Fidelity analysis of HIV-1 reverse transcriptase mutants with an altered amino-acid sequence at residues Leu74, Glu89, Tyr115, Tyr183 and Met184

European Journal of Biochemistry

Volumn 267, Issue 9, 2000, Pages 2658-2665

  Jonckheere, Heidi ^b   De Clercq, Erik ^c   Anné, Jozef ^a  

^a REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^b Virco BVBA   (Belgium)

^c NONE

Author keywords

Fidelity; HIV 1 RT; Mutant reverse transcriptase; Polymerization; Site directed mutagenesis

Indexed keywords

FOSCARNET; GLUTAMIC ACID; LEUCINE; METHIONINE; MUTANT PROTEIN; RNA DIRECTED DNA POLYMERASE; TYROSINE; VIRUS DNA;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; DNA SYNTHESIS; ENZYME ACTIVE SITE; ENZYME ACTIVITY; HUMAN IMMUNODEFICIENCY VIRUS 1; MUTATION RATE; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION; SITE DIRECTED MUTAGENESIS;

AMINO ACID SUBSTITUTION; AMINO ACIDS; BASE SEQUENCE; BIOPOLYMERS; HIV-1 REVERSE TRANSCRIPTASE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; SEQUENCE HOMOLOGY, NUCLEIC ACID;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0000937442     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.2000.01272.x     Document Type: Article

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