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243-250 Soluble tumor necrosis factor (sTNF) receptors: A possible prognostic marker for bone marrow transplantation-related complications Reuven Or, 1 Alexander Kalinkovich, 2 Amnon Nagler, 1 Ziva Weisman, 2 Elizabeth Naparstek, 1 Lola Weiss 1 and Talia Hahn 3 1 Department of Bone Marrow Transplantation and Cancer Immunobiology Research Laboratory, Hadassah University Hospital, Jerusalem, Israel; 2R Ben-Ari Institute of Clinical Immunology and 3Pediatric Research Institute, Kaplan Hospital, Rehovot, Israel Reuven Or, MD, Department of Bone Marrow Transplantation, Hadassah University Hospital, Jerusalem 91120, Israel (Fax +972 2 6422731). Involvement of tumor necrosis factor (TNF) in bone marrow transplantation (BMT)-associated complications has been documented. Biological response to TNF requires interaction with specific cell membrane receptors. Extracellular domains of these receptors are released into body fluids as soluble molecules, and participate in the bioactivity of TNF. Serum levels of p55 and p75 soluble tumor necrosis factor receptors (sTNFR) were determined in 34 patients with different diseases who underwent BMT. Sequential studies initiated 10 days before BMT and continued up to 110 days post-transplantation showed that p55 and p75 sTNFR levels were elevated significantly in patients who subsequently developed major transplantrelated complications (TRC). Moreover, both sTNFR levels were increased 2- to 3-fold over control values during postBMT febrile periods in those patients who at a later stage suffered major TRC. These results indicate that the serum level of sTNFR may be used as a prognostic marker for major TRC in BMT. Key words: Soluble tumor necrosis factor receptors; bone marrow transplantation © 1996 Martin Dunitz Ltd
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