Phosphorylation reactions and the affinity state of platelet integrin αIIbβ3

Platelets

Volumn 8, Issue 4, 1997, Pages 225-234

  Van Willigen, Gijsbert ^a   Akkerman, Jan Willem N ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

INTEGRIN; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN KINASE;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CHO CELL; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN PHOSPHORYLATION; THROMBOCYTE; THROMBOCYTE ANOMALY; THROMBOCYTE FUNCTION;

ANIMALIA;

EID: 0030796711     PISSN: 09537104     EISSN: None     Source Type: Journal    
DOI: 10.1080/09537109777267     Document Type: Article

References (152)

1. Phillips DR, Charo IF, Parise LV, Fitzgerald LA. The platelet membrane glycoprotein IIb-IIIa complex. Blood 1988; 71: 831-43.
2. Isenberg WM, McEver RP, Phillips DR, Shuman MA, Bainton DF. The platelet fibrinogen receptor: an immunogold-surface replica study of agonist-induced ligand binding and receptor clustering. J Cell Biol 1987; 104: 1655-63.
3. Woods VL Jr, Wolff LE, Keller DM. Resting platelets contain a substantially centrally located pool of glycoprotein IIb-IIIa complex which may be accessible to some but not other extracellular proteins. J Biol Chem 1986; 261: 15242-51.
4. Wencel-Drake JD, Plow EF, Kunicki TJ, Woods VL, Keller DM, Ginsberg MH. Localization of internal pools of membrane glycoprotein involved in platelet adhesive responses. Am J Pathol 1986; 124: 324-34.
5. Niiya K, Hodson E, Bader R, Byers-Ward V, Koziol JA, Plow EF, Ruggeri ZM. Increased surface expression of membrane glycoprotein IIb/IIIa complex induced by platelet activation. Relationship between binding of fibrinogen and platelet aggregation. Blood 1987; 70: 475-83.
6. Van Willigen G, Akkerman J-WN. Regulation of glycoprotein IIB/IIIA exposure on platelets stimulated with α-thrombin. Blood 1992; 79: 82-90.
7. Phillips DR, Agin PP. Platelet plasma membrane glycoproteins. Evidence of the presence of nonequivalent disulphide bonds using nonreduced-reduced two-dimensional gel electrophoresis. J Biol Chem 1977; 252: 2121-6.
8. Calvete JJ, Alvarez MV, Rivas G, Hew C-L, Henschen A, González-Rodríguez J. Interchain and intrachain disulphide bonds in human platelet glycoprotein IIb. Biochem J 1989; 261: 551-60.
9. Calvete JJ, Henschen A, González-Rodríguez J. Complete localization of intrachain disulphide bonds and the N-glycosylation points in the α-chain of human platelet glycoprotein lib. Biochem J 1989; 261: 561-8.
10. Calvete JJ, Henschen A, González-Rodríguez J. Assignment of disulphide bonds in human platelet GPIIIa. A disulphide pattern for the β-subunits of the integrin family. Biochem J 1991; 274: 63-71.
11. 2+ dependent complexes of platelet membrane glycoproteins IIb and IIIa in solution as determined by crossed immunoelectrophoresis. Blood 1981; 58: 268-78.
12. Fujimura K, Phillips DR. Calcium cation regulation of glycoprotein IIb-IIIa complex formation in platelet membranes. J Biol Chem 1983; 258: 10247-52.
13. Rivas GA, Usobiaga P, González-Rodríguez J. Calcium and temperature regulation of the stability of the human platelet integrin GPIIb/IIIa in solution: an analytical centrifugation study. Eur Biophys J 1991; 20: 287-92.
14. Jennings LK, Phillips DR. Purification of glycoproteins IIb and III from human platelet plasma membranes and characterization of a calcium-dependent glycoprotein IIb-III complex. J Biol Chem 1982; 257: 10458-66.
15. Lam SC-T. Isolation and characterization of a chymotryptic fragment of platelet glycoprotein IIb-IIIa retaining Arg-Gly-Asp binding activity. J Biol Chem 1992; 267: 5649-55.
16. Poncz M, Eisman R, Heidenreich R. Structure of the platelet membrane glycoprotein IIb. J Biol Chem 1987; 262: 8476-82.
17. 2+-binding properties of the platelet glycoprotein IIb ligand-interacting domain. J Biol Chem 1992; 267: 1001-7.
18. O'Toole TE, Loftus JC, Plow EF, Harper JR, Ginsberg MH. Efficient surface expression of platelet GP IIb-IIIa requires both subunits. Blood 1989; 74: 14-8.
19. Bennet JS, Hoxie JA, Leitman F, Vilaire G, Cines DB. Inhibition of fibrinogen binding to human platelets by a monoclonal antibody. Proc Natl Acad Sci USA 1983; 80: 2417-21.
20. Bennet JS, Vilaire G. Exposure of fibrinogen receptors by ADP and epinephrine. J Clin Invent 1979; 64: 1393-401.
21. Fujimoto T, Ohara S, Hawiger J. Thrombin-induced exposure and prostacyclin inhibition of the receptor for factor VIII/von Willebrand factor on human platelets. J Clin Invest 1982; 69: 1212-22.
22. Smyth SS, Joneckis CC, Parise LV. Regulation of vascular integrins. Blood 1993; 81: 2827-43.
23. Marguerie G, Plow EF, Edgington TS. Human platelets possess an inducable and saturable receptor specific for fibrinogen. J Biol Chem 1979; 254: 5357-63.
24. Plow EF, McEver RP, Coller BS, Woods VL, Marguerie G, Ginsberg MH. Related binding mechanisms for fibrinogen, fibronectin, von Willebrand Factor and thrombospondin on thrombin stimulated platelets. Blood 1985; 64: 724-7.
25. Parise LV, Phillips DR. Fibronectin-binding properties of the purified platelet glycoprotein IIb-IIIa complex. J Biol Chem 1986; 261: 9477-82.
26. Hantgan RR, Nichols WL, Ruggeri ZM. Von Willebrand factor competes with fibrin for occupancy of GPIIb:IIIa on thrombinstimulated platelets. Blood 1990; 75: 889-94.
27. Thiagarajan P, Kelly K. Exposure of binding sites for vitronectin on platelets following stimulation. J Biol Chem 1988; 263: 3035-8.
28. Tomiyama Y, Tsubakio T, Piotrowicz RS, Kurata Y, Loftus JC, Kunicki TJ. The Arg-Gly-Asp (RGD) recognition site of platelet glycoprotein IIb-IIIa on non-activated platelets is accessible to high-affinity macromolecules. Blood 1992; 79: 2303-12.
29. Santoro SA, Lawling WJ Jr. Competition for related but nonidentical sites on glycoprotein IIb-IIIa complex by peptides derived from platelet adhesive proteins. Cell 1987; 48: 867-73.
30. Lam SC-T, Forsyth J, Pierschbacher MD, Ruoslahti E, Plow EF, Ginsberg MH. A synthetic peptide containing a fibrinogen cell attachment sequence inhibits platelet aggregation and binds specifically and saturably to platelets. Fed Proc 1985; 44: 1126-31.
31. Saudek V, Atkinson RA, Pelton JT. Three dimensional structure of echistatin, the smallest active RGD protein. Biochemistry 1991: 30: 7369-72.
32. Adler M, Lazarus RA, Dennis MS, Wagner G. Solution structure of kistrin, a potent platelet aggregation inhibitor and GPIIb-IIIa antagonist. Science 1991; 253: 445-8.
33. 3 (platelet GPIIb-IIIa). Cell 1991; 65: 409-16.
34. Coller BS. A new murine monoclonal antibody reports an activation dependent change in the conformation and/or microenvironment of the platelet glycoprotein IIb/IIIa complex. J Clin Invest 1985; 76: 101-8.
35. 3) mediated by fibrinogen and glycoprotein Ib-von Willebrand factor. J Biol Chem 1992; 267: 11300-6.
36. 3-integrin mediated adhesion of human platelets to a fibrinogen matrix triggers phospholipase C activation and phosphatidylinositol 3′,4′-biphosphate accumulation. FEBS Lett 1996; 389: 253-6.
37. Savage B, Ruggeri ZM. Selective recognition of adhesive sites in surface-bound fibrinogen by glycoprotein IIb-IIIa on non-activated platelets. J Biol Chem 1991; 266: 11227-33.
38. Niewiarowsky S, Budzynski AZ, Morinelli TA, Brudzunski TM, Stewart GJ. Exposure of fibrinogen receptor on human platelets by proteolytic enzymes. J Biol Chem 1981; 256: 917-25.
39. Kornecki E, Niewiarowsky S, Morinelli TA, Kloczewiak M. Effects of chymotrypsin and adenosine diphosphate on the exposure of fibrinogen receptors on normal human and Glanzmann's thrombasthenic platelets. J Biol Chem 1981; 256: 5696-701.
40. Hawiger J, Kloczewiak M, Bednarek MA, Timmons S. Platelet receptor recognition domains on the α-chain of human fibrinogen: structure-function analysis. Biochemistry 1989; 28: 2909-14.
41. Timmons S, Bednarek MA, Kloczewiak M, Hawiger J. Antiplatelet 'hybrid' peptides analogous to receptor recognition domains on gamma and a chains of human fibrinogen. Biochemistry 1989; 28: 2919-23.
42. Andrieux A, Hudry-Clergeon G, Ryckewaert J-J, Chapel A, Ginsberg MH, Plow EF, Marguerie G. Amino acid sequences in fibrinogen mediating its interaction with its platelet receptor. J Biol Chem 1989; 264: 9258-65.
43. Cook NS, Ubben D. Fibrinogen as a major risk factor in cardiovascular disease. Trends Pharmacol Sci 1990; 11: 444-51.
44. Weisel JW, Nagaswami C, Vilaire G, Bennett JS. Examination of the platelet membrane glycoprotein IIb-IIIa complex and its interaction with fibrinogen and other ligands by electron microscopy. J Biol Chem 1992; 267: 16637-43.
45. Taub R, Gould RJ, Garsky VM, Ciccarone TM, Hoxie J, Friedman PA, Shattil SJ. A monoclonal antibody against the platelet fibrinogen receptor contains a sequence that mimics a receptor recognition domain in fibrinogen. J Biol Chem 1989; 264: 259-65.
46. Shattil SJ, Hoxie JA, Cunningham M, Brass LF. Changes in the platelet membrane glycoprotein lib-IIIa complex during platelet activation. J Biol Chem 1985; 260: 11107-14.
47. Yamada T, Song H, Inaka K, Shimada Y, Kikuchi M, Matsushima M. Structure of a conformationally constrained Arg-Gly-Asp sequence inserted into human lysozyme. J Biol Chem 1995; 270: 5687-90.
48. Yamada T, Shimada Y, Uyeda A, Sugiyama S, Kikuchi M. Construction of a divalent cell adhesive lysozyme by introducing the Arg-Gly-Asp sequence at two sites. FEBS Lett 1995; 374: 262-4.
49. 2 to human platelets: Introduction of an RGD sequence by genetic engineering. Thromb Haemostas 1995; 74: 1138-44.
50. 2 to human platelets-introduction of an RGD sequence and acylgroup by chemical modification. Eur J Biochem 1996; 238: 70-6.
51. Yamada T, Shimada Y, Kikuchi M. Integrin-specific tissue-type plasminogen activator engineered by introduction of the Arg-GlyAsp sequence. Biochem Biophys Res Commun 1996; 228: 306-11.
52. 3 J Biol Chem 1995; 270: 30486-90.
53. Farrell DH, Thiagarajan P, Chung DW, Davie EW. Role of fibrinogen a and gamma chain sites in platelet aggregation. Proc Natl Acad Sci USA 1992; 89: 10729-32.
54. 3 J. EMBO J 1996; 15: 5760-71.
55. Calvete JJ, Arias J, Alvarez MV, Lopez MM, Henschen A, González-Rodriguez J. Further studies on the topography of the N-terminal region of human platelet glycoprotein IIIa. Localization of monoclonal antibody epitopes and the putative fibrinogen binding sites. Biochem J 1991; 274: 457-63.
56. D'Souza SE, Ginsberg MH, Burke TA, Lam SC-T, Plow EF. Localization of an Arg-Gly-Asp recognition site within an integrin adhesion receptor. Science 1988; 242: 91-3.
57. Pasquline R, Chamone DF, Brebtain RR. Determination of the putative binding site for fibronectin on platelet glycoprotein IIbIIIa complex through a hydropathic complementary approach. J Biol Chem 1989; 264: 14566-70.
58. D'Souza SE, Ginsberg MH, Matsueda GR, Plow EF. A discrete sequence in a platelet integrin is involved in ligand recognition. Nature 1991; 350: 66-8.
59. D'Souza SE, Ginsberg MH, Burke TA, Plow EF. The ligand binding site of the platelet integrin receptor GPIIb-IIIa is proximal to the second calcium binding domain of its α-subunit. J Biol Chem 1990; 265: 11729-33.
60. Calvete JJ, Schäfer W, Mann K, Henschen A, González-Rodríguez J. Localization of the cross-linking sites of RGD and KQAGDV peptides to the isolated fibrinogen receptor, the human platelet integrin glycoprotein IIb/IIIa. Influence of peptide length. Eur J Biochem 1992; 206: 759-65.
61. 3 (glycoprotein IIb-IIIa) alter receptor affinity, specificity, and function. J Biol Chem 1991; 266: 17106-11.
62. White JG, Leistikow EL, Escolar G. Platelet membrane responses to surface and suspension activation. Blood Cells 1990; 16: 43-72.
63. White JG, Escolar G. Induction of receptor clustering, patching, and capping on surface-activated platelets. Lab Invest 1990; 63: 332-40.
64. Isenberg WM, McEver RP, Phillips DR, Shuman MA, Bainton DF. Immunogold-surface replica study of ADP-induced ligand binding and fibrinogen receptor clustering in human platelets. Am J Anat 1989; 185: 142-8.
65. Leistikow EA, Barnhart MI, Escolar G, White JG. Receptor-ligand complexes are cleared to the open canalicular system of surface-activated platelets. Br J Haematol 1990; 74: 93-100.
66. 3 (glycoprotein IIb/IIIa) in the plasma membrane of a human megakaryocyte. Thromb Haemostas 1997; 77: 143-9.
67. Phillips DR, Jennings LK, Edward HH. Identification of membrane proteins mediating the interaction of human platelets. J Cell Biol 1980; 86: 77-86.
68. Cohen I, Gerrard JM, White JG. Ultrastructure of clots during isometric contraction. J Cell Biol 1982; 93: 775-87.
69. 3 (platelet glycoprotein IIb/IIIa) and the cellular retraction of fibrin polymers. J Biol Chem 1994; 269: 32479-87.
70. 3 (platelet GPIIb-IIIa)-mediated clot retraction. [Abstract] Thromb Haemostas 1993; 69: 1022.
71. Van Willigen G, Akkerman J-WN. Protein kinase C and cyclic AMP regulate reversible exposure of binding sites for fibrinogen on the glycoprotein IIB-IIIA complex of human platelets. Biochem J 1991; 273: 115-20.
72. 2+ mobilization and fibrinogen binding of platelets refractory to adenosine diphosphate stimulation. J Lab Clin Med 1985; 106: 111-22.
73. Kloprogge E, Mommersteeg M, Akkerman JWN. Kinetics of platelet-activating factor 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine-induced fibrinogen binding to human platelets. J Biol Chem 1986; 261: 11071-6.
74. Clark EA, Shattil SJ, Brugge JS. Regulation of protein tyrosine kinases in platelets. Trends Biochem Sci 1994; 19: 464-9.
75. Clark EA, Brugge JS. Integrins and signal transduction pathways: the road taken. Science 1995; 268: 233-9.
76. Uzan G, Frachet P, Lajmanovich A, Prandini M-H, Denarier E, Dupperay A, Loftus J, Ginsberg M, Plow E, Marguerie G. cDNA clones for human platelet GPIIb corresponding to mRNA from megakaryocytes and HEL cells. Eur J Biochem 1988; 171: 87-93.
77. Fitzgerald LA, Steiner B, Rall SC Jr, Lo S-S, Phillips DR. Protein sequence of endothelial glycoprotein IIIa derived from a cDNA clone. J Biol Chem 1987; 262: 3936-9.
78. Hillery CA, Smyth SS, Parise LV. Phosphorylation of human platelet glycoprotein IIIa (GPIIIa). Dissociation from fibrinogen receptor activation and phosphorylation of GPIIIa in vitro. J Biol Chem 1991; 266: 14663-9.
79. 60c-src protein tyrosine kinase. FEBS Lett 1990; 262: 1-4.
80. 3-(GP IIb-IIIa) tyrosine phosphorylation induced by platelet aggregation. J Biol Chem 1996; 271: 10811-5.
81. Parise LV, Criss AB, Nannizzi L, Wardell MR. Glycoprotein IIIa is phosphorylated in intact human platelets. Blood 1990; 75: 2363-8.
82. v integrin cytoplasmic tail. J Biol Chem 1996; 271: 31458-62.
83. Baldassare JJ, Henderson PA, Burns D, Loomis C, Fisher GJ. Translocation of protein kinase C isozymes in thrombin-stimulated human platelets. Correlation with 1,2-diacylgglycerol levels. J Biol Chem 1992; 267: 15585-90.
84. Khan WA, Blobe G, Halpern A, Taylor W, Wetsel WC, Burns D, Loomis C, Hannun YA. Selective regulation of protein kinase C isoenzymes by oleic acid in human platelets. J Biol Chem 1993; 268: 5063-8.
85. Wang F, Naik UP, Ehrlich YH, Freyberg Z, Osada S, Ohno S, Kuroki T, Suzuki K, Kornecki E. A new protein kinase C, nPKCCeta', and nPKCΦ are expressed in human platelets: involvement of nPKCCeta' and nPKCΦ in signal transduction stimulated by PAF. Biochem Biophys Res Commun 1993; 191: 240-6.
86. Chang JD, Xu Y, Raychowdhury MK, Ware JA. Molecular cloning and expression of a cDNA encoding a novel isoenzyme of protein kinase C (nPKC). A new member of the nPKC family expressed in skeletal muscle, megakaryoblastic cells, and platelets. J Biol Chem 1993; 268: 14208-14.
87. Nishizuka Y. The family of protein kinase C for signal transduction. JAMA 1989; 262: 1826-33.
88. Shattil SJ, Brass LF. Induction of the fibrinogen receptor on human platelets by intracellular mediators. J Biol Chem 1987; 262: 992-1000.
89. Hers I, Van Willigen G, Akkerman JWN. Role of protein kinase C and phosphotyrosine kinases in platelet integrin αIIbβ3 exposure [Abstract] Thromb Haemostas 1995; 73: 987.
90. Rubinstein E, Le Naour F, Lagaudrière-Gesbert C, Billard M, Conjeaud H, Boucheix C. CD9, CD63, CD81, and CD82 are components of a surface tetraspan network connected to HLA-DR and VLA integrins. Eur J Immunol 1996; 26: 2657-65.
91. Seehafer J, Logenecker BM, Shaw AER. Biochemical characterization of human carcinoma surface antigen associated with protein kinase activity. Int J Cancer 1984; 34: 821-9.
92. Hato T, Ikeda K, Yasukawa M, Watanabe A, Kobayashi Y. Exposure of platelet fibrinogen receptors by a monoclonal antibody toD9 antigen. Blood 1988; 72: 224-9.
93. IIIa can be topographically associated and transduce functionally similar signals. Eur J Biochem 1997; 244: 168-75.
94. Slupsky JR, Seehafer JG, Tang S-C, Masellis-Smith A, Shaw ARE. Evidence that monoclonal antibodies against CD9 antigen induce specific association between CD9 and the platelet glycoprotein IIb-IIIa complex. J Biol Chem 1989; 264: 12289-93.
95. Hannun YA, Greenberg CS, Bell RM. Sphingosine inhibition of agonist-dependent secretion and activation of human platelets implies that protein kinase C is a necessary and common event of the signal transduction pathways. J Biol Chem 1987; 262: 13620-6.
96. Puri RN, Colman RW. Thrombin- and cathepsin G-induced platelet aggregation: effect of protein kinase C inhibitors. Anal Biochem 1993; 210: 50-7.
97. 2 potentiates platelet aggregation by priming protein kinase C. Blood 1993; 82: 2704-13.
98. Takano S. Staurosporine inhibits STA2-induced platelet aggregation by inhibition of myosin light chain phosphorylation in rabbit washed platelets. Thromb Res 1994; 714: 315-7.
99. Watson SP, McNally J, Shipman LJ, Godfrey PP. The action of the protein kinase C inhibitor, Staurosporine, on human platelets; evidence against a negative feedback role for protein kinase C in platelet activation. Biochem J 1988; 249: 345-50.
100. Watson SP, Hambleton S. Phosphorylation-dependent and -independent pathways of platelet aggregation. Biochem J 1989; 258: 479-85.
101. Watson SP, Blake RA, Lane T, Walker TR. The use of inhibitors of protein kinases and protein phosphatases to investigate the role of protein phosphorylation in platelet activation. Adv Exp Med Biol 1993; 344: 105-18.
102. Murphy CT, Westwick J. Selective inhibition of protein kinase C. Effect on platelet-activating factor-induced platelet functional responses. Biochem J 1992; 283: 159-64.
103. Toullec D, Pianetti P, Coste H, Bellevergue P, Grand-Perret T, Ajakane M, Baudet V, Boissin P, Boursier E, Loriolle F, et al. The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. J Biol Chem 1991; 266: 15771-81.
104. Pulcinelli FM, Daniel JL, Riondino S, Gazzaniga PP, Salganicoff L. Fibrinogen binding is independent of an increase in intracellular calcium concentration in thrombin degranulated platelets. Thromb Haemostas 1995; 73: 304-8.
105. 2+ and protein kinase C is the major factor in determining the level of secretion from human platelets. Biochem J 1993; 289: 277-82.
106. 3 subunit. Biochem J 1996; 314: 769-79.
107. Beltman J, McCormick F, Cook SJ. The selective protein kinase C inhibitor, Ro-31-8220, inhibits mitogen-activated protein kinase phosphatase-1 (MKP-1) expression, induces c-Jun expression, and activates Jun N-terminal kinase. J Biol Chem 1996; 271: 27018-24.
108. Gerrard JM, McNichol A, Saxena SP, Protein kinase C, membrane fusion and platelet granule secretion. Biochem Soc Trans 1993; 21: 289-93.
109. Hashimoto Y, Togo M, Tsukamoto K, Horie Y, Watanabe T, Kurokawa K. Protein kinase C-dependent and -independent mechanisms of dense granule exocytosis by human platelets. Biochim Biophys Acta Mol Cell Res 1994; 1222: 56-62.
110. 2-mediated human platelet responses. Mol Pharmacol 1991; 39: 475-80.
111. Asahi M, Yanagi S, Ohta S, Inazu T, Sakat K, Takeuchi F, Taniguchi T, Yamamura H. Thrombin-induced human platelet aggregation is inhibited by protein-tyrosine kinase inhibitors. ST638 and genistein. FEBS Lett 1992; 309: 10-4.
112. Dhar A, Paul AK, Shukla SD. Platelet-activating factor stimulation of tyrosine kinase and its relationship to phospholipase C in rabbit platelets: studies with Genistein and monoclonal antibody to phosphotyrosine. Mol Pharmacol 1990; 37: 519-25.
113. Salari H, Duronio V, Howard SL, Demos M, Jones K, Reany A, Hudson AT, Pelech SL. Erbstatin blocks platelet activating factor-induced protein-tyrosine phosphorylation, polyphosphoinositide hydrolysis, protein kinase C activation, serotonin secretion and aggregation of rabbit platelets. FEBS Lett 1990; 263: 104-8.
114. Rendu F, Eldor A, Grelac F, Bachelot C, Gazit A, Gilon C, Levy-Toledano S, Levitzki A. Inhibition of platelet activation by tyrosine kinase inhibitors. Biochem Pharmacol 1992; 44: 881-8.
115. Dillon AMR, Heath MF. The effects of tyrphostins B42 and B46 on equine platelet function and protein tyrosine phosphorylation. Biochem Biophys Res Commun 1995; 212: 595-601.
116. Furman MI, Grigoryev D, Bray PF, Dise KR, Goldschmidt-Clermont PJ. Platelet tyrosine kinases and fibrinogen receptor activation. Circ Res 1994; 75: 172-80.
117. Feinstein MB, Pumiglia K, Lau L-F. Tyrosine phosphorylation in platelets: its regulation and possible roles in platelet functions. Adv Exp Med Biol 1993; 344: 129-48.
118. 2+ mobilization in human platelets by affecting polyphosphoinositide turnover. Biochem Pharmacol 1993; 46: 395-403.
119. Wolbring G, Hollenberg MD, Schnetkamaap PPM. Inhibition of GTP-utilizing enzymes by tyrphostins. J Biol Chem 1994; 269: 22470-2.
120. Guinebault C, Payrastre B, Sultan C, Mauco G, Breton M, Levy-Toledano S, Plantavid M, Chap H. Tyrosine kinases and phosphoinositide metabolism in thrombin-stimulated human platelets. Biochem J 1993; 292: 851-6.
121. Taher MM. Herbimycin A inhibits protein kinase C in vascular smooth muscle cells. Biochem Mol Biol Int 1996; 39: 267-77.
122. Pulcinelli FM, Ashby B, Gazzaniga PP, Daniel JL. Protein kinase C activation is not a key step in ADP-mediated exposure of fibrinogen receptors on human platelets. FEBS Lett: 1995; 364: 87-90.
123. Cohen P. The structure and regulation of protein phosphatases. Ann Rev Biochem 1989; 58: 453-508.
124. Walker TR, Watson SP. Okadaic acid inhibits activation of phospholipase C in human platelets hy mimicking the actions of protein kinases A and C. Br J Pharmacol 1992; 105: 627-31.
125. Higashihara M, Takahata K, Kurokawa K, Ikebe M. The inhibitory effects of okadaic acid on platelet function. FEBS Lett 1992; 307: 206-10.
126. Packham MA, Livne A-A, Ruben DH, Rand ML. Activation of phospholipase C and protein kinase C has little involvement in ADP-induced primary aggregation of human platelets: effects of diacylglycerols. the diacylglycerol kinase inhibitor R59022, staurosporine and okadaic acid. Biochem J 1993; 290: 849-56.
127. Murata K, Sakon M, Kambayashi J, Yukuwa M, Ariyoshi H, Shiba E, Kawasaki T, Kang J, Mori T. The effects of okadaic acid and calyculin A on thrombin induced platelet reaction. Biochem Int 1992; 26: 327-34.
128. Lerea KM. Thrombin-induced effects are selectively inhibited following treatment of intact human platelets with okadaic acid. Biochemistry 1991; 30: 6819-24.
129. Pumiglia KM, Lau L-F, Huang C-K, Burroughs S, Feinstein MB, Activation of signal transduction in platelets by the tyrosine phosphatase inhibitor pervanadate (vanadyl hydroperoxide). Biochem J 1992; 286: 441-9.
130. McNicol A, Robertson C, Gerrard JM. Vanadate activates platelets by enhancing arachidonic acid release. Blood 1993; 81: 2329-38.
131. Blake RA, Walker TR, Watson SP. Activation of human platelets hy peroxovanadate is associated with tyrosine phosphorylation of phospholipase Cgamma and formation of inositol phosphates. Biochem J 1993; 290: 471-5.
132. 3 (glycoprotein IIb-IIIa) in a variant of Glanzmann thrombasthenia. Proc Natl Acad Sci USA 1992; 89: 10169-73.
133. Speiser-Ellerton S, Weiss HJ. Studies on platelet protein phosphorylation in patients with impaired responses to platelet agonists. J Lab Clin Med 1990; 115: 104-11.
134. Gabbeta J, Yang X, Sun L, McLane MA, Niewiarowski S, Rao AK. Abnormal inside-out signal transduction-dependent activation of glycoprotein IIb-IIIa in a patient with impaired pleckstrin phosphorylation. Blood 1996; 87: 1368-76.
135. Yang X, Sun L, Ghosh S, Rao AK. Human platelet signaling defect characterized by impaired production of inositol-1,4,5-triphosphate and phosphatic acid and diminished pleckstrin phosphorylation: evidence for defective phospholipase C activation. Blood 1996; 88: 1676-83.
136. Lee SB, Rao AK, Lee KH, Yang X, Bae YS, Rhee SG. Decreased expression of phospholipase C-β2 isozyme in human platelets with impaired function. Blood 1996; 88: 1684-91.
137. O'Toole TE, Katagiri Y, Faull RJ, Peter K, Tamura R, Quaranta V, Loftus JC, Shattil SJ, Ginsberg MH. Integrin cytoplasmic domains mediate inside-out signal transduction. J Cell Biol 1994; 124: 1047-59.
138. IIb. Science 1991; 254: 845-7.
139. 3 integrin (platelet GPIIb-IIIa) is an intrinsic property of the receptor. Cell Regul 1990; 1: 883-93.
140. Williams MJ, Hughes PE, O'Toole TE, Ginsberg MH. The inner world of cell adhesion: integrin cytoplasmic domains. Trends Cell Biol 1994; 4: 109-12.
141. Hughes PE, OToole TE, Ylanne SJ, Ginsberg MH. The conserved membrane-proximal region of an integrin cytoplasmic domain specifies ligand binding affinity. J Biol Chem 1995; 270: 12411-7.
142. Hughes PE, Diaz-Gonzalez F, Leong L, Wu CY, McDonald JA, Shattil SJ, Ginsberg MH. Breaking the integrin hinge - a defined structural constraint regulates integrin signaling. J Biol Chem 1996; 271: 6571-4.
143. Briesewitz R, Kern A, Marcantonio EE. Assembly and function of integrin receptors is dependent on opposing alpha and beta cytoplasmic domains. Mol Biol Cell 1995; 6: 997-1010.
144. 3. J Biol Chem 1996; 271: 30233-41.
145. 3 (platelet glycoprotein IIb-IIIa). Blood 1994; 84: 1857-65.
146. Ginsberg MH, Du XP, O'Toole TE, Loftus JC. Platelet integrins. Thromb Haemost 1995; 74: 352-9.
147. 3, subunit. J Cell Biol 1995; 131: 807-16.
148. IIb cytoplasmic domain. J Biol Chem 1997; 272: 4651-4.
149. 3 in a lymphocyte expression system. J Biol Chem 1995; 270: 18631-6.
150. Chen Y-P, O'Toole TE, Shipley T, Forsyth J, LaFlamme SE, Yamada KM, Shattil SJ, Ginsberg MH. 'Inside-out' signal transduction inhibited by isolated integrin cytoplasmic domains. J Biol Chem 1994; 269: 18307-10.
151. 3 by using cell-permeable peptide analogs. Proc Natl Acad Sci USA 1996; 93: 11819-24.
152. 3 subunit. Differential effects on cell spreading, recruitment to adhesion plaques, endocytosis, and phagocytosis. J Biol Chem 1995; 270: 9550-7.