Pediatric obesity: An overview of etiology and treatment

Pediatric Clinics of North America

Volumn 44, Issue 2, 1997, Pages 339-361

  Schonfeld Warden, N ^a   Warden, C H ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN;

ATHEROSCLEROSIS; BEHAVIOR MODIFICATION; CHILDHOOD DISEASE; CLINICAL TRIAL; DIABETES MELLITUS; DIET THERAPY; GALLBLADDER DISEASE; HUMAN; HYPERTENSION; INSULIN RESISTANCE; KINESIOTHERAPY; MALIGNANT NEOPLASTIC DISEASE; OBESITY; PROTEIN EXPRESSION; REVIEW; RISK FACTOR;

EID: 0030901985     PISSN: 00313955     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0031-3955(05)70480-6     Document Type: Article

References (157)

1. M. Arab Diabetes mellitus in Egypt World Health Stat Q 45 1992 334
2. L.G. Bandini W.H. Dietz Myths about childhood obesity Pediatr Ann 21 1992 647
3. L.G. Bandini A. Must W.H. Dietz Sedentary behavior and physical activity level in premenarchal girls Obes Res 4 1996 88
4. L.G. Bandini D.A. Schoeller H.N. Cyr Validity of reported energy intake in obese and nonobese adolescents Am J Clin Nutr 52 1990 421
5. W. Bao S.R. Srinivasan G.S. Berenson Persistent elevation of plasma insulin levels is associated with increased cardiovascular risk in children and young adults: The Bogalusa Heart Study Circulation 93 1996 54
6. G.S. Berenson S.R. Srinivasan W.A. Wattigney Obesity and cardiovascular risk in children Ann N Y Acad Sci 699 1993 93
7. R.I. Berkowitz J. Hemsley C. Forke DL-Fenfluoramine and Phentermine in the treatment of adolescent obesity Obes Res 4 1996 215
8. E. Bognetti P. Macellaro D. Novelli Prevalence and correlates of obesity in insulin dependent diabetic patients Arch Dis Child 73 1995 239
9. C. Bouchard A. Tremblay J.P. Després The response to long-term overfeeding in identical twins N Engl J Med 322 1990 1477
10. P. Brambilla P. Manzoni S. Sironi Peripheral and abdominal adiposity in childhood obesity Int J Obes Relat Metab Disord 18 1994 795
11. S.J. Bultman E.J. Michaud R.P. Woychik Molecular characterization of the mouse agouti locus Cell 71 1992 1195
12. T.L. Burns P.P. Moll R.M. Lauer Increased familial cardiovascular mortality in obese schoolchildren: The Muscatine Ponderosity Family Study Pediatrics 89 1992 262
13. L.A. Campfield F.J. Smith Y. Guisez Recombinant mouse OB protein: Evidence for a peripheral signal linking adiposity and central neural networks Science 269 1995 546
14. H. Chen O. Charlat L.A. Tartaglia Evidence that the diabetes gene encodes the leptin receptor: Identification of a mutation in the leptin receptor gene in db/db mice Cell 84 1996 491
15. W.R. Clarke R.F. Woolson R.M. Lauer Changes in ponderosity and blood pressure in childhood: The Muscatine study Am J Epidemiol 124 1986 195
16. K. Clement C. Garner J. Hager Indication for linkage of the human OB gene region with extreme obesity Diabetes 45 1996 687
17. K. Clement C. Vaisse B.S.J. Manning Genetic variation in the beta3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity N Engl J Med 333 1995 352
18. G.A. Colditz Economic costs of obesity Am J Clin Nutr 55 suppl 1992 503
19. D.L. Coleman Obese and diabetes: Two mutant genes causing diabetes-obesity syndromes in mice Diabetologia 14 1978 141
20. D.L. Coleman E.M. Eicher Fat (fat) and tubby (tub): Two autosomal recessive mutations causing obesity syndromes in the mouse J Hered 81 1990 424
21. D.L. Coleman L. Herberg Laboratory animals exhibiting obesity and diabetes syndromes Metabolism 26 1977 59
22. S. Collins R.S. Surwit Pharmacologic manipulation of ob expression in a dietary model of obesity J Biol Chem 271 1996 9437
23. R.V. Considine M.K. Sinha M.L. Heiman Serum immunoreactive-leptin concentrations in normal-weight and obese humans [see comments] N Engl J Med 334 1996 292
24. C.B. Corbin P. Fletcher Diet and physical activity patterns of obese and non-obese elementary children Res Q 39 1968 922
25. D.E. Cummins E.P. Brandon J.V. Planas Genetically lean mice result from targeted disruption of the RIIβ subunit of protein kinase A Nature 382 1996 622
26. K. Davis K.K. Christoffel Obesity in preschool and school-age children. Treatment early and often may be best Arch Pediatr Adolesc Med 148 1994 1257
27. M.E. Denen J.V. Hennessey R.J. Markert Outpatient evaluation of obesity in adults and children: A review of the performance of internal medicine/pediatrics residents J Genet Intern Med 8 1993 268
28. W.H. Dietz Therapeutic strategies in childhood obesity Horm Res 39 Suppl 3 1993 86
29. W.H. Dietz L.G. Bandini J.A. Morelli Effect of sedentary activities on resting metabolic rate Am J Clin Nutr 59 1994 556
30. W.H. Dietz T.N. Robinson Assessment and treatment of childhood obesity Pediatr Rev 14 1993 337
31. L.H. Eck R.C. Klesges C.L. Hanson Children at familial risk for obesity: An examination of dietary intake, physical activity, and weight status Int J Obes 16 1992 71
32. L. Epstein M. Meyers K. Anderson The association of maternal psychopathology and family socioeconomic status with psychological problems in obese children Obes Res 4 1996 65
33. L.H. Epstein Family-based treatment for preadolescent obesity M.L. Wolrauch D. Routh Advances in Developmental and Behavioral Pediatrics 1985 JAI Press Greenwich, CT 1
34. L.H. Epstein Exercise and obesity in children J Appl Sport Psychol 4 1992 120
35. L.H. Epstein Methodological issues and ten-year outcomes for obese children Ann N Y Acad Sci 699 1993 237
36. L.H. Epstein R. Koeski R.R. Wing Adherence to exercise in obese children J Cardiac Rehabil 4 1984 185
37. L.H. Epstein J. McCurley R. Wing 10 year follow-ups of behavioral family based treatment for obese children JAMA 264 1990 2519
38. L.H. Epstein A. Valoski J. McCurley Effect of weight loss by obese children on long-term growth Am J Dis Child 147 1993 1076
39. L.H. Epstein A. Valoski R.R. Wing Ten-year outcomes of behavioral family-based treatment for childhood obesity [see comments] Health Psychol 13 1994 373
40. L.H. Epstein A.M. Valoski M.A. Kalarchian Do children lose and maintain weight easier than adults: A comparison of child and parent weight changes from six months to ten years Obes Res 3 1995 411
41. L.H. Epstein R.R. Wing R. Koeski A comparison of lifestyle, exercise, aerobic exercise, and calisthenics on weight loss in obese children Behav Ther 16 1985 345
42. J.C. Erickson K.E. Clegg R.D. Palmiter Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y [see comments] Nature 381 1996 415
43. R. Figueroa-Colon T.K. von Almen F.A. Franklin Comparison of two hypocaloric diets in obese children Am J Dis Child 147 1993 160
44. R.C. Fredrich B. Löllmann A. Hamann Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity J Clin Invest 96 1995 1658
45. S.A. French C. Perry G. Leon Self-esteem and change in body mass index over 3 years in a cohort of adolescents Obes Res 4 1996 27
46. S.A. French M. Story C.L. Perry Self-esteem and obesity in children and adolescents: A literature review Obes Res 3 1995 479
47. J.M. Friedman R.L. Leibel N. Bahary Genetic analysis of complex disorders: Molecular mapping of obesity genes in mice and humans Ann N Y Acad Sci 630 1991 100
48. D.C. Garnsm D.C. Clark Trends in fatness and ongoing obesity: Ad hoc committee to review the Ten State Nutrition Survey Pediatrics 57 1975 307
49. S.S. Gidding W. Bao S.R. Srinivasan Effects of secular trends in obesity on coronary risk factors in children: The Bogalusa Heart Study J Pediatr 127 1995 868
50. R.F. Gillum Central body obesity in young children [letter] Int J Obes Relat Metab Disord 19 1995 761
51. M.I. Goran M. Kaskoun W.P. Shuman Intra-abdominal adipose tissue in young children Int J Obes Relat Metab Disord 19 1995 279
52. S.L. Gortmaker W.H. Dietz A.M. Sobol Increasing pediatric obesity in the United States Am J Dis Child 141 1987 535
53. S.L. Gortmaker A. Must A.M. Sobol Television viewing as a cause of increasing obesity among children in the United States, 1986–1990 Arch Pediatr Adolesc Med 150 1996 356
54. M. Griffiths J.P. Rivers P.R. Payne Energy intake in children at high and low risk of obesity Hum Clin Nutr 41 1987 425
55. E. Gruber M.M. Anderson L. Ponton Overweight and obesity in native-American adolescents: Comparing nonreservation youths with African-American and Caucasian peers Am J Prev Med 11 1995 306
56. B. Gutin S. Islam F. Treiber Fasting insulin concentration is related to cardiovascular reactivity to exercise in children Pediatrics 96 1995 1123
57. J.L. Halaas K.S. Gajiwala M. Maffei Weight-reducing effects of the plasma protein encoded by the obese gene Science 269 1995 543
58. A. Hamann J.S. Flier B.B. Lowell Decreased brown fat markedly enhances susceptibility to diet-induced obesity, diabetes, and hyperlipidemia Endocrinology 137 1996 21
59. S.G. Hassink D.V. Sheslow E. de Lancey Serum leptin in children with obesity: Relationship to gender and development Pediatrics 98 1996 201
60. L.L. Hayman J.C. Meininger P.M. Coates Nongenetic influences of obesity on risk factors for cardiovascular disease during two phases of development Nurs Res 44 1995 277
61. A.J. Hill E. Draper J. Stack A weight on children's minds: Body shape dissatisfactions at 9 years old Int J Obes Relat Metab Disord 18 1994 383
62. A.J. Hill E.K. Silver Fat, friendless and unhealthy: 9-year old children's perception of body shape stereotypes Int J Obes Relat Metab Disord 19 1995 423
63. J.H. Himes W.H. Dietz Guidelines for overweight in adolescent preventive services: Recommendations from an expert committee: The expert committee on clinical guidelines for overweight in adolescent preventive services Am J Clin Nutr 59 1994 307
64. M. Iida T. Murakami K. Ishida Substitution at codon 269 (glutamine → proline) of the leptin receptor (OB-R) cDNA is the only mutation found in the Zucker fatty (fa/fa) rat Biochem Biophys Res Commun 224 1996 597
65. L.S. Inselma A. Milanese A. Deurloo Effect of obesity on pulmonary function in children Pediatr Pulmonol 16 1993 130
66. A.C. Israel C.A. Guile J.E. Baker An evaluation of enhanced self-regulation training in the treatment of childhood obesity J Pediatr Psychol 19 1994 737
67. M.Y. Jackson Height, weight, and body mass index of American Indian schoolchildren, 1990–1991 J Am Diet Assoc 93 1993 1136
68. F. Javier Nieto M. Szklo G.W. Comstock Childhood weight and growth rate as predictors of adult mortality [see comments] Am J Epidemiol 136 1992 201
69. X. Jiang S.R. Srinivasan L.S. Webber Association of fasting insulin level with serum lipid and lipoprotein levels in children, adolescents, and young adults: the Bogalusa Heart Study Arch Intern Med 155 1995 190
70. M.L. Johnson B.S. Burke J. Mayer Relative importance of inactivity and over-eating in the energy balance of obese high school girls Am J Clin Nutr 4 1956 37
71. B.H. Jones J.H. Kim M.B. Zemel Upregulation of adipocyte metabolism by agouti protein: Possible paracrine actions in yellow mouse obesity Am J Physiol 270 1996 E192
72. B.S. Kanders Weighing the options: Criteria for evaluating weight-management programs TPR Pediatric Obesity 1995 National Academy Press Washington, DC 210
73. T.A. Kaplan E. Montana Exercise-induced bronchospasm in nonasthmatic obese children Clin Pediatr (Phila) 32 1993 220
74. E.B. Katz A.E. Stenbit K. Hatton Cardiac and adipose tissue abnormalities but not diabetes in mice deficient in GLUT4 Nature 377 1995 151
75. M.L. Klebig J.E. Wilkison J.G. Geisler Ectopic expression of the agouti gene in transgenic mice causes obesity, features of type II diabetes, and yellow fur Proc Natl Acad Sci USA 92 1995 4728
76. R.C. Klesges M.L. Shelton L.M. Klesges Effects of television on metabolic rate: Potential implications for childhood obesity Pediatrics 91 1993 281
77. P.W. Kleyn W. Fan S.G. Kovats Identification and characterization of the mouse obesity gene tubby: A member of a novel gene family Cell 85 1996 281
78. J. Kopecky G. Clarke S. Enerback Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity J Clin Invest 96 1995 2914
79. R.S. Kuczmarski K.M. Flegal S.M. Campbell Increasing prevalence of overweight among U.S. adults: The National Health and Nutrition Examination Surveys, 1960 to 1991 JAMA 272 1994 205
80. S. Kumanyika Ethnicity and obesity development in children Ann N Y Acad Sci 699 1993 81
81. R. Lazarus L. Baur K. Webb Body mass index in screening for adiposity in children and adolescents: Systematic evaluation using receiver operating characteristic curves Am J Clin Nutr 63 1996 500
82. G.H. Lee R. Proenca J.M. Montez Abnormal splicing of the leptin receptor in diabetic mice Nature 379 1996 632
83. R.L. Leibel M. Rosenbaum J. Hirsch Changes in energy expenditure resulting from altered body weight N Engl J Med 332 1995 621
84. P. Leroy S. Dessolin P. Villageois Expression of ob gene in adipose cells. Regulation by insulin J Biol Chem 271 1996 2365
85. A.K. Leung J.E. Fagan H. Cho Children and television Am Fam Physician 50 1994 909
86. A.K. Leung W.L. Robson Childhood obesity Postgraduate Med 87 1990 123
87. X. Li A study of intelligence and personality in children with simple obesity Int J Obes Relat Metab Disord 19 1995 355
88. S.W. Lichtman K. Pisarska E.R. Berman Discrepancy between self-reported and actual caloric intake and exercise in obese subjects N Engl J Med 327 1992 1893
89. B.B. Lowell V. Susulic A. Hamann Development of obesity in transgenic mice after genetic ablation of brown adipose tissue [see comments] Nature 366 1993 740
90. N.C. Luetteke T.H. Qiu R.L. Peiffer TGFalpha deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice Cell 73 1993 263
91. O.A. MacDougald C.S. Hwang H.Y. Fan Regulated expression of the obese gene product (leptin) in white adipose tissue and 3T3-L1 adipocytes Proc Natl Acad Sci USA 92 1995 9034
92. J.P. Mackenbach Socio-economic health differences in The Netherlands: A review of recent empirical findings Soc Sci Med 34 1992 213
93. M. Maffei H. Fei G.H. Lee Increased expression in adipocytes of ob RNA in mice with lesions of the hypothalamus and with mutations at the db locus Proc Natl Acad Sci USA 92 1995 6957
94. M. Maffei J. Halaas E. Ravussin Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects Nat Med 1 1995 1155
95. F.J. Martinez J.M. Sancho-Rof Epidemiology of high blood pressure and obesity Drugs 46 Suppl 2 1993 160
96. D. McGee G. Rhoads J. Hankin Within-person variability of nutrient intake in a group of Hawaiian men of Japanese ancestory Am J Clin Nutr 36 1982 657
97. C. Mellin To: President Clinton. Re: combating childhood obesity J Am Diet Assoc 93 1993 265
98. L.M. Mellin L. Frost Child and adolescent obesity: The nurse practitioner's use of the Shapedown method J Pediatr Health Care 6 1992 187
99. L.M. Mellin C.E. Irwin Jr S. Scully Prevalence of disordered eating in girls: A survey of middle-class children J Am Diet Assoc 92 1992 851
100. A. Must P.F. Jacques G.E. Dallal Long-term morbidity and mortality of overweight adolescents: A follow up of the Harvard Growth Study of 1922–1935 N Engl J Med 327 1992 1350
101. P. Muzzin J.P. Revelli F. Kuhne An adipose tissue-specific beta-adrenergic receptor. Molecular cloning and down-regulation in obesity J Biol Chem 266 1991 24053
102. J.K. Naggert L.D. Fricker O. Varlamov Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity Nat Genet 10 1995 135
103. K. Noben-Trauth J.K. Naggert M.A. North A candidate gene for the mouse mutation tubby Nature 380 1996 534
104. E. Okamoto L.L. Davidson D.R. Conner High prevalence of overweight in inner-city schoolchildren Am J Dis Child 147 1993 155
105. S.A. Oliveria R.C. Ellison L.I. Moore Parent-child relationships in nutrient intake: The Framingham Children's Study Am J Clin Nutr 56 1992 593
106. M.A. Pelleymounter M.J. Cullen M.B. Baker Effects of the obese gene product on body weight regulation on ob/ob mice Science 269 1995 540
107. M.C. Pepin F. Pothier N. Barden Impaired type II glucocorticoid-receptor function in mice bearing antisense RNA transgene Nature 355 1992 725
108. L. Pérusse C. Bouchard The genetics of obesity C. Bouchard Genetics of Energy Intake and Food Preferences 1994 CRC Press Boca Raton 125
109. M.S. Phillips Q. Liu H.A. Hammond Leptin receptor missense mutation in the fatty Zucker rat Nat Genet 13 1996 18
110. O.T. Raitakari K.V. Porkka S. Taimela Effects of persistent physical activity and inactivity on coronary risk factors in children and young adults: The Cardiovascular Risk in Young Finns Study Am J Epidemiol 140 1994 195
111. E. Ravussin C. Bogardus Energy expenditure in the obese: is there a thrifty gene? Infusionstherapie 17 1990 108
112. D.R. Reed Y. Ding W. Xu Extreme obesity may be linked to markers flanking the human OB gene Diabetes 45 1996 691
113. S.K. Rhodes K.C. Shimoda L.R. Waid Neurocognitive deficits in morbidly obese children with obstructive sleep apnea J Pediatr 127 1995 741
114. R. Rising I.T. Harper A.M. Fontvielle Determinants of total daily energy expenditure: Variability in physical activity Am J Clin Nutr 59 1994 800
115. S.B. Roberts J. Savage W.A. Coward Energy expenditure and intake in infants born to lean and overweight mothers N Engl J Med 318 1988 461
116. E.M. Rohlfs K.W. Daniel R.T. Premont Regulation of the uncoupling protein gene (Ucp) by beta 1, beta 2, and beta 3-adrenergic receptor subtypes in immortalized brown adipose cell lines J Biol Chem 270 1995 10723
117. 2 curve in children: The need for a clear definition [letter; comment] Int J Obes Relat Metab Disord 17 1993 245
118. M.F. Rolland-Cachera F. Bellisle No correlation between adiposity and food intake: Why are working class children fatter? Am J Clin Nutr 44 1986 779
119. C. Rose F. Vargas P. Facchinetti Characterization and inhibition of a cholesytokinin-inactivating serine protease Nature 380 1996 403
120. M. Rosenthal S.H. Bain A. Bush Weight/height as a screening test for obesity or thinness in schoolage children Eur J Pediatr 153 1994 876
121. R. Saladin P. De Vos M. Guerre-Millo Transient increase in obese gene expression after food intake or insulin administration Nature 377 1995 527
122. J.F. Sallis T.L. McKenzie J.E. Alcaraz Project SPARK: Effects of physical education on adiposity in children Ann N Y Acad Sci 699 1993 127
123. H. Sangi W.H. Mueller R.B. Harrist Is body fat distribution associated with cardiovascular risk factors in childhood? Ann Hum Biol 19 1992 559
124. J.D. Sargent D.G. Blanchflower Obesity and stature in adolescence and earnings in young adulthood: Analysis of a British birth cohort [see comments] Arch Pediatr Adolesc Med 148 1994 681
125. J.B. Sherman M.A. Alexander L. Clark Instruments measuring maternal factors in obese preschool children West J Nurs Res 14 1992 555
126. D. Sheslow S. Hassink W. Wallace The relationship between self-esteem and depression in obese children Ann N Y Acad Sci 699 1993 289
127. M. Spina E. Merlo-Pich R.K.W. Chan Appetite-suppressing effects of urocortin, a CRF-related neuropeptide Nature 273 1996 1561
128. S.R. Srinivasan W. Bao G.S. Berenson Coexistence of increased levels of adiposity, insulin and blood pressure in a young adult cohort with elevated very low density lipoprotein cholesterol: The Bolusa Heart Study Metabolism 42 1993 170
129. S.R. Srinivasan C. Ehnholm W.A. Wattigney Relationship between obesity and serum lipoproteins in children with different apolipoprotein E phenotypes: The Bogalusa Heart Study Metabolism 43 1994 470
130. B.G. Stanley K.C. Anderson M.H. Grayson Repeated hypothalamic stimulation with neuropeptide Y increases daily carbohydrate and fat intake and body weight gain in female rats Physiol Behav 46 1989 173
131. P.A. Stefanick F.P. Heald J. Mayer Caloric intake in relation to energy output of obese and non-obese adolescent boys Am J Clin Nutr 7 1959 55
132. T.W. Stephens M. Basinski P.K. Bristow The role of neuropeptide Y in the antiobesity action of the obese gene product Nature 377 1995 530
133. A.J. Stunkard T.T. Foch Z. Hrubec A twin study of human obesity JAMA 256 1986 51
134. J. Sunnegardeth L.E. Bratteby U. Hagman Physical activity in relation to energy intake and body fat in 8- and 13-year old children in Sweden Acta Pediatr Scand 75 1986 966
135. R.M. Suskind M.S. Sothern R.P. Farris Recent advances in the treatment of childhood obesity Ann N Y Acad Sci 699 1993 181
136. K. Tambs T. Moum L. Eaves Genetic and environmental contributions to the variance on the body mass index in a Norwegian sample of first- and second-degree relatives Am J Hum Biol 3 1991 257
137. V. Tarasuk G.H. Beaton The nature and individuality of within-subject variation in energy intake Am J Clin Nutr 54 1991 464
138. L.A. Tartaglia M. Dembski X. Weng Identification and expression cloning of a leptin receptor, OB-R Cell 83 1995 1263
139. L.H. Tecott L.M. Sun S.F. Akana Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptors Nature 374 1995 542
140. P. Trayhurn M.E. Thomas J.S. Duncan Effects of fasting and refeeding on ob gene expression in white adipose tissue of lean and obese (ob/ob) mice FEBS Lett 368 1995 488
141. R.P. Troiano K.M. Flegal R.J. Kuczmarski Overweight prevalence and trends for children and adolescents: The National Health and Nutrition Examination Surveys, 1963 to 1991 Arch Pediatr Adolesc Med 149 1995 1085
142. P. Vajro A. Fontanella C. Perna Persistent hyperaminotransferasemia resolving after weight reduction in obese children J Pediatr 125 1994 239
143. P.D. Vos R. Saladin J. Auwerx Induction of ob gene expression by corticosteroids is accompanied by body weight loss and reduced food intake J Biol Chem 270 1995 15958
144. W.J. Wallace D. Sheslow S. Hassink Obesity in children: a risk for depression Ann N Y Acad Sci 699 1993 301
145. J. Walston K. Silver C. Bogardus Time of onset of non-insulin-dependent diabetes mellitus and genetic variation in the beta3-adrenergic-receptor gene N Engl J Med 333 1995 343
146. C.H. Warden C. Bouchard J.M. Friedman Regulation of body weight: Biological and behavioral mechanisms C. Bouchard G.A. Bray Group Report: How Can We Best Apply the Tools of Genetics to Study Body Weight Regulation? 1996 John Wiley & Sons Ltd West Sussex 285
147. C.H. Warden J.S. Fisler Identification of genes underlying polygenic obesity in animal models C. Bouchard The Genetics of Obesity 1994 CRC Press Boca Raton, Florida 181
148. J. Wardle C. Volz C. Golding Social variation in attitudes to obesity in children Int J Obes Relat Metab Disord 19 1995 562
149. W.A. Wattigney D.W. Harsha S.R. Srinvasan Increasing impact of obesity on serum lipids and lipoproteins in young adults: The Bogalusa Heart Study Arch Intern Med 151 1991 2017
150. E. Widen M. Lehto T. Kanninen Association of a polymorphism in the beta3-adrenergic-receptor gene with features of the insulin resistance syndrome in Finns N Engl J Med 333 1995 348
151. J.L. Wiecha V.A. Casey High prevalence of overweight and short stature among Head Start children in Massachusetts Public Health Rep 109 1994 767
152. P.W. Wilkinson J.M. Parkin G. Pearlson Energy intake and physical activity in obese children Br Med J 1 1977 756
153. C.L. Williams M. Bollella B.J. Carter Treatment of childhood obesity in pediatric practice Ann N Y Acad Sci 699 1993 207
154. R. Zannolli A. Rebeggiani F. Chiarelli Hyperinsulinism as a marker in obese children Am J Dis Child 147 1993 837
155. M.B. Zemel J.H. Kim R.P. Woychik Agouti regulation of intracellular calcium: Role in the insulin resistance of viable yellow mice Proc Natl Acad Sci USA 92 1995 4733
156. Y. Zhang R. Proenca M. Maffel Positional cloning of the mouse obese gene and its human homologue Nature 372 1994 425
157. F. Zurlo R.T. Ferraro A.M. Fontvielle Spontaneous physical activity and obesity: Cross-sectional and longitudinal studies in Pima Indians Am J Physiol 263 1992 E296