메뉴 건너뛰기




Volumn 15, Issue SUPPL. 4, 2004, Pages

Targeted therapy in advanced colon cancer: The role of new therapies

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DIMETHYL 5 (2 OXO 1H INDOL 3 YLMETHYLENE) 3 PYRROLEPROPIONIC ACID; ANTINEOPLASTIC AGENT; BEVACIZUMAB; CAPECITABINE; CELECOXIB; CETUXIMAB; CYCLOOXYGENASE 2 INHIBITOR; CYTOTOXIC AGENT; EPIDERMAL GROWTH FACTOR RECEPTOR ANTIBODY; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; ERLOTINIB; FLUOROURACIL; FOLINIC ACID; GEFITINIB; IRINOTECAN; MATUZUMAB; MONOCLONAL ANTIBODY M225; OXALIPLATIN; PELITINIB; PLACEBO; ROFECOXIB; SEMAXANIB; SUNITINIB; TOPOTECAN; TRASTUZUMAB; UNCLASSIFIED DRUG; UNINDEXED DRUG; VANDETANIB; VASCULOTROPIN ANTIBODY; VASCULOTROPIN INHIBITOR; VATALANIB;

EID: 9744248657     PISSN: 09237534     EISSN: None     Source Type: Journal    
DOI: 10.1093/annonc/mdh905     Document Type: Article
Times cited : (41)

References (48)
  • 1
    • 0037106273 scopus 로고    scopus 로고
    • Targeting the epidermal growth factor receptor for cancer therapy
    • Mendelsohn J. Targeting the epidermal growth factor receptor for cancer therapy. J Clin Oncol 2002; 20: 1S-13S.
    • (2002) J. Clin. Oncol. , vol.20
    • Mendelsohn, J.1
  • 2
    • 0035447953 scopus 로고    scopus 로고
    • Epidermal growth factor receptor immunohistochemical reactivity in patients with American Joint Committee on Cancer stage IV colon adenocarcinoma: Implications for a standardized scoring system
    • Goldstein NS, Armin M. Epidermal growth factor receptor immunohistochemical reactivity in patients with American Joint Committee on Cancer stage IV colon adenocarcinoma: implications for a standardized scoring system. Cancer 2001; 92: 1331-1346.
    • (2001) Cancer , vol.92 , pp. 1331-1346
    • Goldstein, N.S.1    Armin, M.2
  • 3
    • 0002823211 scopus 로고    scopus 로고
    • Cetuximab (IMC-C225) plus irinotecan (CPT-11) is active in CPT-11 refractory colorectal cancer (CRC) that expresses epidermal growth factor receptor (EGFR)
    • (Abstr 7)
    • Saltz L, Rubin M, Hochster H et al. Cetuximab (IMC-C225) plus irinotecan (CPT-11) is active in CPT-11 refractory colorectal cancer (CRC) that expresses epidermal growth factor receptor (EGFR). Proc Am Soc Clin Oncol 2001; 20: 3a (Abstr 7).
    • (2001) Proc. Am. Soc. Clin. Oncol. , vol.20
    • Saltz, L.1    Rubin, M.2    Hochster, H.3
  • 4
    • 0037862765 scopus 로고    scopus 로고
    • Cetuximab (C225) alone or in combination with irinotecan (CPT-11) in patients with epidermal growth factor receptor (EGFR)-positive, irinotecan-refractory metastatic colorectal cancer (MCRC)
    • (Abstr 1012)
    • Cunningham D, Humblet Y, Siena S et al. Cetuximab (C225) alone or in combination with irinotecan (CPT-11) in patients with epidermal growth factor receptor (EGFR)-positive, irinotecan-refractory metastatic colorectal cancer (MCRC). Proc Am Soc Clin Oncol 2003; 22: 252 (Abstr 1012).
    • (2003) Proc. Am. Soc. Clin. Oncol. , vol.22 , pp. 252
    • Cunningham, D.1    Humblet, Y.2    Siena, S.3
  • 5
    • 0026471016 scopus 로고
    • Prognostic markers of colorectal cancer: An evaluation of DNA content, epidermal growth factor receptor, and Ki-67
    • Hemming AW, Davis NL, Kluftinger A et al. Prognostic markers of colorectal cancer: an evaluation of DNA content, epidermal growth factor receptor, and Ki-67. J Surg Oncol 1992; 51: 147-152.
    • (1992) J. Surg. Oncol. , vol.51 , pp. 147-152
    • Hemming, A.W.1    Davis, N.L.2    Kluftinger, A.3
  • 6
    • 0029670014 scopus 로고    scopus 로고
    • KIP1 in G1 arrest mediated by an anti-epidermal growth factor receptor monoclonal antibody
    • KIP1 in G1 arrest mediated by an anti-epidermal growth factor receptor monoclonal antibody. Oncogene 1996; 12: 1397-1403.
    • (1996) Oncogene , vol.12 , pp. 1397-1403
    • Wu, X.1    Rubin, M.2    Fan, Z.3
  • 7
    • 0034114769 scopus 로고    scopus 로고
    • Blockade of receptors for growth factors: An anticancer therapy
    • Mendelsohn J. Blockade of receptors for growth factors: An anticancer therapy. Clin Cancer Res 2000; 6: 747-753.
    • (2000) Clin. Cancer Res. , vol.6 , pp. 747-753
    • Mendelsohn, J.1
  • 8
    • 0034038282 scopus 로고    scopus 로고
    • Induction of apoptosis and activation of the caspase cascade by anti-EGF receptor monoclonal antibodies in DiFi human colon cancer cell lines do not involve the c-jun N-terminal kinase activity
    • Liu B, Fang M, Schmidt M et al. Induction of apoptosis and activation of the caspase cascade by anti-EGF receptor monoclonal antibodies in DiFi human colon cancer cell lines do not involve the c-jun N-terminal kinase activity. Br J Cancer 2000; 82: 1991-1999.
    • (2000) Br. J. Cancer , vol.82 , pp. 1991-1999
    • Liu, B.1    Fang, M.2    Schmidt, M.3
  • 9
    • 0032904485 scopus 로고    scopus 로고
    • Antitumor activity of sequential treatment with topotecan and anti-epidermal growth factor receptor monoclonal antibody C225
    • Ciardiello F, Bianco R, Damiano V et al. Antitumor activity of sequential treatment with topotecan and anti-epidermal growth factor receptor monoclonal antibody C225. Clin Cancer Res 1999; 5: 909-916.
    • (1999) Clin. Cancer Res. , vol.5 , pp. 909-916
    • Ciardiello, F.1    Bianco, R.2    Damiano, V.3
  • 10
    • 0036094194 scopus 로고    scopus 로고
    • Enhanced antitumor activity of anti-epidermal growth factor receptor monoclonal antibody IMC-C225 in combination with irinotecan (CPT-11) against human colorectal tumor xenografts
    • Prewett M, Hooper AT, Bassi R et al. Enhanced antitumor activity of anti-epidermal growth factor receptor monoclonal antibody IMC-C225 in combination with irinotecan (CPT-11) against human colorectal tumor xenografts. Cancer Res 2002; 8: 994-1003.
    • (2002) Cancer Res. , vol.8 , pp. 994-1003
    • Prewett, M.1    Hooper, A.T.2    Bassi, R.3
  • 11
    • 19244366949 scopus 로고    scopus 로고
    • Phase I studies of anti-epidermal growth factor receptor chimeric antibody C225 alone and in combination with cisplatin
    • Baselga J, Pfister D, Cooper MR et al. Phase I studies of anti-epidermal growth factor receptor chimeric antibody C225 alone and in combination with cisplatin. J Clin Oncol 2000; 18: 904-914.
    • (2000) J. Clin. Oncol. , vol.18 , pp. 904-914
    • Baselga, J.1    Pfister, D.2    Cooper, M.R.3
  • 12
    • 0001407135 scopus 로고    scopus 로고
    • Single agent IMC-C225 (ErbituxTM) has activity in CPT-11-refractory colorectal cancer (CRC) that expresses the epidermal growth factor receptor (EGFR)
    • (Abstr 504)
    • Saltz L, Meropol NJ, Loehrer PJ et al. Single agent IMC-C225 (ErbituxTM) has activity in CPT-11-refractory colorectal cancer (CRC) that expresses the epidermal growth factor receptor (EGFR). Proc Am Soc Clin Oncol 2002; 21: 127a (Abstr 504).
    • (2002) Proc. Am. Soc. Clin. Oncol. , vol.21
    • Saltz, L.1    Meropol, N.J.2    Loehrer, P.J.3
  • 13
    • 0012048211 scopus 로고    scopus 로고
    • A phase I/II study of cetuximab (C225) plus irinotecan (CPT-11) and 24h infusional 5FU/folinic acid (FA) in the treatment of metastatic colorectal cancer (MCRC) expressing the epidermal growth factor receptor (EGFR)
    • Lutz MP, Schöffski P, Folprecht G et al. A phase I/II study of cetuximab (C225) plus irinotecan (CPT-11) and 24h infusional 5FU/folinic acid (FA) in the treatment of metastatic colorectal cancer (MCRC) expressing the epidermal growth factor receptor (EGFR). Ann Oncol 2002; 13 (Suppl 5): 73.
    • (2002) Ann. Oncol. , vol.13 , Issue.SUPPL. 5 , pp. 73
    • Lutz, M.P.1    Schöffski, P.2    Folprecht, G.3
  • 14
    • 0001407137 scopus 로고    scopus 로고
    • Erbitux (IMC-C225) plus weekly irinotecan (CPT-11), fluorouracil (5FU) and leucovorin (LV) in colorectal cancer (CRC) that expresses the epidermal growth factor receptor (EGFr)
    • (Abstr 536)
    • Rosenberg AH, Loehrer PJ, Needle MN et al. Erbitux (IMC-C225) plus weekly irinotecan (CPT-11), fluorouracil (5FU) and leucovorin (LV) in colorectal cancer (CRC) that expresses the epidermal growth factor receptor (EGFr). Proc Am Soc Clin Oncol 2002; 21: 135a (Abstr 536).
    • (2002) Proc. Am. Soc. Clin. Oncol. , vol.21
    • Rosenberg, A.H.1    Loehrer, P.J.2    Needle, M.N.3
  • 15
    • 0347187211 scopus 로고    scopus 로고
    • Cetuximab (C225) in combination with bi-weekly irinotecan (CPT-11), infusional 5-fluorouracil (5-FU) and folinic acid (FA) in patients (pts) with metastatic colorectal cancer (CRC) expressing the epidermal growth factor receptor (EGFR). Preliminary safety and efficacy results
    • (Abstr 1058)
    • Van Laethem J-L, Raoul J-L, Mitry E et al. Cetuximab (C225) in combination with bi-weekly irinotecan (CPT-11), infusional 5-fluorouracil (5-FU) and folinic acid (FA) in patients (pts) with metastatic colorectal cancer (CRC) expressing the epidermal growth factor receptor (EGFR). Preliminary safety and efficacy results. Proc Am Soc Clin Oncol 2003; 22: 264 (Abstr 1058).
    • (2003) Proc. Am. Soc. Clin. Oncol. , vol.22 , pp. 264
    • Van Laethem, J.-L.1    Raoul, J.-L.2    Mitry, E.3
  • 16
    • 0347615106 scopus 로고    scopus 로고
    • A phase I PK and serial tumor and skin pharmacodynamic (PD) study of weekly (q1w), every 2-week (q2w) or every 3-week (q3w) 1-hour (h) infusion EMD72000, a humanized monoclonal anti-epidermal growth factor receptor (EGFR) antibody, in patients (pt) with advanced tumors
    • (Abstr 770)
    • Tabernero J, Rojo F, Jimenez E et al. A phase I PK and serial tumor and skin pharmacodynamic (PD) study of weekly (q1w), every 2-week (q2w) or every 3-week (q3w) 1-hour (h) infusion EMD72000, a humanized monoclonal anti-epidermal growth factor receptor (EGFR) antibody, in patients (pt) with advanced tumors. Proc Am Soc Clin Oncol 2003; 22: 192 (Abstr 770).
    • (2003) Proc. Am. Soc. Clin. Oncol. , vol.22 , pp. 192
    • Tabernero, J.1    Rojo, F.2    Jimenez, E.3
  • 17
    • 1542344622 scopus 로고    scopus 로고
    • Phase I study of the humanized antiepidermal growth factor receptor monoclonal antibody EMD72000 in patients with advanced solid tumors that express the epidermal growth factor receptor
    • Vanhoefer U, Tewes M, Rojo F et al. Phase I study of the humanized antiepidermal growth factor receptor monoclonal antibody EMD72000 in patients with advanced solid tumors that express the epidermal growth factor receptor. J Clin Oncol 2004; 22: 175-184.
    • (2004) J. Clin. Oncol. , vol.22 , pp. 175-184
    • Vanhoefer, U.1    Tewes, M.2    Rojo, F.3
  • 18
    • 0347426783 scopus 로고    scopus 로고
    • Multicenter study of ABX-EGF monotherapy in patients with metastatic colorectal cancer
    • (Abstr 1026)
    • Meropol NJ, Berlin J, Hecht JR et al. Multicenter study of ABX-EGF monotherapy in patients with metastatic colorectal cancer. Proc Am Soc Clin Oncol 2003; 22: 256 (Abstr 1026).
    • (2003) Proc. Am. Soc. Clin. Oncol. , vol.22 , pp. 256
    • Meropol, N.J.1    Berlin, J.2    Hecht, J.R.3
  • 19
    • 0012097763 scopus 로고    scopus 로고
    • A translational research study of ZD1839 at a dose of 750mg in patients with pretreated advanced or metastatic colorectal cancer: NCIC CTG IND.122
    • (Abstr 264PD)
    • Seymour L, Goss G, Stewart D et al. A translational research study of ZD1839 at a dose of 750mg in patients with pretreated advanced or metastatic colorectal cancer: NCIC CTG IND.122. Ann Oncol 2002; 13 (Suppl 5): 73 (Abstr 264PD).
    • (2002) Ann. Oncol. , vol.13 , Issue.SUPPL. 5 , pp. 73
    • Seymour, L.1    Goss, G.2    Stewart, D.3
  • 20
    • 0345636045 scopus 로고    scopus 로고
    • Phase II study of erlotinib (OSI-774) in patients with metastatic colorectal cancer
    • (Abstr 785)
    • Oza AM, Townsley CA, Siu LL et al. Phase II study of erlotinib (OSI-774) in patients with metastatic colorectal cancer. Proc Am Soc Clin Oncol 2003; 22: 196 (Abstr 785).
    • (2003) Proc. Am. Soc. Clin. Oncol. , vol.22 , pp. 196
    • Oza, A.M.1    Townsley, C.A.2    Siu, L.L.3
  • 21
    • 0042213489 scopus 로고    scopus 로고
    • A phase II study of gefitinib in combination with FOLFOX-4 (IFOX) in patients with unresectable or metastatic colorectal cancer
    • (Abstr 1062)
    • Cho CD, Fisher GA, Halsey J et al. A phase II study of gefitinib in combination with FOLFOX-4 (IFOX) in patients with unresectable or metastatic colorectal cancer. Proc Am Soc Clin Oncol 2003; 22: 265 (Abstr 1062).
    • (2003) Proc. Am. Soc. Clin. Oncol. , vol.22 , pp. 265
    • Cho, C.D.1    Fisher, G.A.2    Halsey, J.3
  • 22
    • 4444315825 scopus 로고    scopus 로고
    • Erlotinib HCl in combination with FOLFOX-4 in patients with advanced solid tumors
    • (Abstr 789)
    • Hanauske AR, Diaz-Rubio E, Cassidy J et al. Erlotinib HCl in combination with FOLFOX-4 in patients with advanced solid tumors. Proc Am Soc Clin Oncol 2003; 22: 197 (Abstr 789).
    • (2003) Proc. Am. Soc. Clin. Oncol. , vol.22 , pp. 197
    • Hanauske, A.R.1    Diaz-Rubio, E.2    Cassidy, J.3
  • 24
    • 0029881276 scopus 로고    scopus 로고
    • Microvessel quantification and its possible relation with liver metastasis in colorectal cancer
    • Tomisaki S, Ohno S, Ichiyoshi Y et al. Microvessel quantification and its possible relation with liver metastasis in colorectal cancer. Cancer 1996; 77: 1722-1728.
    • (1996) Cancer , vol.77 , pp. 1722-1728
    • Tomisaki, S.1    Ohno, S.2    Ichiyoshi, Y.3
  • 25
    • 0030037264 scopus 로고    scopus 로고
    • Angiogenesis as an unfavorable prognostic factor in human colorectal carcinoma
    • Takebayashi Y, Akiyama S, Yamada K et al. Angiogenesis as an unfavorable prognostic factor in human colorectal carcinoma. Cancer 1996; 78: 226-231.
    • (1996) Cancer , vol.78 , pp. 226-231
    • Takebayashi, Y.1    Akiyama, S.2    Yamada, K.3
  • 26
    • 0030615084 scopus 로고    scopus 로고
    • Tumor angiogenesis and mode of metastasis in patients with colorectal cancer
    • Tanigawa N, Amaya H, Matsumura M et al. Tumor angiogenesis and mode of metastasis in patients with colorectal cancer. Cancer Res 1997; 57: 1043-1046.
    • (1997) Cancer Res. , vol.57 , pp. 1043-1046
    • Tanigawa, N.1    Amaya, H.2    Matsumura, M.3
  • 27
    • 0037699955 scopus 로고    scopus 로고
    • Angiogenesis in health and disease
    • Carmeliet P. Angiogenesis in health and disease. Nat Med 2003; 9: 653-660.
    • (2003) Nat. Med. , vol.9 , pp. 653-660
    • Carmeliet, P.1
  • 28
    • 84970070220 scopus 로고
    • Expression of vascular endothelial growth factor and its receptor, KDR, correlates with vascularity, metastasis, and proliferation of human colon cancer
    • Takahashi Y, Kitadai Y, Bucana CD et al. Expression of vascular endothelial growth factor and its receptor, KDR, correlates with vascularity, metastasis, and proliferation of human colon cancer. Cancer Res 1995; 55: 3964-3968.
    • (1995) Cancer Res. , vol.55 , pp. 3964-3968
    • Takahashi, Y.1    Kitadai, Y.2    Bucana, C.D.3
  • 29
    • 0028935608 scopus 로고
    • Regulation by vascular endothelial growth factor of human colon cancer tumorigenesis in a mouse model of experimental liver metastasis
    • Warren RS, Yuan H, Matli MR et al. Regulation by vascular endothelial growth factor of human colon cancer tumorigenesis in a mouse model of experimental liver metastasis. J Clin Invest 1995; 95: 1789-1797.
    • (1995) J. Clin. Invest. , vol.95 , pp. 1789-1797
    • Warren, R.S.1    Yuan, H.2    Matli, M.R.3
  • 30
    • 0032806309 scopus 로고    scopus 로고
    • Importance of VEGF for breast cancer angiogenesis in vivo: Implications from intravital microscopy of combination treatments with an anti-VEGF neutralizing monoclonal antibody and doxorubicin
    • Borgström P, Gold DP, Hillan KJ et al. Importance of VEGF for breast cancer angiogenesis in vivo: Implications from intravital microscopy of combination treatments with an anti-VEGF neutralizing monoclonal antibody and doxorubicin. Anticancer Res 1999; 19: 4203-4214.
    • (1999) Anticancer Res. , vol.19 , pp. 4203-4214
    • Borgström, P.1    Gold, D.P.2    Hillan, K.J.3
  • 31
    • 0037208589 scopus 로고    scopus 로고
    • Phase II randomized trial comparing Bevacizumab plus Fluorouracil (FU)/Leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer
    • Kabbinavar F, Hurwitz HI, Fehrenbacher L et al. Phase II randomized trial comparing Bevacizumab plus Fluorouracil (FU)/Leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer. J Clin Oncol 2003; 21: 60-65.
    • (2003) J. Clin. Oncol. , vol.21 , pp. 60-65
    • Kabbinavar, F.1    Hurwitz, H.I.2    Fehrenbacher, L.3
  • 32
    • 0043177668 scopus 로고    scopus 로고
    • Bevacizumab (a monoclonal antibody to vascular endothelial growth factor) prolongs survival in first-line colorectal cancer (CRC): Results of a phase III trial of bevacizumab in combination with bolus IFL (irinotecan, 5-fluorouracil, leucovorin) as first-line therapy in subjects with metastatic CRC
    • (Abstr 3646)
    • Hurwitz H, Fehrenbacher L, Cartwright T et al. Bevacizumab (a monoclonal antibody to vascular endothelial growth factor) prolongs survival in first-line colorectal cancer (CRC): Results of a phase III trial of bevacizumab in combination with bolus IFL (irinotecan, 5-fluorouracil, leucovorin) as first-line therapy in subjects with metastatic CRC. Proc Am Soc Clin Oncol 2003; 22: (Abstr 3646).
    • (2003) Proc. Am. Soc. Clin. Oncol. , pp. 22
    • Hurwitz, H.1    Fehrenbacher, L.2    Cartwright, T.3
  • 33
    • 1842569206 scopus 로고    scopus 로고
    • A randomized controlled trial of fluorouracil plus leucovorin, irinotecan and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer
    • Goldberg RM, Sargent DJ, Morton RF et al. A randomized controlled trial of fluorouracil plus leucovorin, irinotecan and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer. J Clin Oncol 2004; 22: 1-8.
    • (2004) J. Clin. Oncol. , vol.22 , pp. 1-8
    • Goldberg, R.M.1    Sargent, D.J.2    Morton, R.F.3
  • 34
    • 0033998238 scopus 로고    scopus 로고
    • Vascular endothelial growth factor in human colon cancer: Biology and therapeutic implications
    • Ellis LM, Takahashi Y, Liu W, Shaheen RM. Vascular endothelial growth factor in human colon cancer: biology and therapeutic implications. Oncologist 2000; 5 (Suppl 1): 11-15.
    • (2000) Oncologist , vol.5 , Issue.SUPPL. 1 , pp. 11-15
    • Ellis, L.M.1    Takahashi, Y.2    Liu, W.3    Shaheen, R.M.4
  • 35
    • 0032893263 scopus 로고    scopus 로고
    • SU5416 is a potent and selective inhibitor of the vascular endothelial growth receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types
    • Fong TAT, Shawver LK, Sun L et al. SU5416 is a potent and selective inhibitor of the vascular endothelial growth receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types. Cancer Res 1999; 59: 99-106.
    • (1999) Cancer Res. , vol.59 , pp. 99-106
    • Fong, T.A.T.1    Shawver, L.K.2    Sun, L.3
  • 36
    • 0033107767 scopus 로고    scopus 로고
    • Inhibition of tumor growth, angiogenesis and microcirculation by the novel Flk-1 inhibitor SU5416 as assessed by intravital multi-fluorescence videomicroscopy
    • Vajkoczy P, Menger MD, Vollmar B et al. Inhibition of tumor growth, angiogenesis and microcirculation by the novel Flk-1 inhibitor SU5416 as assessed by intravital multi-fluorescence videomicroscopy. Neoplasia 1999; 1: 31-41.
    • (1999) Neoplasia , vol.1 , pp. 31-41
    • Vajkoczy, P.1    Menger, M.D.2    Vollmar, B.3
  • 37
    • 0033231069 scopus 로고    scopus 로고
    • Antiangiogenic therapy targeting the tyrosine kinase receptor for vascular endothelial growth factor receptor inhibits the growth of colon cancer liver metastasis and induces tumor and endothelial cell apoptosis
    • Shaheen RM, Davis DW, Liu W et al. Antiangiogenic therapy targeting the tyrosine kinase receptor for vascular endothelial growth factor receptor inhibits the growth of colon cancer liver metastasis and induces tumor and endothelial cell apoptosis. Cancer Res 1999; 59: 5412-5416.
    • (1999) Cancer Res. , vol.59 , pp. 5412-5416
    • Shaheen, R.M.1    Davis, D.W.2    Liu, W.3
  • 38
    • 0035866334 scopus 로고    scopus 로고
    • Tyrosine kinase inhibition of multiple angiogenic growth factors receptors improves survival in mice bearing colon cancer liver metastases by inhibition of endothelial cell survival mechanisms
    • Shaheen RM, Tseng WW, Davis DW et al. Tyrosine kinase inhibition of multiple angiogenic growth factors receptors improves survival in mice bearing colon cancer liver metastases by inhibition of endothelial cell survival mechanisms. Cancer Res 2001; 61: 1464-1468.
    • (2001) Cancer Res. , vol.61 , pp. 1464-1468
    • Shaheen, R.M.1    Tseng, W.W.2    Davis, D.W.3
  • 39
    • 0347615101 scopus 로고    scopus 로고
    • Dynamic contrast-enhanced magnetic resonance imaging as a biomarker for the pharmacological response of PTK787/ZK 222584, an inhibitor of the vascular endothelial growth factor tyrosine kinases, in patients with advanced colorectal cancer and liver metastases: Results from two phase I studies
    • Morgan B, Thomas AL, Drevs J et al. Dynamic contrast-enhanced magnetic resonance imaging as a biomarker for the pharmacological response of PTK787/ZK 222584, an inhibitor of the vascular endothelial growth factor tyrosine kinases, in patients with advanced colorectal cancer and liver metastases: results from two phase I studies. J Clin Oncol 2003; 21: 3955-3964.
    • (2003) J. Clin. Oncol. , vol.21 , pp. 3955-3964
    • Morgan, B.1    Thomas, A.L.2    Drevs, J.3
  • 40
    • 0027993458 scopus 로고
    • Upregulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas
    • Eberhart CE, Coffey RJ, Radhika A et al. Upregulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas. Gastroenterology 1994; 107: 1183-1188.
    • (1994) Gastroenterology , vol.107 , pp. 1183-1188
    • Eberhart, C.E.1    Coffey, R.J.2    Radhika, A.3
  • 41
    • 0030947525 scopus 로고    scopus 로고
    • Inhibition of tumour cell growth by selective inhibition of cyclo-oxygenase-2
    • Sheng H, Shao J, Kirkland SC et al. Inhibition of tumour cell growth by selective inhibition of cyclo-oxygenase-2. J Clin Invest 1997; 99: 2254-2259.
    • (1997) J. Clin. Invest. , vol.99 , pp. 2254-2259
    • Sheng, H.1    Shao, J.2    Kirkland, S.C.3
  • 42
    • 17744418769 scopus 로고    scopus 로고
    • The effect of celecoxib in familial adenomatous polyposis
    • Steinbach G, Lynch PM, Philips RK et al. The effect of celecoxib in familial adenomatous polyposis. N Engl J Med 2000; 342: 1946-1952.
    • (2000) N. Engl. J. Med. , vol.342 , pp. 1946-1952
    • Steinbach, G.1    Lynch, P.M.2    Philips, R.K.3
  • 43
    • 0034326837 scopus 로고    scopus 로고
    • Celecoxib prevents tumor growth in vivo without toxicity to normal gut: Lack of correlation between in vitro and in vivo models
    • Williams CS, Watson AJ, Sheng H et al. Celecoxib prevents tumor growth in vivo without toxicity to normal gut: lack of correlation between in vitro and in vivo models. Cancer Res 2000; 60: 6045-6051.
    • (2000) Cancer Res. , vol.60 , pp. 6045-6051
    • Williams, C.S.1    Watson, A.J.2    Sheng, H.3
  • 44
    • 0037108880 scopus 로고    scopus 로고
    • Cyclooxygenase-2 inhibition with celecoxib enhances antitumor efficacy and reduces diarrhea side effects of CPT-11
    • Trifan OC, Durham WF, Salazar VS et al. Cyclooxygenase-2 inhibition with celecoxib enhances antitumor efficacy and reduces diarrhea side effects of CPT-11. Cancer Res 2002; 62: 5778-5784.
    • (2002) Cancer Res. , vol.62 , pp. 5778-5784
    • Trifan, O.C.1    Durham, W.F.2    Salazar, V.S.3
  • 45
    • 0012887529 scopus 로고    scopus 로고
    • Celecoxib attenuated capecitabine induced hand-and-foot syndrome (HFS) and diarrhea and improved time to tumor progression in metastatic colorectal cancer (MCRC)
    • (Abstr 2364)
    • Lin EH, Morris J, Chau NK et al. Celecoxib attenuated capecitabine induced hand-and-foot syndrome (HFS) and diarrhea and improved time to tumor progression in metastatic colorectal cancer (MCRC). Proc Am Soc Clin Oncol 2002; 21: 138b (Abstr 2364).
    • (2002) Proc. Am. Soc. Clin. Oncol. , vol.21
    • Lin, E.H.1    Morris, J.2    Chau, N.K.3
  • 46
    • 0000539777 scopus 로고    scopus 로고
    • A phase II trial of celecoxib (CX), irinotecan (I), 5-fluorouracil (5FU), and leucovorin (LCV) in patients (pts) with unresectable or metastatic colorectal cancer (CRC)
    • (Abstr 505)
    • Blankem CD, Benson AB, Dragovich T et al. A phase II trial of celecoxib (CX), irinotecan (I), 5-fluorouracil (5FU), and leucovorin (LCV) in patients (pts) with unresectable or metastatic colorectal cancer (CRC). Proc Am Soc Clin Oncol 2002; 21: 127a (Abstr 505).
    • (2002) Proc. Am. Soc. Clin. Oncol. , vol.21
    • Blankem, C.D.1    Benson, A.B.2    Dragovich, T.3
  • 47
    • 3042812558 scopus 로고    scopus 로고
    • A phase II study of irinotecan (I), 5-fluorouracil (F), leucovorin (L) (IFL), celecoxib and glutamine as first line therapy for advanced colorectal cancer (CRC): A Hoosier Oncology Group Study
    • (Abstr 1347)
    • Pan C, Loehrer P, Juliar R et al. A phase II study of irinotecan (I), 5-fluorouracil (F), leucovorin (L) (IFL), celecoxib and glutamine as first line therapy for advanced colorectal cancer (CRC): A Hoosier Oncology Group Study. Proc Am Soc Clin Oncol 2003; 22: 335 (Abstr 1347).
    • (2003) Proc. Am. Soc. Clin. Oncol. , vol.22 , pp. 335
    • Pan, C.1    Loehrer, P.2    Juliar, R.3
  • 48
    • 3042855424 scopus 로고    scopus 로고
    • A phase II study of 5-fluorouracil (5-FU) and leucovorin calcium (LV) plus open-label rofecoxib in patients with metastatic colorectal cancer
    • (Abstr 2240)
    • Becerra CR, Frenkel EP, Gaynor R et al. A phase II study of 5-fluorouracil (5-FU) and leucovorin calcium (LV) plus open-label rofecoxib in patients with metastatic colorectal cancer. Proc Am Soc Clin Oncol 2002; 21: 107b (Abstr 2240).
    • (2002) Proc. Am. Soc. Clin. Oncol. , vol.21
    • Becerra, C.R.1    Frenkel, E.P.2    Gaynor, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.