ-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells. J. Exp. Med. 178:1041.
21. Bette, M., S. Sin, T. Germann, M. K. H. Schäfer, E. Weihe, E. Rüde, and B. Fleischer. 1994. Differential expression of mRNA encoding interleukin-12 p35 and p40 subunits in situ. Eur. J. Immunol. 24:2435.
22. Lopez, D. M., M. Lopez-Cepero, G. A. Watson, A. Ganju, E. M. Sotomayor, and Y-X. Fu. 1991. Modulation of the immune system by mammary tumor-derived factors. Cancer Invest. 9:643.
23. Sotomayor, E. M., Y-X. Fu, M. Lopez-Cepero, L. Herbert, J. J. Jimenez, C. Albarracin, and D. M. Lopez. 1991. Role of tumor-derived cytokines on the immune system of mice bearing a mammary adenocarcinoma. II. Down-regulation of macrophage-mediated cytotoxicity by tumor-derived granulocyte-macrophage colony stimulating factor. J. Immunol. 147:2816.
24. Calderon, H. C., Z-H. Huang, D. A. Gage, E. M. Sotomayor, and D. M. Lopez. 1994. Isolation of a nitric oxide inhibitor from mammary tumor cells and its characterization as phosphatidyl serine. J. Exp. Med. 180:945.
25. Fu, Y.-X., G. A. Watson, M. Kasahara, and D. M. Lopez. 1991. The role of tumor-derived cytokine on the immune system of mice bearing a mammary adenocarcinoma: induction of regulatory macrophages in normal mice by the in vivo administration of rGM-CSF. J. Immunol. 146:783.
26. Chehimi, J., S. E. Starr, I. Frank, A. D'Andrea, X. Ma, R. R. MacGregor, J. Sennelier, and G. Trinchieri. 1994. Impaired interleukin 12 production in human immunodeficiency virus-infected patients. J. Exp. Med. 197:1361.
27. + T cells requires the coordinate action of interleukin-12 and interteron-γ and is inhibited by transforming growth factor-β. Eur. J. Immunol. 24:793.
28. Sad, S., and T. R. Mosmann. 1994. Single IL-2-secreting precursor CD4 cell can develop into either Th1 or Th2 cytokine secretion phenotype. J. Immunol. 153: 3514.
29. Sotomayor, E. M., M. R. DiNapoli, C. Calderon, A. Colsky, Y.-X. Fu, and D. M. Lopez. 1995. Decreased macrophage-mediated cytotoxicity in mammary-tumor-bearins mice is related to alteration of nitric oxide production and/or release. Int. J. Cancer 60:660.
30. Zumkeller, W., and P. N. Schofield. 1995. Growth factors, cytokines and soluble forms of receptor molecules in cancer patients. Anticancer Res. 15:343.
31. 2 is a potent inhibitor of human interleukin 12 production. J. Exp. Med. 181:775.
32. + T cells. J. Immunol. 156:1722.
33. Skeen, M. J., M. A. Miller, T. M. Shinnick, and H. K. Ziegler. 1996. Regulation of murine macrophage IL-12 production: activation of macrophages in vivo, restimulation in vitro, and modulation by other cytokines. J. Immunol. 156:1196.
34. D'Andrea, A., M. Rengaraju, N. M. Valiente, J. Chehimi, M. Kubin, M. Aste, S. H. Chan, M. Kobayashi, D. Young, E. Nickbarg, R. Chizzinite, S. F. Wolf, and G. Trinchieri. 1992. Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells. J. Exp. Med. 176:1387.