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Volumn 6, Issue 4, 1996, Pages 251-260

Interleukin-4 potential immunoregulatory agent in therapy of insulin-dependent diabetes mellitus

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 4; RECOMBINANT INTERLEUKIN 4;

EID: 0029785167     PISSN: 11727039     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03259087     Document Type: Article
Times cited : (8)

References (103)
  • 1
    • 0028026652 scopus 로고
    • Insulin-dependent diabetes mellitus as an autoimmune disease
    • Bach J. Insulin-dependent diabetes mellitus as an autoimmune disease. Endocrine Rev 1994; 15: 516-42
    • (1994) Endocrine Rev , vol.15 , pp. 516-542
    • Bach, J.1
  • 2
    • 0028814161 scopus 로고
    • Autoimmunity in insulin-dependent diabetes mellitus
    • Bosi E, Botazzo GF. Autoimmunity in insulin-dependent diabetes mellitus. Clin Immunother 1995; 3: 125-35
    • (1995) Clin Immunother , vol.3 , pp. 125-135
    • Bosi, E.1    Botazzo, G.F.2
  • 3
    • 0028779842 scopus 로고
    • Mechanisms of disease: The pathogenesis of insulin-dependent diabetes mellitus
    • Atkinson MA, Maclaren NK. Mechanisms of disease: the pathogenesis of insulin-dependent diabetes mellitus. N Engl JMed 1994;331: 1428-36
    • (1994) N Engl JMed , vol.331 , pp. 1428-1436
    • Atkinson, M.A.1    Maclaren, N.K.2
  • 4
    • 0021832966 scopus 로고
    • The inhibitory effect of neonatal thymectomy on the incidence of insulitis in nonobese diabetic (NOD) mice
    • Ogawa M, Maruyama T, Hasegawa T, et al. The inhibitory effect of neonatal thymectomy on the incidence of insulitis in nonobese diabetic (NOD) mice. Biomed Res 1985; 6: 103-5
    • (1985) Biomed Res , vol.6 , pp. 103-105
    • Ogawa, M.1    Maruyama, T.2    Hasegawa, T.3
  • 5
    • 0023544492 scopus 로고
    • Syngeneic transfer of autoimmune diabetes from NOD mice to healthy neonates
    • Bendelac A, Carnaud C, Boitard C, et al. Syngeneic transfer of autoimmune diabetes from NOD mice to healthy neonates. J ExpMed 1987; 166:823-32
    • (1987) J ExpMed , vol.166 , pp. 823-832
    • Bendelac, A.1    Carnaud, C.2    Boitard, C.3
  • 6
    • 0029026658 scopus 로고
    • Islet-infiltrating lymphocytes from prediabetic NOD mice rapidly transfer diabetes to NOD-scid/scid mice
    • Rohane PW, Shimada A, Kim DT, et al. Islet-infiltrating lymphocytes from prediabetic NOD mice rapidly transfer diabetes to NOD-scid/scid mice. Diabetes 1995; 44: 550-4
    • (1995) Diabetes , vol.44 , pp. 550-554
    • Rohane, P.W.1    Shimada, A.2    Kim, D.T.3
  • 7
    • 0027468997 scopus 로고
    • Adoptive transfer of diabetes into immunodeficient NOD-scid/scid mice: Relative contributions of CD4+ and CD8+ T cells from diabetic versus prediabetic NOD.NON-Thy-la donors
    • Christianson SW, Shultz LD, Leiter EH. Adoptive transfer of diabetes into immunodeficient NOD-scid/scid mice: relative contributions of CD4+ and CD8+ T cells from diabetic versus prediabetic NOD.NON-Thy-la donors. Diabetes 1993; 42: 44-55
    • (1993) Diabetes , vol.42 , pp. 44-55
    • Christianson, S.W.1    Shultz, L.D.2    Leiter, E.H.3
  • 8
    • 0025966664 scopus 로고
    • The role of CD4+ and CD8+ T cells in the destruction of islets grafts by spontaneously diabetic mice
    • Wang Y, Pontesilli O, Gill RG, et al. The role of CD4+ and CD8+ T cells in the destruction of islets grafts by spontaneously diabetic mice. Proc Natl Acad Sei USA 1991; 88: 527-31
    • (1991) Proc Natl Acad Sei USA , vol.88 , pp. 527-531
    • Wang, Y.1    Pontesilli, O.2    Gill, R.G.3
  • 9
    • 0028201726 scopus 로고
    • Acquisition of lymphokine-producing phenotype by CD4+ T cells
    • Seder R, Paul WE. Acquisition of lymphokine-producing phenotype by CD4+ T cells. Annu Rev Immunol 1994; 12: 635-73
    • (1994) Annu Rev Immunol , vol.12 , pp. 635-673
    • Seder, R.1    Paul, W.E.2
  • 10
    • 0028179006 scopus 로고
    • Lymphocyte responses and cytokines
    • Paul WE, Seder RA. Lymphocyte responses and cytokines. Cell 1994; 76: 241-51
    • (1994) Cell , vol.76 , pp. 241-251
    • Paul, W.E.1    Seder, R.A.2
  • 11
    • 0028288179 scopus 로고
    • Lymphokine production by human T cells in disease states
    • Romagnani S. Lymphokine production by human T cells in disease states. Annu Rev Immunol 1994; 12: 227-57
    • (1994) Annu Rev Immunol , vol.12 , pp. 227-257
    • Romagnani, S.1
  • 12
    • 0028065540 scopus 로고
    • Human TH1 and TH2 cells: Functional properties, regulation of development and role in autoimmunity
    • De Carli M, D'elios MM, Zancuoghi G, et al. Human TH1 and TH2 cells: functional properties, regulation of development and role in autoimmunity. Autoimmunity 1994; 18: 301-8
    • (1994) Autoimmunity , vol.18 , pp. 301-308
    • De Carli, M.1    D'Elios, M.M.2    Zancuoghi, G.3
  • 14
    • 0028890866 scopus 로고
    • TH1 and TH2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases
    • Liblau RS, Singer SM, McDevitt HO. TH1 and TH2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases. Immunol Today 1995; 16: 34-8
    • (1995) Immunol Today , vol.16 , pp. 34-38
    • Liblau, R.S.1    Singer, S.M.2    McDevitt, H.O.3
  • 15
    • 0029030964 scopus 로고
    • T helper cell subsets in insulindependent diabetes
    • Katz JD, Benoist C, Mathis D. T helper cell subsets in insulindependent diabetes. Science 1995; 268: 1185-8
    • (1995) Science , vol.268 , pp. 1185-1188
    • Katz, J.D.1    Benoist, C.2    Mathis, D.3
  • 17
    • 85033051470 scopus 로고
    • Deficiency in interleukin 4 (IL-4) production by T cells from new onset type 1 diabetes patients [abstract]
    • Berman MA, Wang Z, Sandborg CI, et al. Deficiency in interleukin 4 (IL-4) production by T cells from new onset type 1 diabetes patients [abstract]. Diabetes 1995 May; 44 (Suppl. 1A-333): 137A
    • (1995) Diabetes , vol.44 , Issue.SUPPL. 1A-333
    • Berman, M.A.1    Wang, Z.2    Sandborg, C.I.3
  • 18
    • 0027272228 scopus 로고
    • Interleukin 4 reverses T cell proliferative unresponsiveness and prevents the onset of diabetes in nonobese diabetic mice
    • Rapoport MJ, Jaramillo A, Zipris D, et al. Interleukin 4 reverses T cell proliferative unresponsiveness and prevents the onset of diabetes in nonobese diabetic mice. J Exp Med 1993; 178: 87-99
    • (1993) J Exp Med , vol.178 , pp. 87-99
    • Rapoport, M.J.1    Jaramillo, A.2    Zipris, D.3
  • 19
    • 85033052806 scopus 로고    scopus 로고
    • Effects of interleukin-4 administration and CD28 costimulation in thé pathogenesis of insulin dependent diabetes mellitus in the NOD mouse
    • Mar 20-26: Hilton Head, South Carolina, USA
    • Arreaza G, Cameron M, Chakrabarti S, et al. Effects of interleukin-4 administration and CD28 costimulation in thé pathogenesis of insulin dependent diabetes mellitus in the NOD mouse [abstract]. In: Keystone Symposia on Molecular and Cellular Biology; 1996 Mar 20-26: Hilton Head, South Carolina, USA: E4-4006
    • (1996) In: Keystone Symposia on Molecular and Cellular Biology
    • Arreaza, G.1    Cameron, M.2    Chakrabarti, S.3
  • 20
    • 0028354067 scopus 로고
    • Immunoregulatory and cytokine imbalances in the pathogenesis of IDDM
    • Rabinovitch A. Immunoregulatory and cytokine imbalances in the pathogenesis of IDDM. Diabetes 1994; 43: 613-21
    • (1994) Diabetes , vol.43 , pp. 613-621
    • Rabinovitch, A.1
  • 21
    • 0028116618 scopus 로고
    • Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease
    • Racke MK, Bonomo A, Scott DE, et al. Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease. J Exp Med 1994; 180: 1961-6
    • (1994) J Exp Med , vol.180 , pp. 1961-1966
    • Racke, M.K.1    Bonomo, A.2    De Scott3
  • 22
    • 0029659057 scopus 로고    scopus 로고
    • Immune deviation: The third dimension of nondeletional T cell tolerance
    • Rocken M, Shevach E. Immune deviation: the third dimension of nondeletional T cell tolerance. Immunol Rev 1996; 149: 175-94
    • (1996) Immunol Rev , vol.149 , pp. 175-194
    • Rocken, M.1    Shevach, E.2
  • 23
    • 0025764757 scopus 로고
    • Interleukin-4: A prototypic immunoregulatory lymphokine
    • Paul WE. Interleukin-4: a prototypic immunoregulatory lymphokine. Blood 1991; 77: 1859-70
    • (1991) Blood , vol.77 , pp. 1859-1870
    • Paul, W.E.1
  • 24
    • 0028144786 scopus 로고
    • IL-4: A key cytokine in atopy
    • Ricci M. IL-4: a key cytokine in atopy. Clin Exp Allergy 1994; 24: 801-12
    • (1994) Clin Exp Allergy , vol.24 , pp. 801-812
    • Ricci, M.1
  • 25
    • 0027136295 scopus 로고
    • Structure of the IL-4 receptor and signal transduction mechanism of IL-4
    • Izuhara K, Yang G, Miyajima A, et al. Structure of the IL-4 receptor and signal transduction mechanism of IL-4. Res Immunol 1993; 144:584-90
    • (1993) Res Immunol , vol.144 , pp. 584-590
    • Izuhara, K.1    Yang, G.2    Miyajima, A.3
  • 26
    • 43949160885 scopus 로고
    • Interleukin 4 receptor: Signaling mechanisms
    • Keegan AD, Nelms K, Wang L, et al. Interleukin 4 receptor: signaling mechanisms. Immunol Today 1994; 15: 423-32
    • (1994) Immunol Today , vol.15 , pp. 423-432
    • Keegan, A.D.1    Nelms, K.2    Wang, L.3
  • 28
    • 0029057858 scopus 로고
    • Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-13 but are not required for mitogenesis
    • Quelle F, Shimoda K, Thierfelder W, et al. Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-13 but are not required for mitogenesis. Mol Cell Biol 1995; 15: 3336-43
    • (1995) Mol Cell Biol , vol.15 , pp. 3336-3343
    • Quelle, F.1    Shimoda, K.2    Thierfelder, W.3
  • 29
    • 0029876629 scopus 로고    scopus 로고
    • Statô is required for mediating responses to IL-4 and for the development of TH2 cells
    • Kaplan MH, Schindler U, Smiley ST, et al. Statô is required for mediating responses to IL-4 and for the development of TH2 cells. Immunity 1996; 4: 313-9
    • (1996) Immunity , vol.4 , pp. 313-319
    • Kaplan, M.H.1    Schindler, U.2    Smiley, S.T.3
  • 30
    • 0028027379 scopus 로고
    • Interleukins: Clinical pharmacology and therapeutic use
    • Aulitzky WE, Shuler M, Peschel C, et al. Interleukins: clinical pharmacology and therapeutic use. Drugs 1994; 48: 667-77
    • (1994) Drugs , vol.48 , pp. 667-677
    • Aulitzky, W.E.1    Shuler, M.2    Peschel, C.3
  • 31
    • 0027139375 scopus 로고
    • Regulation of Ihe human IgE response by IL-4 and IL-13
    • de Vries JE, Punnonen J, Cocks BG, et al. Regulation of Ihe human IgE response by IL-4 and IL-13. Res Immunol 1993; 144:597-601
    • (1993) Res Immunol , vol.144 , pp. 597-601
    • De Vries, J.E.1    Punnonen, J.2    Cocks, B.G.3
  • 32
    • 0027136134 scopus 로고
    • Effects of interleukin 4 on monocyte functions: Comparison to interleukin 13
    • de Waal Malefyt R, Figdor CG, de Vries JE. Effects of interleukin 4 on monocyte functions: comparison to interleukin 13. Res Immunol 1993; 144: 629-31
    • (1993) Res Immunol , vol.144 , pp. 629-631
    • De Waal Malefyt, R.1    Figdor, C.G.2    De Vries, J.E.3
  • 33
    • 0026708993 scopus 로고
    • Cytokine production by mature and immature CD4- CD8- T cells: A TCR+ CD4CD8-T cells produce IL-4
    • Zlotnick A, Godfrey DI, Fisher M, et al. Cytokine production by mature and immature CD4- CD8- T cells: a TCR+ CD4CD8-T cells produce IL-4. J Immunol 1992; 149: 1211-5
    • (1992) J Immunol , vol.149 , pp. 1211-1215
    • Zlotnick, A.1    Godfrey, D.I.2    Fisher, M.3
  • 34
    • 0029122495 scopus 로고
    • NK1.1+ T cell receptor-a+ cells: New clues to their origin, specificity and function
    • MacDonald HR. NK1.1+ T cell receptor-a+ cells: new clues to their origin, specificity and function. J Exp Med 1995; 182: 633-8
    • (1995) J Exp Med , vol.182 , pp. 633-638
    • MacDonald, H.R.1
  • 35
    • 0027511242 scopus 로고
    • NK1.1+ CD4+ CD8thymocytes with specific lymphokine secretion
    • Arase H, Arase N, Nakagawa K, et al. NK1.1+ CD4+ CD8thymocytes with specific lymphokine secretion. Eur J Immunol 1993; 23: 307-10
    • (1993) Eur J Immunol , vol.23 , pp. 307-310
    • Arase, H.1    Arase, N.2    Nakagawa, K.3
  • 36
    • 0028177589 scopus 로고
    • CD4+, NK1.1+ T cells promptly produce interleukin 4 in response to in vivo challenge with antiCD3
    • Yoshimoto T, Paul WE. CD4+, NK1.1+ T cells promptly produce interleukin 4 in response to in vivo challenge with antiCD3. J Exp Med 1994; 179: 1285-95
    • (1994) J Exp Med , vol.179 , pp. 1285-1295
    • Yoshimoto, T.1    Paul, W.E.2
  • 37
    • 0026480749 scopus 로고
    • Regulation of IL-4 production and of IL-4 producing cells
    • Holter W. Regulation of IL-4 production and of IL-4 producing cells. Int Arch Allergy Immunol 1992; 98: 273-8
    • (1992) Int Arch Allergy Immunol , vol.98 , pp. 273-278
    • Holter, W.1
  • 38
    • 0027452977 scopus 로고
    • Disruption of the murine IL-4 gene blocks TH2 cytokine responses
    • Kopf M, LegrosG, Bachmann M, et al. Disruption of the murine IL-4 gene blocks TH2 cytokine responses. Nature 1993; 326: 245-7
    • (1993) Nature , vol.326 , pp. 245-247
    • Kopf, M.1    Legros, G.2    Bachmann, M.3
  • 39
    • 0027141284 scopus 로고
    • The anti-tumour and proinflammatory actions of IL4
    • Tepper RI. The anti-tumour and proinflammatory actions of IL4. Res Immunol 1993; 144: 633-7
    • (1993) Res Immunol , vol.144 , pp. 633-637
    • Tepper, R.I.1
  • 40
    • 0027469405 scopus 로고
    • Expression of high affinity interleukin-4 receptors on human renal cell carcinoma cells and inhibition of tumor cell growth in vitro by interleukin-4
    • Obiri NI, Hillman GG, Haas GP, et al. Expression of high affinity interleukin-4 receptors on human renal cell carcinoma cells and inhibition of tumor cell growth in vitro by interleukin-4. J Clin Invest 1993; 91: 88-93
    • (1993) J Clin Invest , vol.91 , pp. 88-93
    • Obiri, N.I.1    Hillman, G.G.2    Haas, G.P.3
  • 41
    • 0028023012 scopus 로고
    • Enhancement of immune reactivity in the lymph nodes draining a murine melanoma engineered to elaborate interleukin-4
    • Kruuss JC, Strome SE, Chang AE, et al. Enhancement of immune reactivity in the lymph nodes draining a murine melanoma engineered to elaborate interleukin-4. J Immunother 1994; 16: 77-84
    • (1994) J Immunother , vol.16 , pp. 77-84
    • Kruuss, J.C.1    Strome, S.E.2    Chang, A.E.3
  • 45
    • 0025133974 scopus 로고
    • Cure of murine leishmaniasis with anti-interleukin 4 monoclonal antibody: Evidence for a T cell-dependent, Interferon gamma-independent mechanism
    • Sadick MD, Heinzel FP, Holaday BJ, et al. Cure of murine leishmaniasis with anti-interleukin 4 monoclonal antibody: evidence for a T cell-dependent, Interferon gamma-independent mechanism. J Exp Med 1990: 171: 115
    • (1990) J Exp Med , vol.171 , pp. 115
    • Sadick, M.D.1    Heinzel, F.P.2    Holaday, B.J.3
  • 47
    • 0027309318 scopus 로고
    • Resolution of cutaneous leishmaniasis: Interleukin 12 initiates a protective T helper type 1 immune response
    • Sypek JP, Chung CL, Mayor SEH, et al. Resolution of cutaneous leishmaniasis: interleukin 12 initiates a protective T helper type 1 immune response. J Exp Med 1993; 177: 1797-802
    • (1993) J Exp Med , vol.177 , pp. 1797-1802
    • Sypek, J.P.1    Chung, C.L.2    Seh, M.3
  • 49
    • 0026012259 scopus 로고
    • Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones
    • Salgame P, Ahrams JS, ClaybergerC.et al. Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones. Science 1991; 254: 279-82
    • (1991) Science , vol.254 , pp. 279-282
    • Salgame, P.1    Ahrams, J.S.2    Clayberger, C.3
  • 51
    • 0027176158 scopus 로고
    • Inverse relation between humoral and cellular immunity to glutamic acid decarboxylase in subjects at risk of insulin-dependent diabetes
    • Harrison LC, Honeyman MC, DeAizpurua HJ, et al. Inverse relation between humoral and cellular immunity to glutamic acid decarboxylase in subjects at risk of insulin-dependent diabetes. Lancet 1993; 341: 1365-9
    • (1993) Lancet , vol.341 , pp. 1365-1369
    • Harrison, L.C.1    Honeyman, M.C.2    Deaizpurua, H.J.3
  • 55
    • 0029091751 scopus 로고
    • Combined therapy with interleukin-4 and interleukin-10 inhibits autoimmune diabetes recurrence in syngeneie islet-transplanted nonobese diabetic mice
    • Rabinovitch A, Suarez-Pinzon WL, Sorensen O. et al. Combined therapy with interleukin-4 and interleukin-10 inhibits autoimmune diabetes recurrence in syngeneie islet-transplanted nonobese diabetic mice. Transplantation 1995: 60: 368-74
    • (1995) Transplantation , vol.60 , pp. 368-374
    • Rabinovitch, A.1    Suarez-Pinzon, W.L.2    Sorensen, O.3
  • 59
    • 0027378612 scopus 로고
    • Following a diabetogenic T cell from genesis through pathogenesis
    • Katz J, Wang B, Haskins K, et al. Following a diabetogenic T cell from genesis through pathogenesis. Cell 1993; 74: 1089-100
    • (1993) Cell , vol.74 , pp. 1089-1100
    • Katz, J.1    Wang, B.2    Haskins, K.3
  • 61
    • 0028979466 scopus 로고
    • New perspectives of CD28-B7-mediated T cell costimulation
    • Bluestone JA. New perspectives of CD28-B7-mediated T cell costimulation. Immunity 1995: 2: 555-9
    • (1995) Immunity , vol.2 , pp. 555-559
    • Bluestone, J.A.1
  • 62
    • 0028949152 scopus 로고
    • B7-I and B7-2 costimulatory molecules activate differentially the TH1/TH2 developmental pathways: Application to autoimmune disease therapy
    • Kuchroo VK, Das MR Brown JA. et al. B7-I and B7-2 costimulatory molecules activate differentially the TH1/TH2 developmental pathways: application to autoimmune disease therapy. Cell 1995:80: 701-18
    • (1995) Cell , vol.80 , pp. 701-718
    • Kuchroo, V.K.1    Das, M.R.2    Brown, J.A.3
  • 64
    • 0029034075 scopus 로고
    • Comparative analysis of B7-1 andB7-2 expression in Langerhans cells: Differential regulation by T helper type 1 and T helper type 2 cytokines
    • KawamuraT, FurueM. Comparative analysis of B7-1 andB7-2 expression in Langerhans cells: differential regulation by T helper type 1 and T helper type 2 cytokines. Eur J Immunol 1995:25: 1913-7
    • (1995) Eur J Immunol , vol.25 , pp. 1913-1917
    • Kawamura, T.1    Furue, M.2
  • 68
    • 0027908753 scopus 로고
    • Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice
    • Tisch R, Yang X-D, Singer SM. el al. Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice. Nature 1993: 366: 72-5
    • (1993) Nature , vol.366 , pp. 72-75
    • Tisch, R.1    Yang, X.-D.2    Singer, S.M.3
  • 70
    • 0029068841 scopus 로고
    • Isohormonal therapy of endocrine autoimmunity
    • Schloot N, Eisenbarth GS. Isohormonal therapy of endocrine autoimmunity. Immunol Today 1995; 16: 289-94
    • (1995) Immunol Today , vol.16 , pp. 289-294
    • Schloot, N.1    Eisenbarth, G.S.2
  • 71
    • 0028202792 scopus 로고
    • Oral tolerance: Immunologie mechanisms of treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens
    • Weiner HL, Friedman A, Miller A, et al. Oral tolerance: immunologie mechanisms of treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens. Annu Rev Immunol 1994; 12: 809-37
    • (1994) Annu Rev Immunol , vol.12 , pp. 809-837
    • Weiner, H.L.1    Friedman, A.2    Miller, A.3
  • 78
    • 0029093933 scopus 로고
    • The role of IL-12 in the induction of organ-specific autoimmune diseases
    • Trembleau S, Germann T, Gately MK, et al. The role of IL-12 in the induction of organ-specific autoimmune diseases. Immunol Today 1995; 16: 383-6
    • (1995) Immunol Today , vol.16 , pp. 383-386
    • Trembleau, S.1    Germann, T.2    Gately, M.K.3
  • 79
    • 0023837232 scopus 로고
    • IFN-y induces islet cell MHC antigens and enhances autoimmune streptozotocin-induced diabetes in the mouse
    • Campbell IL, Oxbrow L, Koulmanda M, et al. IFN-y induces islet cell MHC antigens and enhances autoimmune streptozotocin-induced diabetes in the mouse. J Immunol 1988; 140: 1111-6
    • (1988) J Immunol , vol.140 , pp. 1111-1116
    • Campbell, I.L.1    Oxbrow, L.2    Koulmanda, M.3
  • 80
    • 0025905088 scopus 로고
    • Prevention of diabetes in NOD mice treated with antibody to murine IFN-y
    • Debray-Sachs M, Carnaud C, Boitard C, et al. Prevention of diabetes in NOD mice treated with antibody to murine IFN-y. J Autoimmun 1991; 4: 237-48
    • (1991) J Autoimmun , vol.4 , pp. 237-248
    • Debray-Sachs, M.1    Carnaud, C.2    Boitard, C.3
  • 81
    • 0028966091 scopus 로고
    • Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12
    • Leonard JP, Waldburger KE, Goldman SJ. Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12. JExpMed 1995; 181:381-6
    • (1995) JExpMed , vol.181 , pp. 381-386
    • Leonard, J.P.1    Waldburger, K.E.2    Goldman, S.J.3
  • 82
    • 0028346888 scopus 로고
    • Production of interleukin 10 by islet cells accelerates immune-mediated destruction of cells in nonobese diabetic mice
    • Wogensen L, Lee MS, Sarvetnick N. Production of interleukin 10 by islet cells accelerates immune-mediated destruction of cells in nonobese diabetic mice. J Exp Med 1994; 179: 1379-84
    • (1994) J Exp Med , vol.179 , pp. 1379-1384
    • Wogensen, L.1    Lee, M.S.2    Sarvetnick, N.3
  • 83
    • 0025108875 scopus 로고
    • Loss of pancreatic islet tolerance induced by beta cell expression of interferon gamma
    • Sarvetnick N, Shizurus J, Liggit D, et al. Loss of pancreatic islet tolerance induced by beta cell expression of interferon gamma. Nature 1990; 346: 844-7
    • (1990) Nature , vol.346 , pp. 844-847
    • Sarvetnick, N.1    Shizurus, J.2    Liggit, D.3
  • 84
    • 85033036234 scopus 로고    scopus 로고
    • Amelioration of diabetes by ectopic expression of interleukin-4 in NOD mice
    • Mar 20-26: Hilton Head, South Carolina, USA
    • Mueller R, Krahl T, Sarvetnick N. Amelioration of diabetes by ectopic expression of interleukin-4 in NOD mice [abstract]. In: Keystone Symposia on Molecular and Cellular Biology; 1996 Mar 20-26: Hilton Head, South Carolina, USA: E4-4088
    • (1996) In: Keystone Symposia on Molecular and Cellular Biology
    • Mueller, R.1    Krahl, T.2    Sarvetnick, N.3
  • 86
    • 0029071483 scopus 로고
    • Developmental commitment to the TH2 lineage by extinction of IL-12 signaling
    • Szabo SJ, Jacobson NG, Dighe AS, et al. Developmental commitment to the TH2 lineage by extinction of IL-12 signaling. Immunity 1995; 2: 665-75
    • (1995) Immunity , vol.2 , pp. 665-675
    • Szabo, S.J.1    Jacobson, N.G.2    Dighe, A.S.3
  • 87
    • 0029965236 scopus 로고    scopus 로고
    • Reversibility of T helper 1 and 2 populations is lost after long-term stimulation
    • Murphy E, Shibuya K, Hosken N, et al. Reversibility of T helper 1 and 2 populations is lost after long-term stimulation. JExpMed 1996; 183:901-13
    • (1996) JExpMed , vol.183 , pp. 901-913
    • Murphy, E.1    Shibuya, K.2    Hosken, N.3
  • 88
    • 0025108018 scopus 로고
    • Inhibitory effect of murine recombinant IL-4 on thymocyte development in fetal thymus organ cultures
    • Plum J, De Smedt M, Leclercq G, et al. Inhibitory effect of murine recombinant IL-4 on thymocyte development in fetal thymus organ cultures. J Immunol 1990; 145: 1066-73
    • (1990) J Immunol , vol.145 , pp. 1066-1073
    • Plum, J.1    De Smedt, M.2    Leclercq, G.3
  • 89
    • 33746514376 scopus 로고
    • Elevated T cell PCD susceptibility may mediate onset of insulin-dependent diabetes mellitus [abstract]
    • Gill BM, Delovitch TL. Elevated T cell PCD susceptibility may mediate onset of insulin-dependent diabetes mellitus [abstract]. In: 9th International Congress of Immunology; 1995. San Francisco: 4419
    • (1995) In: 9th International Congress of Immunology , pp. 4419
    • Gill, B.M.1    Delovitch, T.L.2
  • 90
    • 0027651888 scopus 로고
    • Gene expression of macrophage inflammatory protein-1 alpha from human blood monocytes and alveolar macrophages is inhibited by interleukin 4
    • Standiford TJ, Kunkel SL, Liebler JM et al. Gene expression of macrophage inflammatory protein-1 alpha from human blood monocytes and alveolar macrophages is inhibited by interleukin 4. Am J RespirCell Mol Biol 1993; 9: 192-8
    • (1993) Am J RespirCell Mol Biol , vol.9 , pp. 192-198
    • Standiford, T.J.1    Kunkel, S.L.2    Liebler, J.M.3
  • 91
    • 0029004776 scopus 로고
    • Interleukin 4 impairs rat pancreatic islet function in vitro by an action different to that of interleukin 1
    • Sandler S, Sternesjö J. Interleukin 4 impairs rat pancreatic islet function in vitro by an action different to that of interleukin 1. Cytokine 1995; 7: 296-300
    • (1995) Cytokine , vol.7 , pp. 296-300
    • Sandler, S.1    Sternesjö, J.2
  • 92
    • 43949158538 scopus 로고
    • The TH1-TH2 hypothesis of HIV infection: New insights
    • Clerici M, Shearer GM. The TH1-TH2 hypothesis of HIV infection: new insights. Immunol Today 1994; 15: 575-81
    • (1994) Immunol Today , vol.15 , pp. 575-581
    • Clerici, M.1    Shearer, G.M.2
  • 93
    • 0028170510 scopus 로고
    • TH1 - And TH2-like cells in allergy and asthma: Pharmacological perspectives
    • Anderson GP, Coyle AJ. TH1 - and TH2-like cells in allergy and asthma: pharmacological perspectives. Trends Pharmacol Sei 1994; 15: 324-32
    • (1994) Trends Pharmacol Sei , vol.15 , pp. 324-332
    • Anderson, G.P.1    Coyle, A.J.2
  • 94
    • 0029562066 scopus 로고
    • Role of NK 1.1+ T cells in aTH2 response and in immunoglobulin E production
    • Yoshimoto T, Bendelac A, Watson C, et al. Role of NK 1.1+ T cells in aTH2 response and in immunoglobulin E production. Science 1995:270: 1845-7
    • (1995) Science , vol.270 , pp. 1845-1847
    • Yoshimoto, T.1    Bendelac, A.2    Watson, C.3
  • 96
    • 0027527833 scopus 로고
    • Transfer and expression of the human interleukin-4 gene in carcinoma and stromal cell lines derived from lung cancer patients
    • Hunt JD, Pippin BA, Landreneau RJ, et al. Transfer and expression of the human interleukin-4 gene in carcinoma and stromal cell lines derived from lung cancer patients. J Immunother 1993; 14: 314-21
    • (1993) J Immunother , vol.14 , pp. 314-321
    • Hunt, J.D.1    Pippin, B.A.2    Landreneau, R.J.3
  • 97
    • 0029017921 scopus 로고
    • Gene therapy of rheumatoid arthritis via cytokine regulation: Future perspectives
    • Chernajovsky Y, Feldmann M, Maini RN. Gene therapy of rheumatoid arthritis via cytokine regulation: future perspectives. BrMedBull 1995; 51: 503-16
    • (1995) BrMedBull , vol.51 , pp. 503-516
    • Chernajovsky, Y.1    Feldmann, M.2    Maini, R.N.3
  • 98
    • 0027077537 scopus 로고
    • Phase I evaluation of thrice-daily intravenous bolus interleukin-4 in patients with refractory malignancy
    • Atkins MB, Vachino G, Tilg HJ, et al. Phase I evaluation of thrice-daily intravenous bolus interleukin-4 in patients with refractory malignancy. J Clin Oncol 1992; 10: 1802-9
    • (1992) J Clin Oncol , vol.10 , pp. 1802-1809
    • Atkins, M.B.1    Vachino, G.2    Tilg, H.J.3
  • 99
    • 0026696410 scopus 로고
    • Recombinant human interleukin 4 (IL-4) given as daily subcutaneous injections: A phase 1 dose toxicity trial
    • Gilleece MH, Scarffe JH, Ghosh A, et al. Recombinant human interleukin 4 (IL-4) given as daily subcutaneous injections: a phase 1 dose toxicity trial. Br J Cancer 1992; 66: 204-10
    • (1992) Br J Cancer , vol.66 , pp. 204-210
    • Gilleece, M.H.1    Scarffe, J.H.2    Ghosh, A.3
  • 100
    • 0028245157 scopus 로고
    • A phase I trial of continuous infusion interleukin-4 (IL-4) alone and following interleukin2 (1L-2) in cancer patients
    • Sosman J, Fisher S, Kefer C, et al. A phase I trial of continuous infusion interleukin-4 (IL-4) alone and following interleukin2 (1L-2) in cancer patients. Ann Oncol 1994; 5: 447-52
    • (1994) Ann Oncol , vol.5 , pp. 447-452
    • Sosman, J.1    Fisher, S.2    Kefer, C.3
  • 101
    • 0028014562 scopus 로고
    • Phase II studies of recombinant human interleukin-4 in advanced renal cancer and malignant melanoma
    • Margolin K, Aronson FR, Sznol M, et al. Phase II studies of recombinant human interleukin-4 in advanced renal cancer and malignant melanoma. J Immunother 1994; 15: 147-53
    • (1994) J Immunother , vol.15 , pp. 147-153
    • Margolin, K.1    Aronson, F.R.2    Sznol, M.3
  • 102
    • 0027385079 scopus 로고
    • Possible myocardial toxicity associated with interleukin-4 therapy
    • Trehu E, Isner J, Mier J, et al. Possible myocardial toxicity associated with interleukin-4 therapy. J Immunother 1993; 14: 348-51
    • (1993) J Immunother , vol.14 , pp. 348-351
    • Trehu, E.1    Isner, J.2    Mier, J.3
  • 103
    • 0029919962 scopus 로고    scopus 로고
    • Enhanced development of TH2-like CD4 effectors in response to sustained exposure to limited rIL-4 in vivo
    • Yoshimoto K, Swain SL, Bradley LM. Enhanced development of TH2-like CD4 effectors in response to sustained exposure to limited rIL-4 in vivo. J Immunol 1996; 156: 3267-74
    • (1996) J Immunol , vol.156 , pp. 3267-3274
    • Yoshimoto, K.1    Swain, S.L.2    Bradley, L.M.3


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