Novel genetic association between ulcerative colitis and the anti-inflammatory cytokine interleukin-1 receptor antagonist

Gastroenterology

Volumn 106, Issue 3, 1994, Pages 637-642

  Mansfield, John C ^a   Holden, Hazel ^a   Tarlow, Joanna K ^a   Di Giovine, Francesco S ^a   McDowell, Tarra L ^a   Wilson, Anthony G ^a   Holdsworth, C Derek ^b   Duff, Gordon W ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b ROYAL HALLAMSHIRE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT;

ADULT; ALLELE; ARTICLE; CONTROLLED STUDY; CROHN DISEASE; GENE LOCUS; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; HUMAN; HUMAN CELL; INFLAMMATION; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; ULCERATIVE COLITIS;

EID: 0028123647     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1016/0016-5085(94)90696-3     Document Type: Article

References (38)

1. Familial occurrence of inflammatory bowel disease
2. Ulcerative colitis and Crohn's disease in an unselected population of mono-zygotic and dizygotic twins. A study of heritability and the influence of smoking
3. Familial empiric risk estimates of inflammatory bowel disease in Ashkenazi Jews
4. An in-depth study of Crohn's disease in two French families
5. The genetics of Crohn's disease complex segregation analysis of a family study with 265 patients with Crohn's disease and 5387 relatives
6. Investigation of inheritance of chronic inflammatory bowel diseases by complex segregation analysis
7. Distinct associations of HLA class II genes with inflammatory bowel disease
8. Histocompatibility antigens in inflammatory bowel disease
9. HLA-A and -B antigens in inflammatory bowel disease
10. HLA class II genes in primary sclerosing cholangitis and chronic inflammatory bowel disease: no HLA-DRw52a association in Swedish patients with sclerosing cholangitis
11. Peptide regulatory factors in non-malignant disease
12. Cytokines and animal models: a combined path to inflammatory bowel disease pathogenesis
13. Interleukin-1 and interleukin-1 antagonism
14. The pathophysiology of tumour necrosis factors
15. Role of IL-1 in inflammatory bowel disease. Enhanced production during active disease
16. Interleukin 1 receptor antagonist
17. Interleukin-1 gene expression, synthesis, and effect of specific IL-1 receptor blockade in rabbit immune complex colitis
18. Recombinant interleukin-1 receptor antagonist blocks the proinflammatory activity of endogenous interleukin-1 in rabbit immune colitis
19. Interleukin-1 receptor antagonist circulates and is produced in the colon during rabbit immune colitis (abstr)
20. Elevated circulatory interleukin-1 receptor antagonist levels in serum of patients with active Crohn's disease and ulcerative colitis (abstr)
21. Role of interleukin-1 receptor antagonist in inflammatory bowel disease (IBD) (abstr)
22. Expression of interleukin-1 receptor antagonist: a novel immunoregulatory function of human intestinal epithelial cells (abstr)
23. Cytokine messenger RNA profiles in inflammatory bowel disease mucosa detected by polymerase chain reaction amplification
24. Endotoxin-stimulated human monocyte secretion of interleukin-1 tumor necrosis factor-alpha and prostaglandin-E2 shows stable inter-individual differences
25. In vitro production of IL-1α, IL-1β, TNF and IL-2 in healthy subjects: distribution, effect of cyclo-oxygenase inhibition and evidence of independent gene regulation
26. Genetic polymorphism of human interleukin-1 alpha
27. A polymorphism in the 5′ region of the interleukin-1 alpha gene is associated with juvenile chronic arthritis (JCA)
28. Single base polymorphism at -511 in the human interleukin-1β gene
29. Single base polymorphism in human tumour necrosis factor alpha gene detectable by NCOI restriction of PCR product
30. An allelic polymorphism within the human tumour necrosis factor alpha promoter region is strongly associated with HLA A1, B8, DR3 alleles
31. Polymorphism in human IL-1 receptor antagonist gene intron 2 is caused by variable numbers of an 86 base pair tandem repeat
32. Incidence and prevalence of ulcerative colitis and Crohn's disease in the county of Copenhagen, 1962 to 1978
33. Calculating confidence intervals for relative risks, odds ratios, and standardized ratios and rates
34. Prevention and treatment of experimental enterocolitis with a recombinant interleukin-1 receptor antagonist (abstr)
35. The role of interleukin-1 in disease
36. Monozygotic triplets with Crohn's disease of the colon
37. Neutrophil autoantibodies in ulcerative colitis: Familial aggregation and genetic heterogeneity (abstr)