Structure optimization of a leukotriene D4 antagonist by combinatorial chemistry in solution

Bioorganic and Medicinal Chemistry

Volumn 5, Issue 3, 1997, Pages 493-496

  Maehr, Hubert ^a   Yang, Roxana ^a  

^a HOFFMANN LA ROCHE INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CINALUKAST; LEUKOTRIENE D4; LEUKOTRIENE RECEPTOR BLOCKING AGENT;

ANIMAL TISSUE; ARTICLE; BIOASSAY; BRONCHOSPASM; CONTROLLED STUDY; DRUG DESIGN; DRUG SYNTHESIS; GUINEA PIG; IN VITRO STUDY; NONHUMAN; STRUCTURE ACTIVITY RELATION; TRACHEA;

ANIMALS; ANTI-ASTHMATIC AGENTS; CHEMISTRY, PHARMACEUTICAL; GUINEA PIGS; LEUKOTRIENE D4; MUSCLE CONTRACTION; MUSCLE, SMOOTH; SOLUTIONS; THIAZOLES;

EID: 0031106241     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(96)00278-7     Document Type: Article

References (7)

1. 1. Field, G.; Veremeulen, J.; Zally, W. US Patent 5,001,140, March 19, 1991.
2. 2. O'Donnell, M.; Crowley, H. J.; Yaremko, B.; O'Neill, N.; Welton, A. F. J. Pharmacol. Exp. Ther. 1991, 259, 751.
3. 3. Maehr, H.; Yang, R. Tetrahedron Lett. 1996, 31, 5445.
4. 4. Furka, A.; Sebestyén, F.; Asgedom, M.; Dibó, G. Int. J. Peptide Prot. Res. 1991, 31, 487.
5. k).
6. 6. Although the coupling reactions obscure and alter the identity of the building blocks, the formalism A + B → AB, and AB + C → ABC is maintained for the sake of simplicity.
7. 1) would have to be confirmed by complementary methods.