A convergent synthesis of Ro24-5913, a novel leukotriene D4 antagonist

Tetrahedron Letters

Volumn 37, Issue 31, 1996, Pages 5445-5448

  Maehr, Hubert ^a   Yang, Roxana ^a  

^a HOFFMANN LA ROCHE INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CINALUKAST; LEUKOTRIENE RECEPTOR BLOCKING AGENT;

ARTICLE; DRUG SYNTHESIS; REACTION ANALYSIS;

EID: 0030605893     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/0040-4039(96)01190-2     Document Type: Article

References (20)

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3. 3. The E:Z ratios reported for a number of olefinations of aldehydes with 4-(thiazolylmethyl) phosponium ylides range from 84/16 to 52/48: Williams, D. R., Brooks, D. A., Moore, J. L., Stewart, A. O., Tetrahedron Lett. 1996, 37, 443-446.
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19. 19. Similar condensations are traditionally conducted with much stronger bases, e.g., sodium hydride in DME: Knott, E., J. Chem. Soc. 1965, 3793-3795.
20. 2 the addition of HBr in acetic acid rendered the bromination more reproducible. We thank Dr. P. Manchand and Mr. P. Belica for this information.