BRCA2 germline mutations in male breast cancer cases and breast cancer families

Nature Genetics

Volumn 13, Issue 1, 1996, Pages 123-125

  Couch, Fergus J ^a   Farid, Linda M ^a   DeShano, Michelle L ^a   Tavtigian, Scan V ^b   Calzone, Kathleen ^a   Campeau, Lisa ^a   Peng, Yi ^a   Bogden, Bert ^b   Chen, Qian ^b   Neuhausen, Susan ^c   Shattuck Eidens, Donna ^b   Godwin, Andrew K ^d   Daly, Mary ^d   Radford, Diane M ^e   Sedlacek, Scott ^f   Rommens, Johanna ^g   Simard, Jacques ^h   Garber, Judy ⁱ   Merajver, Sofia ^j   Weber, Barbara L ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b Myriad Genetics Laboratories Inc   (United States)

^c UNIVERSITY OF UTAH   (United States)

^d FOX CHASE CANCER CENTER   (United States)

^e WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^g HOSPITAL FOR SICK CHILDREN   (Canada)

^h LAVAL UNIVERSITY   (Canada)

ⁱ DANA FARBER CANCER INSTITUTE   (United States)

^j UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

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Author keywords

[No Author keywords available]

Indexed keywords

BRCA2 PROTEIN; DNA; PRIMER DNA; TRANSCRIPTION FACTOR; TUMOR PROTEIN;

ARTICLE; BLOOD; BREAST TUMOR; CHEMISTRY; DISEASE PREDISPOSITION; EXON; FAMILY; FEMALE; GENETIC MARKER; GENETIC POLYMORPHISM; GENETICS; HUMAN; ISOLATION AND PURIFICATION; MALE; MOLECULAR GENETICS; MUTATION; NUCLEOTIDE SEQUENCE; OVARY TUMOR; POLYMERASE CHAIN REACTION;

BASE SEQUENCE; BRCA2 PROTEIN; BREAST NEOPLASMS; BREAST NEOPLASMS, MALE; DISEASE SUSCEPTIBILITY; DNA; DNA MUTATIONAL ANALYSIS; DNA PRIMERS; EXONS; FAMILY; FEMALE; GENETIC MARKERS; HUMANS; MALE; MOLECULAR SEQUENCE DATA; MUTATION; NEOPLASM PROTEINS; OVARIAN NEOPLASMS; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; TRANSCRIPTION FACTORS;

EID: 0030139524     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/ng0596-123     Document Type: Article

References (5)

1. Wooster, R. et al. Localisation of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13. Science 285, 2088-2090 (1994).
2. Wooster, R. et al. Identification of the breast cancer susceptibility gene BRCA2. Nature 378, 789-792 (1995).
3. Tavtigian, S.V et al. The complete BRCA2 gene and mutations in chromsome 13q-linked kindreds. Nature Genet. 12, 333-337 (1996).
4. Neuhausen, S. et al. Recurrent BRCA2 6174delT mutations in Ashkenazi Jewish women affected by breast cancer. Nature Genet 13, 126-128 (1996).
5. Ganguly, A, Rock, M J., & Prockop, D.J. Conformation-sensitive gel electrophoresis for rapid detection of single base differences in double stranded PCR products and DNA fragments: evidence for solvent induced bends in DNA heteroduplexes. Proc. Natl. Acad. Sci. USA 86, 2766-70 (1989).