메뉴 건너뛰기




Volumn 8, Issue 6, 1996, Pages 878-885

Virus-induced autoimmune disease

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; CYTOKINE; GAMMA INTERFERON;

EID: 0030459470     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(96)80019-7     Document Type: Article
Times cited : (119)

References (73)
  • 1
    • 0028124541 scopus 로고
    • Predictive medicine in autoimmune diseases: From the identification of genetic predisposition and environmental Influence to precocious immunotherapy
    • Bach J-F: Predictive medicine in autoimmune diseases: from the identification of genetic predisposition and environmental Influence to precocious immunotherapy. Clin Immunal Immunopath 1994, 72:156-161.
    • (1994) Clin Immunal Immunopath , vol.72 , pp. 156-161
    • Bach, J.-F.1
  • 2
    • 0028919313 scopus 로고
    • The basis of auto immunity: Part II, genetic predisposition
    • Theophilopoulos A: The basis of auto immunity: part II, genetic predisposition. Immunol Today 1995, 16:150-159.
    • (1995) Immunol Today , vol.16 , pp. 150-159
    • Theophilopoulos, A.1
  • 3
    • 0029954214 scopus 로고    scopus 로고
    • Insulin-dependent diabetes mellltus
    • Tisch R, McDevitl H: Insulin-dependent diabetes mellltus. Ce" 1996, 85:291-297.
    • (1996) Ce" , vol.85 , pp. 291-297
    • Tisch, R.1    McDevitl, H.2
  • 5
    • 0028067008 scopus 로고
    • The immune pathogenesis and regulation of T-cell mediated demyelinating diseases
    • Miller S, Karpus WJ : The immune pathogenesis and regulation of T-cell mediated demyelinating diseases. Immune! Today 1994, 15:358-362.
    • (1994) Immune! Today , vol.15 , pp. 358-362
    • Miller, S.1    Karpus, W.J.2
  • 9
    • 0027954364 scopus 로고
    • Antigen specific immunotherapy: Is it a real possibility to combat T-cell medicated autoimmunity?
    • Tisch R, McDevitt H: Antigen specific immunotherapy: is it a real possibility to combat T-cell medicated autoimmunity? Proc Natl Acad Sci USA 1994, 91:437-438.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 437-438
    • Tisch, R.1    McDevitt, H.2
  • 11
    • 0028333890 scopus 로고
    • Influence of infection on exacerbations of multiple sclerosis
    • Panitch HS: Influence of infection on exacerbations of multiple sclerosis. Ann Neurol 1994, 36:525-28.
    • (1994) Ann Neurol , vol.36 , pp. 525-528
    • Panitch, H.S.1
  • 12
    • 0027313558 scopus 로고
    • Viral infections trigger multiple sclerosis relapses: A prospective seroepidemiological study
    • Andersen O, Lygner PE, Bergstrom T, Andersson M, Varilne A: Viral infections trigger multiple sclerosis relapses: a prospective seroepidemiological study. J Neurol 1993, 240:417-422.
    • (1993) J Neurol , vol.240 , pp. 417-422
    • Andersen, O.1    Lygner, P.E.2    Bergstrom, T.3    Andersson, M.4    Varilne, A.5
  • 13
  • 14
    • 0025087209 scopus 로고
    • The role of genetic factors in development of IDDM
    • Green A: The role of genetic factors in development of IDDM. Curr Top Microbiol Immunol 1990, 164:3-17.
    • (1990) Curr Top Microbiol Immunol , vol.164 , pp. 3-17
    • Green, A.1
  • 15
    • 0029053199 scopus 로고
    • Diet, autoimmunity, and insulin-dependent diabetes mellitus: A controversy
    • Berdanier CD: Diet, autoimmunity, and insulin-dependent diabetes mellitus: a controversy. PSEBM 1995, 209:223-230.
    • (1995) PSEBM , vol.209 , pp. 223-230
    • Berdanier, C.D.1
  • 16
    • 0028791239 scopus 로고
    • Indications that maternal coxsackie B virus Infection during pregnancy is a risk factor for childhood-onset IDDM
    • Dahlquist G, Frisk G, Ivarsson SA, Svanberg L, Forsgren M, Diderholrn H: Indications that maternal coxsackie B virus Infection during pregnancy is a risk factor for childhood-onset IDDM. Diabetologis 1995, 38:1371-1373
    • (1995) Diabetologis , vol.38 , pp. 1371-1373
    • Dahlquist, G.1    Frisk, G.2    Ivarsson, S.A.3    Svanberg, L.4    Forsgren, M.5    Diderholrn, H.6
  • 19
    • 0024306288 scopus 로고
    • Molecular mimicry as a mechanism for the cause and as a probe uncovering etiologic agent(s) of autoimmune disease
    • Oldstane MBA: Molecular mimicry as a mechanism for the cause and as a probe uncovering etiologic agent(s) of autoimmune disease. Curr Top Microbiol Immunol 1989, 145:127-135.
    • (1989) Curr Top Microbiol Immunol , vol.145 , pp. 127-135
    • Oldstane, M.B.A.1
  • 21
    • 0030021722 scopus 로고    scopus 로고
    • Molecular mimicry in the MHC: Hidden clues to autoimmunity?
    • Baum H, Davies H, Peakman M: Molecular mimicry in the MHC: hidden clues to autoimmunity? Immunol Today 1996, 17:64-71. In this article, Baum et al. present a novel hypothesis for how molecular mimicry may be implicated in the development of autoimmune diseases. They postulate that self-MHC peptides presented in the thymus can determine which mimicking peptides elicit an immune response and in this way define the potential for autoimmune disease.
    • (1996) Immunol Today , vol.17 , pp. 64-71
    • Baum, H.1    Davies, H.2    Peakman, M.3
  • 22
    • 0023651203 scopus 로고
    • Molecular mimicry and autoimmune disease
    • Oldstone MBA: Molecular mimicry and autoimmune disease. Cell 1987, 50:819-820.
    • (1987) Cell , vol.50 , pp. 819-820
    • Oldstone, M.B.A.1
  • 23
    • 0028832352 scopus 로고
    • Frequency of molecular mimicry among T cell peptides as the basis for autoimmune disease and autoantibody induction
    • Garza KM, Tung KS: Frequency of molecular mimicry among T cell peptides as the basis for autoimmune disease and autoantibody induction. J Immunol 1995, 155:5444-5448.
    • (1995) J Immunol , vol.155 , pp. 5444-5448
    • Garza, K.M.1    Tung, K.S.2
  • 25
    • 0028926223 scopus 로고
    • Molecular mimicry in T-cell mediated autoimmunity: Viral peptides activate human T-cell clones specific for myelln basic protein
    • Wucherpfennig KW, Stromingsr JL: Molecular mimicry in T-cell mediated autoimmunity: Viral peptides activate human T-cell clones specific for myelln basic protein. Cell 1995, 80:695-705. This study shows that MBP-reactive T-cell clones isolated from patients with MS can cross-react with a variety of infectious agents, thus implicating 'molecular mimicry' directly in the pathogenesis of MS.
    • (1995) Cell , vol.80 , pp. 695-705
    • Wucherpfennig, K.W.1    Stromingsr, J.L.2
  • 26
    • 0029589932 scopus 로고
    • Structural basis for major histocompatibility complex (MHC)-linked susceptibility to autoimmunity: Charged residues of a single MHC binding pocket confer selective presentation of self-peptides in pemphigus vulgaris
    • Wucherpfennig KW, Yu B, Bhol K, Monos DS, Argyris E, Karr RW, Ahmed AR, Strominger JL: Structural basis for major histocompatibility complex (MHC)-linked susceptibility to autoimmunity: charged residues of a single MHC binding pocket confer selective presentation of self-peptides in pemphigus vulgaris. Pmc Natl Acad Sci USA 1995, 92:11935-11939.
    • (1995) Pmc Natl Acad Sci USA , vol.92 , pp. 11935-11939
    • Wucherpfennig, K.W.1    Yu, B.2    Bhol, K.3    Monos, D.S.4    Argyris, E.5    Karr, R.W.6    Ahmed, A.R.7    Strominger, J.L.8
  • 27
    • 0029007485 scopus 로고
    • Intrathymic and extrathymic deletion of T-cells
    • Sprent J, Webb S: Intrathymic and extrathymic deletion of T-cells. Curr Opin Immunol 1995, 7:196-205.
    • (1995) Curr Opin Immunol , vol.7 , pp. 196-205
    • Sprent, J.1    Webb, S.2
  • 30
    • 0027943292 scopus 로고
    • The T cell repertoire against cryptic self determinants and its involvement in autoimmunity and cancer
    • Moudgil KD, Sercarz EE: The T cell repertoire against cryptic self determinants and its involvement in autoimmunity and cancer. Clin Immunol Immunopath 1994, 74:283-289.
    • (1994) Clin Immunol Immunopath , vol.74 , pp. 283-289
    • Moudgil, K.D.1    Sercarz, E.E.2
  • 31
    • 0029029965 scopus 로고
    • Autoimmunity caused by ignorant CD8+ T cells is transient and depends on avidity
    • Heath WR, Karamalis F, Donoghue J, Miller JF: Autoimmunity caused by ignorant CD8+ T cells is transient and depends on avidity. J Immunol 1995, 155:2339-2349.
    • (1995) J Immunol , vol.155 , pp. 2339-2349
    • Heath, W.R.1    Karamalis, F.2    Donoghue, J.3    Miller, J.F.4
  • 32
    • 0025754853 scopus 로고
    • Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: Role of anti-self (virus) immune response
    • Oldstone MBA, Nerenberg M, Southern P, Price J, Lewicki H: Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: role of anti-self (virus) immune response. Cell 1991, 65:319-331.
    • (1991) Cell , vol.65 , pp. 319-331
    • Oldstone, M.B.A.1    Nerenberg, M.2    Southern, P.3    Price, J.4    Lewicki, H.5
  • 34
    • 0030036342 scopus 로고    scopus 로고
    • Induction of bystander T cell proliferation by viruses and type 1 Interferon in vivo
    • Tough DF, Borrow P, Sprent J: Induction of bystander T cell proliferation by viruses and type 1 Interferon in vivo. Science 1996, 272:1947-1950. This article demonstrates that viral infections and IFN secretion can lead to activation of memory cells, which could be implicated in the maintenance of memory as well as induction of autoreactive lymphocytes.
    • (1996) Science , vol.272 , pp. 1947-1950
    • Tough, D.F.1    Borrow, P.2    Sprent, J.3
  • 35
    • 0027505094 scopus 로고
    • Degenerate recognition of a dissimilar antigenic peptide by myelin basic protein-reactive T cells
    • Bhardwaj V, Kumar V, Geyser HM, Sercarz EE: Degenerate recognition of a dissimilar antigenic peptide by myelin basic protein-reactive T cells. J Immunol 1993, 151:5000-5010.
    • (1993) J Immunol , vol.151 , pp. 5000-5010
    • Bhardwaj, V.1    Kumar, V.2    Geyser, H.M.3    Sercarz, E.E.4
  • 36
    • 0028200629 scopus 로고
    • Cross-reactivities in memory CTL recognition of heterologous viruses
    • Selin L, Nahill S, Welsh R: Cross-reactivities in memory CTL recognition of heterologous viruses. J Exp Med 1994, 179:1933-1943.
    • (1994) J Exp Med , vol.179 , pp. 1933-1943
    • Selin, L.1    Nahill, S.2    Welsh, R.3
  • 37
    • 0028007192 scopus 로고
    • Cellular immunity to a determinant common to glutamate decarboxylase and coxsackie virus in Insulin-dependent diabetes
    • Atkinson MA, Bowman MA, Campbell L, Darrow BL, Kaufman DL, MacLaren NK: Cellular immunity to a determinant common to glutamate decarboxylase and coxsackie virus In Insulin-dependent diabetes. J Clin Invest 1994, 94:2125-2129.
    • (1994) J Clin Invest , vol.94 , pp. 2125-2129
    • Atkinson, M.A.1    Bowman, M.A.2    Campbell, L.3    Darrow, B.L.4    Kaufman, D.L.5    MacLaren, N.K.6
  • 40
    • 0002791124 scopus 로고
    • Virus induced diabetes meltitus
    • Edited by Notkins A, Oldstone M. New York: Springer Verlag
    • Notkins AL, Yoon JW Virus induced diabetes meltitus. In Concepts in Viral Pathogenesis. Edited by Notkins A, Oldstone M. New York: Springer Verlag; 1984:241-247.
    • (1984) Concepts in Viral Pathogenesis , pp. 241-247
    • Notkins, A.L.1    Yoon, J.W.2
  • 42
    • 33646319678 scopus 로고
    • The pathology of multiple sclerosis
    • Sorbel RA: The pathology of multiple sclerosis. J Virol 1995, 13:1-21.
    • (1995) J Virol , vol.13 , pp. 1-21
    • Sorbel, R.A.1
  • 43
    • 0028861222 scopus 로고
    • What is the pathogenesis of human T-cell lymphotropic virus type l-associated myelopathy/tropical spastic peraparesis?
    • Hollsberg P, Hafler DA: What is the pathogenesis of human T-cell lymphotropic virus type l-associated myelopathy/tropical spastic peraparesis? Ann Neurol 1995, 37:143-145.
    • (1995) Ann Neurol , vol.37 , pp. 143-145
    • Hollsberg, P.1    Hafler, D.A.2
  • 45
    • 0029877249 scopus 로고    scopus 로고
    • Prevalence of hepatitis C virus infection in Hashimoto's thyroiditis
    • Wagner B, Vierhapper H, Holmann H: Prevalence of hepatitis C virus infection In Hashimoto's thyroiditis. BMJ 1996, 312:640-641.
    • (1996) BMJ , vol.312 , pp. 640-641
    • Wagner, B.1    Vierhapper, H.2    Holmann, H.3
  • 46
    • 0026530150 scopus 로고
    • Mouse cytomegalovirus infection induces antibodies which crossreact with virus and cardiac myosin: A model for the study of molecular mimicry in the pathogenesis of viral myocarditis
    • Lawson CM, O'Donoghue HL, Reed WD; Mouse cytomegalovirus infection induces antibodies which crossreact with virus and cardiac myosin: a model for the study of molecular mimicry in the pathogenesis of viral myocarditis. Immunology 1992, 75:513-519.
    • (1992) Immunology , vol.75 , pp. 513-519
    • Lawson, C.M.1    O'Donoghue, H.L.2    Reed, W.D.3
  • 48
    • 0011319499 scopus 로고
    • T cells cross-reactive to myelin basic protein and human respiratory coronavirus 229E in multiple sclerosis patients
    • Talbot JP, Paquette JS, Ouallet F, Antel JP: T cells cross-reactive to myelin basic protein and human respiratory coronavirus 229E in multiple sclerosis patients. Neurology 1995,45:1383-1384.
    • (1995) Neurology , vol.45 , pp. 1383-1384
    • Talbot, J.P.1    Paquette, J.S.2    Ouallet, F.3    Antel, J.P.4
  • 49
    • 0030030561 scopus 로고    scopus 로고
    • Myelin basic protein and human coronavirus 229E cross-reactive T cells in multiple sclerosis
    • Talbot JP, Paquette JS, Ciurli C, Ante! JP, Quellet F: Myelin basic protein and human coronavirus 229E cross-reactive T cells in multiple sclerosis. Ann Neurol 1996, 39:233-240.
    • (1996) Ann Neurol , vol.39 , pp. 233-240
    • Talbot, J.P.1    Paquette, J.S.2    Ciurli, C.3    Ante, J.P.4    Quellet, F.5
  • 50
    • 0028877432 scopus 로고
    • Discriminated selection among viral peptides with the appropriate anchor residues: Implications for the size of the cytotoxic T-lymphocyte repertoire and control of viral infection
    • Oldstone MBA, Lewicki H, Borrow P, Hjdrisier D, Gairin JE: Discriminated selection among viral peptides with the appropriate anchor residues: implications for the size of the cytotoxic T-lymphocyte repertoire and control of viral infection. J Virol 1995, 69:7423-7429.
    • (1995) J Virol , vol.69 , pp. 7423-7429
    • Oldstone, M.B.A.1    Lewicki, H.2    Borrow, P.3    Hjdrisier, D.4    Gairin, J.E.5
  • 51
    • 0029973138 scopus 로고    scopus 로고
    • b molecules are restricted by dominant negative elements at peptide non-anchor residues
    • b molecules are restricted by dominant negative elements at peptide non-anchor residues. J Biol Chem 1996, 271:17829-17836. This study shows that, although there exists a large variety of viral peptides with the correct MHC binding motif, only very few can be presented by APCs. This is a consequence of the influence of nonanchoring residues.
    • (1996) J Biol Chem , vol.271 , pp. 17829-17836
    • Hudrisier, D.1    Mazarguil, H.2    Laval, F.3    Oldstone, M.B.A.4    Gairin, J.E.5
  • 53
    • 0027468174 scopus 로고
    • Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity
    • Goverman J, Woods A, Larson L, Weiner LP, Hood L, Zaller DM: Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity. Cell 1993, 72:551-560
    • (1993) Cell , vol.72 , pp. 551-560
    • Goverman, J.1    Woods, A.2    Larson, L.3    Weiner, L.P.4    Hood, L.5    Zaller, D.M.6
  • 54
    • 0030210309 scopus 로고    scopus 로고
    • CDB+ T cell-mediated spontaneous diabetes in neonatal mice
    • Morgan D, Liblau R, Scott B, Fleck S, McOevitt HO, Sarfetnick N, Lo D, Sherman L: CDB+ T cell-mediated spontaneous diabetes in neonatal mice. J Immunol 1996, 157:978-984. The authors demonstrate that transgenic mice that express influenza hemaglutinin (HA) in their β-cells and are normally tolerant to the transgene, all develop spontaneous diabetes, when the number of autoreactive T cells is increased by mating these mice to TCR transgenic mice bearing a TCR specific for HA.
    • (1996) J Immunol , vol.157 , pp. 978-984
    • Morgan, D.1    Liblau, R.2    Scott, B.3    Fleck, S.4    McOevitt, H.O.5    Sarfetnick, N.6    Lo, D.7    Sherman, L.8
  • 55
    • 0028446546 scopus 로고
    • How virus induces a rapid or slow onset insulin-dependent diabetes mellitus in transgenic model
    • Von Herrath MG, Dockler J, Oldslone MBA: How virus induces a rapid or slow onset insulin-dependent diabetes mellitus in transgenic model. Immunity 1994, 1:231-242.
    • (1994) Immunity , vol.1 , pp. 231-242
    • Von Herrath, M.G.1    Dockler, J.2    Oldslone, M.B.A.3
  • 56
    • 0029942839 scopus 로고    scopus 로고
    • Development of in su lit s without diabetes in transgenic mice lacking petforin-dependent cytotoxicity
    • Kagi D, Odermall B, Ohashi PS, Zirikarnagel RM, Hengartner H: Development of in su lit s without diabetes in transgenic mice lacking petforin-dependent cytotoxicity. J Exp Med 1996, 183:2143-2150.
    • (1996) J Exp Med , vol.183 , pp. 2143-2150
    • Kagi, D.1    Odermall, B.2    Ohashi, P.S.3    Zirikarnagel, R.M.4    Hengartner, H.5
  • 57
    • 0028080014 scopus 로고
    • Thymic selection and adaptability of cytotoxic T lymphocyte responses in transgenic mice expressing a viral protein in the thymus
    • Vor Herrath MG, Dockter J, Nerenberg M, Gairin JE, Oldstone MBA: Thymic selection and adaptability of cytotoxic T lymphocyte responses in transgenic mice expressing a viral protein in the thymus. J Bip Med 1994, 180:1901-1910.
    • (1994) J Bip Med , vol.180 , pp. 1901-1910
    • Vor Herrath, M.G.1    Dockter, J.2    Nerenberg, M.3    Gairin, J.E.4    Oldstone, M.B.A.5
  • 58
    • 0028844073 scopus 로고
    • An essential role for type 1 Interferon-/ in terminating persistent viral infection
    • Tishon A. Lewicki H, Rail G, Von Herrath MG, Oldstone MBA: An essential role for type 1 Interferon-/ in terminating persistent viral infection. WrcWogy 1995, 212:244-250.
    • (1995) WrcWogy , vol.212 , pp. 244-250
    • Tishon, A.1    Lewicki, H.2    Rail, G.3    Von Herrath, M.G.4    Oldstone, M.B.A.5
  • 59
    • 0027971622 scopus 로고
    • + cytotoxic T-cell responses during chronic viral infection
    • + cytotoxic T-cell responses during chronic viral infection. J Virol 1994, 66:8056-8063.
    • (1994) J Virol , vol.66 , pp. 8056-8063
    • Matloubian, M.1    Concepcion, R.J.2    Ahmed, R.3
  • 60
    • 0030053663 scopus 로고    scopus 로고
    • CD4-deficient mice have reduced levels of memory cytotoxic T lymphocytes after immunization and show diminished resistance to subsequent virus challenge
    • Von Herrath MG, Yokoyama M, Dockter J, Oldstone MBA, Whitton JL : CD4-deficient mice have reduced levels of memory cytotoxic T lymphocytes after immunization and show diminished resistance to subsequent virus challenge. J Virol 1996, 70:1072-1079.
    • (1996) J Virol , vol.70 , pp. 1072-1079
    • Von Herrath, M.G.1    Yokoyama, M.2    Dockter, J.3    Oldstone, M.B.A.4    Whitton, J.L.5
  • 61
    • 0029551987 scopus 로고
    • Coexpression of B7.1 and viral (self) transgenes in pancreatic β-cells can break peripheral ignorance and lead to spontaneous autoimmune diabetes
    • Von Herrath MG, Guerder S, Lewicki H, Flavell R, Oldslone MBA: Coexpression of B7.1 and viral (self) transgenes in pancreatic β-cells can break peripheral ignorance and lead to spontaneous autoimmune diabetes. Immunity 1995, 3:717-738. This article provides evidence from tne RIP-LCMV model for the regulatory role of cytokines in the pathogenesis of IDDM. Furthermore, trie correlation between numbers of autoreactive lymphocytes and ths incidence of virusinduced IDDM is demonstrated.
    • (1995) Immunity , vol.3 , pp. 717-738
    • Von Herrath, M.G.1    Guerder, S.2    Lewicki, H.3    Flavell, R.4    Oldslone, M.B.A.5
  • 63
    • 0028365499 scopus 로고
    • Costimulator B7-1 confers antigen-presenting-cell function to parenchymal tissue and in conjunction with tumor necrosis factor a leads to autoimmunity in transgenic mice
    • Guerder S, Picarella DE, Linsley PS, Flavell RA: Costimulator B7-1 confers antigen-presenting-cell function to parenchymal tissue and in conjunction with tumor necrosis factor a leads to autoimmunity in transgenic mice. Proc Natl Acad Sci USA 1994, 91:5138-5142.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 5138-5142
    • Guerder, S.1    Picarella, D.E.2    Linsley, P.S.3    Flavell, R.A.4
  • 65
  • 66
    • 0028842108 scopus 로고
    • Sensitization to self antigens by in situ expression of interferon-y
    • Lee MS, Von Herrath M, Reiser H, Oldstone MBA, Sarvetnick N: Sensitization to self antigens by in situ expression of interferon-y. J Clin fa/asf 1995, 95:486-492. This article shows that local inflammation induced by a cytokine such as interferon-y can lead to the spontaneous activation of autoreactive lymphocytes and autoimmune disease (IDDM).
    • (1995) J Clin Fa/asf , vol.95 , pp. 486-492
    • Lee, M.S.1    Von Herrath, M.2    Reiser, H.3    Oldstone, M.B.A.4    Sarvetnick, N.5
  • 67
    • 0028878129 scopus 로고
    • Focal expression of IL-2 does not break unresponsiveness to 'self (viral) antigen expressed in β-cells but enhances development of autoimmune disease (diabetes) after initiation of an antiself immune response
    • Von Herrath M, Allison J, Miller JFAP, Oldstone MBA: Focal expression of IL-2 does not break unresponsiveness to 'self (viral) antigen expressed in β-cells but enhances development of autoimmune disease (diabetes) after initiation of an antiself immune response. J Clin Invest 1995, 95:477-485.
    • (1995) J Clin Invest , vol.95 , pp. 477-485
    • Von Herrath, M.1    Allison, J.2    Miller, J.F.A.P.3    Oldstone, M.B.A.4
  • 69
    • 0011267947 scopus 로고    scopus 로고
    • Pancreatic expression of IL-4 abrogates insulitis and diabetes in NOD mice
    • in press
    • Mueller RT, Sarvetnick N: Pancreatic expression of IL-4 abrogates insulitis and diabetes in NOD mice. J Exp Med 1996, in press. This is the first demonstration that by using localized cytokine expression autoreactivity can be diverted and autoimmunity prevented.
    • (1996) J Exp Med
    • Mueller, R.T.1    Sarvetnick, N.2
  • 71
    • 0027158798 scopus 로고
    • Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells
    • Moskophidis D, Lechner F, Pircher H, Zinkernagel RM: Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells. Nature 1993, 362:758-761.
    • (1993) Nature , vol.362 , pp. 758-761
    • Moskophidis, D.1    Lechner, F.2    Pircher, H.3    Zinkernagel, R.M.4
  • 73
    • 33847488082 scopus 로고    scopus 로고
    • Peterson PA: Inhibition of MHC class I antigen presentation by viral proteins
    • in press
    • Fruh K, Kwangseog A. Peterson PA: Inhibition of MHC class I antigen presentation by viral proteins. Mol Med 1996, in press.
    • (1996) Mol Med
    • Fruh, K.1    Kwangseog, A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.