Design, synthesis, and pharmacological evaluation of thapsigargin analogues for targeting apoptosis to prostatic cancer cells

Journal of Medicinal Chemistry

Volumn 44, Issue 26, 2001, Pages 4696-4703

  Jakobsen, C M ^a   Denmeade, S R ^b   Isaacs, J T ^b   Gady, A ^b   Olsen, C E ^c   Christensen, S B ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; O 8 DEBUTANOYLTHAPSIGARGIN; PENAM DERIVATIVE; PRODRUG; PROSTATE SPECIFIC ANTIGEN; THAPSIGARGIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CALCIUM TRANSPORT; CANCER CELL CULTURE; DRUG CONJUGATION; DRUG DESIGN; ENZYME ACTIVITY; ESTERIFICATION; EXTRACELLULAR FLUID; LIPOPHILICITY; PROSTATE CANCER; PROTON NUCLEAR MAGNETIC RESONANCE; SARCOPLASMIC RETICULUM; SKELETAL MUSCLE; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CALCIUM; CALCIUM-TRANSPORTING ATPASES; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MALE; MUSCLE, SKELETAL; PROSTATIC NEOPLASMS; RABBITS; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; STRUCTURE-ACTIVITY RELATIONSHIP; THAPSIGARGIN; TUMOR CELLS, CULTURED;

EID: 0035924210     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010985a     Document Type: Article

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