Abnormal inside-out signal transduction-dependent activation of glycoprotein IIb-IIIa in a patient with impaired pleckstrin phosphorylation

Blood

Volumn 87, Issue 4, 1996, Pages 1368-1376

  Gabbeta, Jagadeesh ^a   Yang, Xu ^a   Sun, Ling ^a   McLane, Mary A ^a   Niewiarowski, Stefan ^a   Rao, A Koneti ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; ALBOLABRIN; CALCIMYCIN; FIBRINOGEN; FIBRINOGEN RECEPTOR; PLECKSTRIN; PROTEIN KINASE C; THROMBOCYTE ACTIVATING FACTOR;

ADOLESCENT; ANTIBODY COMBINING SITE; ARTICLE; BLEEDING; CASE REPORT; HUMAN; HUMAN CELL; HUMAN TISSUE; LIGAND BINDING; MALE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; THROMBOCYTE AGGREGATION; THROMBOCYTE RELEASE REACTION;

EID: 0030023759     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v87.4.1368.bloodjournal8741368     Document Type: Article

References (50)

1. Nurden AT, Caen JP: An abnormal platelet glycoprotein pattern in three cases of Glanzmann's thrombasthenia. Br J Haematol 28:253, 1974
2. Mustard JF, Kinlough-Rathbone RL, Packham MA, Perry DW, Harfenist EJ, Pai KRM: Comparison of fibrinogen association with normal and thrombasthenic platelets on exposure to ADP or chymotrypsin. Blood 54:1987, 1979
3. Bennett JS, Vilaire G: Exposure of platelet fibrinogen receptors by ADP and epinephrine. J Clin Invest 64:1393, 1979
4. Marguerie GA, Plow EF, Edgington TS: Human platelets possess an inducible and saturable receptor specific for fibrinogen. J Biol Chem 254:5357, 1979
5. Gartner TK, Bennett JS: The tetrapeptide analogue of the cell attachment site of fibronectin inhibits platelet aggregation and fibrinogen binding to activated platelets. J Biol Chem 260:11891, 1985
6. Plow EF, Pierschbacher MD, Ruoslahti E, Marguerie GA, Ginsberg MH: The effect of Arg-Gly-Asp-containing peptides on fibrinogen and von Willebrand factor binding to platelets. Proc Natl Acad Sci USA 82:8057, 1985
7. Plow EF, D'Souza SE, Ginsberg MH: Ligand binding to GPIIb-IIIa: A status report. Semin Thromb Hemostas 18:324, 1992
8. Sims PJ, Ginsberg MH, Plow EF, Shattil SJ: Effect of platelet activation on the conformation of the plasma membrane glycoprotein IIb-IIIa complex J Biol Chem 266:7345, 1991
9. Shattil SJ, Hoxie JA, Cunningham M, Brass LF: Change in the platelet membrane glycoprotein IIb-IIIa complex during platelet activation. J Biol Chem 260:11107, 1985
10. Ginsberg MH, Du X, Plow EF: Inside-out integrin signaling. Curr Opin Cell Biol 4:766, 1992
11. 2+ mobilization and fibrinogen binding of platelets refractory to adenosine diphosphate stimulation. J Lab Clin Med 106:111, 1985
12. Shattil SJ, Brass LF: Induction of the fibrinogen receptor on human platelets by intracellular mediators. J Biol Chem 262:992, 1987
13. Shattil SJ, Cunningham M, Wiedermer, T, Zhao J, Sims PJ, Brass LF: Regulation of glycoprotein IIb-IIIa receptor function studied with platelets permeabilized by the pore-forming complement protein C5b-9. J Biol Chem 267:1842, 1992
14. van Willigen G, Akkerman J-W: Protein kinase C and cyclic AMP regulate reversible exposure of binding sites for fibrinogen on the glycoprotein IIb-IIIa complex of human platelets Biochem J 273:115, 1991
15. van Willigen G, Akkerman JW: Regulation of glycoprotein IIb-IIIa exposure on platelets stimulated with α-thrombin. Blood 79:82, 1992
16. Frelinger AL III, Lam SC-T, Plow EF, Smith MA, Loftus JC, Ginsberg MH: Occupancy of an adhesive glycoprotein receptor modulates expression of an antigenic site involved in cell adhesion. J Biol Chem 263:12397, 1988
17. 3 (glycoprotein IIb-IIIa) after receptor affinity, specificity and function. J Biol Chem 266:17106, 1991
18. 3 (platelet GPIIb-IIIa). Cell 65:409, 1991
19. 3. J Biol Chem 268:23087, 1993
20. Trybulec M, Kowalska MA, McLane MA, Silver L, Lu W, Niewiarowski S: Exposure of platelet fibrinogen receptors by zinc ions. Role of protein kinase C. Proc Soc Exp Biol Med 203:108, 1993
21. 3) is modulated by lipids. J Biol Chem 267:15568, 1992
22. O'Toole TE, Katagiri Y, Faull RJ, Peter K, Tamura R, Quaranta V, Loftus JC, Shattil SJ, Ginsberg MH: Integrin cytoplasmic domains mediate inside-out signal transduction. J Cell Biol 124:1047, 1994
23. 3 (glycoprotein IIb-IIIa) in a variant of Glanzmann thrombasthenia. Proc Natl Acad Sci USA 89:10169, 1992
24. 3. Thromb Haemost 70:224, 1993
25. FAK in platelets requires coordinated signaling through integrin and agonist receptors. J Biol Chem 269:14738, 1994
26. Hillery CA, Smyth SS, Parise LV: Phosphorylation of human platelet glycoprotein IIIa (GP IIIa). J Biol Chem 266:14663, 1991
27. Coller BS, Peerschke EI, Scudder LE, Sullivan CA: A murine monoclonal antibody that completely blocks the binding of fibrinogen to platelets produces a thrombasthenic-like state in normal platelets and binds to glycoprotein IIb and/or IIIa. J Clin Invest 72:325, 1983
28. Bennett JS, Hoxie JA, Leitman SF, Vilaire G, Cines DB: Inhibition of fibrinogen binding to stimulated human platelets by a monoclonal antibody. Proc Natl Acad Sci USA 80:2417, 1983
29. 3 integrin, (platelet GPIIb-IIIa) is an intrinsic property of the receptor. Cell Regul 1:883, 1990
30. Shattil SJ, Cunningham M, Hoxie JA: Detection of activated platelets in whole blood using activation dependent monoclonal antibodies and flow cytometry. Blood 70:307, 1987
31. Lasz EC, McLane MA, Trybulec M, Kowalska MA, Khan S, Budzynski AZ, Niewiarowski S: β3 integrin derived peptide 217-230 inhibits fibrinogen binding and platelet aggregation: Significance of RGD sequences and fibrinogen A α-chain. Biochem Biophys Res Commun 190:118, 1993
32. Hannun YA, Greenberg CS, Bell RM: Sphingosine inhibition of agonist-dependent secretion and activation of human platelets implies that protein kinase C is a necessary and common event of the signal transduction pathways. J Biol Chem 262:13620, 1987
33. Rao AK, Koike K, Willis J, Daniel JL, Beckett C, Hassel B, Day HJ, Smith JB, Holmsen H: Platelet secretion defect associated with impaired liberation of arachidonic acid and normal myosin light chain phosphorylation. Blood 64:914, 1984
34. Holmsen H, Storm E, Day HJ: Determination of ATP and ADP in blood platelets: A modification of the firefly luciferase assay for plasma. Anal Biochem 46:489, 1972
35. 2 in peripheral blood of patients with Prinzmetal's angina. Prostaglandins Med 5:243, 1979
36. Kowalska MA, Rao AK, Disa J: High concentrations of arachidonate inhibit calcium mobilization in platelets by stimulation of adenylate cyclase. Biochem J 253:255, 1988
37. Kornecki E, Niewiarowski S, Morinelli TA, Kloczewiak M: Effects of chymotrypsin and adenosine diphosphate on the exposure of fibrinogen receptors on normal human and Glanzmann's thrombasthenic platelets. J Biol Chem 256:5696, 1981
38. Pidard D, Frelinger AL, Bouillot C, Nurden AT: Activation of the fibrinogen receptor on human platelets exposed to alpha chymotrypsin: Relationship with a major proteolytic cleavage at the carboxyterminus of membrane glycoprotein IIb heavy chain. Eur J Biochem 200:347, 1991
39. Ginsberg MH, Frelinger AL, Lam SCT, Forsyth J, McMillan R, Plow EF, Shattil SJ: Analysis of platelet aggregation disorders based on flow cytometric analysis of membrane glycoprotein IIb-IIIa with conformation-specific monoclonal antibodies. Blood 76:2017, 1990
40. Coller BS, Seligsohn U, Peretz H, Newman PJ: Glanzmann thrombasthenia: New insights from an historical perspective. Semin Hematol 31:301, 1994
41. Loftus JC, O'Toole TE, Plow EF, Glass A, Frelinger AL, Ginsberg MH: A beta 3 integrin mutation abolishes ligand binding and alters divalent cation-dependent conformation. Science 249:915, 1990
42. 3 receptor on resting and activated human platelets. Biochem J 301:429, 1994
43. Lages B, Weiss HJ: Heterogeneous defects of platelet secretion and responses to weak agonists in patients with bleeding disorders. Br J Haematol 68:53, 1988
44. Lages B, Weiss HJ: Impairment of phosphatidylinositol metabolism in a patient with a bleeding disorder associated with defects of initial platelet responses. Thromb Haemost 59:1175, 1988
45. Speiser-Ellerton S, Weiss HJ: Studies on platelet protein phosphorylation in patients with impaired responses to platelet agonists. J Lab Clin Med 115:104, 1990
46. Kornecki E, Cooper BA, Ehrlich YH: Identification of a unique type of thrombopathy of human platelets: Defect in the exposure of active fibrinogen receptors in a patient with Friedreich's ataxia. J Lab Clin Med 111:618, 1988
47. Holmsen H: Platelet secretion and energy metabolism, in Colman RW, Hirsh J, Marder VJ, Salzman EW (eds): Hemostasis and Thrombosis. Basic Principles and Clinical Practice. Philadelphia, PA, Lippincott, 1994, p 524
48. 3 formation in human platelets. FEBS Lett 246:109, 1987
49. Fisher GJ, Baksian S, Baldassarre JJ: Activation of human platelets by ADP causes a rapid rise in cytoplasmic free calcium without hydrolysis of phosphatidyl inositol-4,5-biphosphate. Biochem Biophy Res Commun 129:958, 1985
50. Sage SO, Rink TJ: The kinetics of changes in intracellular calcium concentration in fura-2 loaded human platelets. J Biol Chem 262:16364, 1987