A high incidence of BRCA1 mutations in 20 breast-ovarian cancer families

American Journal of Human Genetics

Volumn 58, Issue 1, 1996, Pages 42-51

  Serova, Olga ^a   Montagna, Marco ^a   Torchard, Delphine ^b   Narod, Steven A ^c   Tonin, Patricia ^c   Sylla, Bakary ^a   Lynch, Henry T ^d   Feunteun, Jean ^b   Lenoir, Gilbert M ^a  

^a INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

^b INSTITUT GUSTAVE ROUSSY   (France)

^c MCGILL UNIVERSITY   (Canada)

^d CREIGHTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; BREAST CANCER; CANCER FAMILY; CHROMOSOME 12Q; FEMALE; GENE MUTATION; GENETIC LINKAGE; GERM LINE; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; OVARY CANCER; PRIORITY JOURNAL;

EID: 0029655346     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (8)

1. Baserga SJ, Benz EJ (1992) Beta-globin nonsense mutation:deficient accumulation of mRNA occurs despite normal cytoplasmic stability. Proc Natl Acad Sci USA 89:2935-2939
2. Castilla LH, Couch FJ, Erdos MR, Hoskins KF, Calzone K, Garber JE, Boyd J, et al (1994) Mutations in the BRCA1 gene in families with early onset breast and ovarian cancer. Nat Genet 8:387-391
3. Claus EB, Risch N, Thompson WD (1991) Genetic analysis of breast cancer in the Cancer and Steroid Hormone Study. Am J Hum Genet 48:232-242
4. Easton DF, Bishop DT, Ford D, Crockford GP and the Breast Cancer Linkage Consortium (1993) Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families. Am J Hum Genet 52:678-701
5. Easton DF, Ford C, Bishop DT, the Breast Cancer Linkage Consortium (1995) Breast and ovarian cancer incidence in BRCAl-mutation carriers. Am J Hum Genet 56:265-271
6. Feunteun J, Narod SA, Lynch HT, Watson P, Conway T, Lynch J, Parboosingh J, et al (1993) A breast cancer susceptibility gene maps to chromosome 17q21. Am J Hum Genet 52:736-743
7. Friedman LS, Ostermeyer EA, Szabo CI, Dowd P, Lynch ED, Rowell SE, King M-C (1994) Confirmation of BRCA1 by analysis of germline mutations linked to breast and ovarian cancer in ten families. Nat Genet 8:399-404
8. Go RCP, King M-C, Bailey-Wilson J, Elston RC, Lynch HT (1983) Genetic epidemiology of bresat cancer and associated cancers in high risk families. I. Segregation analysis. J Natl Cancer Inst 71:455-461