Interactive Effects of Neurochemicals on Ingestive Behavior

Nutritional Neuroscience

Volumn 3, Issue 3, 2000, Pages 161-172

  Roth, Jonathan D ^a   Rowland, Neil E ^a  

^a University of Florida ^*  (United States)

Author keywords

Feeding; Intake; Interaction; Neuropeptide; Neurotransmitter

Indexed keywords

EID: 0005681222     PISSN: 1028415X     EISSN: None     Source Type: Journal    
DOI: 10.1080/1028415X.2000.11747313     Document Type: Article

References (90)

1. Bai, F.L., Yamano, M., Shiotani, Y., Emson, P.C., Smith, A.D., Powell, J.F. and Tohyama, M. (1985) An arcuato-paraventricular and -dorsomedial hypothalamic neuropeptide-Y containing system which lacks noradrenaline in the rat. Brain Research, 331, 172-175.
2. Beck, B. and Richey, S. (1999) Hypothalamic hypocretin/orexin and neuropeptide Y: divergent interaction with energy depiction and leptin. Biochemical and Biophysical Research Communications, 258, 119-122.
3. Berntson, G.G. and Micco, D.J. (1976) Organization of brainstem behavioral systems. Brain Research Bulletin, 5, 471-483.
4. Blackburn, R.E., Demko, A.D., Hoffman, G.E., Stricker, E.M. and Verbalis, J.G. (1992a) Central oxytocin inhibition of angiotensin-induced salt appetite in rats. American Journal of Physiology, 263, R1347-R1353.
5. Blackburn, R.E., Stricker, E.M. and Verbalis, J.G. (1992b) Central oxytocin mediates inhibition of sodium appetite by naloxone in hypovolemic rats. Neuroendocrinology, 56, 255-263.
6. Blessing, W.W. (1997) The lower brainstem and bodily homeostasis (Oxford University Press), pp. 323-373.
7. Blomqvist, A.G. and Herzog, H. (1997) Y-receptor subtypes -how many more? Trends in Neuroscience, 20, 294-298.
8. Boston, B.A., Blaydon, K.M., Varnerin, J. and Cone, R.D. (1997) Independent and additive effects of central POMC and leptin pathways on murine obesity. Science, 278, 1641-1644.
9. Brady, L.S., Smith, M.A., Gold, P.W. and Herkenham, M. (1990) Altered expression of hypothalamic neuropeptide mRNAs in food-restricted and food-deprived rats. Neuroendocrinology, 52, 441-447.
10. Broberger, C., Johansen, J., Johansson, C., Schalling, M. and Hokfelt, T. (1998) The neuropeptide Y/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice. Proceedings of the National Academy of Sciences, 95, 15 043-15 048.
11. Brown, K.S., Gentry, R.M. and Rowland, N.E. (1998) Central injection of the α-melanocyte-stimulating hormone analog: effects on food intake and brain Fos. Regulatory Peptides, 78, 89-94.
12. Cheung, C.C., Clifton, D.K. and Steiner, R.A. (1997) Proopiomelanocortin neurons are direct targets for leptin in the hypothalamus. Endocrinology, 138, 4489-4492.
13. Chronwall, B.M., Dimaggio, D.A., Massari, V.J., Pickel, V.M., Ruggiero, D.A. and O'Donahue, T.L. (1985) The anatomy of neuropeptide Y-containing neurons in the rat brain. Neuroscience, 15, 1159-1181.
14. Clark, J.T., Kalra, P.S., Crowley, W.R. and Kalra, S.P. (1984) Neuropeptide Y and pancreatic polypeptide stimulates feeding behavior in rats. Endocrinology, 115, 427-429.
15. Cone, R.D., Lu, D., Koppula, S., Vage, D.I., Klungland, H., Boston, B., Chen, W., Orth, D.N., Pouton, C. and Kesterson, R.A. (1996) The melanocortin receptors: agonists, antagonists, and the hormonal control of pigmentation. Recent Progress in Hormone Research, 51, 287-316.
16. Contreras, R.J., Kosten, T. and Bird, E. (1984) Area postrema: part of an autonomie circuitry of caloric homeostasis. Fed. Proc., 43, 2966-2968.
17. Couceyro, P., Koylu, E.O. and Kuhar, M.J. (1997) Further studies on the anatomical distribution of CART by in situ hybridization. Journal of Chemical Neuroanatomy, 12, 229-241.
18. Date, U., Ueta, Y., Yamashita, H., Yamaguchi, H., Matsukara, S., Kangawa, K., Sakurai, T., Yanagisawa, M. and Nakazato, M. (1999) Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems. Proceedings of the National Academy of Sciences, 96, 748-753.
19. de Lecea, L., Kilduff, T.S., Peyron, C., Gao, G.B., Foye, P.E., Danielson Pe, Fukuhara, C., Battenberg, E.L.F., Gautvik, V.T., Bartlett II, F.S., Frankel, W.N., van den Pol, A.N., Bloom, F.E., Gautvik, K.M. and Sutcliffe, J.G. (1998) The hypocretins: two hypothalamic peptides with neuroexcitatory activity. Proceedings National Academy of Sciences, 95, 322-327.
20. Douglass, J., McKinzie, A.A. and Couceyro, P. (1995) PCR differential display identifies a rat brain mRNA that is transcriptionally regulated by cocaine and amphetamine. Journal of Neuroscience, 15, 2471-2481.
21. Dryden, S., McCarthy, D., Malabu, U.H., Ware, M. and Williams, G. (1993) Increased neuropeptide Y concentrations in specific hypothalamic nuclei of the rat following treatment with methysergide: evidence that NPY may mediate serotonin's effects on food intake. Peptides, 14, 791-796.
22. Dryden, S., Frankish, H.M., Wang, Q., Pickavance, L. and Williams, G. (1996) The serotonergic agent fluoxetine reduces neuropeptide Y levels and neuropeptide secretion in the hypothalamus of lean and obese rats. Neuroscience, 72, 557-566.
23. Dube, M.G., Sahu, A., Phelps, C.P., Kalra, P.S. and Kalra, S.P. (1992) Effect of d-fenfluramine on neuropeptide Y concentration and release in the paraventricular nucleus of food-deprived rats. Brain Research Bulletin, 26, 865-869.
24. Everitt, B.J., Hokfelt T., Terenius, L., Tatemoto, K., Mutt, V. and Goldstein, M. (1984) Differential co-existence of neuropeptide Y (NPY)-like immunoreactivity with catecholamines in the central nervous system of the rat. Neuroscience, 11, 443-462.
25. Fan, W., Boston, B.A., Kesterson, R.A., Hruby, V.J. and Cone, R.D. (1997) Role of melanocortinergic neurons in feeding and the agouti-obesity syndrome. Nature, 385, 165-168.
26. Gerald, C., Walker, M.W., Criscione, L., Gustafson, E.L., Batzl-Hartmann, C., Smith, K.E., Vaysse, P., Durkin, M.M., Laz, T.M., Linemeyer, D.L., Schaufhauser, A.O., Whitebread, S., Hofbauer, K.G., Taber, R.I., Branchek, T.A. and Weinshank, R.L. (1996) A receptor subtype involved in neuropeptide Y-induced food intake. Nature, 382, 168-171.
27. Giraudo, S.Q., Billington, C.J. and Levine, A.S. (1998) Feeding effects of hypothalamic injection of melanocortin 4 receptor ligands. Brain Research, 809, 302-306.
28. Goke, R., Fehmann, H.C. and Goke, B. (1991) Glucagon-like peptide-1(7-36) amide is a new incretin/enterogastrone candidate. European Journal of Clinical Investigation, 21, 135-144.
29. Goldstone, A.P., Mercer, J.G., Gunn, I., Moar, K.M., Edwards, M.C., Rossi, M., Howard, J., Rasheed, S., Turton, M.D., Small, C., Heath, M.M., O'shea, D., Steers, J., Meeran, K., Ghatei, M.A., Hoggard, N. and Bloom, S.R. (1997) Leptin interacts with glucagon-like peptide-1 neurons to reduce food intake and bodyweight in rodents. FEBS Letters, 415, 134-138.
30. Grill, H.J. (1986) Caudal brainstem integration of taste and internal state factors in behavioral and autonomie responses. In: Interaction of The Chemical Senses With Nutrition (Academic Press), pp. 347-371.
31. Grill, H.J. and Kaplan, J.M. (1990) Caudal brainstem participates in the neural control of feeding. In: Stricker E.M. (Ed.) Handbook of Behavioral Neurobiology (Plenum Press, New York), pp. 125-129.
32. Grill, H.J., Ginsberg, A.B., Seeley, R.J. and Kaplan, J.M. (1998) Brainstem application of melanocortin receptor ligands produces long-lasting changes effects on feeding and body-weight. Journal of Neuroscience, 18, 10 128-10 135.
33. Hadley, M.E., Hruby, V.J., Jiang, J., Sharma, S.D., Fink, J.L., Haskell-Luevano, C., Bentley, D.L., al-Obeidi, F. and Sawyer, T.K. (1996) Melanocortin receptors: identification and characterization by melanotropic peptide agonists and antagonists. Pigment Cell Research, 9, 213-234.
34. Halaas, J.L., Boozer, C., Blair-West, J., Fidahusein, N., Denton, D.A. and Friedman, J.M. (1997) Physiological response to long-term peripheral and central leptin infusion in lean and obese mice. Proceeding of the National Academy of Sciences, 94, 8878-8883.
35. Harrison, T.A., Chen, C.T., Dun, N.J. and Chang, J. (1999) Hypothalamic orexin A-immunoreactive neurons project to the rat dorsal medulla. Neuroscience Letters, 273, 17-20.
36. Haynes, A.C., Arch, J.R.S., Wilson, S., Clue, S.M. and Buckingham, R.E. (1998) Characterization of the neuropeptide Y receptor that mediates feeding in the rat: a role for the Y5 receptor? Regulatory Peptides, 75-76, 355-361.
37. Haynes, A.C., Jackson, B., Overned, P., Buckingham, R.E., Wilson, S., Tadayyon, M. and Arch, J.R.S. (1999) Effects of single and chronic intracerebroventricular administration of the orexins on feeding in the rat. Peptides, 20, 1099-1105.
38. Heinrichs, S.C., Cole, B.J., Pich, E.M., Menzaghi, F., Koob, G.F. and Hauger, R.L. (1992) Endogenous corticotropin-releasing factor modulates feeding induced by neuropeptide Y or a tail-pinch stressor. Peptides, 13, 879-884.
39. Holets, V.R., Hokfelt, T., Rokeaus, A., Terenius, L. and Goldstein, M. (1988) Locus ceruleus neurons in the rat containing neuropeptide Y, tyrosine hydroxylase or galanin and their efferent projections to the spinal cord, cerebral cortex and hypothalamus. Neuroscience, 24, 893-906.
40. Hollopeter, G., Erickson, J.C., Seeley, R.J., Marsh, D.J. and Palmiter, R.D. (1998) Response of neuropeptide Y-deficient mice to feeding effectors. Regulatory Peptides, 75-76, 383-389.
41. Horvath, T.L., Naftolin, F., Leranth, C., Sahu, A. and Kalra, S.P. (1996) Morphological and pharmacological evidence for neuropeptide Y-galanin interaction in the rat hypothalamus. Endocrinology, 137, 3069-3077.
42. Horvarth, T.L., Diano, S. and van den Pol, A.N. (1999) Synaptic interaction between hypocretin (orexin) and neuropeptide Y cells in the rodent and primate hypothalamus: a novel circuit implicated in metabolic and endocrine regulation. Journal of Neuroscience, 19, 1072-1087.
43. Huszar, D., Lynch, C.A., Fairchild-Huntress, V., Dunmore, J.H., Berkemeier, L.R., Gu, W., Kesterson, R.A., Boston, B.A., Cone, R.D., Smith, F.J., Campfield, L.A., Burn, P. and Lee, F. (1997) Targted disruption of the melanocortin-4 receptor results in obesity in mice. Cell, 88, 131-141.
44. Kalra, S.P., Dube, M.G., Sahu, A., Phelps, C.P. and Kalra, P.S. (1991) Neuropeptide Y secretion increases in the paraventricular nucleus in association with increased appetite for food. Proceedings of the National Academy of Sciences, 88, 10 931-10 935.
45. Kalra, S.P., Dube, M.G., Shuye, P., Xu, B., Horvath, T.L. and Kalra, P.S. (1999) Interacting appetite-regulating pathways in the hypothalamic regulation of body weight. Endocrine Reviews, 20, 68-100.
46. Kreymann, B., Yiangou, Y., Kanse, S., Williams, G., Ghatei, M.A. and Bloom, S.R. (1988) Isolation and characterisation of GLP-1 7-36 amide from rat intestine. Elevated levels in diabetic rats. FEBS Letter., 241, 209-212.
47. Kristensen, P., Judge, M.E., Thim, L., Ribel, U., Christiansen, K.M., Wulff, B.S., Calusen, J.T., Jensen, P.B., Madsen, O.D., Vrang, N., Larsen, P.J. and Hastrup, S. (1998) Hypothalamic CART is a new anorectic peptide regulated by leptin. Nature, 393, 72-76.
48. Krukoff, T.L., Vu, T., Harris, K.H., Aippersbach, S. and Jhamandas, J.H. (1992) Neurons in the rat medulla oblongata containing neuropeptide Y-, angiotensin II- or galanin-like immunoreactivity project to the parabrachial nucleus. Neuroscience, 47, 175-184.
49. Krykouli, S.E., Stanley, B.G. and Leibowitz, S.F. (1986) Galanin: stimulation of feeding induced by medial hypothalamic injection of this novel peptide. European Journal of Pharmacology, 122, 159-160.
50. Lambert, P.D., Couceyro, P.R., McGirr, K.M., Dall-Vechia, S.E., Smith, Y. and Kuhar, M.J. (1998) CART peptides in the central control of feeding and interactions with neuropeptide Y. Synapse, 29, 293-298.
51. Larsen, P.J., Tang-Christensen, Holst, J.J. and Orskov, C. (1997) Distribution of glucagon-like peptide-1 and other preproglucagon-derived peptides in the rat hypothalamus and brainstem. Neuroscience, 77, 257-270.
52. Levine, A.S. and Morley, J.E. (1984) Neuropeptide Y: a potent inducer of consummatory behavior in rats. Peptides, 5, 1025-1029.
53. Liposits, Z., Sievers, L. and Paull, W.K. (1988) Neuropeptide Y and ACTH-immunoreactive innervation of corticotropin-releasing factor (CRF)-synthesizing neurons in the hypothalamus of the rat. Histochemistry, 88, 227-234.
54. Lu, D., Willard, D., Patel, I.R., Kadwell, S., Overton, L., Kost, T., Luther, M., Chen, W., Woychik, R.P., Wilkison, W.O. and Cone, R.D. (1994) Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor. Nature, 371, 799-802.
55. Menzaghi, F., Heinrichs, S.C., Pich, E.M., Tilders, F.J.H. and Koob, G. (1993) Functional impairment of hypothalamic corticotropin releasing factor neurons with immunotargeted toxins enhances food intake induced by neuropeptide Y. Brain Research, 618, 76-82.
56. Miselis, R.R., Hyde, T.M. and Shapiro, R.E. (1984) Area postrema and adjacent solitary nucleus in water and energy balance. Fed. Proc., 43, 2969-2971.
57. Mondal, M.S., Nakazato, M., Date, Y., Murakami, N., Hanada, R., Sakata, T. and Matsukura, S. (1999) Characterization of orexin-A and orexin-B in the microdissected rat brain nuclei and their contents in two obese rat models. Neuroscience Letters, 273, 45-48.
58. Moriguchi, T., Sakurai, T., Nambu, T., Yanagisawa, M. and Goto, K. (1999) Neurons containing orexin in the lateral hypothalamic area of the adult rat brain are activated by insulin-induced acute hypoglycemia. Neuroscience Letters, 264, 101-104.
59. Mountjoy, K.G., Mortrud, M.T., Low, M.J., Simerly, R.B. and Cone, R.D. (1994) Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain. Molecular Endocrinology, 8, 1298-1308.
60. Naveilhan, P., Hassani, H., Canals, J.M., Ekstrand, A.J., Larefalk, A., Chhajlani, V., Arenas, E., Gedda, K., Svensson, L., Thoren, P. and Ernfors, P. (1999) Normal feeding behavior, body weight and leptin response require the neuropeptide Y Y2 receptor. Nature Medicine, 5, 1188-1193.
61. Olson, B.R., Drutarosky, M.D., Chow, M.S., Hruby, V.J., Stricker, E.M. and Verbalis, J.G. (1991a) Oxytocin and an oxytocin agonist administered centrally decrease food intake in rats. Peptides, 12, 113-118.
62. Olson, B.R., Drutarosky, M.D., Stricker, E.M. and Verbalis, J.G. (1991b) Brain oxytocin receptor antagonism blunts the effects of anorexigenic treatments in rats: evidence for central oxytocin inhibition of food intake. Endocrinology, 129, 785-791.
63. Olson, B.R., Drutarosky, M.D., Stricker, E.M. and Verbalis, J.G. (1991c) Brain oxytocin receptors mediate corticotropin-releasing hormone-induced anorexia. American Journal of Physiology, 260, R448-R452.
64. O'shea, D., Morgan, D.G.A., Meeran, K., Edwards, C.M.B., Turton, M.D., Choi, S.J., Heath, M.M., Gunn, I., Taylor, G.M., Howards, J., Bloom, C.I., Small, C.J., Haddo, O., Ma, J.J., Callinan, W., Smith, D.M., Ghatei, M.A. and Bloom, S.R. (1997) Neuropeptide Y induced feeding in the rat is mediated by a novel receptor. Endocrinology, 138, 196-202.
65. Pages, N., Gourch, A., Orosco, M., Comoy, E., Bohoun, C., Rodriguez, M., Martinez, J., Jacquot, C. and Cohen, Y. (1990) Changes in brain neuropeptide Y induced by cholecystokinin peptides, Neuropeptides, 17, 141-145.
66. Renaud, L.P., Tang, M., McCann, M.J., Stricker, E.M. and Verbalis, J.G. (1987) Cholecystokinin and gastric distention activate oxytocinergic cells in rat hypothalamus. American Journal of Physiology, 253, R661-R665.
67. Ritter, R.C. (1984) The role of the rat in research on control of ingestion: a commentary and review on recent advances in understanding brain control of food intake. Journal of Animal Science, 59, 1373-1380.
68. Rogers, P., McKibbin, P.E. and Williams, G. (1991) Acute fenfluramine administration reduces neuropeptide Y concentrations in specific hypothalamic regions of the rat: possible implications for the anorectic effect of fenfluramine. Peptides, 12, 251-255.
69. Roth, J.D. and Rowland, N.E. (1998) Efficacy of administration of dexfenfluramine and phentermine, alone and in combination on ingestive behavior and body weight in rats. Psychopharmacology, 137, 99-106.
70. Roth, J.D. and Rowland, N.E. (1999) Anorectic efficacy of the fenfluramine/phentermine combination in rats: additivity or synergy? European Journal of Pharmacology, 373, 127-134.
71. Rowland, N.E. and Kalra, S.P. (1997) Potential role of neuropeptide ligands in the treatment of overeating. CNS drugs, 7, 419-426.
72. Rowland, N.B., Morien, A. and Li, B.-H. (1996) The physiology and brain mechanisms of feeding. Nutrition, 12, 626-639.
73. Rowland, N.E., Crews, E.C. and Gentry, R.M. (1997) Comparison of Fos induced in rat brain by GLP-1 and amylin. Regulatory Peptides, 71, 171-174.
74. Sahu, A., Kalra, S.P., Crowley, W.R. and Kalra, P.S. (1988) Evidence that NPY-containing neurons in the brainstem project into selected hypothalamic nuclei: implication in feeding behavior. Brain Research, 457, 376-378.
75. Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R.M., Tanaka, H., Williams, S.C., Richardson, J.A., Kozlowski, G.P., Wilson, S., Arch, J.R.S., Buckingham, R.E., Haynes, A.C., Carr, S.A., Annan, R.S., McNulty, D.E., Liu, W.-S., Terrett, J.A., Elshourbagy, N.A., Bergsma, D.J. and Yanagisawa, M. (1998) Orexins and orexin receptors: a family of hypothalamic neuropeptides and G-protein coupled receptors that regulate feeding behavior. Cell, 92, 573-585.
76. Seeley, R.J., Yagaloff, K.A., Fisher, S.L., Burn, P., Thiele, T.E., van Dijk, G., Baskin, D.G. and Schwartz, M. (1997) Melanocortin receptors in leptin effects. Nature, 390, 349.
77. Stanley, B.G., Krykouli, S.E., Lampert, S. and Leibowitz, S.F. (1986) Neuropeptide Y chronically into the hypothalamus: a powerful neurochemical inducer of hyperphagia and obesity. Peptides, 7, 1189-1192.
78. Tatemoto, K., Rokaeus, A., Jornvall, H., McDonald, T.J. and Mutt, V. (1983) Galanin: a novel biologically active peptide from porcine intestine. FEBS Letters, 164, 124-128.
79. Teitelbaum, P. and Pellis, S.M. (1992) Toward a synthetic physiological psychology. Psychological Science, 3, 4-20.
80. Tempel, D.L., Leibowitz, K.J. and Leibowitz, S.F. (1988) Effects of PVN galanin on macronutrient selection, Peptides, 9, 309-314.
81. Thiele, T.E., Van Dijk, G., Campfield, L.A., Smith, F.J., Burn, P., Woods, S.C., Bernstein, I.L. and Seeley, R.J. (1997) Central infusion of GLP-1 but not leptin produces conditioned taste aversion in rats. American Journal of Physiology, 272, R726-R730.
82. Tritos, N.A., Vicent, D., Gillette, T., Ludwig, D.S., Flier, E.S. and Maratos-Flier, E. (1998) Functional interactions between melanin-concentrating hormone, neuropeptide Y and anorectic neuropeptides in the rat hypothalamus. Diabetes, 47, 1687-1692.
83. Triveldi, P., Yu, H., MacNeil, D.J., VanderPloeg, L.H.T. and Guan, X.M. (1998) Distribution of orexin recepotr mRNA in the rat brain. FEBS Letters, 438, 71-75.
84. Turton, M.D., O'shea, D., Gunn, I., Beak, S.A., Edwards, C.M.B., Meeran, K., Choi, S.J., Taylor, G.M., Heath, M.M., Lambert, P.D., Wilding, J.P.H., Smith, D.M., Ghatei, M.A., Herbert, J. and Bloom, S.R. (1996) A role for glucagon-like peptide-1 in the central regulation of feeding. Nature, 79, 69-72.
85. Van Dijk, G., Thiele, T.E., Donahey, J.C.K., Campfield, L.A., Smith, F.J., Burn, P., Bernstein, I.L., Woods, S.C. and Seeley, R.J. (1996) Central infusions of leptin and GLP-1-(7-36) amide differentially stimulate c-FLI in the rat brain. American Journal of Physiology, 40, R1096-R1100.
86. Verbalis, J.G., McCann, M.J., McHale, C.M. and Stricker, E.M. (1986) Oxytocin secretion in response to cholecystokinin and food intake: differentiation of nausea from satiety. Science, 232, 1417-1419.
87. Weintraub, M. (1992) Long-term weight control: the national heart, lung, and blood institute funded multi-modal intervention study, Clinical Pharmacology and Therapeutics, 5, 581-646.
88. White, J.D. and Kershaw, M. (1990) Increased hypothalamic neuropeptide Y expression following food deprivation. Molecular Cellular Neuroscience, 1, 41-48.
89. Wilding, J.P.H., Gilbey, S.G., Bailey, C.J., Batt, R.A.L., Willson, G., Ghatei, M.A. and Bloom, S.R. (1993) Increased neuropeptide Y messenger ribonucleic acid (mRNA) and decreased neurotensin mRNA is found in the hypothalamus of the obese (ob/ob) mouse. Endocrinology, 132, 1939-1944.
90. Yamamoto, Y., Ueta, Y., Date, Y., Nakazato, M., Hara, Y., Serino, R., Nomura, M., Shibuya, I., Matsukara, S. and Yamashita, H. (1999) Down regulation of the prepro-orexin gene expression in genetically obese mice. Molecular Brain Research, 65, 14-22.