Cytokine- and costimulation-mediated therapy of IDDM

Critical Reviews in Immunology

Volumn 17, Issue 5-6, 1997, Pages 537-544

  Cameron, Mark J ^a   Arreaza, Guillermo A ^a   Delovitch, Terry L ^a  

^a ROBARTS RESEARCH INSTITUTE   (Canada)

Author keywords

Costimulation; Cytokines; Diabetes mellitus; Inbred NOD; Insulin dependent; Mice; Th2 cells; Thl cells

Indexed keywords

CD28 ANTIGEN; CHEMOKINE; CYTOKINE; INTERLEUKIN 2; INTERLEUKIN 4; MONOCLONAL ANTIBODY;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; CONFERENCE PAPER; CONTROLLED STUDY; INSULIN DEPENDENT DIABETES MELLITUS; INSULITIS; INTRAPERITONEAL DRUG ADMINISTRATION; LYMPHOCYTE MIGRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIALOADENITIS; T LYMPHOCYTE ACTIVATION; THYROIDITIS;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD28; CELL DIVISION; CHEMOKINES, CC; CYTOKINES; DIABETES MELLITUS, TYPE 1; DISEASE MODELS, ANIMAL; HUMANS; INTERLEUKIN-4; MICE; MICE, INBRED NOD; T-LYMPHOCYTES; TH2 CELLS;

EID: 0030707588     PISSN: 10408401     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (58)

1. Bach, J. F., Insulin-dependent diabetes mellitus as an autoimmune disease, Endocrine Rev., 15, 516-542, 1994.
2. Atkinson, M. A. and Maclaren, N. K., Mechanisms of disease: the pathogenesis of insulin-dependent diabetes mellitus, N. Engl. J. Med., 331, 1428-1436, 1994.
3. Tisch, R. and McDevitt, H., Insulin-dependent diabetes mellitus, Cell, 85, 291-297, 1996.
4. Serreze, D. V., Chapman, H. D., Varnum, D. S., Hanson, M. S., Reifsnyder, P. C., Richard, S. D., Fleming, S. A., Leiter, E. H., and Shultz, L. D., B-lymphocytes are essential for the initiation of T-cell-mediated autoimmune diabetes-analysis of a new speed congenic stock of NOD.Ig-mu(null) mice, J. Exp. Med., 184, 2049-2053, 1996.
5. Noorchashm, H., Noorchashm, N., Kern, J., Rostami, S. Y., Barker, C. F., and Naji, A., B cells are required for the initiation of insulitis and sialitis in NOD mice, Diabetes, 46, 941-946, 1997.
6. Bendelac, A., Carnaud, C., Boitard, C., and Bach, J. F., Syngeneic transfer of autoimmune diabetes from NOD mice to healthy neonates. Requirement for both L3T4+ and Lyt-2+ T cells, J. Exp. Med., 166, 823-832, 1987.
7. Christianson, S. W., Shultz, L. D., and Leiter, E. H., Adoptive transfer of diabetes into immunodeficient NOD-scid/scid mice: relative contributions of CD4+ and CD8+ T cells from diabetic versus prediabetic NOD.NON-Thy-1a donors, Diabetes, 42, 44-55, 1993.
8. Rohane, P. W., Shimada, A., Kim, D. T., Edwards, C. T., Charlton, B., Shultz, L. D., and Fathman, C. G., Islet-infiltrating lymphocytes from prediabetic NOD mice rapidly transfer diabetes to NOD-scid/scid mice, Diabetes, 44, 550-554, 1995.
9. Haskins, K. and McDuffie, M., Acceleration of diabetes in young NOD mice with a CD4+ islet specific T cell clone, Science, 249, 1433-1436, 1990.
10. + T cells in the destruction of islets grafts by spontaneously diabetic mice, Proc. Natl. Acad. Sci. U.S.A., 88, 527-532, 1991.
11. Rabinovitch, A., Immunoregulatory and cytokine imbalances in the pathogenesis of IDDM: therapeutic intervention by immunostimulation? Diabetes, 43, 613-621, 1994.
12. Liblau, R. S., Singer, S. M., and McDevitt, H. O., Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases, Immunol. Today, 16, 34-38, 1995.
13. Katz, J. D., Benoist, C., and Mathis, D., T helper cell subsets in insulin-dependent diabetes, Science, 268, 1185-1188, 1995.
14. Arreaza, G. A., Cameron, M. J., and Delovitch, T. L., Interleukin-4: potential immunoregulatory agent in therapy of insulin-dependent diabetes mellitus, Clin. Immunother., 4, 251-260, 1996.
15. Shehadeh, N. N., LaRosa, F., and Lafferty, K. J., Altered cytokine activity in adjuvant inhibition of autoimmune diabetes, J. Autoimmun., 6, 291-300, 1993.
16. Fox, C. J. and Danska, J. S., IL-4 expression at the onset of islet inflammation predicts nondestructive insulitis in nonobese diabetic mice, J. Immunol., 158, 2414, 1997.
17. Zipris, D., Lazarus, A. H., Crow, A. R., Hadzija, M., and Delovitch, T. L., Defective thymic T cell activation by concanavalin A and anti-CD3 in autoimmune nonobese diabetic mice, J. Immunol., 146, 3763-3771, 1991.
18. Rapoport, M. J., Jaramillo, A., Zipris, D., Lazarus, A. H., Serreze, D. V., Leiter, E. H., Cyopick, P., Danska, J. S., and Delovitch, T. L., Interleukin 4 reverses T cell proliferative unresponsiveness and prevents the onset of diabetes in nonobese diabetic mice, J. Exp. Med., 178, 87-99, 1993.
19. Jaramillo, A., Gill, B. M., and Delovitch, T. L., Insulin-dependent diabetes mellitus in the non-obese diabetic mouse: a disease mediated by T cell anergy? Life Sci., 55, 1163-1177, 1994.
20. Berman, M. A., Sandborg, C. I., Wang, Z., Imfeld, K. L., Zaldivar, F., Dadufalza, V., and Buckingham, B. A., Decreased IL-4 production in new onset type I insulin-dependent diabetes mellitus, J. Immunol., 157, 4691-4696, 1996.
21. Mueller, R., Krahl, T., and Sarvetnick, N., Pancreatic expression of interleukin-4 abrogates insulitis and autoimmune diabetes in nonobese diabetic (NOD) mice, J. Exp. Med., 184, 1093-1099, 1996.
22. Cameron, M. J., Arreaza, G. A., Zucker, P., Chensue, S. W., Strieter, R. M., Chakrabarti, S., and Delovitch, T. L., IL-4 prevents insulitis and IDDM in nonobese diabetic mice by potentiation of regulatory Th2 cell function, J. Immunol., 160, in press, 1997.
23. Marfaing-Koka, A., Devergne, O., Gorgone, G., Portier A., Schall, T. J., Galanaud, P., and Emilie, D., Regulation of the production of the RANTES chemokine by endothelial cells. Synergistic induction by IFN-gamma plus TNF-alpha and inhibition by IL-4 and IL-13, J. Immunol., 154, 1870-1878, 1995.
24. Mantovani, A., Bussolino, M., and Introna, M., Cytokine regulation of endothelial cell function: from molecular level to the bedside, Immuno. Today, 18, 231-239, 1997.
25. Rocken, M. R., Racke, M., and Schevach, E. M., IL-4-induced immune deviation as antigen-specific therapy for inflammatory autoimmune disease, Immunol. Today, 17, 225, 1996.
26. Swain, S. L., Generation and in vivo persistence of polarized Th1 and Th2 memory cells, Immunity, 1, 543, 1994.
27. Thompson, C. B., Distinct roles for the costimulatory ligands B7-1 and B7-2 in T helper cell differentiation? Cell, 81, 979-982, 1995.
28. Lenschow, D. J., Walunas, T. L., and Bluestone, J. A., CD28/B7 system T cell costimulation, Annu. Rev. Immunol., 14, 233-258, 1996.
29. Schwartz, R. H., Models of T cell anergy. Is there a common molecular mechanism? J. Exp. Med., 184, 1-8, 1996.
30. Seder, R. A., Germain, R. N., Linsley, P. S., and Paul, W. E., CD28-mediated costimulation of interleukin 2 (IL-2) production plays a critical role in T cell priming for IL-4 and interferon-γ production, J. Exp. Med., 179, 299-304, 1994.
31. Kuchroo, V. K., Das, M. P., Brown, J. A., Ranger, A. M., Zamvil, S. S., Sobel, R. A., Weiner, H. L., Nabavi, N., and Glimcher, L. H., B7-1 and B7-2 costimulatory molecules activate differentially the Th1/ Th2 developmental pathways: application to autoimmune disease therapy, Cell, 80, 707-718, 1995.
32. Lenschow, D., Ho, S., Sattar, H., Rhee, L., Gray, G., Nabavi, N., Herold, K., and Bluestone, J. A., Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse, J. Exp. Med., 181, 1145-1155, 1995.
33. Corry, D. B., Reiner, S. L., Linsley, P. S., and Locksley, R. M., Differential effects of blockade of CD28-B7 on the development of Th1 or Th2 effector cells in experimental leishmaniasis, J. Immunol., 153, 4142-4148, 1994.
34. Rulifson, I. C., Sperling, A. I., Fields, P. E., Fitch, F. W., and Bluestone, J. A., CD28 costimulation promotes the production of Th2 cytokines, J. Immunol., 158, 658-665, 1997.
35. + T cells and defective antibody production in vivo, J. Exp. Med., 179, 299-304, 1994.
36. Bachmaier, K., Pummerer, C., Shahinian, A., Ionescu, J., Neu, N., Mak, T., and Penninger, J. M., Induction of autoimmunity in the absence of CD28, J. Immunol., 157, 1752-1757, 1996.
37. Lenschow, D. J., Herold, K. C., Rhee, L., Patel, B., Koons, A., Qin, H-Y., Fuchs, E., Singh, B., Thompson, C. B., and Bluestone, J. A., CD28/B7 regulation of Th1 and Th2 subsets in the development of autoimmune diabetes, Immunity, 5, 285-293, 1996.
38. King, C. L., Stupi, R. J., Craighead, N., June, G. H., and Thyphronitis, G., CD28 activation promotes Th2 subset differentiation by human CD4+ cells, Eur. J. Immunol., 25, 587-595, 1995.
39. Kalinski, P., Hilkens, C. M. U., Wierenga, E. A., van der Pouw-Kraan, T. C., van Lier, R., Bos, J. D., Kapsenberg, M. L., and Snidjewint, F. G. M., Functional maturation of human naive T helper cells in the absence of accessory cells. Generation of IL-4-producing cells does not require exogenous IL-4, J. Immunol., 154, 3753-3760, 1995.
40. Webb, L. and Feldman, M., Critical role of CD28/ B7 costimulation in the development of human Th2 cytokine-producing cells, Blood, 86, 3479-3486, 1995.
41. Freeman, G. J., Boussiotis V. A., Anumanthan, A., Bernstein, G. M., Ke, X-Y., Rennert, P. D., Gray, G. S., Gribben, J. G., and Nadler, L. M., B7-1 and B7-2 do not deliver identical costimulatory signals, as B7-2 but B7-1 preferentially costimulates the initial production of IL-4, Immunity, 2, 523-532, 1995.
42. Ranger, A. M., Das, M. P., Kuchroo, V. K., and Glimcher, L. H., B7-2 (CD86) is essential for the development of IL-4-producing T cells, Int. Immunol., 8, 1549-1560, 1996.
43. Kawamura, T. and Furue, M., Comparative analysis of B7-1 and B7-2 expression in Langerhans cells: differential regulation by T helper type 1 and T helper type 2 cytokines, Eur. J. Immunol., 25, 1913-1917, 1995.
44. Stack, R. M., Lenschow, D. J., Gray, J. S., Bluestone, J. A., and Fitch, F. W., IL-4 treatment of small splenic B cells induces costimulatory molecules B7-1 and B7-2, J. Immunol., 152, 5723-5733, 1994.
45. Serreze, D. V. and Leiter, E. H., Defective activation of T suppressor cell function in nonobese diabetic mice. Potential relation to cytokine deficiencies, J. Immunol., 140, 3801-3807, 1988.
46. Serreze, D. V., Gaskins, H. R., and Leiter, E. H., Defects in the differentiation and function in antigen-presenting cells in NOD/Lt mice, J. Immunol., 150, 2534-2540, 1993.
47. Arreaza, G. A., Cameron, M. J., Jaramillo, A., Gill, B. M., Hardy, D., Laupand, K. B., Rapoport, M. J., Zucker, P., Chensue, S. W., Chakrabarti, S., Qin, H-Y., Singh, B., and Delovitch, T. L., Neonatal activation of CD28 signaling overcomes T cell anergy and prevents autoimmune diabetes by an IL-4-dependent mechanism, J. Clin. Invest., 101, in press, 1997.
48. Gross, J. A., Callas, E., and Allison, J. P., Identification and distribution of the costimulatory receptor CD28 in the mouse, J. Immunol., 149, 380-387, 1992.
49. Shizuru, J. A., Taylor-Edwards, C., Banks, B. A., Gregory, A. K., and Fathman, C. G., Immunotherapy of the non-obese diabetic mouse: treatment with an antibody to T helper lymphocytes, Science, 240, 659-662, 1988.
50. Chatenoud, L., Thervet, E., Primo, J., and Bach, J. F., Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice, Proc. Natl. Acad. Sci. U.S.A., 91, 123-127, 1994.
51. L., Immunity, 3, 87-98, 1995.
52. Sperling, A., Auger, J. A., Ehst, B. D., Rulifson, I. C., Thompson, C. B., and Bluestone, J. A., CD28/B7 interactions deliver a unique signal to naive T cells that regulates cell survival but not early proliferation, J. Immunol., 157, 3909-3917, 1996.
53. Radvanyi, L. G., Shi, Y., Vaziri, H., Sharma, A., Dhala, R., Mills, G. B., and Miller, R., CD28 costimulation inhibits TCR-induced apoptosis during a primary T cell response, J. Immunol., 156, 1788-1798, 1996.
54. Taub, D. D., Longo, D. L., Turcovski-Corrales, S. M., Murphy, W. J., and Key, M. L., Chemokines and T lymphocyte activation. I. Beta chemokines costimulate human T lymphocyte activation in vitro, J. Immunol., 156, 2095-2103, 1996.
55. Standiford, T. J., Kunkel, S. L., Liebler, J. M., Burdick, M. D., Gilbert, A. R., and Strieter, R. M., Gene expression of macrophage inflammatory protein-1a from human blood monocytes and alveolar macrophages is inhibited by interleukin-4, Am. J. Respir. Cell Mol. Biol., 9, 192-198, 1993.
56. Gill, B. M., Jaramillo, A., Ma, L., Laupland, K. B., and Delovitch, T. L., Genetic linkage of thymic T cell proliferative unresponsiveness to mouse chromosome 11 in NOD mice. A possible role for chemokine genes, Diabetes, 44, 614-619, 1995.
57. Pennline, K. J., Roque-Gaffney, E., and Monahan, M., Recombinant human IL-10 prevents the onset of diabetes in the nonobese diabetic mouse, Clin. Immunol. Immunopathol., 71, 169-175, 1994.
58. Zheng, X. X., Steele, A. W., Hancock, W. W., Stevens, A. C., Nickerson, P. W., Roychaudhury, P., Tian, Y., and Strom, T. B., A noncytolytic IL-10/ fc fusion protein prevents diabetes, blocks autoimmunity, and promotes suppressor phenomena in NOD mice, J. Immunol., 158, 4507-4513, 1997.