Recent advances in epithelial sodium-coupled phosphate transport

Current Opinion in Nephrology and Hypertension

Volumn 8, Issue 4, 1999, Pages 407-414

  Tenenhouse, Harriet S ^a,b  

^a RESEARCH INSTITUTE OF THE MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^b MONTREAL CHILDREN S HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATE; SODIUM;

APICAL MEMBRANE; BONE METABOLISM; GENE DISRUPTION; GENE TARGETING; HUMAN; INTESTINE ABSORPTION; KIDNEY EPITHELIUM; MUTAGENESIS; NONHUMAN; PHOSPHATE BALANCE; PHOSPHATE TRANSPORT; PRIORITY JOURNAL; REVIEW; SODIUM TRANSPORT;

ANIMALS; BONE AND BONES; CARRIER PROTEINS; HUMANS; MICE; MICE, KNOCKOUT; MUTAGENESIS, SITE-DIRECTED; PHOSPHATES; SODIUM; SODIUM-PHOSPHATE COTRANSPORTER PROTEINS; SODIUM-PHOSPHATE COTRANSPORTER PROTEINS, TYPE I; SODIUM-PHOSPHATE COTRANSPORTER PROTEINS, TYPE II; SODIUM-PHOSPHATE COTRANSPORTER PROTEINS, TYPE III; SYMPORTERS;

EID: 0033458865     PISSN: 10624821     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041552-199907000-00003     Document Type: Review

References (80)

1. Mizgala CL, Quamme GA. Renal handling of phosphate. Physiol Rev 1985; 65;431-466.
2. Gmaj P, Murer H. Cellular mechanisms of inorganic phosphate transport in kidney. Physiol Rev 1986; 66:36-70.
3. Wehrle JP, Pedersen PL. Phosphate transport processes in eukaryotic cells. J Membr Biol 1989; 111:199-213.
4. Murer H, Werner A, Reshkin S, Wuarin R, Biber J. Cellular mechanisms in proximal tubular reabsorption of inorganic phosphate. Am J Physiol 1991; 260:C885-C899.
5. Berndt TJ, Knox FG. Renal regulation of phosphate excretion. In: The kidney, physiology and pathophysiology. Seldin DW, Giebisch G (editors). New York: Raven Press; 1992. pp. 2511-2532.
6. Murer H. Cellular mechanisms in proximal tubular Pi reabsorption. Some answers and more questions. J Am Soc Nephrol 1992; 2:1649-1665.
7. Murer H, Biber J. Renal sodium-phosphate cotransport. Curr Opin Nephrol Hypertens 1994; 3:504-510.
8. Murer H, Biber J. Molecular mechanisms of renal apical Na phosphate cotransport. Annu Rev Physiol 1996; 58:607-618.
9. Levi M, Kempson SA, Lotscher M, Biber J, Murer H. Molecular regulation of renal phosphate transport. J Membr Biol 1996; 154:1-9.
10. Tenenhouse HS. Cellular and molecular mechanisms of renal phosphate transport. J Bone Miner Res 1997; 12:159-164.
11. Murer H, Biber J. A molecular view of proximal tubular inorganic phosphate (Pi) reabsorption and of its regulation. Pflügers Arch 1997; 433:379-389.
12. +-Pi cotransporter and the molecular mechanisms involved in its regulation by dietary Pi and PTH. A kinetic model of the Npt2 transporter is also presented.
13. Werner A, Moore ML, Mantei N, Biber J, Semenza G, Murer H. Cloning and expression of cDNA for a Na/Pi cotransport system of kidney cortex. Proc Natl Acad Sci U S A 1991; 88:9608-9612.
14. Chong SS, Kristjansson K, Zoghbi HY, Hughes MR. Molecular cloning of the cDNA encoding a human renal sodium phosphate transport protein and its assignment to chromosome 6p21.3-p23. Genomics 1993; 18:355-359.
15. Chong SS, Kozak CA, Liu L, Kristjansson K, Dunn ST, Bourdeau JE, Hughes MR. Cloning, genetic mapping, and expression analysis of a mouse renal sodium-dependent phosphate cotransporter. Am J Physiol 1995; 268:F1038-F1045.
16. Magagnin S, Werner A, Markovich D, Sorribas V, Stange G, Biber J, Murer H. Expression cloning of human and rat renal cortex Na/Pi cotransport. Proc Natl Acad Sci USA 1993; 90:5979-5983.
17. Sorribas V, Markovich D, Hayes G, Stange G, Forgo J, Biber J, Murer H. Cloning of a Na/Pi cotransporter from opossum kidney cells. J Biol Chem 1994; 269:6615-6621.
18. Werner A, Murer H, Kinne RKH. Cloning and expression of a renal Na-Pi cotransport system from flounder. Am J Physiol 1995; 267:F311-F317.
19. Verri T, Markovich D, Perego C, Norbis F, Stange G, Sorribas V, et al. Cloning of a rabbit renal Na-Pi cotransporter, which is regulated by dietary phosphate. Am J Physiol 1995; 268:F626-F633.
20. +/Pi) transporter in the control and hypophosphatemic mouse. FASEB J 1994; 8:862-868.
21. Hartmann CM, Wagner CA, Busch AE, Markovich D, Biber J, Lang F, Murer H. Transport characteristics of a murine renal Na/Pi-cotransporter. Pflügers Arch 1995; 430:830-836.
22. Helps C, Murer H, McGivan J. Cloning, sequence analysis and expression of the cDNA encoding a sodium-dependent phosphate transporter from the bovine renal epithelial cell line NBL-1. Eur J Biochem 1995; 228:927-930.
23. Kavanaugh MP, Miller DG, Zhang W, Law W, Kozak SL, Kabat D, Miller AD. Cell-surface receptors for gibbon ape leukemia virus and amphotropic murine retrovirus are inducible sodium-phosphate symporters. Proc Natl Acad Sci USA 1994; 91:7071-7075.
24. +-phosphate cotransporter genes, NPT1 and NPT2, in human and rabbit. Cytogenet Cell Genet 1996; 75:22-24.
25. +/phosphate cotransporter gene. Biochim Biophys Acta 1998; 1396:267-272. The features of the Npt1 promoter are described. In addition, Npt1 promoter activity is examined in transfected cells using Npt1 promoter-luciferase reporter gene constructs.
26. +-Pi cotransporter.
27. +/Pi cotransporter-1 gene expression. The roles of glucose and insulin. Am J Physiol 1996; 271:E1021-E1028.
28. +-dependent phosphate cotransporter from human kidney. cDNA cloning and functional expression. Biochem J 1995; 305:81-85.
29. Custer M, Meier F, Schlatter E, Greger R, Garcia-Perez A, Biber J, Murer H. Localization of NaPi-1, a Na-Pi-cotransporter, in rabbit kidney proximal tubules. I. mRNA-localization by RT-PCR. Pflügers Arch 1993; 424:203-209.
30. Biber J, Custer M, Werner A, Kaissling B, Murer H. Localization of NaPi-1, a Na/Pi cotransporter, in rabbit kidney proximal tubules. II. Localization by immunohistochemistry. Pflügers Arch 1993; 424:210-215.
31. Yabuuchi H, Tamai I, Morita K, Kouda T, Miyamoto K, Takeda E, Tsuji A. Hepatic sinusoidal membrane transport of anionic drugs mediated by anion transporter Npt1. J Pharmacol Exp Ther 1998; 286:1391-1396. Npt1 protein was localized to the hepatic sinusoidal membrane by immunocytochemistry. The study also demonstrates that Npt1 mediates the transport of organic anions, such as benzylpenicillin, in cRNA injected oocytes.
32. Busch AE, Schuster A, Waldegger S, Wagner CA, Zempel G, Broer S, et al. Expression of a renal type I sodium/phosphate transporter (NaPi-1) induces a conductance in Xenopus oocytes permeable for organic and inorganic anions. Proc Natl Acad Sci U S A 1996; 93:5347-5351.
33. +-Pi cotransport rather than function as a transporter itself.
34. +-phosphate cotransporter gene, Npt1, and construction of an Npt1 targeting vector [abstract]. J Bone Miner Res 1998; 23:S465.
35. Kos CH, Tihy F, Econs MJ, Murer H, Lemieux N, Tenenhouse HS. Localization of a renal sodium phosphate cotransporter gene to human chromosome 5q35. Genomics 1994; 19:176-177.
36. +-phosphate cotransporter genes (Npt2 and NPT2). Proc Natl Aced Sci U S A 1996; 93:7409-7414.
37. +/phosphate cotransporter. Biochem J 1997; 324:927-934.
38. Custer M, Lötscher M, Biber J, Murer H, Kaissling B. Expression of Na-Pi cotransport in rat kidney, localization by RT-PCR and immunohistochemistry. Am J Physiol 1994; 266:F767-F774.
39. +/Pi cotransport mediated by a transporter cloned from rat kidney and expressed in Xenopus oocytes. Proc Natl Acad Sci U S A 1994; 91:8205-8208.
40. +-Pi cotransporter, over a wide range of membrane potentials and substrate concentrations, is reported. From the data generated, the authors propose an ordered binding model for Npt2 in which sodium is the first and last substrate to bind the transporter.
41. 1 cells by transfection. Am J Physiol 1996; 270:F220-F228.
42. +-Pi cotransport in Npt2 cDNA-transfected human renal cells are described.
43. +-Pi cotransport in cRNA-injected oocytes. Although the data suggest that the isoforms function as dominant-negative inhibitors of Npt2, their precise role in the regulation of Npt2 in vivo remains to be elucidated.
44. Kempson SA, Lotscher M, Kaissling B, Biber J, Murer H, Levi M. Parathyroid hormone action on phosphate transporter mRNA and protein in rat renal proximal tubules. Am J Physiol 1995; 258:F784-F791.
45. Pfister MK, Ruf I, Stange G, Ziegler U, Lederer E, Biber J. Parathyroid hormone leads to the lysosomal degradation of the renal type II Na/Pi cotransporter. Proc Natl Acad Sci U S A 1998; 95:1909-1914. The authors demonstrate that PTH-stimulated endocytic retrieval of Npt2 protein from the renal brush border membrane is followed by proteolytic degradation of Npt2 protein in the late endosomal/lysosomal fraction of proximal tubular cells. These data suggest that internalized Npt2 protein is not recycled to the BBM.
46. Malstrom K, Murer H. Parathyroid hormone regulates phosphate transport in OK cells via an irreversible inactivation of a membrane protein. FEBS Lett 1987; 216:257-260.
47. Sorribas V, Markovich D, Verri T, Biber J, Murer H. Thyroid hormone stimulation of Na/Pi cotransport in opossum kidney cells. Pflügers Arch 1995; 431:266-271.
48. Caverzasio J, Bonjour J-P. Insulin-like growth factor I stimulates Na-dependent Pi transport in cultured kidney cells. Am J Physiol 1989; 257:F712-F717.
49. Levi M, Shayman JA, Abe A, Gross SK, McCluer RH, Biber J, et al. Dexamethasone modulates rat renal brush border membrane phosphate transporter mRNA and protein abundance and glycosphingolipid composition. J Clin Invest 1995; 96:207-216.
50. Arar M, Baum M, Biber J, Murer H, Levi M. Epidermal growth factor inhibits Na-Pi cotransport and mRNA in OK cells. Am J Physiol 1995; 268:F309-F314.
51. Hilfiker H, Hartmann CM, Stange G, Murer H. Characterization of the 5′-flanking region of OK cell type II Na-Pi cotransporter gene. Am J Physiol 1998; 274:F197-F204. The OK cell Npt2 promoter was characterized and promoter activity examined in OK cells transfected with Npt2 promoter-luciferase reporter gene constructs. The data suggest that post-transcriptional mechanisms are involved in the regulation of renal Npt2 gene expression.
52. 2D may be ascribed to increased Npt2 gene transcription.
53. Wagner GF, Vozzolo BL, Jaworski E, Haddad M, Kline RL, Olsen HS, et al. Human stanniocalcin inhibits renal phosphate excretion in the rat. J Bone Miner Res 1997; 12:165-171.
54. Ishibashi K, Miyamoto K, Taketani Y, Morita K, Takeda E, Sasaki S, Imai I. Molecular cloning of a second human stanniocalcin homologue (STC2). Biochem Biophys Res Commun 1998; 250:252-258. The cloning of a second human stanniocalcin cDNA is reported. In addition, the data suggest that stanniocalcin 2 inhibits Npt2 promoter activity.
55. Pfister MF, Hilfiker H, Forgo J, Lederer E, Biber J, Murer H. Cellular mechanisms involved in the acute adaptation of OK cell Na/Pi-cotransport to high- or low-Pi medium. Pflügers Arch 1998; 435:713-719. The authors show that both acute and chronic exposure of OK cells to low Pi elicits an increase in Npt2 protein but not Npt2 mRNA, and that exposure to high Pi leads to lysozomal degradation of internalized Npt2 protein.
56. Lotscher M, Kaissling B, Biber J, Murer H, Levi M. Role of microtubules in the rapid regulation of renal phosphate transport in response to acute alterations in dietary phosphate content. J Clin Invest 1997; 99:1302-1312.
57. 2D, hypercalciuria and hypoparathyroidism, features typical of patients with HHRH.
58. +-phosphate cotransport in mouse distal convoluted tubule cells. Evidence for Glvr-1 and Ram-1 gene expression. J Bone Miner Res 1998; 13:590-597. Evidence is presented for abundant Glvr-1 and Ram-1 mRNA expression in mouse distal convoluted tubule cells.
59. Boyer CJC, Baines AD, Beaulieu E, Beliveau R. Immunodetection of a type III sodium-dependent phosphate cotransporter in tissues and OK cells. Biochim Biophys Acta 1998; 1368:73-83. The immunodetection of Glvr-1 in a variety of murine tissues is described. In addition, the study demonstrates that low Pi has no effect on the abundance of Glvr-1 protein.
60. Custer M, Spindler B, Verrey F, Murer H, Biber J. Identification of a new gene product (diphor-1) regulated by dietary phosphate. Am J Physiol 1997; 273:F801-F806.
61. Norbis F, Boll M, Stange G, Markovich D, Verrey F, Biber J, Murer H. Identification of a cDNA/protein leading to an increased Pi-uptake in Xenopus laevis oocytes. J Membr Biol 1997; 156:19-24.
62. Rasmussen H, Tenenhouse HS. Mendelian hypophosphatemias. In: The metabolic and molecular basis of inherited disease, 7th ed. Scriver CR, Beaudet AL, Sly WS, Valle D (editors). New York: McGraw Hill Book Co.: 1995. pp. 3717-3745.
63. Econs MJ, McEnery PT, Lennon F, Speer MC. Autosomal dominant hypophosphatemic rickets is linked to chromosome 12p13. J Clin Invest 1997; 100:2653-2657. The gene responsible for ADHR was localized to human chromosome 12p13. This work represents the first step towards the identification of yet another gene that plays a role in the maintenance of Pi homeostasis.
64. +-phosphate cotransport in murine X-linked hypophosphatemic rickets. Molecular characterization. J Clin Invest 1994; 93:671-676.
65. +-phosphate cotransporter mRNA and protein. Effect of the Gy mutation and low phosphate diet. Pflügers Arch 1996; 431:936-941.
66. Beck L, Soumounou Y, Martel J, Krishnamurthy G, Gauthier C, Goodyer C, Tenenhouse HS. Pex/PEX tissue distribution and evidence for a deletion in the 3′ region of the Pex gene in X-linked hypophosphatemic mice. J Clin Invest 1997; 99:1200-1209.
67. Strom TM, Francis F, Lorenz B, Boeddrich A, Econs M, Lehrach H, Meitinger T. Pex gene deletions in Gy and Hyp mice provide mouse models for X-linked hypophosphatemia. Hum Mol Genet 1997; 6:165-171.
68. HYP Consortium. A gene (PEX) with homologies to endopeptidases is mutated in patients with X-linked hypophosphatemic rickets. Nat Genet 1995; 11:130-136.
69. Ruchon AF, Marcinkiewicz M, Siegfried G, Tenenhouse HS, DesGroseillers L, Crine P, Boileau G. Pex mRNA is localized in developing mouse osteoblasts and odontoblasts. J Histochem Cytochem 1998; 46:459-468. The authors demonstrate that Phex mRNA is expressed in osteoblasts and odontoblasts of day 15 mouse embryos and that the abundance of Phex mRNA decreases after birth.
70. Danisi G, Murer H. Inorganic phosphate absorption in small intestine. In: Handbook of physiology - the gastrointestinal system IV. Field M, Frizzel RA (editors). New York; Oxford University Press; 1991. pp. 323-336.
71. Cross HS, Debiec H, Peterlik M. Mechanism and regulation of intestinal phosphate absorption. Miner Electrolyte Metab 1990; 16:115-124.
72. 3 synthesis in rat kidney in vitro. J Biol Chem 1983; 258:1152-1155.
73. +-Pi cotransport decreases significantly during the first 7 days after birth.
74. +-Pi cotransporter gene (type IIb) that is expressed in the intestinal BBM, is homologous to Npt2 at the N-terminal but not the C-terminal end, and has the functional characteristics of an intestinal Pi transporter. The authors postulate that the type IIb transporter serves intestinal Pi absorption.
75. Caverzasio J, Bonjour J. Characteristics and regulation of Pi transport in osteogenic cells for bone metabolism. Kidney Int 1996; 49:975-980.
76. 2 or phorbol ester is inhibited by protein kinase C inhibitors and is not associated with changes in cell number or protein content.
77. Palmer G, Bonjour J-P, Caverzasio J. Expression of a newly identified phosphate transporter/retrovirus receptor in human SaOS-2 osteoblast-like cells and its regulation by insulin-like growth factor I. Endocrinology 1997; 138:5202-5209.
78. Palmer G, Zhao J, Bonjour J, Hofstetter W, Caverzasio J. In vivo expression of transcripts encoding the Glvr-1 phosphate transporter/retroviral receptor during bone development. Bone 1999; 24:1-7. The authors show, by in-situ hybridization, that Glvr-1 mRNA is expressed in hypertrophic chondrocytes, but not in osteoblasts, of developing embryonic murine endochondral bone. On the basis of these results, they suggest that Glvr-1 may play a role in bone matrix calcification.
79. Gupta A, Miyauchi A, Fujimori A, Hruska KA. Phosphate transport in osteoclasts. A functional and immunochemical characterization. Kidney Int 1996; 49:968-974.
80. Gupta A, Guo X, Alvarez UM, Hruska KA. Regulation of sodium-dependent phosphate transport in osteoclasts. J Clin Invest 1997; 100:538-549.