Parallel-compound synthesis: Methodology for accelerating drug discovery

Bioorganic and Medicinal Chemistry

Volumn 4, Issue 5, 1996, Pages 645-654

  Selway, Christopher N ^a   Terrett, Nicholas K ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; NEUROKININ 2 RECEPTOR ANTAGONIST;

AUTOMATION; CONFERENCE PAPER; DRUG DESIGN; DRUG SYNTHESIS; HERPES SIMPLEX VIRUS; QUANTITATIVE STRUCTURE ACTIVITY RELATION; TECHNIQUE;

EID: 0029904314     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/0968-0896(96)00058-2     Document Type: Conference Paper

References (21)

1. Combinatorial chemistry as applied to drug discovery has been reviewed. See: Gallop, M. A.; Barrett, R. W.; Dower, W. J.; Foder, S. P. A.; Gordon, E. M. J. Med. Chem. 1994, 37, 1233, 1385. Janda, K. D. Proc. Natl. Acad. Sci. U.S.A. 1994, 91, 10779. DeWitt, S. H. Pharmaceut. News 1994, 1, 11. Nielsen, J. Chem. Ind. 1994, 902. Terrett, N. K.; Gardner, M.; Gordon, D. W.; Kobylecki, R. J.; Steele, J. Tetrahedron 1995, 51, 8135-8173.
2. Combinatorial chemistry as applied to drug discovery has been reviewed. See: Gallop, M. A.; Barrett, R. W.; Dower, W. J.; Foder, S. P. A.; Gordon, E. M. J. Med. Chem. 1994, 37, 1233, 1385. Janda, K. D. Proc. Natl. Acad. Sci. U.S.A. 1994, 91, 10779. DeWitt, S. H. Pharmaceut. News 1994, 1, 11. Nielsen, J. Chem. Ind. 1994, 902. Terrett, N. K.; Gardner, M.; Gordon, D. W.; Kobylecki, R. J.; Steele, J. Tetrahedron 1995, 51, 8135-8173.
3. Combinatorial chemistry as applied to drug discovery has been reviewed. See: Gallop, M. A.; Barrett, R. W.; Dower, W. J.; Foder, S. P. A.; Gordon, E. M. J. Med. Chem. 1994, 37, 1233, 1385. Janda, K. D. Proc. Natl. Acad. Sci. U.S.A. 1994, 91, 10779. DeWitt, S. H. Pharmaceut. News 1994, 1, 11. Nielsen, J. Chem. Ind. 1994, 902. Terrett, N. K.; Gardner, M.; Gordon, D. W.; Kobylecki, R. J.; Steele, J. Tetrahedron 1995, 51, 8135-8173.
4. Combinatorial chemistry as applied to drug discovery has been reviewed. See: Gallop, M. A.; Barrett, R. W.; Dower, W. J.; Foder, S. P. A.; Gordon, E. M. J. Med. Chem. 1994, 37, 1233, 1385. Janda, K. D. Proc. Natl. Acad. Sci. U.S.A. 1994, 91, 10779. DeWitt, S. H. Pharmaceut. News 1994, 1, 11. Nielsen, J. Chem. Ind. 1994, 902. Terrett, N. K.; Gardner, M.; Gordon, D. W.; Kobylecki, R. J.; Steele, J. Tetrahedron 1995, 51, 8135-8173.
5. Combinatorial chemistry as applied to drug discovery has been reviewed. See: Gallop, M. A.; Barrett, R. W.; Dower, W. J.; Foder, S. P. A.; Gordon, E. M. J. Med. Chem. 1994, 37, 1233, 1385. Janda, K. D. Proc. Natl. Acad. Sci. U.S.A. 1994, 91, 10779. DeWitt, S. H. Pharmaceut. News 1994, 1, 11. Nielsen, J. Chem. Ind. 1994, 902. Terrett, N. K.; Gardner, M.; Gordon, D. W.; Kobylecki, R. J.; Steele, J. Tetrahedron 1995, 51, 8135-8173.
6. Desai, M. C.; Stephens Stramiello, L. M. Tetrahedron Lett. 1993, 34, 7685.
7. The general use and advantages of polymer-bound reagents has been reviewed. See: Patchornik, A. Chemtech 1987, 58. Leznoff, C. C. Chem. Soc. Rev. 1974, 3, 65. Leznoff, C. Acc. Chem. Res. 1978, 11, 327. Akelah, A.; Sherrington, D. C. Chem. Rev. 1981, 81, 557.
8. The general use and advantages of polymer-bound reagents has been reviewed. See: Patchornik, A. Chemtech 1987, 58. Leznoff, C. C. Chem. Soc. Rev. 1974, 3, 65. Leznoff, C. Acc. Chem. Res. 1978, 11, 327. Akelah, A.; Sherrington, D. C. Chem. Rev. 1981, 81, 557.
9. The general use and advantages of polymer-bound reagents has been reviewed. See: Patchornik, A. Chemtech 1987, 58. Leznoff, C. C. Chem. Soc. Rev. 1974, 3, 65. Leznoff, C. Acc. Chem. Res. 1978, 11, 327. Akelah, A.; Sherrington, D. C. Chem. Rev. 1981, 81, 557.
10. The general use and advantages of polymer-bound reagents has been reviewed. See: Patchornik, A. Chemtech 1987, 58. Leznoff, C. C. Chem. Soc. Rev. 1974, 3, 65. Leznoff, C. Acc. Chem. Res. 1978, 11, 327. Akelah, A.; Sherrington, D. C. Chem. Rev. 1981, 81, 557.
11. Masu, Y.; Nakayama, A.; Tamaki, H.; Harada, Y.; Kuno, M.; Nakanishi, S. Nature 1987, 329, 836.
12. Miyaura, N.; Ishiyama, T.; Sasaki, H.; Ishikawa, M.; Sato, M.; Suzuki, A. J. Am. Chem. Soc. 1989, 111, 314.
13. Lawrence, K. B.; Venepalli, B. R.; Appell, K. C.; Goswami, R.; Logan, M. E.; Tomczuk, B. E.; Yanni, J. M. J. Med. Chem. 1992, 35, 1273. Advenier, C.; Emonds-Alt, X.; Vilain, P.; Goulaouic, P.; Protietto, V.; Van Broeck, D.; Naline, E.; Le Fur, G.; Breliere, J. C. Br. Pharmaceuti. Soc. 1991, C82. Emonds-Alt, X.; Vilain, P.; Protietto, V.; Van Broeck, D.; Naline, E.; Neliat, G.; Le Fur, G.; Breliere, J. C. Life Sci. 1992, 50, PL-101.
14. Lawrence, K. B.; Venepalli, B. R.; Appell, K. C.; Goswami, R.; Logan, M. E.; Tomczuk, B. E.; Yanni, J. M. J. Med. Chem. 1992, 35, 1273. Advenier, C.; Emonds-Alt, X.; Vilain, P.; Goulaouic, P.; Protietto, V.; Van Broeck, D.; Naline, E.; Le Fur, G.; Breliere, J. C. Br. Pharmaceuti. Soc. 1991, C82. Emonds-Alt, X.; Vilain, P.; Protietto, V.; Van Broeck, D.; Naline, E.; Neliat, G.; Le Fur, G.; Breliere, J. C. Life Sci. 1992, 50, PL-101.
15. Lawrence, K. B.; Venepalli, B. R.; Appell, K. C.; Goswami, R.; Logan, M. E.; Tomczuk, B. E.; Yanni, J. M. J. Med. Chem. 1992, 35, 1273. Advenier, C.; Emonds-Alt, X.; Vilain, P.; Goulaouic, P.; Protietto, V.; Van Broeck, D.; Naline, E.; Le Fur, G.; Breliere, J. C. Br. Pharmaceuti. Soc. 1991, C82. Emonds-Alt, X.; Vilain, P.; Protietto, V.; Van Broeck, D.; Naline, E.; Neliat, G.; Le Fur, G.; Breliere, J. C. Life Sci. 1992, 50, PL-101.
16. Lowe, J. A.; Seeger, T. F.; Nagel, A. A.; Howard, H. R.; Seymour, P. A.; Heym, J. H.; Ewing, F. E.; Newman, M. E.; Schmidt, A. W.; Furman, J. S.; Vincent, L. A.; Maloney, P. R.; Robinson, G. L.; Reynolds, L. S.; Vinick, F. J. J. Med. Chem. 1991, 34, 1860.
17. 4-Bromophenethyl alcohol and 4-benzylpiperazine were obtained from the Aldrich Chemical Company.
18. Emonds-Alt, X.; Goulaouic, P.; Proietto, V.; van Broeck, D. European Patent, 0 474 561 A1, 1991.
19. Elion, G. B.; Furman, P. A.; Fyfe, J. A.; De Miranda, P.; Beauchamp, L.; Schaeffer, H. J. Proc. Natl. Acad. Sci. U.S.A. 1977, 74, 5716. Schaeffer, H. J.; Beauchamp, L.; De Miranda, P.; Elion, G. B.; Bauer, D. J.; Collins, P. Nature 1978, 272, 583.
20. Elion, G. B.; Furman, P. A.; Fyfe, J. A.; De Miranda, P.; Beauchamp, L.; Schaeffer, H. J. Proc. Natl. Acad. Sci. U.S.A. 1977, 74, 5716. Schaeffer, H. J.; Beauchamp, L.; De Miranda, P.; Elion, G. B.; Bauer, D. J.; Collins, P. Nature 1978, 272, 583.
21. Bergstrom, L.; Beaujouan, L. C.; Torrens, Y.; Saffroy, M.; Glowinski, J.; Lavielle, S.; Chassaing, G.; Marquet, A.; D'Orleans-Juste, P.; Dion, S. Mol. Pharmacol. 1987, 32, 764.