The quasispecies of hepatitis C virus and the host immune response

Springer Seminars in Immunopathology

Volumn 19, Issue 1, 1997, Pages 5-26

  Farci, Patrizia ^a,b   Bukh, Jens ^b   Purcell, Robert H ^b  

^a UNIVERSITY OF CAGLIARI   (Italy)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERFERON;

GENETIC HETEROGENEITY; HEPATITIS C; HEPATITIS C VIRUS; IMMUNE RESPONSE; LIVER TRANSPLANTATION; PRIORITY JOURNAL; REVIEW; VIRAL GENETICS; VIRUS IMMUNITY;

ANTIGENIC VARIATION; GENOTYPE; HEPACIVIRUS; HEPATITIS A VACCINES; HEPATITIS C; HUMANS; INTERFERONS; LIVER TRANSPLANTATION; VIRAL HEPATITIS VACCINES;

EID: 0030773306     PISSN: 03444325     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00945022     Document Type: Review

References (147)

1. Alter HJ (1995) To C or not to C: these are the questions. Blood 85:1681
2. Alter MJ, Margolis HS, Krawczynski K, Judson IN, Mares A, Alexander WJ, Hu PY, Miller JK, Gerber MA, Samplimer RE, Meeks EL, Beach Mj (1992) The natural history of community-acquired hepatitis C in the United States. N Engl J Med 327:1899
3. Benn S, Rutledge R, Folks T, Gold J, Baker L, McCormick J, Feorino P, Piot P, Quinn T, Martin M (1985) Genomic heterogeneity of AIDS retroviral isolates from North America and Zaire. Science 230:949
4. Brechot C (1994) Hepatitis C virus genetic variability: clinical implications. Am J Gastroenterol 89:S41
5. Bukh J, Apgar CL (1997) Five new or recently discovered (GBV-A) virus species are indigenous to New World monkeys and may constitute a separate genus of the Flaviviridae virology. Virology 229:429
6. Bukh J, Purcell RH (1996) Genomic structure and variability of hepatitis C virus. Antiviral Ther 1 [Suppl 3]:39
7. Bukh J, Purcell RH, Miller RH (1992) Sequence analysis of the 5′ noncoding region of hepatitis C virus. Proc Natl Acad Sci USA 89:4942
8. Bukh J, Purcell RH, Miller RH (1993) At least 12 genotypes of hepatitis C virus predicted by sequence analysis of the putative E1 gene of isolates collected worldwide. Proc Natl Acad Sci USA 90:8234
9. Bukh J, Purcell RH, Miller RH (1994) Sequence analysis of the core gene of 14 hepatitis C virus genotypes. Proc Natl Acad Sci USA 91:8239
10. Bukh J, Miller RH, Purcell RH (1995) Genetic heterogeneity of hepatitis C virus.In: Kobayashi K, Purcell RH, Shimotohno K, Tabor E (eds) Hepatitis C virus and its involvement in the development of hepatocellular carcinoma. Princeton Scientific Publishing, Princeton, pp 75-91
11. Bukh J, Miller RH, Purcell RH (1995) Genetic heterogeneity of hepatitis C virus: quasispecies and genotypes. Semin Liver Dis 15:41
12. Bukh J, Apgar CL, Purcell RH (1997) Natural history of GBV-A and GBV-B in primate animal models: discovery of indigenous Flaviviridae-like viruses in several species of New World monkeys. Proceedings of the 1996 International Symposium on Viral Hepatitis and Liver Diseases (in press)
13. Bukh J, Emerson SU, Purcell RH (1997) Genetic heterogeneity of hepatitis C virus and related viruses. Proceedings of the 1996 International Symposium on Viral Hepatitis and Liver Diseases (in press)
14. Cerny A, Chisary FV (1994) Immunological aspects of HCV infection. Intervirology 37:119
15. Chan S-W, McOmish F, Holmes EC, Dow B, Peutherer JF, Follett E, Yap PL, Simmonds P (1992) Analysis of a new hepatitis C virus type and its phylogenetic relationship to existing variants. J Gen Virol 73:1131
16. Choo Q-L, Richman KH, Han JH, Berger K, Lee C, Dong C, Gallegos C, Coit D, Medina-Selby A, Barr PJ, Weiner AJ, Bradley DW, Kuo G, Houghton M (1991) Genetic organization and diversity of the hepatitis C virus. Proc Natl Acad Sci USA 88:2451
17. Choo QL, Kuo G, Ralston R, Weiner AJ, Chien D, Van Nest G, Han J, Berger K, Thudium K, Kuo C, Kansopon J, McFarland J, Tabrizi A, Ching K, Moss B, Cummins LB, Houghton M, Muchmore E (1994) Vaccination of chimpanzees against infection by the hepatitis C virus. Proc Natl Acad Sci USA 91:1294
18. Chu CM, Sheen IS, Liaw YF (1994) The role of hepatitis C virus in fulminant viral hepatitis in an area with endemic hepatitis A and B. Gastroenterology 107:189
19. Di Bisceglie AM, Goodman ZD, Ishask KG, Hoofnagle JH, Melpolder JJ, Alter HJ (1991) Long-term clinical and histopathological follow-up of chronic post-transfusion hepatitis. Hepatology 14:969
20. Di Marzo Veronese F, Reitz MS, Gupta G, Robert-Gouroff M, Boyer-Thompson C, Gallo RC, Lusso P (1993) Loss of a neutralizing epitope by a spontaneous point-mutation in the V3 loop of HIV-1 isolated from an infected laboratory worker. J Biol Chem 268:25894
21. Domingo E, Martinez-Salas E, Sobrino F, Torre JC de la, Portela A, Ortin J, Lopez-Galindez C, Perez-Brena P, Villanueva N, Najera R, VandePol S, Steinhauer D, DePolo N, Holland J (1985) The quasispecies (extremely heterogeneous) nature of viral RNA genome populations: biological relevance - a review. Gene 40:1
22. Eigen M, Biebricher CK (1988) Sequence space and quasispecies distribution. In: Domingo E, Holland JJ, Ahlquist P (eds) RNA genetics. CRC Press, Boca Raton, pp 211-245
23. Enomoto N, Sakuma I, Asahina Y, Kurosaki M, Murakami T, Yamamoto C, Izumi N, Marumo F, Sato C (1995) Comparison of full-length sequences of interferon-sensitive and resistant hepatitis C virus 1b. J Clin Invest 96:224
24. Enomoto N, Sakuma I, Asahina Y, Kurosaki M, Murakami T, Yamamoto C, Ogura Y, Izumi N, Marumo F, Sato C (1996) Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infection. N Engl J Med 334:77
25. Esteban JL, Lopez-Talavera JC, Genesca J, Madoz P, Viladomiu L, Muniz E, Martin-Vega C, Rosell M, Allende H, Vidal X, Gonzalez A, Hernandez JM, Esteban R, Guardia J (1991) High rate of infectivity and liver disease in blood donors with antibodies to hepatitis C virus. Ann Intern Med 115:443
26. Evans DM, Dunn G, Minor PD, Schild GC, Cann AJ, Stanway G, Almond JW, Currey K, Maizel JV Jr (1985) Increased neurovirulence associated with a single nucleotide change in a noncoding region of the Sabin type 3 poliovaccine genome. Nature 314:548
27. Farci P, Purcell RH (1997) Natural history and experimental models. In: Zuckerman AJ, Thomas HC (eds) Viral hepatitis: scientific basis and clinical management. Churchill Livingstone, Edinburgh, (in press)
28. Farci P, Alter HJ, Wong D, Miller RH, Shih JW, Jett B, Purcell, RH (1991) Longterm study of hepatitis C virus replication in non-A, non-B hepatitis. N Engl J Med 325:98
29. Farci P, Alter HJ, Govindarajan S, Wong DC, Engle R, Lesniewski RR, Mushahwar IK, Desai SM, Miller RH, Ogata N, Purcell RH (1992) Lack of protective immunity against reinfection with hepatitis C virus. Science 258:135
30. Farci P, Alter HJ, Wong DC, Miller RH, Govindarajan S, Engle R, Shapiro M, Purcell RH (1994) Prevention of hepatitis C virus infection in chimpanzees after antibody-mediated in vitro neutralization. Proc Natl Acad Sci USA 91: 7792
31. Farci P, Munoz S, Alter HJ, Shimoda A, Govindarajan S, Chung L, Shih J, Purcell RH (1994) Hepatitis C virus (HCV) associated fulminant hepatitis and its transmission to a chimpanzee. Hepatology 20:264A.
32. Farci P, Alter HJ, Shimoda A, Govindarajan S, Cheung LC, Melpolder JC, Sacher RA, Shih JW, Purcell RH (1996) Hepatitis C virus-associated fulminant hepatic failure. N Engl J Med 335:631
33. Farci P, Melpolder JC, Shimoda A, Peddis G, Strazzera A, Munoz S, Purcell RH, Alter HJ (1996) Studies of HCV quasispecies in patients with acute resolving hepatitis compared to those who progress to chronic hepatitis. Hepatology 24:350A.
34. Farci P, Shimoda A, Wong D, Cabezon T, De Gioannis D, Strazzera A, Shimizu Y, Shapiro M, Alter HJ, Purcell RH (1996) Prevention of hepatitis C virus infection in chimpanzees by hyperimmune serum against the hypervariable region 1 of the envelope 2 protein. Proc Natl Acad Sci USA 93:15394
35. Feinstone SM, Alter HJ, Dienes H, Shimizu YK, Popper H, Blackmore D, Sly D, London WT, Purcell RH (1981) Non-A, non-B hepatitis in chimpanzees and marmosets. J Infect Dis 144:588
36. Feray C, Gigou M, Samuel D, Reyes G, Bernuau J, Reynes M, Bismuth H, Brechot C (1993) Hepatitis C virus RNA and hepatitis B virus DNA in serum and liver of patients with fulminant non-A, non-B hepatitis. Gastroenterology 104:549
37. Feray C, Gigou M, Samuel D, Paradis V, Mishiro S, Maertens G, Reynes M, Okamoto H, Bismuth H, Brechot C (1995) Influence of the genotypes of hepatitis C virus on the severity of recurrent liver disease after liver transplantation. Gastroenterology 108:1088
38. Fried MW, Hoofnagle JH (1995) Therapy of hepatitis C. Semin Liver Dis 15:82
39. Fujii K, Hino K, Okazaki M, Okuda M, Kondoh S, Okita K (1996) Differences in hypervariable region 1 quasispecies of hepatitis C virus between human serum and peripheral blood mononuclear cells. Biochem Biophys Res Commun 225:771
40. Gane EJ, Naoumov NV, Quian K-P, Mondelli MU, Maertens G, Portmann BC, Lau JYN, Williams R (1996) A longitudinal analysis of hepatitis C virus replication following liver transplantation. Gastroenterology 110:167
41. Gane EJ, Portmann BC, Naoumov NV, Smith HM, Underhill JA, Donaldson PT, Maertens G, Williams R (1996) Long-term outcome of hepatitis C infection after liver transplantation. N Engl J Med 334:815
42. Gonzalez-Peralta RP, Quian K, She JY, Davis GL, Ohno T, Mizokami M, Lau JYN (1996) Clinical implications of viral quasispecies heterogeneity in chronic hepatitis C. J Med Virol 49:242
43. Gretch DR, Polyak SJ, Wilson JJ, Carithers RL, Perkins JD, Corey L (1996) Tracking hepatitis C virus quasispecies major and minor variants in symptomatic and asymptomatic liver transplant recipients. J Virol 70:7622
44. Han JH, Shyamala V, Richman KH, Brauer MJ, Irvine B, Urdea MS, Tekamp-Olson P, Kuo G, Choo Q-L, Houghton M (1991) Characterization of the terminal regions of hepatitis C viral RNA: Identification of conserved sequences in the 5′ untranslated region and poly(A) tails at the 3′ end. Proc Natl Acad Sci USA 88:1711
45. Higashi Y, Kakumu S. Yoshioka K, Wakita T, Mizokami M, Ohba K, Ito T, Ishikawa T, Takayanagi M, Nagai Y (1993) Dynamics of genome change in the E2/NS1 region of hepatitis C virus in vivo. Virology 197:659
46. Hijikata M, Kato N, Ootsuyama Y, Nakagawa M, Ohkoshi S, Shimotohno K (1991) Hypervariable regions in the putative glycoprotein of hepatitis C virus. Biochem Biophys Res Commun 175:220
47. Hijikata M, Mizuno K, Rikihisa T, Shimizu YK, Iwamoto A, Nakajima N, Yoshikura K (1995) Selective transmission of hepatitis C virus in vivo and in vitro. Arch Virol 140:1623
48. Holland J, Spindler K, Horodyski F, Grabau E, Nichol S, VandePol S (1982) Rapid evolution of RNA genomes. Science 215:1577
49. Holland J, Domingo E, De La Torre JC, Steinhauer DA (1990) Mutation frequencies at defined single codon sites in vesicular stomatitis virus can be increased only slightly by chemical mutagenesis. J Virol 64:3960
50. Honda M, Kaneko S, Sakai A, Unoura M, Murakami S, Kobayashi K (1994) Degree of diversity of hepatitis C virus quasispecies and progression of liver disease. Hepatology 20:1144
51. Horie C, Iwahana H, Horie T, Shimizu I, Yoshimoto K, Yogita S, Tashiro S, Ito S, Itakura M (1996) Detection of different quasispecies of hepatitis C virus core region in cancerous and noncancerous lesions. Biochem Biophys Res Commun 26:674
52. Houghton M (1996) Hepatitis C virus. In: Fields BN, Knipe DM, Howley PM, Chanok RH (eds) Virology. Lippincott-Raven, Philadelphia pp 1035-1058
53. Houghton M, Weiner A, Han J, Kuo G, Choo Q-L (1991) Molecular biology of the hepatitis C viruses: implications for diagnosis, development and control of viral disease. Hepatology 14:381
54. Houghton M, Choo Q-L, Kuo G, Weiner A, Chien D, Ralston R, Urdea M, Moss B, Purcell R, Cummins L, Muchmore E (1995) Prospects for prophylactic and therapeutic hepatitis C virus vaccines. In: Kobayashi K, Purcell RH, Shimotohno K, Tabor E (eds) Hepatitis C virus and its involvement in the development of hepatocellular carcinoma. Princeton Scientific Publishing, Princeton, pp 237
55. Jameson BA, Bonin J, Wimmer E, Kew OM (1985) Natural variants of the Sabin type 1 vaccine strain of poliovirus and correlation with a poliovirus neutralization site. Virology 143:337
56. Jarvis LM, Ludlam CA, Ellender JA, Nemes L, Field SP, Song E, Chuansumrit A, Preston FE, Simmonds P (1996) Investigation of the relative infectivity and pathogenicity of different hepatitis C virus genotypes in hemophiliacs. Blood 87:3007
57. Kanazawa Y, Hayashi N, Mita E, Li T, Hagiwara H, Kasahara A, Fusamoto H, Kamada T (1994) Influence of viral quasispecies on effectiveness of interferon therapy in chronic hepatitis C patients. Hepatology 20:1121
58. Kao JH, Chen PJ, Lai MY, Chen DS (1992) Superinfection of heterologous hepatitis C virus in a patient with chronic type C hepatitis. Gastroenterology 105: 583
59. Kao JH, Chen PJ, Lai MY, Wang TH, Chen DS (1995) Quasispecies of hepatitis C virus and genetic drift of the hypervariable region in chronic type C hepatitis. J Infect Dis 172:261
60. Kato N, Hijikata M, Ootsuyama Y, Nakagawa M, Ohkoshi S, Sugimura T, Shimotohno K (1990) Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis. Proc Natl Acad Sci USA 87:9524
61. Kato N, Ootsuyama Y, Tanaka T, Nakagawa M, Nakazawa T, Muraiso K, Ohkoshi S, Hijikata M, Shimotohno K (1992) Marked sequence diversity in the putative envelope proteins of hepatitis C viruses. Virus Res 22:107
62. Kato N, Sekiya H, Ootsuyama Y, Nakazawa T, Hijikata M, Ohkoshi S, Shimotohno K (1993) Humoral immune response to hypervariable region 1 of the putative envelope glycoprotein (gp70) of hepatitis C virus. J Virol 67:3923
63. Kato N, Ootsuyama Y, Sekiya H, Ohkoshi S, Nakazawa T, Hijikata M, Shimotohno K (1994) Genetic drift in hypervariable region 1 of the viral genome in persistent hepatitis C virus infection. J Virol 68:4776
64. Kiyosawa K, Sodeyama T, Tanaka E, Gibo Y, Yoshizawa K, Nakano Y, Furuta S, Akahane Y, Nishioka K, Purcell RH (1990) Interrelationship of blood transfusion, non-A, non-B hepatitis and hepatocellular carcinoma: analysis by detection of antibody to hepatitis C virus. Hepatology 12:671
65. Koizumi K, Enomoto N, Kurosaki M, Murakami T, Izumi N, Marumo F, Sato C (1995) Diversity of quasispecies in various disease stages of chronic hepatitis C virus infection and its significance in interferon treatment. Hepatology 22:30
66. Kolykhalov AA, Feinstone SM, Rice CM (1996) Identification of a highly conserved sequence element at the 3′ terminus of hepatitis C virus genome RNA. J Virol 70:3363
67. Krawczynski K, Alter MJ, Tankersley DL, Tankersley DL, Beach M, Robertson BH, Lambert S, Kuo G, Speibring JE, Meeks E, Sinha S, Carson DA (1996) Effect of immune globulin on the prevention of experimental hepatitis C virus infection. J Infect Dis 173:822
68. Kumar U, Brown J, Monjardino J, Thomas HC (1993) Sequence variation in the large envelope glycoprotein (E2/NS1) of hepatitis C virus during chronic infection. J Infect Dis 167:726
69. Kumar U, Monjardino J, Thomas HC (1994) Hypervariable region of hepatitis C virus envelope glycoprotein (E2/NS1) in an agammaglobulinemic patient. Gastroenterology 106:1072
70. Kurosaki M, Enomoto N, Marumo F, Sato C (1993) Rapid sequence variation of the hypervariable region of hepatitis C virus during the course of chronic infection. Hepatology 18:1293
71. Kuwada SK, Patel VM, Hollinger FB, Lin HJ, Yarbough PO, Wiesner RH, Kaese D, Rakela J (1994) Non-A, non-B fulminant hepatitis is also non-E and non-C. Am J Gastroenterol 89:57
72. Lai ME, Mazzoleni AP, Argiolu F, De Virgilis S, Balestrieri A, Purcell RH, Farci P (1994) Hepatitis C virus in multiple episodes of acute hepatitis in polytransfused thalassemic children. Lancet 343:388
73. Larder BA, Kemp SD (1989) Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT). Science 246:1155
74. Laskus T, Wanf LF, Rakela J, Vargas H, Pinna AD, Tsamandas AC, Demetris AJ, Fung J (1996) Dynamic behavior of hepatitis C virus in chronically infected patients receiving liver graft from infected donors. Virology 220:171
75. Lau JYN, Davis GL, Prescott LE, Maertens G, Lindsay KL, Quian KP, Mizokami M, Simmonds P (1996) Distribution of hepatitis C virus genotypes determined by line probe assay in patients with chronic hepatitis C seen at tertiary referral centers in the United States. Ann Intern Med 124:868
76. Leary TP, Desai SM, Yamaguchi J, Chalmers ML, Schlauder GG, Dawson GJ, Mushahwar IK (1996) Species-specific variants of GB virus A in captive monkeys. J Virol 70:9028
77. Leary TP, Muerhoff AS, Simons JN, Pilot-Matias TJ, Erker JC, Chalmers ML, Schlauder GG, Dawson GJ, Desai SM, Mushahwar IK (1996) Sequence and genomic organization of GBV-C: a novel member of the Flaviviridae associated with human non-A-E hepatitis. J Med Virol 48:60
78. Lesniewski RR, Boardway KM, Casey JM, Desai SM, Devare SG, Leung TK, Mushahwar IK (1993) Hypervariable 5′-terminus of hepatitis C virus E2/NS1 encodes antigenically distinct variants. J Med Virol 40:150
79. Liang TJ, Jeffers L, Reddy RK, Silva MO, Cheinquer H, Findor A, De Medina M, Yarbough PO, Reyes GR, Schiff ER (1993) Fulminant or subfulminant non-A, non-B hepatitis: the role of hepatitis C and E viruses. Gastroenterology 104:556
80. Linnen J, Wages J, Zhang-Keck Z-Y, Fry KE, Krawczynski KZ, Alter HJ, Koonin E, Gallagher M, Alter M, Hadziyannis S, Karayannis P, Fung K, Nakatsuji Y, Shin JW, Young L, Piatak M Jr, Hoover C, Fernandez J, Chen S, Zou JC, Morris T, Hyams KC, Ismay S, Lifson JD, Hess G, Foung SKH, Thomas H, Bradley D, Margolis H, Kim JP (1996) Molecular cloning and disease association of hepatitis G virus: a transfusion-transmissible agent. Science 271:505
81. Martell M, Esteban JL, Quer J, Genesca J, Weiner A, Esteban R, Guardia J, Gomez J (1992) Hepatitis C virus (HCV) circulates as a population of different but closely related genomes: quasispecies nature of HCV genome distribution. J Virol 66:3225
82. Martell M, Esteban JI, Quer J, Vargas V, Esteban R, Guardia J, Gomez J (1994) Dynamic behavior of hepatitis C virus quasispecies in patients undergoing orthotopic liver transplantation. J Virol 68:3425
83. Mellor J, Holmes EC, Jarvis LM, Yap PL, Simmonds P, the International HCV Collaborative Study Group (1995) Investigation of the pattern of hepatitis C virus sequence diversity in different geographical regions: implications for virus classification. J Gen Virol 76:2493
84. Miller RH, Purcell RH (1990) Hepatitis C virus shares amino acid sequence similarity with pestiviruses and flaviviruses as well as members of two plant virus supergroups. Proc Natl Acad Sci USA 87:2057
85. Miyakawa Y, Okamoto H, Mayumi M (1995) Classifying hepatitis C virus genotypes. Mol Med Today 1:20
86. Mizokami M, Lau JYN, Suzuki K, Nakano T, Gojobori T (1994) Differential sensitivity of hepatitis C virus quasispecies to interferon-a therapy. J Hepatol 21:884
87. Moribe T, Hayashi N, Kanazawa Y, Mita E, Fusamoto H, Negi M, Kaneshige T, Igimi H, Kamada T (1995) Hepatitis C viral complexity detected by single-strand conformation polymorphism and response to interferon therapy. Gastroenterology 108:789
88. Muerhoff AS, Leary TP, Simons JN, Pilot-Matias TJ, Dawson GJ, Erker JC, Chalmers ML, Schlauder GG, Desai SM, Mushahwar IK (1995) Genomic organization of GB viruses A and B: Two new members of the Flaviviridae associated with GB agent hepatitis. J Virol 69:5621
89. Murakawa K, Esumi M, Kato T, Kambara H, Shikata T (1992) Heterogeneity within the nonstructural protein 5-encoding region of hepatitis C viruses from a single patient. Gene 117:229
90. Muto Y, Sugihara J, Ohnishi H, Moriwaki H, Nishioka K (1990) Anti-hepatitis C virus antibody prevails in fulminant hepatic failure. Gastroenterol Jpn 25:32
91. Naito M, Hayashi N, Moribe T, Hagiwara H, Mita E, Kanazawa Y, Kasahara A, Fusamoto H, Kamada T (1995) Hepatitis C viral quasispecies in hepatitis C virus carriers with normal liver enzymes and patients with type C chronic liver disease. Hepatology 22:407
92. Nousbaum J-B, Pol S, Nalpas B, Landais P, Berthelot P, Brechot C, the collaborative study group (1995) Hepatitis C virus 1b (II) in France and Italy. Ann Intern Med 122:161
93. Ogata N, Alter HJ, Miller RH, Purcell RH (1991) Nucleotide sequence and mutation rate of the H strain of hepatitis C virus. Proc Natl Acad Sci USA 88:3392
94. Okamoto H, Mishiro S (1994) Genetic heterogeneity of hepatitis C virus. Intervirology 43:68
95. Okamoto H, Kojima M, Okada S-I, Yoshizawa H, Iizuka H, Tanaka T, Muchmore EE, Peterson DA, Ito Y, Mishiro S (1992) Genetic drift of hepatitis C virus during an 8.2-year infection in a chimpanzee: variability and stability. Virology 190:894
96. Okamoto H, Kurai K, Okada S-I, Yamamoto K, Iizuka H, Tanaka T, Fukuda S, Tsuda F, Mishiro S (1992) Full-length sequence of a hepatitis C virus genome having poor homology to reported isolates: comparative study of four distinct genotypes. Virology 188:331
97. Okamoto H, Mishiro S, Tokita H, Tsuda F, Miyarawa Y, Mayumi M (1994) Superinfection of chimpanzees carrying hepatitis C virus of genotype II/1b with that of genotype III/2a or I/1a. Hepatology 1994; 20:1131
98. Pawlotsky J-M, Tsakiris L, Roudot-Thoraval F, Pellet C, Stuyver L, Duval J, Dhumeaux D (1995) Relationship between hepatitis C virus genotypes and sources of infection in patients with chronic hepatitis C. J Infect Dis 171:1607
99. Pol S, Thiers V, Nousbaum J-B, Legendre C, Berthelot P, Kreis H, Brechot C (1995) The changing relative prevalence of hepatitis C virus genotypes: evidence in hemodialyzed patients and kidney recipients. Gastroenterology 108:581
100. Prince AM, Brotman B, Huima T, Pascual D, Jaffery M, Inchauspe G (1992) Immunity in hepatitis C infection. J Infect Dis 165:438
101. Purcell RH (1995) Hepatitis C and its sequelae: the biology of hepatitis C virus and implications for its control. In. Kobayashi K, Purcell RH, Shimotohno K, Tabor E (eds) Hepatitis C virus and its involvement in the development of hepatocellular carcinoma. Princeton Scientific Publishing, Princeton, pp 1-13
102. Remington KM, Chesebro B, Wehrly K, Pedersen NC, North TW (1991) Mutants of feline immunodeficiency virus resistant to 3′-azido-3′deoxythimidine. J Virol 65:318
103. Rice CM (1996) Flaviviridae: the viruses and their replication In: Fields BN, Knipe DM, Howley PM, Chanok RH (eds) Virology. Lippincott-Raven, Philadelphia pp 931-959
104. Rogers GN, Paulson JC, Daniels RS, Skehel JJ, Wilson IA, Wiley DC (1983) Single amino acid substitutions in influenza haemagglutinin change receptor binding specificity Nature 364:76
105. Rosa D, Campagnoli S, Moretto C, Guenzi E, Cousens L, Chin M, Dong C, Weiner AJ, Lau JYN, Choo Q-L, Chien D, Pileri P, Houghton M, Abrignani S (1996) A quantitative test to estimate neutralizing antibodies to hepatitis C virus: cytofluorometric assessment of envelope glycoprotein E2 binding to target cells. Proc Natl Acad Sci USA 93:1759
106. Rusche JR, Javaherian K, McDanal C, Petro J, Lynn DL, Grimaila R, Langlois A, Gallo RC, Arthur LO, Fischinger PG (1988) Antibodies that inhibit fusion of human immunodeficiency virus-infected cells bind a 24-amino acid sequence of the viral envelope, gp120. Proc Natl Acad Sci USA 85:3198
107. Sakamoto N, Enomoto N, Kurosaki M, Marumo F, Sato C (1994) Sequential change of the hypervariable region of the hepatitis C virus genome in acute infection. J Med Virol 42:103
108. Sallie R, Silva AE, Purdy M, Smith H, McCaustland K, Tibbs C, Portmann B, Eddleston A, Bradley D, Williams R (1994) Hepatitis C and E in non-A, non-B fulminant hepatic failure: a polymerase chain reaction and serological study. J Hepatol 20:580
109. Scarselli E, Cerino A, Esposito G, Silini E, Mondelli MU, Traboni C (1995) Occurrence of antibodies reactive with more than one variant of the putative envelope glycoprotein (E2;gp70) hypervariable region 1 in hepatitis C viremic patients. J Virol 69:4407
110. Seeff LB (1995) Natural history of viral hepatitis, type C. Semin Gastrointest Dis 6:20
111. Seeff LB, Buskell-Bales Z, Wright EC, Durako SJ, Alter HJ, Iber FL, Hollinger FB, Gitnick G, Knodell RG, Perillo RP, Stevens CE, Hollingsworth CG (1992) Long-term mortality after transfusion-associated non-A, non-B hepatitis. N Engl J Med 327: 1906
112. Shimizu YK, Hijikata M, Iwamoto A, Alter HJ, Purcell RH, Yoshikura H (1994) Neutralizing antibodies against hepatitis C virus and the emergence of neutralization escape mutants. J Virol 68:1494
113. Shimizu YK, Igarashi H, Kiyohara T, Cabezon T, Farci P, Purcell RH, Yoshikura H. (1996) A hyperimmune serum against a synthetic peptide corresponding to the hypervariable region 1 of hepatitis C virus can prevent viral infection in cell cultures. Virology 223:409
114. Silini E, Bottelli R, Asti M, Bruno S, Candusso ME, Brambilla S, Bono F, Iamoni G, Tinelli C, Mondelli MU, Ideo G (1996) Hepatitis C virus genotypes and risk of hepatocellular carcinoma in cirrhosis: A case control study. Gastroenterology 111:199
115. Simmonds P (1995) Variability of hepatitis C virus. Hepatology 21:570
116. Simmonds P, Holmes EC, Cha T-A, Chan S-W, McOmish F, Irvine B, Beall E, Yap P-L, Kolberg J, Urdea MS (1993) Classification of hepatitis C virus into six major genotypes and a series of subtypes by phylogenetic analysis of the NS-5 region. J Gen Virol 74:2391
117. Simmonds P, Mellor J, Craxi A, Sanchez-Tapias J-M, Alberti A, Prieto J, Colombo M, Rumi MG, Lo Iacano O, Ampurdanes-Mingall S, Forns-Bernhardt X, Chemello L, Civeira MP, Frost C, Dusheiko G (1996) Epidemiological, clinical and therapeutic associations of hepatitis C types in western European patients. J Hepatol 24:517
118. Simons JN, Leary TP, Dawson GJ, Pilot-Matias TJ, Muerhoff AS, Schlauder GG, Desai SM, Mushahwar IK (1995) Isolation of novel virus-like sequences associated with human hepatitis. Nature Med 1:564
119. Simons JN, Pilot-Matias TJ, Leary TP, Dawson GJ, Desai SM, Schlauder GG, Muerhoff AS, Erker JC, Buijk SL, Chalmers ML, Van Sant C, Mushahwar IK (1995) Identification of two flavivirus-like genomes in the GB hepatitis agent. Proc Natl Acad Sci USA 92:3401
120. Smith DB, Mellor J, Jarvis LM, Davidson F, Kolberg J, Urdea M, Yap P-L, Simmonds P, the International HCV Collaborative Study Group. (1995) Variation of the hepatitis C virus 5′ non-coding region: implications for secondary structure, virus detection and typing. J Gen Virol 76:1749
121. Smith DB, Davidson F, Yap P-L, Brown H, Kolberg JA, Detmer J, Urdea M, Simmonds P, the International HCV Collaborative Study Group (1996) Levels of hepatitis C virus in blood donors infected with different virus genotypes. J Infect Dis 173:727
122. Strader DB, Seeff LB (1996) The natural history of chronic hepatitis C infection. Eur J Gastroenterol Hepatol 8:324
123. Takamizawa A, Mori C, Fuke I, Manabe S, Murakami S, Fujita J, Onishi E, Andoh T, Yoshida I, Okayama H (1991) Structure and organization of the hepatitis C virus genome isolated from human carriers. J Virol 65:1105
124. Tanaka T, Kato N, Nakagawa M, Ootsuyama Y, Cho Mj, Nakazawa T, Hijikata M, Ishimura Y, Shimotohno K (1992) Molecular cloning of hepatitis C virus genome from a single Japanese carrier: sequence variation within the same individual and among infected individuals. Virus Res 23:39
125. Tanaka T, Kato N, Cho M-J, Shimotohno K (1995) A novel sequence found at the 3′ terminus of hepatitis C virus genome. Biochem Biophys Res Commun 215:744
126. Tanaka T, Kato N, Cho M-J, Sugiyama K, Shimotohno K (1996) Structure of the 3′ terminus of the hepatitis C virus genome. J Virol 70:3307
127. Tanaka K, Ikematsu H, Hirohata T, Kashiwagi S (1996) Hepatitis C virus infection and risk of hepatocellular carcinoma among Japanese: possible role of type 1b (II) infection. J Natl Cancer Inst 88: 742
128. Taniguchi S, Okamoto H, Sakamoto M, Kojima M, Tsuda F, Tanaka T, Munekata E, Muchmore EE, Peterson DA, Mishiro S (1993) A structurally flexible and antigenically variable N-terminal domain of the hepatitis C virus (E2/NS1) protein: implication for an escape from antibody. Virology 195:297
129. Theilmann L, Solbach C, Toex V, Muller HM, Pfaff E, Otto G, Goeser T (1992) Role of hepatitis C virus infection in German patients with fulminant and subacute hepatic failure. Eur J Clin Invest 22:569
130. Tokita H, Okamoto H, Tsuda F, Song P, Nakata S, Chosa T, Iizuka H, Mishiro S, Miyakawa Y, Mayumi M (1994) Hepatitis C virus variants from Vietnam are classifiable into the seventh, eighth and ninth major genetic groups. Proc Natl Acad Sci USA 91:11022
131. Tokita H, Okamoto H, Luengrojanakul P, Vareesangthip K, Chainuvati T, Iizuka H, Tsuda F, Miyakama Y, Mayumi M (1995) Hepatitis C virus variants from Thailand classifiable into five novel genotypes in the sixth [6b], seventh (7c, 7d) and ninth (9b, 9c) major genetic groups. J Gen Virol 76:2329
132. Tokita H, Okamoto H, Iizuka H, Kishimoto J, Tsuda F, Lesmana LA, Miyakawa Y, Mayumi M (1996) Hepatitis C virus variants from Jakarta, Indonesia classifiable into novel genotypes in the second (2c and 2f), tenth [10a] and eleventh (11a) genetic groups. J Gen Virol 77:293
133. Tong MJ, el-Farra NS, Reikes AR, Co RL (1995) Clinical outcomes after transfusion-associated hepatitis C. N Engl J Med 332: 1463
134. Toyoda H, Fukuda Y, Koyama Y, Nakano I, Kinoshita M, Hadama T, Takamatsu J, Hayakawa T (1996) Nucleotide sequence diversity of hypervariable region 1 of hepatitis C virus in Japanese hemophiliacs with chronic hepatitis C and patients with chronic post-transfusion hepatitis C Blood 88:1488
135. Van Doorn LJ, Capriles I, Maertens G, DeLeys R, Murray K, Kos T, Schellekens H, Quint W (1995) Sequence evolution of the hypervariable region in the putative envelope region E2/NS1 of hepatitis C virus is correlated with specific humoral immune response. J Virol 69: 773
136. Villamil FG, Hu KQ, Yu CH, Lee CH, Rojter SE, Podesta LG, Makowka L, Geller SA, Vierling JM (1995) Detection of hepatitis C virus with RNA polymerase chain reaction in fulminant hepatic failure. Hepalology 22:1379
137. Weiner AJ, Brauer MJ, Rosemblatt J, Richman KH, Tung J, Crawford K, Bonino F, Saracco G, Choo Q-L, Houghton M (1991) Variable and hypervariable domains are found in the regions of HCV corresponding to the flavivirus envelope and NS1 proteins and the pestivirus envelope glycoproteins. Virology 180:842
138. Weiner AJ, Geysen HM, Christopherson C, Hall JE, Mason TJ, Saracco G, Bonino F, Crawford K, Marion CD, Crawford KA, Brunetto M, Barr PJ, Miyamura T, McHutchinson J, Houghton M (1992) Evidence for immune selection of hepatitis C virus (HCV) putative envelope glycoprotein variants: potential role in chronic HCV infection. Proc Natl Acad Sci USA 89:3468
139. Weiner AJ, Thaler MM, Crawford K, Ching K, Kansopon J, Chien DY, Hall JE, Hu F, Houghton M (1993) A unique, predominant hepatitis C virus variant found in an infant born to a mother with multiple variants. J Virol 67:4365
140. Weiner A, Erickson AL, Kansopon J, Crawford K, Muchmore E, Hughes A, Houghton M, Walker C (1995) Persistent hepatitis C virus infection in a chimpanzee is associated with emergence of a cytotoxic T lymphocyte escape variant. Proc Natl Acad Sci USA 92:2755
141. Wright TL (1992) Liver transplantation for hepatitis C viral infection. In: Lake TR (ed) Advances in Liver Transplantation. Saunders, Philadelphia, pp 231
142. Wright TL (1993) Etiology of fulminant hepatic failure: is another virus involved? Gastroenterology 104:640
143. Wright TL, Hsu H, Donegan E, Feinstone S, Greemberg H, Read A, Ascher NL, Roberts JP, Lake JR (1991) Hepatitis C virus not found in fulminant non-A, non-B hepatitis. Ann Intern Med 115:111
144. Yanagi M, Kaneko S, Unoura M, Murakami S, Kobayashi K, Sugihara J, Ohnishi H, Muto Y (1991) Hepatitis C virus in fulminant hepatic failure (Letter). N Engl J Med 324:1895
145. Yeh BI, Han KH, Oh SH, Kim HS, Hong SH, Oh SH, Kim YS (1996) Nucleotide sequence variation in the hypervariable region of the hepatitis C virus in the sera of chronic hepatitis C patients undergoing controlled interferon-α therapy. J Med Virol 49:95
146. Yotsuyanagi H, Koike K, Yasuda K, Moriya K, Hino K, Kurokawa K, Iino S (1995) Hepatitis C virus genotypes and development of hepatocellular carcinoma. Cancer 76:1352
147. Zibert A, Schreier E, Roggendorf M (1994) Antibodies in human sera specific to hypervariable region 1 of hepatitis C virus can block viral attachment. Virology 208:653