Evolutionary perspectives on amyloid and inflammatory features of Alzheimer disease

Neurobiology of Aging

Volumn 17, Issue 5, 1996, Pages 809-815

  Finch, Caleb E ^a   Marchalonis, John J ^b  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b NONE

Author keywords

Alzheimer's disease; Amyloid inflammatory features; Senile plaques

Indexed keywords

AMYLOID BETA PROTEIN;

AGED; ALZHEIMER DISEASE; COMPLEMENT SYSTEM; EVOLUTION; HUMAN; NERVOUS SYSTEM INFLAMMATION; PRIORITY JOURNAL; REVIEW; SENILE PLAQUE;

EID: 0030250886     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/0197-4580(96)00119-4     Document Type: Article

References (133)

1. 1Antichymotrypsin is associated solely with amyloid deposits containing the β-protein. Amyloid and cell localization of a 1-antichymotrypsin. Neurobiol. Aging. 11:123-129; 1990.
2. 2. Aisen, P. S.; Davis, K. L. Inflammatory mechanisms in Alzheimer's disease: Implications for therapy. Am. J. Psychiatry 151:1105-1113; 1994.
3. 3. Armstrong, P. B. Immunocytes and their immune reactions. In: Gupta, A. P., ed. Cellular and humoral immunity in the horsehoe crab (Limulus polyphemus). Immunology of Insects and other Arthropods. Boca Raton: CRC Press; 1991:3-17.
4. 4. Armstrong, P. B.; Misquith, S.; Srimal, S.; Melchior, R.; Quigley, J. P. Identification of limulin as a major cytoylic protein in the plasma of the American horseshoe crab, Limulus polyphemus. Biol. Bull. 187:227-228; 1994.
5. 5. Barondes, S. H. Soluble lectins: A new class of extracellular proteins. Science 223:1259-1264; 1984.
6. 6. Bartl, S.; Baltimore, D.; Weissman, I. L. Molecular evolution of the vertebrate immune-system. Proc. Natl. Acad. Sci. USA 91:10769-10770; 1994.
7. 7. Baumann, H.; Gauldie, J. The acute phase response. Immunol. Today 15:74-80; 1994.
8. 8. Beck, G.; Habicht, G. S. Isolation and characterization of a primitive interleukin-1-like protein from an invertebrate, Asterias forbesi. Proc. Natl. Acad. Sci. USA 83:7429-7433; 1986.
9. 9. Beck, G.; Vasta, G. R.; Marchalonis, J. J.; Habicht, G. S. Characterization of interleukin-1 activity in tunicates. Comp. Biochem. Physiol. 92:93-98; 1989.
10. 10. Bernstein, R. M.; Schluter, S. F.; Lake, D. F.; Marchalonis, J. J. Evolutionary conservation and molecular cloning of the recombinase activating gene-1. Biochem. Biophys. Res. Commun. 205:687-692; 1994.
11. 11. Bilej, M.; Sima, P.; Slipka, J. Repeated antigenic challenge induces earthworm coelomocyte proliferation. Immunol. Lett. 32:181-184; 1992.
12. 12. Birnbaum, G.; Van Ness, B. Quantitation of T-cell receptor v-beta chain expression on lymphocytes from blood, brain, and spinal-fluid in patients with multiple-sclerosis and other neurological diseases. Ann. Neurol. 32:24-30; 1992.
13. 13. Bons, N.; Mastre, N.; Petter. A. Senile plaques and neurofibrillary changes in the brain of an aged lemurian primate, Microcebus murinus. Neurobiol. Aging. 13:99-105; 1991.
14. 14. Borczuk, A.; Mannion, C.; Dickson, D.; Alt, E. Intestinal pseudo-obstruction and ischemia secondary to both β2-microglobulin and serum A amyloid deposition. Modern Pathol. 8:577-582; 1995.
15. 15. Bowman, B. H. Hepatic plasma proteins. Mechanisms of function and regulation. San Diego: Academic Press; 1993.
16. 16. Bradbury, M. The concept of a blood-brain barrier. Chichester, UK: Wiley; 1979.
17. 17. Brooks, A. J.; St. Clair, D. Synuclein proteins and Alzheimer's disease. Trends Neurosci. 17:404-405; 1992.
18. 18. Brugg, B.; Dubreuil, Y. L.; Huber, G.; Wollman, E. E. Inflammatory processes induce beta-amyloid precursor protein changes in mouse brain. Proc. Natl. Acad. Sci. USA 92:3032-3035; 1995.
19. 19. Buxbaum, J. D.; Oishi, M.; Chen, H. I.; Pinkas-Kramarski, R. Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer beta/A4 amyloid protein precursor. Proc. Natl. Acad. Sci. USA 89:10075-10078; 1992.
20. 20. Chadwick, J. S.; Aston, W. P. Antibacterial immunity in Lepidoptera. In: Gupta, A. P., ed. Immunology in insects and other arthropods. Boca Raton: CRC Press; 1991:348-370.
21. 21. Cherayil, B. J.; Weiner, S. J.; Pillai, S. The Mac-2 antigen is a galactose-specific lectin that binds IgE. J. Exp. Med. 170:1959-1972; 1989.
22. 22. Coombe, D. R.; Schluter, S. F.; Ey, P. L.; Jenkin, C. R. Identification of the HA-2 agglutinin in the haemolymph of the ascidian Botrylloides leachii as the factor promoting adhesion of sheep erythrocytes to mouse macrophages. Dev. Comp. Immunol. 6:65-73; 1982.
23. 23. Cooper, E. L.; Rinkevich, B.; Uhlenbruck, G.; Valembois, P. Invertebrate immunity: Another viewpoint. Scand. J. Immunol. 35:247-266; 1992.
24. 24. Cooper, N. R. The classical complement pathway: Activation and regulation of the first complement component. Adv. Immunol. 37: 151-216; 1985.
25. 25. Cork, L. C.; Masters, C.; Beyreuther, K.; Price, D. Development of senile plaques: Relationships of neuronal abnormalities and amyloid deposits. Am. J. Pathol. 137:1383-1392; 1990.
26. 26. Cserr, H. F.; Bundgaard, M. Blood-brain interfaces in vertebrates: A comparative approach. Am. J. Physiol. 246:R277-R288; 1984.
27. 26a. Cummings, B. J.; Head, E.; Afagh, A. J.; Milgram, N. W.; Cotman, C. W. β-Amyloid accumulation correlates with cognitive dysfunction in the aged canine. Neurobiol. Learn. Mem. 65: (in press).
28. 26b. Daigle, I.; Li, C. apl-1 a caenorhabditis elegans gene encoding a protein related to the β-amyloid protein precursor. Proc. Natl. Acad. Sci. 90:12045-12049; 1993.
29. 27. Das, S.; Potter, H. Expression of the Alzheimer amyloid-promoting factor antichymotrypsin is induced in human astrocytes by IL-1. Neuron 14:447-456; 1995.
30. 28. Davidson, E. H. Spatial mechanisms of gene regulation in metazoan embryos. Development 113:1-26; 1991.
31. 29. Day, J. R.; Laping, N. J.; McNeill, T. H.; Schreiber, S. S.; Pasinetti, G. M.; Finch, C. E. Castration enhances expression of glial fibrillary acidic protein sulfated glycoprotein-2 in the intact and lesion-altered hippocampus of the adult male rat. Mol. Endocrinol. 4:1995-2002; 1990.
32. 30. Debets, R.; Salvekoul, H. F. Cytokine antagonists and their potential therapeutic use. Immunol. Today 15:455-458; 1994.
33. 31. Dickson, D. W.; Lee, S. C.; Mattiace, L. A.; Yen, S. H. C.; Brosnan, C. Microglia and cytokines in neurological disease with special reference to AIDS and Alzheimer's disease. Glia 7:75-83; 1993.
34. 32. Dodds, A. W.; Petry, F. The phytogeny and evolution of the first component of complement, C1. Behave. Instit. Mitt. 93:87-102; 1993.
35. 33. Drickamer, K.; Dordal, M. S.; Reynolds, L. Mannose-binding proteins isolated from rat liver contain carbohydrate-recognition domains linked to collagenous tails. Complete primary structures and homology with pulmonary surfactant apoprotein. J. Biol. Chem. 261: 6878-6887; 1986.
36. 34. Dunn, P. E.; Bohnert, T. J.; Russell, V. Regulation of antibacterial protein synthesis following infection and during metamorphosis of Manduca sexta. Ann. NY Acad. Sci. 712:137-130; 1994.
37. 35. Eikelenboom, P.; Zhan, S.-S.; Kamphorst, W.; van der Valk, P.; Rozemuller, J. M. Cellular and substrate adhesion molecules (integrins) and their ligands in cerebral amyloid plaques in Alzheimer's disease. Virchows Arch. 424:421-427; 1994.
38. 36. Eikelenboom, P.; Zhan, S.-S.; van Gool, W. A.; Allsop, D. Inflammatory mechanisms in Alzheimer's disease. Trends Pharmacol. Sci. 15:447-450; 1994.
39. 37. Fabry, Z.; Raine, C. S.; Hart, M. N. Nervous tissue as an immune compartment: The dialect of the immune response in the CNS. Immunol. Today 15:218-224; 1994.
40. 38. Fernandez-Moran, J.; Marchalonis, J. J.; Edelman, G. M. Electron microscopy of a hemagglutinin from Limulus polyphemus. J. Mol. Biol. 32:467-469; 1968.
41. 39. Finch, C. E.; May, P. Recent findings on clusterin in neural tissues: Neuroanatomy, cell sources, development and aging, Alzheimer disease and other brain lesions. In: Harmony, J., ed. Clusterin: Function in vertebrate organ development and adaptation. Austin, TX: R. G. Landis Co; 1996.
42. 40. Flanders, K. C.; Lippa, C. F.; Smith, T. W.; Pollen, D. A.; Sporn, M. B. Altered expression of TGF-β in Alzheimer's disease. Neurology 45:1561-1569; 1995.
43. 41. Floege, J.; Schaffer, J.; Koch, K.M.; Shaldon, S. Dialysis related amyloidosis: A disease of chronic retention and inflammation. Kidney Int. 42:S78-S85; 1992.
44. 42. Goldgaber, D.; Harris, H. W.; Hla, T.; Maciag, T.; Donnelly, R. J.; Jacobsen, J. S.; Vitek, M. P.; Gajdusek, D. C. Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells. Proc. Natl. Acad. Sci. USA 86:7606-7612; 1989.
45. 43. Gordon, M. N.; Holcomb, L. A.; Schreier, W. A.; Morgan, D. G. MHC class II antigen expression by microglial after deafferentation in aged rats. Soc. Neurosci. Abstr. 20:1033; 1994.
46. 44. Griffin, W. S. T.; Stanley, L. C.; Ling, C.; White, L.; MacLeod, V.; Perrot, L. J.; White, C. L., III; Araoz, C. Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease. Proc. Natl. Acad. Sci. USA 86:7611-7615; 1989.
47. 45. Griffin, W. S.; Sheng, J. G.; Roberts, G. W.; Mrak, R. E. Interleukin-1 expression in different plaque types in Alzheimer's disease: Significance in plaque evolution. J. Neuropathol. Exp. Neurol. 54: 276-281; 1995.
48. 46. Hirabayashi, J.; Satoh, M.; Kasai, K. Evidence that Caenorhabditis elegans 32-kDA beta-galactoside-binding protein is homologous to vertebrate beta-galactoside-binding lectins. cDNA cloning and deduced amino acid sequence. J. Biol. Chem. 267:15485-15490; 1992.
49. 47. Hopkins, S. J.; Rothwell, N. J. Cytokines and the nervous system. I: Expression and recognition. Trends Neurosci. 18:83-88; 1995.
50. 48. Hyman, B. T.; Marzloff, K.; Arriagada, P. V. The lack of accumulation of senile plaques or amyloid burden in Alzheimer's disease suggests a dynamic balance between amyloid deposition and resolution. J. Neuropathol. Exp. Neurol. 52:594-600; 1993.
51. 49. Itagaki, S.; McGeer, P. L.; Akiyama, H.; Zhu, S.; Selkoe, D. Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease. J. Neuroimmunol. 24:173-182; 1989.
52. 50. Iwamoto, N.; Nishiyama, E.; Ohwada, J.; Arai, H. Demonstration of CRB immunoreactivity in brains of Alzheimer's disease: Immunohistochemical study using formic acid pretreatment of tissue sections. Neurosci. Lett. 177:23-26; 1994.
53. 51. Iwanaga, S. The Limulus clotting reaction. Cur. Opin. Immunol. 5:74-82; 1993.
54. 52. Iwanaga, S.; Muta, T.; Shigenaga, T.; Miura, Y.; Seki, N.; Saito, T.; Kawabata, S.-I. Role of hemocyte-derived granular components in invertebrate defense. Ann. NY Acad. Sci. 712:102-116; 1994.
55. 53. Iwatsubo, T.; Odaka, A.; Suzuki, N.; Mizusawa, H.; Nukina, N.; Ihara, Y. Visualization of Aβ 42(43) and Aβ 40 in senile plaques with end-specific A monoclonals: Evidence that an initially deposited species is Aβ 42(43). Neuron 13:45-53; 1994.
56. 54. Janeway, C. A. Natural killer cells: A primitive immune system. Nature 341:108; 1989.
57. 55. Jiang, H. X.; Burdick, D.; Glabe, C. G.; Cotman, C. W.; Tenner, A. J. Beta-amyloid activates complement by binding to a specific region of the collagen-like domain of the C1q A-chain. J. Immunol. 152:5050-5059; 1994.
58. 56. Johnson, S. A; McNeill, T; Cordell, B.; Finch, C. E. Neuronal APP-751/APP-695 mRNA ratio correlates with neuritic plaque density in Alzheimer's disease. Science 248:854-857; 1990.
59. 57. Johnson, S.A.; Lampert-Etchells, M.; Rozovsky, I.; Pasinetti, G.; Finch, C. E. Complement mRNA in the mammalian brain: Responses to Alzheimer's disease and experimental lesions. Neurobiol. Aging. 13:641-648; 1992.
60. 58. Johnson, S. A.; Young-Chan, C. S.; Laping, N. J.; Finch, C. E. Perforant path transaction induces complement C9 deposition in hippocampus. Exp. Neurol. 138:198-205; 1996.
61. 59. Kilpatarick, J. M.; Volanakis. J. E. Molecular genetics, structure, and function of C-reactive protein. Immunol. Res. 10:43-53; 1991.
62. 60. Kisilevsky, R. Inflammation-associated amyloidogenesis: Lessons for Alzheimer's amyloidogenesis. Mol. Neurobiol. 8:65-66; 1994.
63. 61. Klein, J. Are invertebrates capable of anticipatory immune responses? Scand. J. Immunol. 29:499-505; 1989.
64. 62. Liang, J.-S.; Sipe, J. D. Recombinant human serum amyloid A (apoSAAp) binds cholesterol and modulates cholesterol flux. J. Lipid Res. 36:37-46; 1995.
65. 63. Lippa, C. F.; Smith, T. W.; Flanders, K. C. Transforming growth factor-β: Neuronal and glial expression in CNS degenerative diseases. Neurodegeneration 4:425-432; 1995.
66. 64. Luo, L.; Martin-Morris, L. E.; White, K. Identification, secretion, and neural expression of APPL, a Drosophila protein simular to human amyloid protein precursor. J. Neurosci. 10:3849-3861; 1990.
67. 65. Mackenzie, I. R. A.; Hao, C.; Munoz, D. G. Role of microglia in senile plaque formation. Neurobiol. Aging. 16:797-804; 1995.
68. 66. Marchalonis, J. J. Immunity in evolution. Cambridge: Harvard University Press; 1977.
69. 67. Masliah. E.; Iwai, A.; Mallory, M.; Ueda, K.; Saitoh, T. Altered presynaptic protein NACP is associated with plaque formation and neurodegeneration in Alzheimer's disease. Am. J. Pathol. 148:201-210; 1996.
70. 68. May, P. C.; Finch, C. E. Sulfated glycoprotein-2: New relationships of this multifunctional protein to neurodegeneration. Trends Neurosci. 15:391-396; 1992.
71. 69. McGeer, P. L.; McGeer, E. G. Complement proteins and complement inhibitors in Alzheimer's disease. Res. Immunol. 143:621-623; 1992.
72. 70. Mesulam, M.-M.; Guela, C. Butyrylcholinesterase reactivity differentiates the amyloid plaques of aging from those of dementia. Ann. Neurol. 36:722-727; 1994.
73. 71. Morgan, T. E.; Laping, N.J.; Rozovsky, I.; Oda, T.; Hogan, H.; Finch, C. E.; Pasinetti, G. M. Clusterin expression in astrocytes is influenced by TGF-β 1 and heterotypic cell interactions. J. Neuroimmunol. 58:101; 1995.
74. 72. Morgan, T. E.; Nichols, N. R.; Pasinetti, G. M.; Finch, C. E. TGF-β 1 mRNA increases in macrophage/microglia cells of the hippocampus in response to deafferentation and kainic acid-induced in neurodegeneration. Exp. Neurol. 120:291-301; 1993.
75. 73. Neumann, H.; Cavalie, A.; Jenne, D. E.; Wekerle, H. Induction of MHC class I genes in neurons. Science 269:549-552; 1995.
76. 74. Nichols, N. R.; Finch, C. E.; Morgan, T. E. Age-related increase TGF-β 1 mRNA in rat hippocampus is localized to activated microglia. Soc. Neurosci. Abstr. 21:2029; 1995.
77. 75. Owens, T.; Renno, T.; Taupin, V.; Krakowski, M. Inflammatory cytokines in the brain - Does the CNS shape immune responses. Immunol. Today 15:566-571; 1994.
78. 76. Pasinetti, G. M.; Johnson, S. A.; Rozovsky, I.; Lampert-Etchells, M.; Morgan, D. G.; Gordon, M. N.; Morgan, T. E.; Willoughby, D. A.; Finch, C. E. Complement mRNA responses to lesioning in rat brain. Exp. Neurol. 118:117-125; 1992.
79. 77. Pasinetti, G. M.; Nichols, N. R.; Tocco, G.; Morgan, T.; Laping, N.; Finch, C. E. Transforming Growth factor-β1 (TGF-β1) and fibronectin mRNA in rat brain: Responses to injury and cell-type localization. Neuroscience 54:893-897; 1993.
80. 78. Pepys, M. B. Amyloidosis. In: Samter, M.; Talmage, D. W.; Frank, M. M.; Austen, K. F; Claman, H. N., eds. Immunological diseases. Boston: Little, Brown and Company; 1988:631-674.
81. 79. Perlmutter, L. S.; Scott, S. A.; Chui, H. C. The role of microglia in the cortical neuropathology of Alzheimer disease. Bull. Clin. Neurosci. 56:120-130; 1991.
82. 80. Perry, V. H.; Matyszak, M. K.; Fearn, S. Altered antigen expression of microglia in the aged rodent CNS. Glia 7:60-67; 1993.
83. 81. Pike, C. J.; Burdick, D.; Walencewicz, A. J.; Glabe, C. G.; Cotman, C. W. Neurodegeneration induced by beta-amyloid peptides in vitro: The role of peptide assembly state. J. Neurosci. 13:1676-1687; 1993.
84. 82. Poirier, J. ApoE in animal models of CNS injury and Akheimer's disease. Trends Neurosci. 17:525-530; 1994.
85. 83. Poirier, J.; Hess, M.; May, P. C.; Finch, C. E. Astrocytic apolipoprotein E mRNA and GFAP mRNA in hippocampus after entorhinal cortex lesioning. Mol. Brain. Res. 11:97-106; 1991.
86. 84. Price, D. L.; Sisodia, S. S. Cellular and molecular-biology of Alzheimer's disease and animal-models. Annu. Rev. Med. 45:435-446; 1994.
87. 85. Quigley, J. P.; Ikai, A.; Arakawa, H.; Osada, T.; Armstrong, P. B. Reaction of preoteinases with alpha 2-macroglobulin from the American horseshoe crab, Limulus. J. Biol. Chem. 266:19426-19431; 1991.
88. 86. Raftos, D. A.; Stillman, D. L.; Cooper, E. L. Interleukin-2 and phytobaemagglutinin stimulate the proliferation of tunicate cells. Immunol. Cell. Biol. 69:225-234; 1991.
89. 87. Raftos, D. A.; Raison, R. L. The echinoid immune-system revisited. Immunol. Today 14:92-93; 1993.
90. 88. Raftos, D. A. Allorecognition and humoral immunity in tunicates. Ann. NY Acad. Sci. 712:227; 1994.
91. 89. Rebeck, G. W.; Reiter, J. S.; Strickland, D. K.; Hyman, B. T. Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions. Neuron 11:575-580; 1993.
92. 90. Rejnek, J.; Tuckova, L.; Sima, P.; Bilej, M. The fate of protein antigen in earthworms: Study in vivo. Immunol. Lett. 36:131-136; 1993.
93. 91. Rogers, J.; Cooper, N. R.; Webster, S.; Schultz, J.; McGeer, P. L.; Styren, S. D.; Civin, W. H.; Brachova, L.; Bradt, B.; Ward, P.; Lieberburg, I. Complement activation by β-amyloid in Alzheimer disease. Proc. Natl. Acad. Sci. USA 89:1016-1020; 1992.
94. 92. Rogers, J.; Luber-Narod, J.; Styren, S. D.; Civin, W. H. Expression of immune system-associated antigens by cells of the human central nervous system: Relationship to the pathology of Alzheimer's disease. Neurobiol. Aging. 9:339-349; 1988.
95. 93. Rozovsky, I.; Morgan, T. E.; Willoughby, D. A.; Dugich-Djordevich, M. N.; Pasinetti, G. M.; Johnson, S. A.; Finch, C. E. Selective expression of clusterin (SG-2) and complement C1q and C4 during responses to neurotoxins in vivo and in vitro. Neuroscience 62:741-758; 1994.
96. 94. Schlimgen, A. K.; Helms, J. A.; Vogel, H.; Perin, M.S. Neuronal pentraxin, a secreted protein with homology to acute-phase proteins of the immune-system. Neuron 14:519-526; 1995.
97. 95. Schluter, S. F.; Schroeder, J.; Wang, E.; Marchalonis, J. J. Recognition molecules and immunoglobulin domains in invertebrates. Ann. NY Acad. Sci. 712:74-81; 1994.
98. 96. Schobitz, B.; Voorhuis, D. A. M.; Dekloet, E. R. Localization of interleukin-6 messenger-RNA and interleukin-6 receptor messenger-RNA in rat brain. Neurosci. Lett. 136:189-192; 1992.
99. 97. Schubert, D. The structure and function of Alzheimer's amyloid beta proteins. Austin: R. G. Landes Company; 1994.
100. 98. Schwartz, P. Amyloidosis: Cause and manifestations of senile deterioration. Springfield: Charles C. Thomas; 1970.
101. 99. Scofield, V.L.; Puntambekar, L.; Schluter, S. F.; Coombes, D. R. Serum amyloid P component (SAP) like protein from botryllid ascidians provides a clue to amyloid function. Dev. Immunol. 3:67-84; 1992.
102. 100. Selkoe, D. J. Normal and abnormal biology of the β-amyloid precursor protein. Annu. Rev. Neurosci. 17:489-517; 1994.
103. 101. Singhrao, S. K.; Morgan, B. P.; Neal, J. W.; Newman, G. R. A functional role for corpora amylacae based on evidence from complement studies. Neurodegeneration 4:335-345; 1995.
104. 102. Sipe, J. D. Amyloidosis. Annu. Rev. Biochem. 61:947-975; 1992.
105. 103. Sipe, J. D. Amyloidosis. Crit. Rev. Clin. Lab. Sci. 31:325-354; 1994.
106. 104. Slayter, H. S.; Alexander, R. J.; Steiner, L. A. Electron microscopy of the complement protein C1q from the bullfrog, Rana catesbeiana. Eur. J. Immunol. 13:102-106; 1983.
107. 105. Smith, L. C.; Davidson, E. H. The echinid immune system and the phylogeneic occurence of immune mechanisms in deutorostomes. Immunol. Today 13:356-362; 1982.
108. 106. Snow, A.D.; Sekiguchi, R.; Nochlin, D.; Fraser, P.; Kimata, K.; Mizutani, A.; Aral, M.; Schreier, W. A.; Morgan, D. G. An important role of heparan sulfate proteoglycan (perlecan) in a model system for the deposition and persistence of fibrillar Aβ-amyloid in rat brain. Neuron 12:219-234; 1994.
109. 107. Soderheall, K.; Cerenius, L.; Johansson, M. W. The prophenoloxidase activating system and its role in invertebrate defense. Ann. NY Acad. Sci. 712:155-161; 1994.
110. 108. Srinivasan, N.; White, H. E.; Ernsley, J.; Wood, S. P.; Pepys, M. B.; Blundell, T. L. Comparative analyses of pentraxins: Implications for protomer assembly and ligand binding. Structure 2:1017-1027; 1994.
111. 109. Steel, D. M.; Whitehead, A. S. The major acute phase reactants: C-reactive protein, serum amyloid P component and serum amyloid A protein. Immunol. Today 15:81-88; 1994.
112. 110. Stein, E. A.; Cooper, E. L. In vitro agglutinin production by earthworm leukocytes. Dev. Comp. Immunol. 12:531-547; 1988.
113. 111. Stinissen, P.; Vandevyver, C.; Medaer, R.; Vandegaer, L.; Nies, J.; Tuyls, L.; Hafler, D. A.; Raus, J.; Zhang, J. Increased frequence of gamma delta T cells in cererospinal fluid and peripheral blood of patients with multiple sclerosis. Reactivity, cytotoxicity, and T cell receptor V gene rearrangements. J. Immunol. 154:4883-4894; 1995.
114. 112. Storrs, S. B.; Kolb, W. P.; Olson, M. S. C1q binding and C1 activation by various isolated cellular membranes. J. Immunol. 131:416-422; 1983.
115. 113. Styren, S. D.; Harold Civin, W.; Rogers, J. Molecular, cellular, and pathologic characterization of HLA-DR immunoreactivity in normal elderly and Alzheimer's disease brain. Exp. Neurol. 110:93-104; 1992.
116. 114. Szentistvanyi, I.; Patlak, C. S.; Ellis, R. A.; Cserr, H. F. Drainage of interstitial fluid form different regions of the rat brain. Am. J. Physiol. 246:F835-F844; 1984.
117. 115. Tennent, G. A.; Lovat, L. B.; Pepys, M. B. Serum amyloid P component prevents proteolysis of the amyloid fibrils of Alzheimer disease and systemic amyloidosis. Proc. Natl. Acad. Sci. USA 92:4299-4303; 1995.
118. 116. Urban, B. A.; Fishman, E. K.; Goldman, S. M.; Scott, W. W.; Jones, B.; Humphrey, R. L.; Hruban, R. H. CT evaluation of amyloidosis: Spectrum of disease. Radiographics 13:1295-1308; 1993.
119. 117. Utz, U.; McFarland, H. F. The role of T cells in multiple sclerosis: Implications for therapies targeting the T cell receptor. J. Neuropathol. Exp. Neurol. 53:351-358; 1994.
120. 118. van der Wal, E. A.; Gomez-Pinilla, F.; Cotman, C. W. Transforming growth faactor-β1 is in plaques in Alzheimer's and Down's pathologies. Neuroreport 4:69-72; 1993.
121. 119. Vandenabeele, P.; Fiers, W. Is amyloidogenesis during Alzheimer's disease due to an IL-1/-IL-6-mediated 'acute phase response' in the brain. Immunol. Today 12:217-219; 1991.
122. 120. Vandeuren, M.; Dofferhoff, A. S. M.; Vandermeer, J. W. M. Cytokines and the response to infection. J. Pathol. 168:349-356; 1992.
123. 121. Vasta, G. R.; Cheng, T. C.; Marchalonis, J. J. A lectin on the hemocyte membrane of the oyster (Crassostrea virginica). Cell. Immunol. 88:475-188; 1984.
124. 122. Vasta, G. R.; Marchalonis, J. J.; Kohler, H. Invertebrate recognition protein cross-reacts with an immunoglobulin idiotype. J. Exp. Med. 159:1270; 1984.
125. 123. Vasta, G. R.; Ahmed, H.; Fink, N.B.; Elola, M. T.; Marsh, A. G.; Snowden, A.; Odom. E. W. Animal lectins as self/non-self recognition molecules. Ann. NY Acad. Sci. 712:55-73; 1994.
126. 124. Veerhuis, Rr.; Janssen, I., Hack, C. E.; Eikelenboom, P. Early complement components in Alzheimer's disease brains. Acta Neuropathol. 91:53-60; 1996
127. 125. Warren, H. S.; Glennon, M. L.; Wainwright, N.; Amato, S. F.; Black, K. M.: Kirsch, S. J.; Riveau, G. R.; Whyte, R. I.; Zapol, W. M.; Novitsky, T. J. Binding and neutralization of endotoxin by Limulus antilipopolysaccharide factor. Infect. Immun. 60:2506-2513; 1992.
128. 126. Wasco, W.; Brooke, J. D.; Tanzi, R. E. The amyloid precursor-like protein (APLP) gene maps to the long arm of human chromosome-19. Genomics 15:237-239; 1993.
129. 127. Wisniewski, H. M.; Ghetti, B.; Terry, R. D. Neuritic (senile) plaques and filamentous changes in aged rhesus monkeys. J. Neuropathol. Exp. Neurol. 32:566-584; 1973.
130. 128. Wisniewski, H. M.; Weigel, J. Migration of perivascular cells into the neuropil and their involvement in β-amyloid plaque formation. Acta Neuropathol. 85:586-595; 1993.
131. 129. Ying, S.-C.; Marchalonis, J. J.; Gewurz, A. T.; Siegel, J. N.; Jiang, H.; Gewurz, B. E.; Gewurz, H. Reactivity of anti-human C-reactive protein (CRP) and serum amyloid P component (SAP) monoclonal antibodies with limulin and pentraxins of other species. Immunology 76:324-330; 1992.
132. 130. Zhan, S.-S.; Veerhuis, R.; Janssen, I.; Kamphorst, W.; Eikelenboom, P. Immunornstochemical distribution of the inhibitors of the terminal complement complex in Alzheimer's disease. Neurodegeneration 3: 111-117; 1994.
133. 131. Zwain, I. H.; Grima, J.; Cheng, C. Y. Regulation of clusterin secretion and mRNA expression in astrocytes by cytokines. Mol. Cell. Neurosci. 5:229-237; 1994.