The application of non-combinatorial chemistry to lead discovery

Drug Discovery Today

Volumn 6, Issue 15, 2001, Pages 779-785

  Everett, Jeremy ^a   Gardner, Mark ^a   Pullen, Frank ^a   Smith, Graham F ^a   Snarey, Mike ^a   Terrett, Nick ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID;

AUTOMATION; COMBINATORIAL CHEMISTRY; COMPUTER AIDED DESIGN; COMPUTER PROGRAM; COMPUTER SYSTEM; DATA BASE; DRUG INDUSTRY; INFORMATION SYSTEM; QUALITY CONTROL; REVIEW;

EID: 0035424914     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6446(01)01876-1     Document Type: Review

References (8)

1. RPR's approach to high-speed parallel synthesis for lead generation
2. Automated synthesis: New tools for the organic chemist
3. Comprehensive survey of combinatorial library synthesis: 1999
4. Successful implementation of automation in medicinal chemistry
5. Combinatorial synthesis - The design of compound libraries and their application to drug discovery
6. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
7. High-throughput purification of compound libraries
8. Evaluation of evaporative light-scattering detector for combinatorial library quantitation by reversed phase HPLC