Mercury chloride assisted cyclization toward benzimidazoles by focused microwave irradiation

Tetrahedron Letters

Volumn 46, Issue 1, 2005, Pages 177-180

  Su, Yuh Sheng ^a   Lin, Mei Jung ^a   Sun, Ming Chung ^a  

^a NATIONAL DONG HWA UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ARGON; BENZIMIDAZOLE DERIVATIVE; MERCURY CHLORIDE; SULFUR DERIVATIVE;

ARTICLE; CHEMICAL REACTION; CYCLIZATION; DRUG PURITY; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MICROWAVE IRRADIATION; PROTON NUCLEAR MAGNETIC RESONANCE;

EID: 9944264126     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2004.10.170     Document Type: Article

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29. The control reaction was also performed under normal thermal heating in refluxing chloroform (preheated oil bath) for 4 min, using identical stoichiometry. However, after cleavage we obtained only the un-reacted compound 4. The same reaction was found completion in six hours by conventional heating. Similar enhancement through microwave irradiation has also been observed during the cleavage step. Compared to conventional thermal hearting, microwave irradiation decreased the reaction time on the support from several hours to several minutes
30. All the microwave assisted polymer-supported reactions described here were performed in CEM Discover Microwave System at a frequency of 2450 MHz (0-300 W)