ATP-sensitive K+ Channels in the Regulation of Feeding Behavior: A Hypothesis

Nutritional Neuroscience

Volumn 2, Issue 4, 1999, Pages 209-225

  Roane, David S ^a   Bounds, Jeffrey K ^a  

^a UNIVERSITY OF LOUISIANA AT MONROE   (United States)

Author keywords

CNS; Feeding behavior; Glucostatic; Kir6.x; Metabolism; Potassium channel; Sulfonylurca; SUR

Indexed keywords

EID: 0012637559     PISSN: 1028415X     EISSN: None     Source Type: Journal    
DOI: 10.1080/1028415X.1999.11747278     Document Type: Article

References (113)

1. + channel in the beta-cell? Peptides 10(2): 453-457.
2. + channels. Science 247(4944): 852-854.
3. + channel opener, potentiated morphine analgesia. Masui 45(11): 1342-1346.
4. + channels. Pflugers Archiv 415: 479-483.
5. + channels. British Journal of Pharmacology 101(3): 531-540.
6. Babenko, A.P., Aguilar-Bryan, L. and Bryan, J. (1998) A view of SUR/KIR6.X, KATP channels. Annual Reviews of Physiology 60: 667-687.
7. Baile, C.A., McLaughlin, C.L. and Della-Fera, M.A. (1986) Role of cholecystokinin and opioid peptides in control of food intake. Physiological Reviews 66(1): 172-234.
8. Bartfai, T., Hoklelt, T. and Langel, U. (1993) Galanin - a neuroendocrine peptide. Critical Reviews in Neurobiology 7(3/4): 229-274.
9. Bodnar, R.J. (1991) Roles of opioid receptor subtypes in rats' feeding behavior. Appetite 17: 239.
10. Bodnar, R.J., Kelly, K.K. and Glusman, M. (1979) 2-Deoxy-d-glucose analgesia: influences of opiate and non-opiate factors. Pharmacology Biochemistry and Behavior 11(3): 297-301.
11. Bounds, J.K. and Roane, D.S. (1999) The effects of centrally administered glibenclamide, tolbutamide and diazoxide on feeding behavior. Nutritional Neuroscience (in press).
12. Broekkamp, C. and van Rossum, J.M. (1972) Clonidine induced intrahypothalamic stimulation of eating in rats. Psychopharmacologia 25(2): 162-168.
13. Chang, C.H., Chey, W.Y., Coy, D.H. and Chang, T.M. (1995) Galanin inhibits cholecystokinin secretion in STC-1 cells. Biochemical and Biophysical Research Communications 216(1): 20-25.
14. Charles, M.A., Morange, P., Eschwege, E., Andre, P., Vague, P. and Juhan-Vague, I. (1998) Effect of weight change and metformin on fibrinolysis and a the von willebrand factor in obese nondiabetic subjects: the BIGPRO1 study. Biguanuides and the prevention of the risk of obesity. Diabetes Care 21(11): 1967-1972.
15. Clement 4th, J.P., Kunjilwar, K., Gonzalez, G., Schwanstecher, M., Panten, U., Aguilar-Bryan, L. and Bryan, J. (1997) Association and stoichiometry of K(ATP) channel subunits. Neuron 18(5): 827-838.
16. Danguir, J. (1988) Food intake in rats is increased by intracerebroventricular infusion of the somatostatin analogue SMS 201-995 and is decreased by somatostatin antiserum. Peptides 9(1): 211-213.
17. + channels that are blocked by hypoglycemia-inducing sulfonylureas in insulin-secreting cells are activated by galanin, a hyperglycemia-inducing hormone. Proceedings of the National Academy of Sciences of the United States of America 85(4): 1312-1316.
18. + channels inhibit the regulatory effects of somatostatin and GH-releasing factor on growth hormone secretion. Biochemical and Biophysical Research Communications 187(2): 1007-1014.
19. Doring, H., Schwarzer, K., Nuesslein-Hildesheim, B. and Schmidt, I. (1998) Leptin selectively increases energy expenditure of food-restricted lean mice. International Journal of Obesity and Related Disorders 22(2): 83-88.
20. + channels in insulin-secreting cells via a pertussis toxin-sensitive G-protein. EMBO Journal 8(2): 413-420.
21. During, M.J., Leone, P., Davis, K.E., Kerr, D. and Sherwin, R.S. (1995) Glucose modulates rat substantia nigra GABA release in vivo via ATP-sensitive potassium channels. Journals of Clinical Investigation 95(5): 2403-2408.
22. Faggioni, R., Fanruzzi, G., Fuller, J., Dinarello, C.A., Feingold, K.R. and Grunfeld, C (1998) IL-1 beta mediates leptin induction during inflammation. American Journal of Physiology 274(1 Pt 2): R204-R208.
23. Fantus, I.G. and Brosscau, R. (1986) Mechanism of action of metformin: insulin receptor and postreceptor effects in vitro and in vivo. Journal of Clinical Endocrinology and Metabolism 63(4): 898-905.
24. Fehmann, H.C., Peiser, C., Bode, H.P., Stamm, M., Staats, P., Hedetoft, C., Lang, R.E. and Goke, B. (1997) Leptin: a potent inhibitor of insulin secretion. Peptides 18(8): 1267-1273.
25. Feifel, D. and Vaccarino, V.J. (1990) Central somatostatin: a re-examination of its effects on feeding. Brain Research 535(2): 189-194.
26. Fery, F., Plat, L. and Balasse, E.O. (1997) Effects of metformin on the pathways of glucose utilization after oral glucose in non-insulin dependent diabetes mellitus patients. Metabolism 46(2): 227-233.
27. Finta, E.P., Harms, L., Sevcik, J., Fischer, H.-D. and Illes, P. (1993) Effects of potassium channel openers and their antagonists on rat locus coeruoeus neurones. British Journal of Pharmacology 109(2): 308-315.
28. + channels in insulinoma cells via a G-protein. FEBS Letters 242(1): 94-96.
29. Friedman, M.I., Tordoff, M.G. and Ramirez, I. (1986) Integrated metabolic control of food intake. Brain Research Bulletin 17(6): 855-859.
30. Friedman, J.M. (1998) Leptin, leptin receptors, and the control of body weight. Nutrition Reviews 56(2 Pt 2): S38-S46.
31. George, A.V. and Augusti, K.T. (1976) Effects of long-term feeding of glibenclamide on normal rats. Experientia 32(7): 846-847.
32. Gimenez-Gallego, G., Rodkey, J., Bennett, C., Rios-Candelore, M., DiSalvo, J. and Thomas, K. (1985) Brian-derived acidic fibroblast growth factor complete amino acid sequence and homologies. Science 230(4732): 1385-1388.
33. Haffner, S.M., Hanefeld, M., Fischer, S., Fücker, K. and Leonhardt, W. (1997) Glibenclamide, but not acarbose, increases leptin concentration parallel to changes in insulin in subjects with NIDDM. Diabetes Care 20(9): 1430-1434.
34. Hanai, K., Oomura, Y., Kai, Y., Nishikawa, K., Shimizu, N., Morita, H. and Plata-Salaman, C.R. (1989) Central action of acidic fibroblast growth factor in feeding regulation. American Journal of Physiology 256(1 Pt 2): R217-R223.
35. Harvey, J., McKenna, F., Herson, P.S., Spanswick, D. and Ashford, M.L. (1997) Leptin activates ATP-sensitive potassium channels in the rat insulin-secreting cell line, CR1-G1. Journal of Physiology (London) 504(3): 527-535.
36. Hellman, B., Idahl, L.A., Tjalve, H., Danielsson, A. and Lernmark, A. (1969) Beobachtungen sum wirkungsmechanismus des hypoglykamisch wirksamen sulfonylharnstoff praparates HB 419. Arzneimittelforschung 19(8): Suppl.: 1472-1476.
37. Heron, L., Virsovy, A., Peyrollier, K., Cribble, F.M., LeCam, A., Ashcroft, F.M. and Bataille, D. (1998) Human alpha-endosulfine, a possible regulator of sulfonylurea-sensitive KATP channel: molecular cloning, expression and biological properties. Proceedings of the National Academy of Sciences of the United States of America 95(14): 8387-8391.
38. + channels. Neuron 16(5): 1011-1017.
39. Ishiyama, T., Dohi, S. and Iida, H. (1998) The vascular effects of topical and intravenous alpha2-adrenoceptor agonist clonidine on canine pial microcirculation. Anesthesia and Analgesia 86(4): 766-772.
40. + channel. Journal of Biological Chemistry 271(40): 24321-24324.
41. Jackson, W.F. (1993) Arteriol tone is determined by activity of ATP-sensitive potassium channels. American Journal of Physiology 265: H1797-H1803.
42. Josephkutty, S. and Potter, J.M. (1990) Comparison of tolbulamide and metformin I elderly diabetic patients. Diabetic Medicine 7(6): 510-514.
43. Kellner, H.M., Christ, O., Rupp, W. and Heptner, W. (1969) Resorption, veteilung und ausscheidung nach gabe von 14C-markiertem HB 419 an kaninchen, ratten and hunde. Arzneimittelforschung 19(8): Suppl.: 1388-1400.
44. + channels in pancreatic beta-cells. Diabetes 46(6): 1087-1093.
45. Klasing, K.C. (1988) Nutritional aspects of leukocytic cytokines. Journal of Nutrition 118(12): 1436-1446.
46. Klip, A. and Leiter, L.A. (1990) Cellular mechanism of action of metformin. Diabetes Care 13(6): 696-704.
47. Kotz, C.M., Briggs, J.E., Pomonis, J.D., Grace, M.K., Levine, A.S. and Billington, C.J. (1998) Neural site of leptin influence on neuropeptide Y signaling pathways altering feeding and uncoupling protein. American Journal of Physiology 275(2 Pt 2): R478-R484.
48. Kristensen, P., Judge, M.E., Thim, L., Ribel, U., Christjansen, K.N., Wulff, B.S., Clausen, J.T., Jensen, P.B., Madsen, O.D., Vrang, N., Larsen, P.J. and Hastrup, S. (1998) Hypothalamic CART is a new anorecric peptide regulated by leptin. Nature 393(6680): 72-76.
49. Lee, A. and Morley, J.E. (1998) Metformin decreases food consumption and induces weight loss in subjects with obesity with type II non-insulin-dependent diabetes. Obesity Research 6(1): 47-53.
50. Lee, K., Dixon, A.K., Richardson, P.J. and Pinnock, R.D. (1999) Glucose-receptive neurons in the rat ventromedial hypothalamus express KATP channels composed of Kir 6.1 and SUR1 subunits. Journal of Physiology (London) 515(Pt 2): 439-452.
51. Levin, B.E., Triscari, J. and Sullivan, A.C. (1983) Relationship between sympathetic activity and diet-induced obesity in two rat strains. American Journal of Physiology 243(3): R364-R371.
52. Levin, B.E., Triscari, J. and Sullivan, A.C. (1986) Metabolic features of diet-induced obesity without hyperphagia in young rats. American Journal of Physiology 251(3): R433-R440.
53. Levin, B.E., Brown, K.L., Dunn-Meynell, A.A. (1996) Differential effects of diet and obesity on high and low affinity sulfonylurea binding sites in the rat brain. Brain Research 739(1-2): 293-300.
54. Levin, B.E., Dunn-Meynell, A.A., Balkan, B. and Keesey, R.E. (1997) Selective breeding for diet-induced obesity and resistance in Sprague-Dawley rats. American Journal of Physiology 273(2 Pt 2): R725-R730.
55. Levine, A.S., Morley, J.E., Gosnell, B.A., Billington, C.J. and Bartness, T.J. (1985) Opioids and consummatory behavior. Brain Research Bulletin 14(6): 663-672.
56. Levine, A.S. and Atkinson, R.L. (1987) Opioids in the regulation of food intake and energy expenditure. Federation Proceedings 46(1): 159-162.
57. Lohrke, G.B., Derno, M., Matthes, H.D., Scholze, H. and Jentsch, W. (1997a) Involvement of alpha 2-adrenergic activities in thermogenic responses to feeding, feeding level, and ambient temperature. Zeitschrift fur Ernahrungswissenschaft 36(4): 290-293.
58. Lohrke, G.B., Derno, M., Kruger, B., Viergutz, T., Matthes, H. and Jentsch, W. (1997b) Expression of sulphonylurea receptors in bovine monocytes from animals with a different metabolic rates. Pflugers Archiv 434(6): 712-720.
59. + channels. Pharmacology 46(2): 109-114.
60. Mangel, A.W., Prpic, V., Scot, L. and Liddle, R.A. (1994) Inhibitors of ATP-sensitive potassium channels stimulate intestinal cholecystokinin secretion. Peptides 15(8): 1565-1566.
61. Martz, A., Jo, I. and Jung, C.Y. (1989) Sulfonylurea binding to adipocyte membranes and potentiation of insulin-stimulated hexose transport. The Journal of Biological Chemistry 264(23): 13672-13678.
62. Mayer, J. and Marshall, N.B. (1954) Specificity of gold thioglucose for ventromedial hypothalamic lesions and hyperphagia. Nature 178: 1399-1400.
63. Menzies, D.G., Campbell, I.W., McBain, A. and Brown, I.R. (1989) Metformin efficacy and tolerance in obese noninsulin dependent diabetics: a comparison of two dosage schedules. Current Medical Research and Opinion 11(5): 273-278.
64. Micromedex Healthcare Series (1999) Micromedex Incorporated, Engelwood, Colorado.
65. Mueller, W.M., Gregoire, F.M., Stanhope, K.L., Mobbs, C.V., Mizuno, T.M., Warden, C.H., Stern, J.S. and Havel, P.J. (1998) Evidence that glucose metabolism regulates leptin secretion from cultured rat adipocytes. Endocrinology 139(2): 551-558.
66. Mizuno, T.M., Kleopoulos, S.P., Bergen, H.T., Roberts, J.L., Priest, C.A. and Mobbs, C.V. (1998) Hypothalamic proopinomelanocortin mRNA is reduced by fasting and in ob/ ob and db/db mice, but is stimulated by leptin. Diabetes 47(2): 294-297.
67. Narita, M., Suzuki, T., Misawa, M. and Nagase, H. (1992a) Role of central ATP-sensitive potassium channels in the hyperthermic effect of morphine in mice. Psychopharmacology (Berl) 109(1-2): 239-240.
68. Narita, M., Suzuki, T., Misawa, M., Nagase, H., Nabeshima, A., Ashizawa, T., Ozawa, H., Saito, T. and Takahata, N. (1992b) Role of central ATP-sensitive potassium channels in the analgesic effect and spinal noradrenaline turnover-enhancing effect of intracerebroventricularly injected morphine in mice. Brain Research 596(1-2): 209-214.
69. Narita, M., Takamori, K., Kawashima, N., Funada, M., Kamei, J., Suzuki, T., Misawa, M., Nagase, H. (1993) Activation of central ATP-sensitive potassium channels produces the antinociception and spinal noradrenaline turnover-enhancing effect in mice. Psychopharmacology (Berl) 113(1): 11-14.
70. Ocana, M., Del Pozo, E., Barrios, M., Robles, L.I. and Baeyens, J.M. (1990) An ATP-dependcnt potassium channel blocker antagonizes morphine analgesia. European Journal of Pharmacology 186: 377-378.
71. + channel blockers on antinociception induced by alpha 2-adrenoceptor, GABAB and kappa-opioid receptor agonists. British Journal of Pharmacology 110(3): 1049-1054.
72. Ocana, M., Barrios, M. and Baeyens, J.M. (1996) Cromakalim differentially enhances antinociception induced by agonists of alpha(2)adrenoceptors, gamma-aminobutyric acid(B), mu and kappa opioid receptors. Journal of Pharmacology and Experimental Therapeutics 276(3): 1136-1142.
73. Oomura, Y., Ono, T., Ooyama, H. and Wayner, M.J. (1969) Glucose and osmosensitive neurones of the rat hypothalamus. Nature 222: 282-284.
74. Oomura, Y., Sasaki, K., Suzuki, K., Muto, T., Li, A., Ogita, Z., Hanai, K., Tooyama, I., Kimura, H. and Yanaihara, N. (1992) A new glucosensor and its physiological significance. American Journal of Clinical Nutrition 55: 278S-282S.
75. Paolisso, G., Amato, L., Eccellente, R., Gambardella, A., Tagliamonte, M.R., Varricchio, G., Carrella, C., Giugliano, D. and D'Onofrio, F. (1998) Effect of metformin on food intake in obese subjects. European Journal of Clinical Investigation 28(6): 441-446.
76. Petit, P. and Loubatieres-Mariani, M.M. (1992) Potassium channels of the insulin-secreting B cell. Fundamentals in Clinical Pharmacology 6(3): 123-134.
77. Pieribone, V.A., Xu, Z.Q., Zhang, X., Grillner, S., Bartfai, T. and Hokfelt, T. (1995) Galanin induces a hyperpolarization of norepinephrine-containing locus coeruleus neurons in the brainstem slice. Neuroscience 64(4): 861-874.
78. Quintela, M., Senaris, R., Heiman, M.L., Casanueva, F.F. and Dieguez, C. (1997) Leptin inhibits in vitro hypothalamic somatostatin secretion and somatostatin mRNA levels. Endocrinology 138(12): 5641-5644.
79. + channels. Brain Research 650(1): 146-148.
80. Raffa, R.B. and Martinez, R.P. (1995) The 'glibenclamide-shift' of centrally-acting antinociceptive agents in mice. Brain Research 677(2): 277-282.
81. Rajan, A.S., Luo, Z.T., Kahn, B.B., Comstock, J.P., Cushman, S.W. and Boyd 3rd, A.E. (1994) Do adipocytes contain high affinity sulfonylurea receptors. Endocrinology 134(3): 1581-1588.
82. Riccio, A., Del Prato, S., Vigili de Kreutzenberg, S. and Tiengo, A. (1991) Glucose and lipid metabolism in noninsulin dependent diabetes. Effect of metformin. Diabetes and Metabolism 17(1 Pt 2): 180-184.
83. Roane, D.S. and Porter, J.R. (1986) Nociception and opioid-induced analgesia in lean (Fa/-) and obese (fa/fa) Zucker rats. Physiology and Behavior 38(2): 215-218.
84. Roane, D.S. and Boyd, N.E. (1993) Reduction of food intake and morphine analgesia by central glybenclamide. Pharmacology Biochemistry and Behavior 46(1): 205-207.
85. + channel in mouse pancreatic B cells. Nature 349(6304): 77-79.
86. Rouru, J., Huupponen, R., Pesonen, U. and Koulu, M. (1992) Subchronic treatment with metformin produces anorectic effect and reduces hyperinsulinemia in genetically obese Zucker rats. Life Sciences 50(23): 1813-1820.
87. + channel in the ventromedial hypothalamic neuclcus. Brain Research 778(1): 107-119.
88. Rydberg, T., Jonsson, A. and Melander, A. (1995) Comparison of the kinetics of glyburide and its active metabolites in humans. Journal of Clinical Pharmacy and Therapeutics 20(5): 283-295.
89. Sahu, A. (1998) Evidence suggesting that galanin (GAL), melanin-concentrating hormone (MCH), neurotensin (NT), proopiomelanocortin (POMC) and neuropeptide Y (NPY) are targets of leptin signaling in the hypothalamus. Endocrinology 139(2): 795-798.
90. Sambol, N.C., Chiang, J., C'Conner, M., Liu, C.Y., Lin, E.T., Goodman, A.M., Benet, L.Z. and Karam, J.H. (1996) Pharmacokinetics and pharmacodynamics of metformin is healthy subjects and patients with noninsulin-dependent diabetes mellitus. Journal of Clinical Pharmacology 36(11): 1012-1021.
91. Sarraf, P., Frederich, R.C., Turner, E.M., Ma, G., Jaskowiak, N.T., Rivet 3rd, D.J., Flier, J.S., Lowell, B.B., Fraker, D.L. and Alexander, H.R. (1997) Multiple cytokines and acute inflammation raise mouse leptin levels: potential role in inflammatory anorexia. Journal of Experimental Medicine 185(1): 171-175.
92. Schultz, J.E., Hsu, A.K. and Gross, G.J. (1996) Morphine mimics the cardioprotective effect of ischemic preconditioning via a glibenclamide-sensitive mechanism in the rat heart. Circulation Research 78(6): 1100-1104.
93. + channels. American Journal of Physiology 269: H997-H1002.
94. Shibasaki, T., Kim, Y.S., Yamauchi, N., Masuda, A., Imaki, T., Hotta, M., Demura, H., Wakabayashi, I., Ling, N. and Shizume, K. (1988) Antagonistic effect of somatostatin on corticotropin-releasing factor-induced anorexia in the rat. Life Sciences 42(3): 329-334.
95. Silva, E.G., Feres, T., Vianna, L.M., Okuyama, P. and Paiva, T.B. (1996) Dual effect of clonidine on mesentery artery adrenoceptors: agonistic (alpha 2) and antagonistic (alpha 1). Journal of Pharmacology and Experimental Therapeutics 277(2): 872-876.
96. Singh, I.S., Chatterjee, T.K. and Ghosh, J.J. (1983) Modification of morphine antinociceptive response by blood glucose status: possible involvement of cellular energetics. European Journal of Pharmacology 90(4): 437-439.
97. Song, H. and Tyml, K. (1993) Evidence for sensing and integration of biological signals by the capillary network. American Journal of Physiology 265: H1235-1242.
98. Spanswick, D., Smith, M.A., Groppi, V.E., Logan, S.D. and Ashford, M.L. (1997) Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels. Nature 390(6659): 521-525.
99. Schwarte, M.W., Seeley, R.J., Campfield, L.A., Burn, P. and Baskin, D.G. (1996) Identification of targets of leptin action in rat hypothalamus. Journal of Clinical Investigation 98(5): 1101-1106.
100. Takata, Y., Shimada, F. and Kato, H. (1992) Differential effects of diazoxide, cromakalim and pinacidil on adrenergic neurotransmission and 86Rb+ efflux in rat brain cortical slices. Journal of Pharmacology and Experimental Therapeutics 263(3): 1293-1301.
101. + channels mediate alpha 2D-adrenergic receptor contraction of arteriolar smooth muscle and reversal of contraction by hypoxia. Circulation Research 76(1): 53-63.
102. Tokuyama, Y., Fan, Z., Furuta, H., Makielski, J.C., Polonsky, K.S., Bell, G.I. and Yano, H. (1996) Rat inwardly rectifying potassium channel Kir6.2: cloning electrophysiological characterization, and decreased expression in pancreatic islets of male Zucker diabetic fatty rats. Biochemical and Biophysical Research Communications 220(3): 532-538.
103. Tooyama, I., Hara, Y., Yashuhara, O., Oomura, Y., Sasaki, K., Muto, T., Suzuki, K., Hanai, K. and Kimure, H. (1991) Production of antisera to acidic fibroblast growth factor and their application to immunohistochemical study in the rat brain. Neuroscience 40(3): 769-779.
104. Triggle, D.J. (1990) Potassium channels and potassium channel blockcrs. Neurotransmissions 6(3): 1-5.
105. Tsujii, S. and Bray, G.A. (1990) Effects of glucose, 2-deoxyglucose, phlorizin, and insulin on food intake of lean and fatty rats. American Journal of Physiology 258: E476-E481.
106. United Kingdom Prospective Diabetes Study Group (1995) United Kingdom Prospective Diabetes Study (UKPDS). 13: Relative efficacy of randomly allocated diet, sulphonylurea, insulin, or metformin in patients with newly diagnosed non-insulin dependent diabetes followed for three years. British Medical Journal 310(6972): 83-88.
107. Vijayan, E. and McCann, S.M. (1977) Suppression of feeding and drinking activity in rats following intraventricular injection of thyrotropin releasing hormone (TRH). Endocrinology 100(6): 1727-1730.
108. Virsolvy-Vergine, A., Leray, H., Kuroki, S., Lupo, B., Dufour, M. and Bataille, D. (1992) Endosulfine, an endogenous peptidic ligand for the sulfonylurea receptor: purification and partial characterization from ovine brain. Proceedings of the National Academy of Sciences of the United States of America 89(14): 6629-6633.
109. Widen, E.I., Eriksson, J.G. and Groop, L.C. (1992) Metfromin normalizes nonoidative glucose metabolism in insulin-resistant normoglycemic first degree relatives of patients with NIDDM. Diabetes 41(3): 354-358.
110. Wiesenfetd-Hallin, Z., Xu, X.J., Villar, M.J. and Hokfelt, T. (1990) Intrathecal galanin potentiates the spinal analgesic effect of morphine: electrophysiological and behavioural studies. Neuroscience Letters 109(1-2): 217-221.
111. Wild, K.D., Vanderah, T., Mosberg, H.I. and Porreca, F. (1991) Opioid delta receptor subtypes associated with different potassium channels. European Journal of Pharmacology 193: 135-136.
112. Woods, S.C., Chavez, M., Park, C.R., Riedy, C., Kaiyala, K., Richardson, R.D., Figlewicz, D.P., Schwartz, M.W., Porte Jr., D. and Sceley, R.J. (1996) The evaluation of insulin as a metabolic signal influencing behavior via the brian. Neuroscience and Biobehavioral Reviews 20(1): 139-144.
113. Xu, J.Z., Tanemoto, M. and Hebert, S.C. (1998) Cloning, localization and characterization of a new isoform of sulfonylurea receptor (SUR2k) from rat kidney. Abstracts of the Southeastern Pharmacology Society, Abstract T4.