A photolabile carbamate based dual linker analytical construct for facile monitoring of solid phase chemistry: 'TLC' for solid phase?

Tetrahedron Letters

Volumn 40, Issue 12, 1999, Pages 2407-2410

  McKeown, Stephen C ^a   Watson, Stephen P ^a   Carr, Robin A E ^a   Marshall, Peter ^b  

^a Physical Sciences Unit   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CARBAMIC ACID;

ARTICLE; DECOMPOSITION; INTERMETHOD COMPARISON; IONIZATION; MASS SPECTROMETRY; PHOTOCHEMISTRY; REACTION ANALYSIS; SOLID PHASE EXTRACTION; STRUCTURE ANALYSIS; THIN LAYER CHROMATOGRAPHY;

EID: 0033582970     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(99)00115-X     Document Type: Article

References (13)

1. 1 For reviews of solid phase organic synthesis see: Früchtel, J.S.; Jung, G. Angew. Chem. Int. Ed. Engl. 1996, 35, 17. Hermkens, P.H.H.; Ottenheijm, H.C.J.; Rees, D. Tetrahedron Report No. 394 Tetrahedron 1996, 52, 4527.
2. 1 For reviews of solid phase organic synthesis see: Früchtel, J.S.; Jung, G. Angew. Chem. Int. Ed. Engl. 1996, 35, 17. Hermkens, P.H.H.; Ottenheijm, H.C.J.; Rees, D. Tetrahedron Report No. 394 Tetrahedron 1996, 52, 4527.
3. 2 Czarnik, A. W. Anal. Chem. 1998, 70, 367A.
4. 3 Geyson, H.M.; Wagner, C.D.; Bodnar, W.M.; Markworth, C.J.; Parke, G.J.; Schoenen, F.J.; Wagner, D.S.; Kinder, D.S. Chem. Biol. 1996, 3, 679. Geyson also reported the analytical construct concept at the following meetings: LibraryTechnologies Conference, Washington DC, April 27-28,1998; 5th International Workshop on Molecular and Cell Biology -UNC, Chapel Hill, NC, Sept. 18-21, 1997. Geyson, M.; Schoenen, F.J. Manuscript in preparation.
5. 3 Geyson, H.M.; Wagner, C.D.; Bodnar, W.M.; Markworth, C.J.; Parke, G.J.; Schoenen, F.J.; Wagner, D.S.; Kinder, D.S.Chem. Biol. 1996, 3, 679. Geyson also reported the analytical construct concept at the following meetings: Library Technologies Conference, Washington DC, April 27-28,1998; 5th International Workshop on Molecular and Cell Biology -UNC, Chapel Hill, NC, Sept. 18-21, 1997. Geyson, M.; Schoenen, F.J. Manuscript in preparation.
6. 3 Geyson, H.M.; Wagner, C.D.; Bodnar, W.M.; Markworth, C.J.; Parke, G.J.; Schoenen, F.J.; Wagner, D.S.; Kinder, D.S.Chem. Biol. 1996, 3, 679. Geyson also reported the analytical construct concept at the following meetings: LibraryTechnologies Conference, Washington DC, April 27-28,1998; 5th International Workshop on Molecular and Cell Biology -UNC, Chapel Hill, NC, Sept. 18-21, 1997. Geyson, M.; Schoenen, F.J. Manuscript in preparation.
7. 3 Geyson, H.M.; Wagner, C.D.; Bodnar, W.M.; Markworth, C.J.; Parke, G.J.; Schoenen, F.J.; Wagner, D.S.; Kinder, D.S.Chem. Biol. 1996, 3, 679. Geyson also reported the analytical construct concept at the following meetings: LibraryTechnologies Conference, Washington DC, April 27-28,1998; 5th International Workshop on Molecular and Cell Biology -UNC, Chapel Hill, NC, Sept. 18-21, 1997. Geyson, M.; Schoenen, F.J. Manuscript in preparation.
8. 4 (a) Wagner D.S.; Shampine L.J.; Patel H.; Wagner C.D.; Wild J.J.; Geysen H.M., Proceedings of the 46th ASMS Conference on Mass Spectrometry and Allied Topics, 1029.
9. (b) Schoenen F.J.; Geysen H.M.; Bodnar W.M.; Craddock L.; Jeganathan I.; Kinder D.; Kinsey K.E.; Markworth J.A.; Nelson J.C.; Parke G.; Patel H.; Salovich J.M.; Shampine L.; Wagner C.D.; Wagner D.S.; Wild J.J.; Wilgus R.L. ibid. 1139.
10. 5 Carrasco, M.R.; Fitzgerald, M.C.; Oda, Y.; Kent, B.H.; Tetrahedron Lett 1997, 38, 6331.
11. 6 Holmes, C. P.; Jones, D.G. J. Org. Chem., 1995, 60, 2318.
12. 7 The MS analysis was performed on a Finnigan MAT LCQ Ion Trap Mass Spectrometer in positive electrospray mode.
13. 2 (or ca. 0.1mg resin in 50μl DMSO) for 30 min and the solution subjected to electrospray MS.