A rapid screening method to test apoptotic synergisms of ochratoxin A with other nephrotoxic substances

Toxicology in Vitro

Volumn 19, Issue 1, 2005, Pages 135-143

  Weber, Florian ^a   Freudinger, Ruth ^a   Schwerdt, Gerald ^a   Gekle, Michael ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Apoptosis; Cisplatin; Kidney; Nephrotoxin; Ochratoxin A

Indexed keywords

AMPHOTERICIN B; CADMIUM; CASPASE 3; CISPLATIN; HYDROGEN PEROXIDE; OCHRATOXIN;

APOPTOSIS; ARTICLE; CELL DEATH; CELL LINE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; KIDNEY CELL; KIDNEY EPITHELIUM; NEPHROTOXICITY; PROTEIN CONTENT; SCREENING TEST; TOXICITY TESTING;

APOPTOSIS; CADMIUM; CASPASE 3; CASPASES; CELL LINE, TRANSFORMED; CISPLATIN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMBINATIONS; DRUG SYNERGISM; HUMANS; KIDNEY DISEASES; KIDNEY TUBULES, PROXIMAL; MYCOTOXINS; OCHRATOXINS; PROTEINS; TOXICITY TESTS; TRYPAN BLUE;

EID: 9944232625     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2004.08.002     Document Type: Article

References (34)

1. A. Benesic, S. Mildenberger, and M. Gekle Nephritogenic ochratoxin A interferes with hormonal signalling in immortalized human kidney epithelial cells Pflügers Arch 439 2000 278 287
2. A. Breitholtz-Emanuelsson, F. Minervini, K. Hult, and A. Visconti Ochratoxin A in human serum samples collected in southern Italy from healthy individuals and individuals suffering from different kidney disorders Nat Toxins 2 1994 366 370
3. S. Eder, A. Benesic, R. Freudinger, J. Engert, G. Schwerdt, K. Drumm, and M. Gekle Nephritogenic ochratoxin A interferes with mitochondrial function and pH homeostasis of immortalized human kidney epithelial cells Pflügers Arch. 440 2000 521 529
4. M. Enari, H. Sakahira, H. Yokoyama, K. Okawa, A. Iwamatsu, and S. Nagata A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD Nature 391 1998 43 50
5. M. Gekle, C. Sauvant, G. Schwerdt, and S. Silbernagl Tubulotoxic mechanisms of ochratoxin A Kidney Blood Press Res 21 1998 277 279
6. M. Gekle, G. Schwerdt, R. Freudinger, S. Mildenberger, D. Wilflingseder, V. Pollack, M. Dander, and H. Schramek Ochratoxin A induces JNK activation and apoptosis in MDCK-C7 cells at nanomolar concentrations J. Pharmacol Exp. Ther. 293 2000 837 844
7. M. Gekle, S. Wünsch, H. Oberleithner, and S. Silbernagl Characterization of two MDCK-cell subtypes as a model system to study principal and intercalated cell properties Pflügers Arch. 428 1994 157 162
8. T. Hamada, S. Nakano, S. Iwai, A. Tanimoto, K. Ariyoshi, and O. Koide Pathological study on beagles after long-term oral administration of cadmium Toxicol Pathol 19 1991 138 147
9. M.O. Hengartner The biochemistry of apoptosis Nature 407 2000 770 776
10. P. Huang, L. Feng, E.A. Oldham, M.J. Keating, and W. Plunkett Superoxide dismutase as a target for the selective killing of cancer cells Nature 407 2000 390 395
11. M. Ishido, S. Homma-Takeda, C. Tohyama, and T. Suzuki Apoptosis in rat renal proximal tubular cells induced by cadmium J. Toxicol Environ Health A 55 1998 1 12
12. G. Kroemer, P. Petit, N. Zamzami, J. Vayssiere, and B. Mignotte The biochemistry of programmed cell death FASEB. J.s 9 1995 1277 1287
13. P. Krogh, N.H. Axelsen, F. Elling, N. Gryd-Hansen, B. Hald, J. Hyldgaard-Jensen, A.E. Larsen, A. Madsen, H.P. Mortensen, T. Moller, O.K. Petersen, U. Ravnskov, M. Rostgaard, and O. Aalund Experimental porcine nephropathy Acta Pathol Microbiol Scand A Suppl.No.246 1974 1 21
14. P. Krogh, N.H. Axelsen, F. Elling, N. Gyrd-Hansen, B. Hald, J. Hyldgaard-Jensen, A.E. Larsen, A. Madsen, H.P. Mortensen, T. Moller, O.K. Petersen, U. Ravnskov, M. Rostgaard, and O. Aalund Experimental porcine nephropathy. Changes of renal function and structure induced by ochratoxin A- contaminated feed Acta Pathol Microbiol Scand A 1974 1 21
15. M. Leist, B. Single, A.F. Castoldi, S. Kühnle, and P. Nicotera Intracellular adenosine triphosphate (ATP) concentration: a switch in the decision between apoptosis and necrosis J. Exp. Med. 185 1997 1481 1486
16. M. Leist, B. Single, H. Naumann, E. Fava, B. Simon, S. Kuhnle, and P. Nicotera Inhibition of mitochondrial ATP generation by nitric oxide switches apoptosis to necrosis Exp. Cell. Res. 249 1999 396 403
17. W. Lieberthal, V. Triaca, and J. Levine Mechanisms of death induced by cisplatin in proximal tubular epithelial cells: apoptosis vs. necrosis Am. J. Physiol. 270 1996 F700 F708
18. T. Ludwig, C. Riethmüller, M. Gekle, G. Schwerdt, and H. Oberleithner Nephrotoxicity of platinum complexes is related to basolateral organic cation transport Kidney Int. 66 2004 196 202
19. S.J. Martin, D.M. Finucane, G.P. Amarante-Mendes, G.A. O'Brien, and D.R. Green Phosphatidylserine externalization during CD95-induced apoptosis of cells and cytoplasts requires ICE/CED-3 protease activity J. Biol. Chem. 271 1996 28753 28756
20. P. Nicotera, and G. Melino Regulation of the apoptosis-necrosis switch Oncogene 23 2004 2757 2765
21. S. Obrecht-Pflumio, and G. Dirheimer In vitro DNA and dGMP adducts formation caused by ochratoxin A Chem. Biol. Interact. 127 2000 29 44
22. S. Obrecht-Pflumio, and G. Dirheimer Horseradish peroxidase mediates DNA and deoxyguanosine 3′-monophosphate adduct formation in the presence of ochratoxin A Arch Toxicol 75 2001 583 590
23. N. Ozcelik, A. Koar, and D. Soysal Ochratoxin A in human serum samples collected in Isparta-Turkey from healthy individuals and individuals suffering from different urinary disorders Toxicol Lett 121 2001 9 13
24. A.L. Pinto, and S.J. Lippard Binding of the antitumor drug cis-diamminedichloroplatinum(II) (cisplatin) to DNA Biochim Biophys Acta 780 1985 167 180
25. H. Schramek, D. Wilflingseder, V. Pollack, R. Freudinger, S. Mildenberger, and M. Gekle Ochratoxin A-induced stimulation of extracellular signal- regulated kinases 1/2 is associated with Madin-Darby canine kidney-C7 cell dedifferentiation J. Pharmacol Exp. Ther. 283 1997 1460 1468
26. G. Schwerdt, R. Freudinger, S. Mildenberger, S. Silbernagl, and M. Gekle The nephrotoxin ochratoxin A induces apoptosis in cultured human proximal tubule cells Cell Biol. Toxicol. 15 1999 405 415
27. G. Schwerdt, R. Freudinger, C. Schuster, S. Silbernagl, and M. Gekle Inhibition of mitochondria prevents cell death in kidney epithelial cells by intra- and extracellular acidification Kidney Int. 63 2003 1725 1735
28. M.A. Skaug Levels of ochratoxin A and IgG against conidia of Penicillium verrucosum in blood samples from healthy farm workers Ann. Agric. Environ. Med. 10 2003 73 77
29. X.M. Sun, M. MacFarlane, J. Zhuang, B.B. Wolf, D.R. Green, and G.M. Cohen Distinct caspase cascades are initiated in receptor-mediated and chemical-induced apoptosis J. Biol. Chem. 274 1999 5053 5060
30. F. Thevenod Nephrotoxicity and the proximal tubule. Insights from cadmium Nephron Physiol 93 2003 87 93
31. K. Tsuruya, M. Tokumoto, T. Ninomiya, M. Hirakawa, K. Masutani, M. Taniguchi, K. Fukuda, H. Kanai, H. Hirakata, and M. Iida Antioxidant ameliorates cisplatin-induced renal tubular cell death through inhibition of death receptor-mediated pathways Am. J. Physiol. Renal. Physiol. 285 2003 F208 F218
32. G. Tveito, I. Hansteen, H. Dalen, and A. Haugen Immortalization of normal human kidney epithelial cells by nickel(II) Cancer Res 49 1989 1829 1835
33. D.E. Varlam, M.M. Siddiq, L.A. Parton, and H. Russmann Apoptosis contributes to amphotericin B-induced nephrotoxicity Antimicrob Agents Chemother 45 2001 679 685
34. H. Zhang, Q. Xu, S. Krajewski, M. Krajewska, Z. Xie, S. Fuess, S. Kitada, A. Godzik, and J.C. Reed BAR: An apoptosis regulator at the intersection of caspases and bcl-2 family proteins Proc. Natl. Acad. Sci. USA 97 2000 2597 2602