Effect of erythropoietin on endothelial cell apoptosis induced by high glucose

Diabetes Research and Clinical Practice

Volumn 66, Issue SUPPL., 2004, Pages

  Sekiguchi, Naotaka ^a   Inoguchi, Toyoshi ^a   Kobayashi, Kunihisa ^a   Nawata, Hajime ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

Apoptosis; Diabetic nephropathy; Endothelial cell; Erythropoietin

Indexed keywords

ERYTHROPOIETIN; GLUCOSE;

APOPTOSIS; ARTERY ENDOTHELIUM; CONCENTRATION RESPONSE; CONFERENCE PAPER; CONTROLLED STUDY; DRUG EFFECT; ENDOTHELIUM CELL; ENZYME ACTIVITY; HUMAN; HUMAN CELL; NICK END LABELING; PROTEIN PHOSPHORYLATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; AORTA; APOPTOSIS; CASPASE 3; CASPASES; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; ERYTHROPOIETIN; GLUCOSE; HUMANS; IN SITU NICK-END LABELING; PHOSPHORYLATION;

EID: 9644283149     PISSN: 01688227     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.diabres.2004.05.007     Document Type: Conference Paper

References (27)

1. O'Brien B.A., Harmon B.V., Cameron D.P., Allan D.J. Apoptosis is the mode of beta-cell death responsible for the development of IDDM in the nonobese diabetic (NOD) mouse. Diabetes. 46:1997;750-757
2. Lupi R., Dotta F., Marselli L., et al. Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated. Diabetes. 51:2002;1437-1442
3. Gorogawa S., Kajimoto Y., Umayahara Y., et al. Probucol preserves pancreatic beta-cell function through reduction of oxidative stress in type 2 diabetes. Diab. Res. Clin. Pract. 57:2002;1-10
4. Laybutt D.R., Weir G.C., Kaneto H., et al. Overexpression of c-Myc in beta-cells of transgenic mice causes proliferation and apoptosis, downregulation of insulin gene expression, and diabetes. Diabetes. 51:2002;1793-1804
5. Savinov A.Y., Tcherepanov A., Green E.A., Flavell R.A., Chervonsky A.V. Contribution of Fas to diabetes development. Proc. Natl. Acad. Sci. U.S.A. 100:2003;628-632
6. Mizutani M., Kern T.S., Lorenzi M. Accelerated death of retinal microvascular cells in human and experimental diabetic retinopathy. J. Clin. Invest. 97:1996;2883-2890
7. Podesta F., Romeo G., Liu W.H., et al. Bax is increased in the retina of diabetic subjects and is associated with pericyte apoptosis in vivo and in vitro. Am. J. Pathol. 156:2000;1025-1032
8. Mohr S., Xi X., Tang J., Kern T.S. Caspase activation in retinas of diabetic and galactosemic mice and diabetic patients. Diabetes. 51:2002;1172-1179
9. Yamagishi S., Inagaki Y., Okamoto T., et al. Advanced glycation end product-induced apoptosis and overexpression of vascular endothelial growth factor and monocyte chemoattractant protein-1 in human-cultured mesangial cells. J. Biol. Chem. 277:2002;20309-20315
10. Baumgartner-Parzer S.M., Wagner L., Pettermann M., Grillari J., Gessl A., Waldhausl W. High-glucose-triggered apoptosis in cultured endothelial cells. Diabetes. 44:1995;1323-1327
11. Ho F.M., Liu S.H., Liau C.S., Huang P.J., Lin-Shiau S.Y. High glucose-induced apoptosis in human endothelial cells is mediated by sequential activations of c-Jun NH(2)-terminal kinase and caspase-3. Circulation. 101:2000;2618-2624
12. Min C., Kang E., Yu S.H., Shinn S.H., Kim Y.S. Advanced glycation end products induce apoptosis and procoagulant activity in cultured human umbilical vein endothelial cells. Diab. Res. Clin. Pract. 46:1999;197-202
13. Artwohl M., Graier W.F., Roden M., et al. Diabetic LDL triggers apoptosis in vascular endothelial cells. Diabetes. 52:2003;1240-1247
14. Schmeichel A.M., Schmelzer J.D., Low P.A. Oxidative injury and apoptosis of dorsal root ganglion neurons in chronic experimental diabetic neuropathy. Diabetes. 52:2003;165-171
15. Celik M., Gokmen N., Erbayraktar S. Erythropoietin prevents motor neuron apoptosis and neurologic disability in experimental spinal cord ischemic injury. Proc. Natl. Acad. Sci. U.S.A. 99:2002;2258-2263
16. Siren A.L., Fratelli M., Brines M., et al. Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress. Proc. Natl. Acad. Sci. U.S.A. 98:2001;4044-4049
17. Bossy-Wetzel E., Newmeyer D.D., Green D.R. Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization. EMBO J. 17:1998;37-49
18. Xu J., Yeh C.H., Chen S., et al. Involvement of de novo ceramide biosynthesis in tumor necrosis factor-alpha/cycloheximide-induced cerebral endothelial cell death. J. Biol. Chem. 273:1998;16521-16526
19. Thornberry N.A., Lazebnik Y. Caspases: enemies within. Science. 281:1998;1312-1316
20. Sun X.M., MacFarlane M., Zhuang J., Wolf B.B., Green D.R., Cohen G.M. Distinct caspase cascades are initiated in receptor-mediated and chemical-induced apoptosis. J. Biol. Chem. 274:1999;5053-5060
21. Du X.L., Sui G.Z., Stockklauser-Farber K., et al. Introduction of apoptosis by high proinsulin and glucose in cultured human umbilical vein endothelial cells is mediated by reactive oxygen species. Diabetologia. 41:1998;249-256
22. Baynes J.W., Thorpe S.R. Role of oxidative stress in diabetic complications: a new perspective on an old paradigm. Diabetes. 48:1999;1-9
23. Roy S. Caspases at the heart of the apoptotic cell death pathway. Chem. Res. Toxicol. 13:2000;961-962
24. Wu W., Lee W.L., Wu Y.Y., et al. Expression of constitutively active phosphatidylinositol 3-kinase inhibits activation of caspase-3 and apoptosis of cardiac muscle cells. J. Biol. Chem. 275:2000;40113-40119
25. Brines M.L., Ghezzi P., Keenan S., et al. Erythropoietin crosses the blood-brain barrier to protect against experimental brain injury. Proc. Natl. Acad. Sci. U.S.A. 97:2000;10526-10531
26. Grimm C., Wenzel A., Groszer M., et al. HIF-1-induced erythropoietin in the hypoxic retina protects against light-induced retinal degeneration. Nat. Med. 8:2002;718-724
27. Anagnostou A., Liu Z., Steiner M., et al. Erythropoietin receptor mRNA expression in human endothelial cells. Proc. Natl. Acad. Sci. U.S.A. 91:1994;3974-3978