Severity of alopecia areata is associated with a polymorphism in the interleukin-1 receptor antagonist gene

Journal of Investigative Dermatology

Volumn 103, Issue 3, 1994, Pages 387-390

  Tarlow, Joanna K ^b   Clay, Frances E ^b   Cork, Michael J ^b   Blakemore, Alexandra I F ^b   McDonagh, Andrew J G ^a   Messenger, Andrew G ^a   Duff, Gordon W ^b  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b NONE

Author keywords

cytokines gemotype severity factors

Indexed keywords

INTERLEUKIN 1 RECEPTOR;

ALOPECIA AREATA; ARTICLE; CONTROLLED STUDY; GENETIC POLYMORPHISM; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; PRIORITY JOURNAL;

ALLELES; ALOPECIA; CYTOKINES; GENES; HUMAN; POLYMORPHISM (GENETICS); RECEPTORS, INTERLEUKIN-1; REPETITIVE SEQUENCES, NUCLEIC ACID; SUPPORT, NON-U.S. GOV'T;

EID: 0028033166     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1111/1523-1747.ep12395398     Document Type: Article

References (29)

1. Gollnick H. Orfanos C.E. Alopecia areata: pathogenesis and clinical picture C.E. Orfanos R. Happle Hair and Hair Diseases 1990 Springer-Verlag Berlin 529 569
2. Scerri L. Pace J.L. Identical twins with identical alopecia areata J Am Acad Dermatol 27 1992 766 767
3. Hacham-Zadeh S. Brautbar C. Cohen C.A. Cohen T. HLA and alopecia areata in Jerusalem Tissue Antigens 18 1981 71 74
4. Deng J.H. HLA antigens in alopecia areata (translated title) Chung-Hua I Hseuh Tsa Chih 69 1989 44 45
5. Kianto U. Reunala T. Karvonen J. Lassus A. Tiilikainen A. HLA-B12 in alopecia areata Arch Dermatol 113 1977 1716
6. Zhang L. Weetman A.P. Friedman P.S. Oliveira D.B.G. HLA associations with alopecia areata Tissue Antigens 38 1991 89 91
7. Orecchia G. Belvedere M.C. Martinetti M. Capelli E. Rabbiosi G. Human leukocyte antigen region involvement in the genetic predisposition to alopecia areata Dermatologica 175 1987 10 14
8. Morling N. Frenz G. Fugger L. Georgsen J. Jakobsen B. Odum N. Svejgaard A. DNA polymorphism of HLA class II genes in alopecia areata Disease Markers 9 1991 35 42
9. Mitchell A.J. Balle M.R. Alopecia areata Dermatol Clin 5 1987 553 564
10. Friedmann P.S. Alopecia areata and autoimmunity Br J Dermatol 105 1981 153 157
11. Werth V.P. White W.L. Sanchez M.R. Franks A.G. Incidence of alopecia areata in lupus erythematosus Arch Dermatol 128 1992 368 371
12. Tan R.S. Ulcerative colitis, myasthenia gravis, atypical lichen planus, alopecia areata, vitiligo Proc R Soc Med 67 1974 195 196
13. Cunliffe W.J. Hall R. Newell D.J. Stevenson C.J. Vitiligo, thyroid disease and autoimmunity Br J Dermatol 80 1968 135 139
14. McDonagh A.J.G., Messenger A.G.: The aetiology and pathogenesis of alopecia areata. J Dermatol Sci. in press.
15. Messenger A.G. Blechen S.S. Expression of HLA-DR by anagen hair follicles in alopecia areata J Invest Dermatol 85 1985 569 572
16. Brocker E. Echternacht-Happle K. Hamm H. Happle R. Abnormal expression of class I and class II major histocompatibility antigens in alopecia areata: modulation by topical immunotherapy J Invest Dermatol 88 1987 564 568
17. McDonagh A.J.G. Snowden J.A. Stierle C. Elliott K. Messenger A.G. HLA and ICAM expression in alopecia areata in vivo and in vitro : the role of cytokines Br J Dermatol 129 1993 250 256
18. Kalish R.S. Johnson K.L. Hordinsky M.K. Alopecia areata: autoreactive T cells are variably enriched in scalp lesions relative to peripheral blood Arch Dermatol 128 1992 1072 1077
19. Kristensen M. Deleuran B. Eedy D.J. Feldmann M. Breathnach S.M. Brennan F.M. Distribution of interleukin-1α receptor antagonist protein (IRAP), interleukin 1 receptor, and interleukin 1α in normal and psoriatic skiu. Decreased expression of IRAP in psoriatic lesional epidermis Br J Dermatol 127 1992 305 311
20. Steinkasserer A. Spurr N.K. Cox S. Jeggo P. Sim R.B. The human IL-1 receptor antagonist gene (IL-1rn) maps to chromosome 2q14-q21 in the region of the IL-1α and IL-1β loci Genomics 13 1992 654 657
21. Nicklin M.J.H. Weith A. Duff G.W. A physical map of the region encompassing the human interleukin-1α, β and interleukin-1 receptor antagonist genes Genomics 19 1994 382 384
22. Eisenbirg S.P. Evans R.J. Arend W.P. Verderber E. Brewer M.T. Hannum C.H. Thompson R.C. Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist Nature 343 1990 341 346
23. Haskill J.S. Martin G. Van Le L. Morris J. Peace A. Bigler C.F. Jaffe G.J. Hammerberg C. Sporn S.A. Fong S. Arend W.P. Ralph P. cDNA cloning of an intracellular form of the human interleukin 1 receptor antagonist associated with epithelium Proc Natl Acad Sci USA 88 1991 3681 3685
24. Tarlow J.K. Blakemore A.I.F. Lennard A. Solan R. Hughes H.N. Steinkasserer A. Duff G.W. Polymorphism in human IL-1 receptor antagonist gene intron 2 is caused by variable numbers of an 86-bp tandem repeat Hum Genetics 91 1993 403 404
25. Mansfield J.C. Holden H. Tarlow J.K. di Giovine F.S. McDowell T.L. Wilson A.G. Holdsworth C.D. Duff G.W. Novel generic association between ulcerative colitis and the anti-inflammatory cytokine interleukin-1 receptor antagonist Gastroenterology 106 1994 637 642
26. Sambrook J. Fritsch E.F. Maniatis T. Molecular cloning: a laboratory manual 2nd ed 1989 Cold Spring Harbor Laboratory Press New York
27. Jinks D.C. Minter M. Tarver D.A. Vanderford M. Hejrmancik J.F. McCabe E.R.B. Molecular genetic diagnosis of sickle cell disease using dried blood specimens on blotters used for newborn screening Hum Gen 81 1989 363 366
28. Cooper K.D. Hammerberg C. Baadsgaard O. Elder J.T. Chan L.S. Sauder D.N. Voorhees J.J. Fisher G. IL-1 activity is reduced in psoriatic skin: decreased IL-1α and increased nonfunctional IL-1β J Immunol 144 1990 4593 4603
29. diGiovine F.S. Takhsh E. Blakemore A.I.F. Duff G.W. Single base polymorphism at – 511 in the human interleukin-1 beta gene Hum Mol Gen 6 1992 450