Engineering An Experimental Platform for High Throughput Reactivity Screening

JALA - Journal of the Association for Laboratory Automation

Volumn 6, Issue 6, 2001, Pages 99-106

  Kiser, Patrick F ^a   Collupy, Glenn C ^a   Eichenbaum, Gary M ^a   Rush, Chad ^a   Baumann, Stephan ^a   Kust, Mark P ^a   Greaves, Michael D ^a   Frederick, Erik D ^a   Soltmann, Bernd ^a   Vasina, Helen ^a   Orji, Charles ^a   Bienfiat, Bruno ^a   Brown, John D ^a   Davies, John ^a   Atkins, Marquitta ^a   Lee, Jeffrey R ^a   Labow, Eric ^a   Harp, Melissa ^a   Goodrich, Ann E ^a   Conyers, Hilton ^a   Geysen, H Mario ^a   more..

^a ChemCodes Inc   (United States)

Author keywords

Analytical constructs; Cheminformatics; High throughput synthesis; Quantitative mass spectroscopy; Reaction optimization

Indexed keywords

EID: 0011291985     PISSN: 15355535     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1535-5535(04)00172-8     Document Type: Article

References (13)

1. Szwartz, M. E. Analytical Techniques in Combinatorial Chemistry, Marcel Dekker, New York, 2000.
2. Everett, J. et al. The Application of Non-Combinatorial Chemistry to Lead Discovery, Drug Devel. Tech., 6, 15, 779, 2001.
3. Geysen, H. M. et al. Isotope or Mass Encoding of Combinatorial Libraries, Chem. Biol., 3, 8, 679-688, 1996.
4. Geysen, H. M., Kinder, D. S. & Wagner, Mass-based Encoding and Qualitative Analysis of Combinatorial Libraries, PCT International, 09737953 WO, 1997.
5. Carrasco, M. R., Fitzgerald, M. C., Oda, Y. & Kent, S. B. H. Direct Monitoring of Organic Reactions on Polymer Supports, Tetrahedron Lett., 38, 2407, 1997.
6. Murray, P. J. et al. Rapid Reaction Scanning of Solid Phase Chemistry Using Resins Incorporating Analytical Constructs, Tetrahedron Letters, 40, 5609, 1999.
7. Lorthioir, O. et al. Single Bead Characterization Using Analytical Constructs: Application to Quality Control of Libraries, Anal. Chem, 73, 5, 963, 2001.
8. Zaramella, A. et al. Dansyl and Dabsyl Analytical Constructs as Tools for the Accurate Estimation of Compounds in Solid-Phase Synthesis, J. Combi. Chem., 3410, 2001.
9. McKeown, S. C., Watson, S. P., Carr, R. A. & Marshall, P. A. Photolabile Carbamate based Dual Linker Analytical Construct For Facile Monitoring of Solid Phase Chemistry: TLC for Solid Phase?, Tetrahedron Lett., 40, 2407, 1999.
10. Williams, G. M. et al. Analysis of Solid Phase Reactions: Product Identification and Quantitation by Use of UV-Chromophore Containing Dual-Linker Analytical Constructs, Angew. Chem. Int. Ed., 39, 18, 3293, 2000.
11. Geysen, H. M. Patent Pending, results to be published else where.
12. Geysen, H. M., Nelson, J. C. & Buckner, Bead picking apparatus and method, US Patent, 6151973 2000).
13. Details to be published elsewhere.