Drug design based on natural products;Planejamento racional de fármacos baseado em produtos naturais

Quimica Nova

Volumn 24, Issue 1, 2001, Pages 105-111

  Montanari, Carlos Alberto ^a   Bolzani, Vanderlan Da S ^b  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^b SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

Medicinal chemistry; Natural products; Pharmaceutical industry

Indexed keywords

EID: 0005479155     PISSN: 01004042     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (68)

1. Gottlieb, O. R., Kaplan, M, A.; Borin, M. R.; Biodiversidade um Enfoque Quimio-biológico; Editora UERJ; Rio de Janeiro, RJ, 1996.
2. Wheelwrigh, E. G.: Medicinal Plants and their History; Dover Publications; New York, NY, 1974.
3. Vanhaelen, M.; J. Pharm. Belg. 1989, 44, 242.
4. Phillpson, J. D.; Anderson, L. A.; J. Ethnopharmacol. 1898, 25, 61.
5. Reinbothe, C.; Diettrich, B.; Luckner, M.J.; Plant. Physiol. 1990, 137, 224.
6. Brito, N. R. S.; Tese de Doutorado, USP, São Paulo, SP, 1986.
7. Rosenthal, G. A.; Jansen, D. H.; Herbivores and Their Interaction with Secondary Metabolites; Academic Press; New York, 1979; p 3-160 e p 309-350.
8. Fleuretin, J.; Pelt, J-M.; La Recherche 1990, 21, 810.
9. Miller, R. W.; Powell, R. G.; Smith, C. R. Jr.; Arnold, E.; Clardy, J.; J. Org. Chem. 1981, 46, 1469.
10. Powell, R. G.; Miller, R. W.; Smith Jr., C. R.; J. Chem. Soc. Chem. Commun. 1979, 102.
11. Stinson, S. C.; Chem. Eng. News 1995, 9, 44.
12. Caldwell, J.; Modern Drug Discov. 1999, 7/8, 51.
13. Littlehales, C.; Anal. Chem. 1999, 71, 749.
14. Montanari, C. A.; Quim. Nova 1995, 18, 56.
15. (a) Leitão, A.; Montanari, C. A.; Donnici, C. L.; Quim. Nova 2000, 23, 178
16. (b) Ooms, F.; Curr. Med. Chem. 2000, 7, 141.
17. Stafford, A. M.; Pazoles, C. J.; Scott Siegel, S.; Yeh, Li-An.; Plant Cell Culture: a vehicle for Drug Discovery, In Advances in Drug Dicovery Techniques, John Willey & Sons; New York; 1998.
18. Kniaz, D.; Modern Drug Discov. 2000, 5, 67.
19. IBC's Fourth International Simposium on Natural Drug Discovery & Development: Novel Technologies, Diverse Sources & Therapeutic Developments, June 15-16 1998, Annapolis, MD-USA.
20. Silverman, R. B., In The Organic Chemistry of Drug Design and Drug Action; Academic Press, Inc; San Diego, 1992.
21. (a) Cumming, J. N.; Ploypradith, P.; Posner, G. H.; Adv. Pharmacol. 1997, 37, 253.
22. (b) Posner, G. H.; O'Dowd, H.; Ploypradith, P.; Cumming, J. N.; Xie, S.; Shapiro, T. A.; J.Med. Chem. 1998, 41, 2164.
23. White, R. E.; Annu. Rev. Pharmacol. 2000, 40, 133.
24. Cordell, G. A.; Shin, Y. G.; Pure Appl. Chem. 1999, 71, 1089.
25. Lanzov, V. A.; Mol. Genet. Metab. 1999, 68, 276.
26. Montanari, M.L.C.; Beezer, A.E.; Montanari, C.A.; Thermochim. Acta. 1999, 328, 91.
27. (a) Lima, P. C.; Lima, L. M.; da Silva, K. C. M.; Leda, P. H. O.; de Miranda, A. L. P.; Fraga, C. A. M.; Barreiro, E. J.; Eur. J. Med. Chem. 2000, 35, 187.
28. (b) Clark, R. D.; Ferguson, A. M.; Cramer, R. D.; Perspect. Drug Discov. 1998, 9-11, 213.
29. (c) Patani, G. A.; LaVoie, E. J.; Chem. Rev. 1996, 96, 3147.
30. Montanari, C. A.; Tute, M. S.; Beezer, A. E.; Mitchell, J. C.; J. Comput.-Aid. Mol. Des. 1996, 10, 67.
31. (a) Meyer, E. F.; Swanson, S. M.; Williams, J. A.; Pharmacol. Therapeut. 2000, 85, 113.
32. (b) Kuntz, I. D.; Science 1992, 257, 1078
33. (c) Fairlie, D. P.; Tyndall, J. D. A.; Reid, R. C.; Wong, A. K.; Abbenante, G.; Scanlon, M. J.; March, D. R.; Bergman, D. A.; Chai, C. L. L.; Burkett, B. A.; J. Med. Chem. 2000, 43, 1271.
34. Van de Waterbeem, H.; Testa, B.; Folkers, G.; Computer-Assisted Lead Finding and Optimization. Current Tools for Medicinal Chemistry. Wiley-VCH, Weinheim, 1997
35. Hopfinger, A. J.; Wang, S.; Tokarski, J. S.; Jin, B. Q.; Albuquerque, M.; Madhav, P. J.; Duraiswami, C.; J. Am. Chem. Soc. 1997, 119, 10509.
36. Gschwend, D. A.; Good, A. C; Kuntz, I. D.; J. Mol. Recognit. 1996, 9, 175.
37. Sandak, B.; Wolfson, H. J.; Nussinov, R.; Prot.Struct. Funct. Gen. 1998, 32, 159.
38. Edgcomb, S. P.; Murphy, K. P.; Cur. Opin. Biotechnol. 2000, 11, 62.
39. Fastrez, J.; Mol. Biotechnol. 1997, 7, 37.
40. Gebhardt, R.; Planta Med. 2000, 66, 99.
41. (a) Watt, A. P.; Morrison, D.; Evans, D. C.; Drug Discov. Today 2000, 5, 17.
42. (b) Smith, D. A.; Van de Waterbeemd, H.; Curr. Opin. Chem. Biol. 1999, 3, 373.
43. (a) Lipinski, C. A.; Lombardo, F.; Dominy, B. W.; Feeney, P. J.; Adv. Drug Del. Rev. 1997, 23, 3.
44. (b) Ajay, Walters, W. P.; Murcko, M. A.; J. Med. Chem. 1998, 41, 3314.
45. (c) Sadowski, J.; Kubinyi, H.; J. Med. Chem. 1998, 41, 3325.
46. TSAR, versão 3.21, Oxoford Molecular, Ltd., Oxford, U.K..
47. Hajduk, P. J.; Gerfin, T.; Boehlen, J. M.; Haberli, M.; Marek, D.; Fesik, S. W.; J. Med. Chem. 1999, 42, 2315.
48. Bohm, H. J.; J. Comput. Aid. Mol. Des. 1998, 12, 309.
49. Kuntz, I. D.; Blaney, J. M.; Oatley, S. J.; Langridge, R.; Ferrin, T. E.; J. Mol. Biol. 1982, 161, 269.
50. Goodford, P.J.; J. Med. Chem. 1985, 28, 849.
51. (a) Moon, J. B.; Howe, W. J.; Proteins 1991, 11, 314.
52. (b) Moon, J. B.; Howe, W. J.; Tetrahedron Comput. Methodol. 1990, 3, 681.
53. (a) Kubinyi, H.; 3D QSAR in Drug Design. Theory, Methods and Applications, ESCOM, Leiden, 1993
54. (b) Kubinyi, H.; Folker, G.; Martin Y. C., 3D QSAR in Drug Design. Ligand-Protein Interactions and Molecular Similarity, Vol. 2, KLUWER/ESCOM, Dordrecht/Boston/ London, 1998
55. (c) Kubinyi, H.; Folker, G.; Martin Y. C.; 3D QSAR in Drug Design. Recent Advances, Vol. 3, KLUWER/ESCOM, Dordrecht/Boston/London, 1998.
56. (a) Referência (29).
57. (b) Hopfinger, A. J.; Vankatarangan, P.; Tseng, Y. F.; Wang, S.; Duca, J. S.; Internet J. Chem. 2000, 3, U23.
58. Montanari, C. A.; Tute, M. S.; Quant. Struct-Act. Rel. 1997, 16, 480.
59. Cruciani, G.; Clementi, S.; Pastor, M.; Perspect. Drug Discov. 1998, 12, 71.
60. Frank, R.; Gruska, A.;, In Methods and Principles in Medicinal Chemistry. Chemometric Methods in Molecular Design. Van de Waterbeemd, H., Ed..
61. (a) Principal Components and Factor Analysis, p 113-163.
62. (b) SIMCA Pattern Recognition and Classification, p 179-193. VCH; Weinheim, 1995.
63. Kubinyi, H.; Drug Disc. Develop. 1998, 1, 4.
64. Hansch, C.; Accounts Chem. Res. 1993, 26, 147.
65. Xiang, X. D.; Schultz, P. G.; Physica 1997, 282, 428.
66. Turner, D. M. J.; Ethnopharmacol. 1996, 51, 39.
67. Newman, D. J.; Cragg, G. M.; Snader, K. M.; Nat. Prod. Rep. 2000, 17, 215.
68. Reich, M. R.; Science 2000, 287, 1979.