Markers for the gene ob and serum leptin levels in human morbid obesity

Human Genetics

Volumn 99, Issue 5, 1997, Pages 559-564

  Oksanen, Laura ^a   Öhman, Miina ^b   Heiman, Mark ^c   Kainulainen, Katariina ^a   Kaprio, Jaakko ^a   Mustajoki, Pertti ^d   Koivisto, Veikko ^a   Koskenvuo, Markku ^e   Jänne, Olli A ^f   Peltonen, Leena ^b   Kontula, Kimmo ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^c ELI LILLY AND COMPANY   (United States)

^d PEIJAS HOSPITAL   (Finland)

^e UNIVERSITY OF TURKU   (Finland)

^f UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN; MICROSATELLITE DNA;

ADULT; AGED; ALLELE; ARTICLE; BODY FAT; BODY MASS; CALORIC RESTRICTION; CONTROLLED STUDY; FEMALE; GENETIC ANALYSIS; GENETIC LINKAGE; HUMAN; MAJOR CLINICAL STUDY; MALE; MARKER GENE; MORBID OBESITY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL;

EID: 0030896656     PISSN: 03406717     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004390050406     Document Type: Article

References (41)

1. Banauch D, Brummer W, Ebeling W, Metz H, Rindfrey H, Lang H (1975) Eine Glucose-Dehydrogenase für die Glucose-Bestimmung in Körperflüssigkeiten. Z Klin Chem Klin Biochem 13: 101-107
2. Bergmeyer (1974) Methoden der enzymatischen Analyse, 3. Auflage, Bd. II. Verlag Chemie, Weinheim, p 1878
3. 125I-containing acylating agent. Biochem J 133:529-539
4. Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P (1995) Recombinant mouse ob protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 269: 546-549
5. Chen H, Charlat O, Tartaglia LA, Woolf EA, Weng X, Ellis SJ, Lakey ND, Culpepper J, Moore KJ, Breitbart RE, Duyk GM, Tepper RI, Morgenstern JP (1996) Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell 84:491-495
6. Chua Jr SC, Chung WK, Wu-Peng S, Yiying Z, Liu SM, Tartaglia L, Leibel RL (1996) Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science 271:994-996
7. Clément K, Garner C, Hager J, Philippi A, LeDuc C, Carey A, Harris TJR, Jury C, Cardon LR, Basdevant A, Demenais F, Guy-Grand B, North M, Froguel P (1996) Indication for linkage of the human ob gene region with extreme obesity. Diabetes 45:687-690
8. Considine RV, Considine EL, Williams CJ, Nyce MR, Magosin SA, Bauer TL, Rosato EL, Colberg J, Caro JF (1995) Evidence against either premature stop codon or the absence of obese gene mRNA in human obesity. J Clin Invest 95:2986-2988
9. Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee LJ, Bauer TL, Caro JF (1996a) Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 334: 292-295
10. Considine RV, Considine EL, Williams CJ, Nyce MR, Zhang P, Opentova I, Ohannesian JP, Kolaczynski JW, Bauer TL, Moore JH, Caro JF (1996b) Mutation screening and identification of a sequence variation in the human ob gene coding region. Biochem Biophys Res Commun 220:735-739
11. Dagogo-Jack S, Fanelli C, Paramore D, Brothers J, Landt M (1996) Plasma leptin and insulin relationships in obese and nonobese humans. Diabetes 45:695-698
12. Desbuquois B, Aurbach GD (1971) Use of polyethylene glycol to separate free and antibody-bound peptide hormones in radioimmunoassays. J Clin Endocrinol 33:732-738
13. Fasman KH, Cuticchia AJ, Kingsbury DT(1994) The GDB (TM) Human Genome Data Base Anno 1994. Nucleic Acids Res 22: 3462-3469
14. 2+/dextran sulphate in its enzymic measurement. Clin Chem 24:931-933
15. Haffner SM, Stern MP, Miettinen H, Wei M, Gingerich RL (1996) Leptin concentrations in diabetic and nondiabetic Mexican-Americans. Diabetes 45:822-824
16. Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, Lallone RL, Burley SK, Friedman JM (1995) Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269:543-546
17. Hamilton BS, Paglia D, Kwan AYM, Deitel M (1995) Increased obese mRNA expression in omental fat cells from massively obese humans. Nat Med 1:953-956
18. Klein S, Coppack SW, Mohamed-Ali V, Landt M (1996) Adipose tissue leptin production and plasma leptin kinetics in humans. Diabetes 45:984-987
19. Kolaczynski JW, Nyce MR, Considine RV, Boden G, Nolan G, Henry R, Sunder RM, Olefsky J. Caro JF (1996) Acute and chronic effect of insulin on leptin production in humans. Diabetes 45:699-701
20. Korkeila M, Kaprio J, Rissanen A, Koskenvuo M (1991) Effects of gender and age on the heritability of body mass index. Int J Obesity 15:647-654
21. Kruglyak L, Lander E (1995) Complete multipoint sib-pair analysis of qualitative and quantitative traits. Am J Hum Genet 57: 439-454
22. Kuokkanen S, Sundvall M, Terwilliger JD, Tienari PJ, Wikström J, Holmdahl R, Pettersson U, Peltonen L (1996) A putative vulnerability locus to multiple sclerosis maps to 5p14-p12 in a region syntenic to the murine locus Eae2. Nat Genet 13:477-480
23. Lee GH, Proenca R, Montez JM, Carroll KM, Darvishzadeh JG, Lee JI, Friedman JM (1996) Abnormal splicing of the leptin receptor in diabetic mice. Nature 379:632-635
24. Lönnqvist F, Arner P, Nordfors L, Schalling M (1995) Overexpression of the obese (ob) gene in adipose tissue of human obese subjects. Nat Med 1:950-953
25. Maffei M, Halaas J, Ravussin E, Pratley RE, Lee GH, Zhang Y, Fei H, Kim S, Lallone R, Ranganathan S, Kern PA, Friedman JM (1995) Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med 1:1155-1161
26. Maffei M, Stoffel M, Barone M, Moon B, Dammerman M, Ravussin E, Bogardus C, Ludwig DS, Flier JS, Talley M, Auerbach S, Friedman JM (1996) Absence of mutations in the human ob gene in obese/diabetic subjects. Diabetes 45:679-682
27. Malmström R, Taskinen MR, Karonen SL, Yki-Järvinen H (1996) Insulin increases leptin concentrations in normal subjects and patients with NIDDM. Diabetologia 39:993-996
28. McGregor GP, Desaga JF, Ehlenz K, Fischer A, Heese F, Hegele A, Lämmer C, Peiser C, Lang RE (1996) Radioimmunological measurement of leptin in plasma of obese and diabetic human subjects. Endocrinology 137:1501-1504
29. McGuire RE, Jordan SA, Braden VV, Bouffard GG, Humphries P, Green ED, Daiger SP (1996) Mapping the RP10 locus for autosomal dominant retinitis pigmentosa on 7q: refined genetic positioning and localization within a well-defined YAC contig. Genome Res 6:255-266
30. Morton NE, Collins A, Lawrence S, Shields DC (1992) Algorithms for a location database. Ann Hum Genet 56:223-232
31. Nevanlinna H (1972) The Finnish population structure: a genetic and genealogical study. Hereditas 71:195-236
32. Niki T, Mori H, Tamori Y, Kishimoto-Hashiramoto M, Ueno H, Araki S, Masugi J, Sawant N, Majithia HR, Rais N, Hashiramoto M, Tanigucchi H, Kasuga M (1996) Human obese gene: molecular screening in Japanese and Asian Indian NIDDM patients associated with obesity. Diabetes 45:675-678
33. Norio R, Nevanlina H, Perheentupa J (1973) Hereditary diseases in Finland: rare flora in rare soil. Ann Clin Res 5:109-141
34. Pelleymounter MA, Cullen MJ, Baker MB, Hecht R, Winters D, Boone T, Collins F (1995) Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269:540-543
35. Reed DR, Ding Y, Xu W, Cather C, Green ED, Price RA (1996) Extreme obesity may be linked to markers flanking the human ob gene. Diabetes 45:691-694
36. Segal KR, Landt M, Klein S (1996) Relationship between insulin sensitivity and plasma leptin concentration in lean and obese men. Diabetes 45:988-991
37. Siedel J, Hägele EO, Ziegenhorn J, Wahlefeld AW (1983) Reagent for the enzymatic determination of serum total cholesterol with improved lipolytic efficiency. Clin Chem 29:1075-1080
38. Tartaglia LA, Dembski M, Weng X, Deng N, Culpepper J, Devos R, Richards GJ, Campfield LA, Clark FT, Deeds J, Muir C, Sanker S, Moriarty A, Moore KJ, Smutko JS, Mays GG, Woolf EA, Monroe CA, Tepper RI (1995) Identification and expression cloning of a leptin receptor, OB-R. Cell 83:1263-1271
39. Terwilliger JD (1995) A powerful likelihood method for the analysis of linkage disequilibrium between trait loci and one or more polymorphic marker loci. Am J Hum Genet 56:777-787
40. Vandenplas S, Wild I, Grobler-Rabie A, Brebner K, Ricketts M, Wallis G, Bester A, Boyd C, Mathew C (1984) Blot hybridization analysis of genomic DNA. J Med Genet 21:164-172
41. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM (1994) Positional cloning of the mouse obese gene and its human homologue. Nature 372:425-432