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Current Opinion in Immunology
Volumn 5, Issue 5, 1993, Pages 794-799
Cytokine dysregulation as a mechanism of graft versus host disease
Author keywords

[No Author keywords available]
Indexed keywords

ALLOANTIGEN; CYTOKINE;
EID: 0027451923     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/0952-7915(93)90139-J     Document Type: Article
Times cited : (205)
References (36)
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    • Cytokine Dysregulation and Acute Graft-Versus-Host Disease
    • of outstanding interest, A concise review that synthesizes much of the current experimental data into a conceptual framework in which cytokines are incorporated into an integral pathophysiology of acute GVHD.
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    • Antin1    Ferrara2
  • 3
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    • Viral Infections and Graft-vs.-Host Disease
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    • IL-1 Receptor Antagonist and IL-1-β Production in Human Monocytes are Regulated Differently
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    • Arend1    Smith2    Janson3    Josun4
  • 8
    • 0026660658 scopus 로고
    • The Role of Cytokines in Graft-Versus-Host Reactions and Disease
    • of special interest, A comprehensive review of cytokine production in experimental GVHD model systems and proposals of cytokine circuits.
    • (1992) Bone Marrow Trans plant , vol.10 , pp. 1-14
    • Jadus1    Wepsic2
  • 9
    • 0026457877 scopus 로고
    • Host-Specific Interleukin-2-Secreting Donor T-Cell Precursors as Predictors of Acute Graft-Versus-Host Disease in Bone Marrow Transplantation Between HLA-Identical Siblings
    • of outstanding interest, A demonstration that the number of donor T cells that secrete IL-2 in response to host antigens will accurately predict the development of GVHD after HLA-identical sibling BMT.
    • (1992) N Engl J Med , vol.327 , pp. 1613-1617
    • Theobald1    Nierle2    Bunjes3    Arnold4    Heimpel5
  • 10
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    • Frequency of Anti-Recipient Alloreactive Helper T-Cell Precursors in Donor Blood and Graft-Versus-Host Disease After HLA-Identical Sibling Bone-Marrow Transplantation
    • of outstanding interest, Another demonstration that the pHTL frequency predicts the development of acute GVHD using a simplified LDA technique.
    • (1993) Lancet , vol.341 , pp. 203-205
    • Schwarer1    Jiang2    Brookes3    Barrett4    Batchelor5    Goldman6    Lechler7
  • 11
    • 0027476056 scopus 로고
    • Quantitative Assessment of Posttransplant Host-Specific Interleukin-2-Secreting T-Helper Cell Precursors in Patients With and Without Acute Graft-Versus-Host Disease After Allogeneic HLA-Identical Sibling Bone Marrow Transplantation
    • (1993) Blood , vol.81 , pp. 841-848
    • Nierle1    Bunjes2    Arnold3    Heimpel4    Theobald5
  • 12
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    • Kinetics of T Cell Activation in Acute and Chronic Forms of Graft Versus Host Disease
    • (1991) J Immunol , vol.146 , pp. 2603-2609
    • Via1
  • 13
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    • In Vitro Administratration of Interleukin 2 Plus T Cell-Depleted Syngeneic Marrow Prevents Graft-Versus-Host Disease Mortality and Permits Alloengraftment
    • (1990) J Exp Med , vol.171 , pp. 645-658
    • Sykes1    Romick2    Hoyles3    Sachs4
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    • Antibodies to IFN-γ Prevent Immunological Mediated Intestinal Damage in Murine Graft-Versus-Host Reactions
    • (1989) Immunology , vol.68 , pp. 18-24
    • Mowat1
  • 19
    • 0026635596 scopus 로고
    • Enumeration of Lymphokine mRNA-Containing Cells In Vivo in a Murine Graft-Versus-Host Reaction Using the PCR
    • of special interest, Combination of PCR technique and LDA shows dramatic increases in cytokine-secreting cells that are further increased after in vitro stimulation.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 5276-5280
    • Troutt1    Kelso2
  • 20
    • 0027452843 scopus 로고
    • Differential Cytokine Expression in Acute and Chronic Murine Graft-Versus-Host Disease
    • (1993) Eur J Immunol , vol.23 , pp. 333-337
    • Allen1    Staley2    Sidman3
  • 22
    • 0026571951 scopus 로고
    • Effects of in Vivo Administration of Interferon (IFN)-γ, Anti-IFN-γ, or Anti-Interleukin-4 Monoclonal Antibodies in Chronic Autoimmune Graft-Versus-Host Disease
    • of special interest, IL-4 is induced in this model of chronic GVHD and anti-IL-4 reduces mortality and kidney pathology associated with the disease.
    • (1992) Clin Immunol Immunopathol , vol.63 , pp. 66-73
    • Umland1    Razac2    Nahrebne3    Seymour4
  • 24
    • 0023620524 scopus 로고
    • Tumor Necrosis Factor/Cachectin is an Effector of Skin and Gut Lesions of the Acute Phase of Graft-Versus-Host Disease
    • (1987) J Exp Med , vol.166 , pp. 1280-1289
    • Piguet1    Grau2    Allet3    Vassalli4
  • 25
    • 0026573134 scopus 로고
    • Macrophage Priming and Lipopolysaccharide-Triggered Release of Tumor Necrosis Factor a During Graft-Versus-Host Disease
    • of outstanding interest, Macrophages from mice with GVHD are primed to secrete TNF-α in response to small doses of LPS. Small amounts of LPS cause death in animals with GVHD but not in controls, and death can be abrogated through the use of an antibody against TNF-α.
    • (1992) J Exp Med , vol.175 , pp. 405-413
    • Nestel1    Price2    Seemayer3    Lapp4
  • 26
    • 0027465343 scopus 로고
    • Role of Tumor Necrosis Factor a in Acute Graft-Versus-Host Disease and Complications Following Allogeneic Bone Marrow Transplantation
    • of outstanding interest, Elevated levels of serum TNF-α before BMT predict for severe complications and a high GVHD rate. A phase I/II trial using a monoclonal antibody against TNF-α to prevent GVHD looks promising.
    • (1993) Transplant Proc , vol.25 , pp. 1234-1236
    • Holler1    Kolb2    Hintermeier-Knabe3    Mittermuller4    Thierfelder5    Kaul6    Wilmanns7
  • 28
    • 0026754027 scopus 로고
    • Phase I–II Trial of a Monoclonal Anti-Tumor Necrosis Factor α Antibody for the Treatment of Refractory Severe Acute Graft-Versus-Host Disease
    • of special interest, A monoclonal antibody against TNF-α produced a large number of partial (i.e. significant, but incomplete or temporary) responses, particularly in gut GVHD.
    • (1992) Blood , vol.79 , pp. 3362-3368
    • Herve1    Flesch2    Tiberghien3    Wijdenes4    Racadot5    Bordigoni6    Plouvier7    Stephan8    Bourdeau9    Holler10
  • 31
    • 0027410737 scopus 로고
    • Cytokine Storm of Graft-Versus-Host Disease: a Critical Effector Role for Interleukin-1
    • of special interest, A quantitative PCR technique shows the level of IL-1α mRNA is increased during acute GVHD, whereas the level of IL-2 mRNA is not increased and the level of TNF-α mRNA increased much less.
    • (1993) Transplant Proc , vol.25 , pp. 1216-1217
    • Ferrara1    Abhyankar2    Gilliland3
  • 33
    • 0026649761 scopus 로고
    • Nitric Oxide Mediates Intestinal Pathology in Graft-vs-Host Disease
    • of special interest, An inhibitor of NO synthase reduces the gastrointestinal pathology of GVHD in a dose-dependent manner.
    • (1992) Eur J Immunol , vol.22 , pp. 2141-2145
    • Garside1    Hutton2    Severn3    Liew4    Mowat5
  • 35
    • 0026734847 scopus 로고
    • Stimulation of the Nitric Oxide Synthase Pathway in Human Hepotocytes by Cytokines and Endotoxin
    • of outstanding interest, IL-1, TNF-α, IFN-γ, and LPS all synergize to induce NO synthase in human hepatocytes, whereas none will do it alone.
    • (1992) J Exp Med , vol.176 , pp. 261-264
    • Nussler1    Di Silvio2    Billiar3    Hoffman4    Geller5    Selby6    Madariaga7    Simmons8

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.